Search Results - "BRADWELL, A. R."

Serum free light chains for monitoring multiple myeloma by Mead, G. P., Carr‐Smith, H. D., Drayson, M. T., Morgan, G. J., Child, J. A., Bradwell, A. R.

“…Summary Monoclonal immunoglobulin free light chains (FLC) are found in the serum and urine of patients with a number of B‐cell proliferative disorders,…”
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Suppression of uninvolved immunoglobulins defined by heavy/light chain pair suppression is a risk factor for progression of MGUS by Katzmann, J A, Clark, R, Kyle, R A, Larson, D R, Therneau, T M, Melton, L J, Benson, J T, Colby, C L, Dispenzieri, A, Landgren, O, Kumar, S, Bradwell, A R, Cerhan, J R, Rajkumar, S V

“…We hypothesized that the suppression of uninvolved immunoglobulin in monoclonal gammopathy of undetermined significance (MGUS) as detected by suppression of…”
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Quantitative analysis of serum free light chains: A new marker for the diagnostic evaluation of primary systemic amyloidosis by ABRAHAM, Roshini S, KATZMANN, Jerry A, CLARK, Raynell J, BRADWELL, A. R, KYLE, Robert A, GERTZ, Morie A

“…Primary systemic amyloidosis is a plasma cell dyscrasia characterized by the accumulation of excess free immunoglobulin light chains (FLCs) as amyloid. One of…”
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Effect of exercise on cerebral perfusion in humans at high altitude by Imray, C. H. E, Myers, S. D, Pattinson, K. T. S, Bradwell, A. R, Chan, C. W, Harris, S, Collins, P, Wright, A. D, Birmingham Medical Research Expeditionary Society

“…1 Coventry and Warwickshire County Vascular Unit, University Hospitals Coventry and Warwickshire National Health Service Trust, Coventry; 2 QinetiQ,…”
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Pituitary Tumor Transforming Gene and Fibroblast Growth Factor-2 Expression: Potential Prognostic Indicators in Differentiated Thyroid Cancer by Boelaert, K., McCabe, C. J., Tannahill, L. A., Gittoes, N. J. L., Holder, R. L., Watkinson, J. C., Bradwell, A. R., Sheppard, M. C., Franklyn, J. A.

“…Differentiated thyroid cancers are the most common endocrine cancers, but there are no reliable molecular markers of prognosis. Pituitary tumor transforming…”
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Hormonal and Biochemical Normalization and Tumor Shrinkage Induced by Anti-Parathyroid Hormone Immunotherapy in a Patient with Metastatic Parathyroid Carcinoma by Betea, D., Bradwell, A. R., Harvey, T. C., Mead, G. P., Schmidt-Gayk, H., Ghaye, B., Daly, A. F., Beckers, A.

“…Parathyroid carcinoma is a rare cause of primary hyperparathyroidism, and the efficacy of medical therapy and chemo- and radiotherapy is poor in recurrent or…”
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Highly Sensitive, Automated Immunoassay for Immunoglobulin Free Light Chains in Serum and Urine by Bradwell, Arthur R, Carr-Smith, Hugh D, Mead, Graham P, Tang, Lian X, Showell, Paul J, Drayson, Mark T, Drew, Roger

“…Bence Jones proteins or monoclonal immunoglobulin kappa and lambda free light chains (FLCs) are important markers for identifying and monitoring many patients…”
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Relationship between elevated immunoglobulin free light chain and the presence of IgH translocations in multiple myeloma by Kumar, S, Zhang, L, Dispenzieri, A, Van Wier, S, Katzmann, J A, Snyder, M, Blood, E, DeGoey, R, Henderson, K, Kyle, R A, Bradwell, A R, Greipp, P R, Rajkumar, S V, Fonseca, R

“…Elevated immunoglobulin free light chain (FLC) level and abnormal FLC ratio are commonly seen in multiple myeloma (MM) and have prognostic implications. We…”
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ATM Mutations and Phenotypes in Ataxia-Telangiectasia Families in the British Isles: Expression of Mutant ATM and the Risk of Leukemia, Lymphoma, and Breast Cancer by Stankovic, T., Kidd, A.M.J., Sutcliffe, A., McGuire, G.M., Robinson, P., Weber, P., Bedenham, T., Bradwell, A.R., Easton, D.F., Lennox, G.G., Haites, N., Byrd, P.J., Taylor, A.M.R.

