Search Results - "BRANSTETTER, Bryan J"

Characterization of 2-(2,6-dichloro-benzyl)-thiazolo[5,4- d]pyrimidin-7-yl]-(4-trifluoromethyl-phenyl)-amine (JNJ-39729209) as a novel TRPV1 antagonist by Maher, Michael P., Bhattacharya, Anindya, Ao, Hong, Swanson, Nadia, Wu, Nyan-Tsz, Freedman, Jamie, Kansagara, Mena, Scott, Brian, Li, Dong H., Eckert, William A., Liu, Yi, Sepassi, Kia, Rizzolio, Michele, Fitzgerald, Anne, Liu, Jing, Branstetter, Bryan J., Rech, Jason C., Lebsack, Alec D., Breitenbucher, J. Guy, Wickenden, Alan D., Chaplan, Sandra R.

“…As an integrator of multiple nociceptive and/or inflammatory stimuli, TRPV1 is an attractive therapeutic target for the treatment of various painful disorders…”
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The discovery and preclinical characterization of 6-chloro-N-(2-(4,4-difluoropiperidin-1-yl)-2-(2-(trifluoromethyl)pyrimidin-5-yl)ethyl)quinoline-5-carboxamide based P2X7 antagonists by Rech, Jason C., Bhattacharya, Anindya, Branstetter, Bryan J., Love, Christopher J., Leenaerts, Joseph E., Cooymans, Ludwig P., Eckert, William A., Ao, Hong, Wang, Qi, Chaplan, Sandra R., Wickenden, Alan D., Lebsack, Alec D., Breitenbucher, J. Guy

“…[Display omitted] The synthesis, SAR and preclinical characterization of a series of…”
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Discovery and synthesis of 6,7,8,9-tetrahydro-5H-pyrimido-[4,5-d]azepines as novel TRPV1 antagonists by HAWRYLUK, Natalie A, MERIT, Jeffrey E, FREEDMAN, Jamie M, SCOTT, Brian P, WICKENDEN, Alan D, CHAPLAN, Sandra R, BREITENBUCHER, J. Guy, LEBSACK, Alec D, BRANSTETTER, Bryan J, HACK, Michael D, SWANSON, Nadia, HONG AO, MAHER, Michael P, BHATTACHARYA, Anindya, QI WANG

“…Utilization of a tetrahydro-pyrimdoazepine core as a bioisosteric replacement for a piperazine-urea resulted in the discovery a novel series of potent…”
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Identification and synthesis of 2,7-diamino-thiazolo[5,4- d]pyrimidine derivatives as TRPV1 antagonists by Lebsack, Alec D., Branstetter, Bryan J., Hack, Michael D., Xiao, Wei, Peterson, Matthew L., Nasser, Nadia, Maher, Michael P., Ao, Hong, Bhattacharya, Anindya, Kansagara, Mena, Scott, Brian P., Luo, Lin, Rynberg, Raymond, Rizzolio, Michele, Chaplan, Sandra R., Wickenden, Alan D., Guy Breitenbucher, J.

“…The identification and synthesis of 2,7-diamino-thiazolo[5,4- d]pyrimidines as TRPV1 antagonists is described. An exploration of the structure–activity…”
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1,2-Diamino-ethane-substituted-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepines as TRPV1 antagonists with improved properties by LEBSACK, Alec D, RECH, Jason C, HONG AO, MAHER, Michael P, HERRMANN, Michelle, FREEDMAN, Jamie, SCOTT, Brian P, LIN LUO, BHATTACHARYA, Anindya, QI WANG, CHAPLAN, Sandra R, WICKENDEN, Alan D, BRANSTETTER, Bryan J, BREITENBUCHER, J. Guy, HAWRYLUK, Natalie A, MERIT, Jeffrey E, ALLISON, Brett, RYNBERG, Raymond, BUMA, Johnathan, RIZZOLIO, Michele, SWANSON, Nadia

“…Based upon a previously reported lead compound 1, a series of 1,2-diamino-ethane-substituted-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepines were synthesized and…”
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The discovery and preclinical characterization of 6-chloro-N-(2-(4,4-difluoropiperidin-1-yl)-2-(2-(trifluoromethyl)p y rimidin-5-yl)ethyl)quinoline-5-carboxamide based P2X7 antagonists by Rech, Jason C, Bhattacharya, Anindya, Branstetter, Bryan J, Love, Christopher J, Leenaerts, Joseph E, Cooymans, Ludwig P, Eckert, William A, Ao, Hong, Wang, Qi, Chaplan, Sandra R, Wickenden, Alan D, Lebsack, Alec D, Breitenbucher, JGuy

“…The synthesis, SAR and preclinical characterization of a series of 6-chloro-N-(2-(4,4-difluoropiperidin-1-yl)-2-(2-(trifluoromethyl)p y…”
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Discovery and synthesis of 6,7,8,9-tetrahydro-5 H-pyrimido-[4,5- d]azepines as novel TRPV1 antagonists by Hawryluk, Natalie A., Merit, Jeffrey E., Lebsack, Alec D., Branstetter, Bryan J., Hack, Michael D., Swanson, Nadia, Ao, Hong, Maher, Michael P., Bhattacharya, Anindya, Wang, Qi, Freedman, Jamie M., Scott, Brian P., Wickenden, Alan D., Chaplan, Sandra R., Breitenbucher, J. Guy

“…Utilization of a tetrahydro-pyrimdoazepine core as a bioisosteric replacement for a piperazine-urea resulted in the discovery a novel series of potent…”
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1,2-Diamino-ethane-substituted-6,7,8,9-tetrahydro-5 H-pyrimido[4,5- d]azepines as TRPV1 antagonists with improved properties by Lebsack, Alec D., Rech, Jason C., Branstetter, Bryan J., Hawryluk, Natalie A., Merit, Jeffrey E., Allison, Brett, Rynberg, Raymond, Buma, Johnathan, Rizzolio, Michele, Swanson, Nadia, Ao, Hong, Maher, Michael P., Herrmann, Michelle, Freedman, Jamie, Scott, Brian P., Luo, Lin, Bhattacharya, Anindya, Wang, Qi, Chaplan, Sandra R., Wickenden, Alan D., Breitenbucher, J. Guy

“…A series of 1,2-diamino-ethane-substituted-6,7,8,9-tetrahydro-5 H-pyrimido[4,5- d]azepines were synthesized and evaluated for improved physiochemical and…”
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