Search Results - "BRANCHEK, THERESA"

Antidepressant, anxiolytic and anorectic effects of a melanin-concentrating hormone-1 receptor antagonist by Forray, Carlos, Borowsky, Beth, Durkin, Margaret M, Ogozalek, Kristine, Marzabadi, Mohammad R, DeLeon, John, Heurich, Rainer, Lichtblau, Harvey, Shaposhnik, Zoya, Daniewska, Irena, Blackburn, Thomas P, Branchek, Theresa A, Gerald, Christophe, Vaysse, Pierre J

“…Melanin concentrating hormone (MCH) is an orexigenic hypothalamic neuropeptide, which plays an important role in the complex regulation of energy balance and…”
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Anxiolytic- and Antidepressant-like Profiles of the Galanin-3 Receptor ($Gal_3$) Antagonists SNAP 37889 and SNAP 398299 by Chad J. Swanson, Thomas P. Blackburn, Xuexiang Zhang, Zheng, Kang, Xu, Zhi-Qing David, Hökfelt, Tomas, Toni D. Wolinsky, Michael J. Konkel, Heidi Chen, Huailing Zhong, Mary W. Walker, Craig, Douglas A., Christophe P. G. Gerald, Branchek, Theresa A.

“…The neuropeptide galanin mediates its effects through the receptor subtypes$Gal_1$,$Gal_2$, and$Gal_3$and has been implicated in anxiety-and depression-related…”
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Galanin receptor subtypes by Branchek, Theresa A, Smith, Kelli E, Gerald, Christophe, Walker, Mary W

“…The neuropeptide galanin, which is widely expressed in brain and peripheral tissues, exerts a broad range of physiological effects. Pharmacological studies…”
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Identification and Characterization of Two G Protein-coupled Receptors for Neuropeptide FF by Bonini, James A., Jones, Kenneth A., Adham, Nika, Forray, Carlos, Artymyshyn, Roman, Durkin, Margaret M., Smith, Kelli E., Tamm, Joseph A., Boteju, Lakmal W., Lakhlani, Parul P., Raddatz, Rita, Yao, Wen-Jeng, Ogozalek, Kristine L., Boyle, Noel, Kouranova, Evguenia V., Quan, Yong, Vaysse, Pierre J., Wetzel, John M., Branchek, Theresa A., Gerald, Christophe, Borowsky, Beth

“…The central nervous system octapeptide, neuropeptide FF (NPFF), is believed to play a role in pain modulation and opiate tolerance. Two G protein-coupled…”
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Trace amine receptors as targets for novel therapeutics: legend, myth and fact by Branchek, Theresa A, Blackburn, Thomas P

“…Trace amines are attracting attention as neurotransmitters because they are believed to play a role in human disorders such as schizophrenia, depression,…”
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Trace Amines: Identification of a Family of Mammalian G Protein-Coupled Receptors by Borowsky, Beth, Adham, Nika, Jones, Kenneth A., Raddatz, Rita, Artymyshyn, Roman, Ogozalek, Kristine L., Durkin, Margaret M., Lakhlani, Parul P., Bonini, James A., Pathirana, Sudam, Boyle, Noel, Pu, Xiaosui, Kouranova, Evguenia, Lichtblau, Harvey, Ochoa, F. Yulina, Branchek, Theresa A., Gerald, Christophe

“…Tyramine, β-phenylethylamine, tryptamine, and octopamine are biogenic amines present in trace levels in mammalian nervous systems. Although some "trace amines"…”
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Molecular Biology and Pharmacology of Galanin Receptors by BRANCHEK, THERESA, SMITH, KELLI E., WALKER, MARY W.

“…: Galanin was first isolated 15 years ago. Diversity of galanin receptors has been suspected from the study of native tissues and functional responses to…”
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Distribution of a rat galanin receptor mRNA in rat brain by Gustafson, E L, Smith, K E, Durkin, M M, Gerald, C, Branchek, T A

“…In situ hybridization histochemistry has been employed to determine the distribution of the mRNA encoding a recently cloned rat galanin receptor (rGalR1). The…”
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5-HT1F receptor agonists inhibit neurogenic dural inflammation in guinea pigs by Johnson, Kirk W, Schaus, John M, Durkin, Margaret M, Audia, James E, Kaldor, Stephen W, Flaugh, Michael E, Adham, Nika, Zgombick, John M, Cohen, Marlene L, Branchek, Theresa A, Phebus, Lee A

“…THE serotonin (5-HT) receptor subtype mediating inhibition of neurogenic dural inflammation in guinea pigs was investigated using a series of serotonin…”
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Novel Potent 5-HT1F Receptor Agonists:  Structure−Activity Studies of a Series of Substituted N-[3-(1-Methyl-4-piperidinyl)-1H-pyrrolo[3,2-b]pyridin-5-yl]amides by Filla, Sandra A, Mathes, Brian M, Johnson, Kirk W, Phebus, Lee A, Cohen, Marlene L, Nelson, David L, Zgombick, John M, Erickson, Jon A, Schenck, Kathryn W, Wainscott, David B, Branchek, Theresa A, Schaus, John M

“…Compound 1a (LY334370), a selective 5-HT1F receptor agonist (SSOFRA), inhibited dural inflammation in the neurogenic plasma protein extravasation model of…”
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Cloning and Functional Expression of a Human Y4 Subtype Receptor for Pancreatic Polypeptide, Neuropeptide Y, and Peptide YY () by Bard, Jonathan A., Walker, Mary W., Branchek, Theresa A., Weinshank, Richard L.