“…We report the spectrum of 59 ATM mutations observed in ataxia-telangiectasia (A-T) patients in the British Isles. Of 51 ATM mutations identified in families…”
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Placental Iodothyronine Deiodinase Expression in Normal and Growth-Restricted Human Pregnancies by Chan, S., Kachilele, S., Hobbs, E., Bulmer, J. N., Boelaert, K., McCabe, C. J., Driver, P. M., Bradwell, A. R., Kester, M., Visser, T. J., Franklyn, J. A., Kilby, M. D.

“…We have described the expression of specific iodothyronine deiodinase mRNAs (using quantitative RT-PCR) and activities in normal human placentas throughout…”
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Acetazolamide can impair exercise performance; it depends upon the cohort studied by Joyce, K E, Lucas, S J E, Bradwell, A R

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Immunoglobulin heavy/light chain ratios improve paraprotein detection and monitoring, identify residual disease and correlate with survival in multiple myeloma patients by Ludwig, H, Milosavljevic, D, Zojer, N, Faint, J M, Bradwell, A R, Hübl, W, Harding, S J

“…The novel heavy/light chain (HLC) assay was used for the detection and measurement of monoclonal immunoglobulins, response evaluation and prognostication. This…”
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Effects of breathing air containing 3% carbon dioxide, 35% oxygen or a mixture of 3% carbon dioxide/35% oxygen on cerebral and peripheral oxygenation at 150 m and 3459 m by Imray, C H E, Walsh, S, Clarke, T, Tiivas, C, Hoar, H, Harvey, T C, Chan, C W M, Forster, P J G, Bradwell, A R, Wright, A D

“…The effects of gas mixtures comprising supplementary 3% carbon dioxide, 35% oxygen or a combination of 3% CO(2) plus 35% O(2) in ambient air have been compared…”
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Control of hypercalcaemia of parathyroid carcinoma by immunisation by Bradwell, Arthur R, Harvey, Timothy C

“…Patients with parathyroid tumours can develop extreme hypercalcaemia and osteitis fibrosa cystica. Clinical features result from the action of parathyroid…”
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Structure, function and properties of antibody binding sites by Mian, I S, Bradwell, A R, Olson, A J

“…Do antibody combining sites possess general properties that enable them to bind different antigens with varying affinities and to bind novel antigens? Here, we…”
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Identification of susceptibility loci for insulin-dependent diabetes mellitus by trans-racial gene mapping by Todd, J. A, Mijovic, C, Fletcher, J, Jenkins, D, Bradwell, A. R, Barnett, A. H

“…INSULIN-dependent (type I) diabetes mellitus (IDDM) follows an autoimmune destruction of the insulin-producing beta-cells of the pancreas. Family and…”
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Immunoglobulin heavy/light chain ratios improve paraprotein detection and monitoring, identify residual disease and correlate with survival in multiple myeloma patients by Ludwig, H, Milosavljevic, D, Zojer, N, Faint, J.M, Bradwell, A.R, Hubl, W, Harding, S.J

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Paraneoplastic neurological syndromes associated with Yo, Hu, and Ri autoantibodies by Bradwell, A R

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Serum free light-chain measurements for identifying and monitoring patients with nonsecretory multiple myeloma by Drayson, Mark, Tang, Lian X., Drew, Roger, Mead, Graham P., Carr-Smith, Hugh, Bradwell, Arthur R.

“…Using sensitive, automated immunoassays, increased concentrations of either κ or λ free light chains (and abnormal κ/λ ratios) were detected in the sera of 19…”
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Capillary filtration coefficient and urinary albumin leak at altitude by LEWIS, D. M., BRADWELL, A. R., SHORE, A. C., BEAMAN, M., TOOKE, J. E.

“…Rapid ascent to altitude risks the development of acute mountain sickness. This study demonstrates changes in peripheral capillary filtration coefficient and…”
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