“…The pancreatic polypeptide family includes pancreatic polypeptide (PP), neuropeptide Y (NPY), and peptide YY (PYY). Members of the PP family regulate numerous…”
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Identification and Characterization of Two Neuromedin U Receptors Differentially Expressed in Peripheral Tissues and the Central Nervous System by Raddatz, Rita, Wilson, Amy E., Artymyshyn, Roman, Bonini, James A., Borowsky, Beth, Boteju, Lakmal W., Zhou, Siqun, Kouranova, Evguenia V., Nagorny, Raisa, Guevarra, Maricel S., Dai, Meng, Lerman, Gabriel S., Vaysse, Pierre J., Branchek, Theresa A., Gerald, Christophe, Forray, Carlos, Adham, Nika

“…Two structurally related, G-protein-coupled receptors were identified as receptors for the neuropeptide, neuromedin U. This peptide is found in highest levels…”
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5-ht6 receptors as emerging targets for drug discovery by Branchek, T A, Blackburn, T P

“…5-ht6 receptors are the latest serotonin receptors to be identified by molecular cloning. Their high affinity for a wide range of drugs used in psychiatry,…”
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Expression of a Novel Neuropeptide Y Receptor Subtype Involved in Food Intake: An in Situ Hybridization Study of Y5 mRNA Distribution in Rat Brain by Durkin, Margaret M., Walker, Mary W., Smith, Kelli E., Gustafson, Eric L., Gerald, Christophe, Branchek, Theresa A.

“…Our group has reported on the cloning of a novel rat neuropeptide Y (NPY) receptor involved in NPY-induced food intake, the Y5 receptor. The distribution in…”
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The role of conserved aspartate and serine residues in ligand binding and in function of the 5‐HT1A receptor: A site‐directed mutation study by Ho, Begonia Y., Karschin, Andreas, Branchek, Theresa, Davidson, Norman, Lester, Henry A.

“…Wild‐type and mutant serotonin 1A receptors were transiently expressed in COS‐7 cells using the infection‐transfection variant of the vaccinia virus/ T7…”
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A receptor autoradiographic and in situ hybridization analysis of the distribution of the 5‐ht7 receptor in rat brain by Gustafson, Eric L., Durkin, Margaret M., Bard, Jonathan A., Zgombick, John, Branchek, Theresa A.

“…1 Receptor autoradiography and in situ hybridization histochemistry have been used to delineate the distribution of the 5‐ht7 receptor and its mRNA in rat…”
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Expression Cloning and Pharmacological Characterization of a Human Hippocampal Neuropeptide Y/Peptide YY Y2 Receptor Subtype () by Gerald, Christophe, Walker, Mary W., Vaysse, Pierre J.-J., He, Chaogang, Branchek, Theresa A., Weinshank, Richard L.

“…The pancreatic polypeptide family includes neuropeptide Y (NPY), one of the most abundant neuropeptides in the mammalian nervous system, as well as peptide YY…”
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Expression Cloning of a Rat Hypothalamic Galanin Receptor Coupled to Phosphoinositide Turnover by Smith, Kelli E., Forray, Carlos, Walker, Mary W., Jones, Kenneth A., Tamm, Joseph A., Bard, Jonathan, Branchek, Theresa A., Linemeyer, David L., Gerald, Christophe

“…The neuropeptide galanin is widely distributed throughout the central and peripheral nervous systems and participates in the regulation of processes such as…”
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Design, Synthesis and Evaluation of Substituted Triarylnipecotic Acid Derivatives as GABA Uptake Inhibitors: Identification of a Ligand with Moderate Affinity and Selectivity for the Cloned Human GABA Transporter GAT-3 by Dhar, T. G. Murali, Borden, Laurence A, Tyagarajan, Sriram, Smith, Kelli E, Branchek, Theresa A, Weinshank, Richard L, Gluchowski, Charles

“…gamma-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian central nervous system. Molecular biology has revealed the presence of…”
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Substituted furo[3,2-b]pyridines: novel bioisosteres of 5-HT1F receptor agonists by MATHES, Brian M, HUDZIAK, Kevin J, FILLA, Sandra A, SCHAUS, John M, XU, Yao-Chang, NELSON, David L, WAINSCOTT, David B, NUTTER, Suzanne E, GOUGH, Wendy H, BRANCHEK, Theresa A, ZGOMBICK, John M

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