Search Results - "BRADBURY, N. A"

Mcl-1 promotes lung cancer cell migration by directly interacting with VDAC to increase mitochondrial Ca2+ uptake and reactive oxygen species generation by Huang, H, Shah, K, Bradbury, N A, Li, C, White, C

“…Mcl-1 is an antiapoptotic member of the Bcl-2 family frequently upregulated in non-small cell lung carcinoma (NSCLC). We now report the physiological…”
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Role of membrane trafficking in plasma membrane solute transport by Bradbury, N A, Bridges, R J

“…Cells can rapidly and reversibly alter solute transport rates by changing the kinetics of transport proteins resident within the plasma membrane. Most notably,…”
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Regulation of Plasma Membrane Recycling by CFTR by Bradbury, Neil A., Jilling, Tamas, Berta, Gabor, Sorscher, Eric J., Bridges, Robert J., Kirk, Kevin L.

“…The gene that encodes the cystic fibrosis transmembrane conductance regulator (CFTR) is defective in patients with cystic fibrosis. Although the protein…”
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A Cystic Fibrosis Pancreatic Adenocarcinoma Cell Line by Schoumacher, R. A., Ram, J., Iannuzzi, M. C., Bradbury, N. A., Wallace, R. W., Hon, C. Tom, Kelly, D. R., Schmid, S. M., Gelder, F. B., Rado, T. A., Frizzell, R. A.

“…We established a pancreatic adenocarcinoma cell line (CFPAC-1) from a patient with cystic fibrosis (CF) and assessed some of its properties. The cells show…”
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Biochemical and biophysical identification of cystic fibrosis transmembrane conductance regulator chloride channels as components of endocytic clathrin-coated vesicles by BRADBURY, N. A, COHN, J. A, VENGLARIK, C. J, BRIDGES, R. J

“…Cystic fibrosis results from mutations in the gene encoding the CFTR Cl- channel. Although CFTR occurs as an integral component of the plasma membrane, recent…”
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Characterization of PKA isoforms and kinase-dependent activation of chloride secretion in T84 cells by Singh, A K, Taskén, K, Walker, W, Frizzell, R A, Watkins, S C, Bridges, R J, Bradbury, N A

“…Chloride exit across the apical membranes of secretory epithelial cells is acutely regulated by the cAMP-mediated second messenger cascade. To better…”
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Regulated endocytosis in a chloride secretory epithelial cell line by Bradbury, N A, Jilling, T, Kirk, K L, Bridges, R J

“…The colonic epithelial cell line T84 has been shown to be a good model to investigate the regulation of Cl- secretion by the adenosine 3',5'-cyclic…”
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Electrogenic bicarbonate secretion by prairie dog gallbladder by Moser, A James, Gangopadhyay, A, Bradbury, N A, Peters, K W, Frizzell, R A, Bridges, R J

“…Pathological rates of gallbladder salt and water transport may promote the formation of cholesterol gallstones. Because prairie dogs are widely used as a model…”
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E3KARP Mediates the Association of Ezrin and Protein Kinase A with the Cystic Fibrosis Transmembrane Conductance Regulator in Airway Cells by Sun, Fei, Hug, Martin J., Lewarchik, Christopher M., Yun, C.-H. Chris, Bradbury, Neil A., Frizzell, Raymond A.

“…Although it is generally recognized that cystic fibrosis transmembrane conductance regulator (CFTR) contains a PSD-95/Disc-large/ZO-1 (PDZ)-binding motif at…”
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Protein Kinase A Associates with Cystic Fibrosis Transmembrane Conductance Regulator via an Interaction with Ezrin by Sun, Fei, Hug, Martin J., Bradbury, Neil A., Frizzell, Raymond A.

“…The cystic fibrosis transmembrane conductance regulator (CFTR) is an epithelial Cl− channel whose activity is controlled by cAMP-dependent protein kinase…”
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p27Kip1 localizes to detergent-insoluble microdomains within lymphocyte membranes by Yaroslavskiy, B B, Stolz, D B, Watkins, S C, Alber, S M, Bradbury, N A, Steinman, R A

“…Low levels of the cyclin-dependent kinase inhibitor p27Kip1 are associated with poor prognosis in cancer. It is unclear whether this is related strictly to…”
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Mu 2 binding directs the cystic fibrosis transmembrane conductance regulator to the clathrin-mediated endocytic pathway by Weixel, K M, Bradbury, N A

“…The cystic fibrosis transmembrane conductance regulator (CFTR) contains a conserved tyrosine-based internalization motif, (1424)YDSI, which interacts with the…”
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Endocytosis is regulated by protein kinase A, but not protein kinase C in a secretory epithelial cell line by Bradbury, N A, Bridges, R J

“…Endocytosis in the chloride secreting epithelial cell line T84 was monitored by uptake of the fluid-phase markers FITC-dextran and horseradish peroxidase…”
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The Carboxyl Terminus of the Cystic Fibrosis Transmembrane Conductance Regulator Binds to AP-2 Clathrin Adaptors by Weixel, Kelly M., Bradbury, Neil A.

“…The cystic fibrosis transmembrane conductance regulator (CFTR) undergoes rapid and efficient endocytosis. Since functionally active CFTR is found in purified…”
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Protein kinase-A-mediated secretion of mucin from human colonic epithelial cells by Bradbury, Neil A.

“…Both Ca2+‐ and cAMP‐mediated second messenger cascades acutely regulate mucin secretion from human colonic epithelial cells. To better understand the…”
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Isoproterenol-induced desensitization of mucin release in isolated rat submandibular acini by Bradbury, N A, McPherson, M A

“…Release of [14C]glucosamine-labelled mucins was studied in vitro using well-characterised preparations of rat submandibular acini. Mucin release was stimulated…”
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Introduction of cyclic AMP phosphodiesterase into rat submandibular acini prevents isoproterenol-stimulated cyclic AMP rise without affecting mucin secretion by Bradbury, N A, Dormer, R L, McPherson, M A

“…Cyclic AMP phosphodiesterase has been incorporated into isolated rat submandibular acini by hypotonic swelling. This resulted in complete inhibition of the…”
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Biochemical and genetic exclusion of calmodulin as the site of the basic defect in cystic fibrosis by SCAMBLER, P. J, MCPHERSON, M. A, BATES, G, BRADBURY, N. A, DORMER, R. L, WILLIAMSON, R

“…Recent physiological studies have shown a defective beta-adrenergic regulation of chloride transport and protein secretion in tissues affected by cystic…”
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Estrogen inhibition of cystic fibrosis transmembrane conductance regulator-mediated chloride secretion by Singh, A K, Schultz, B D, Katzenellenbogen, J A, Price, E M, Bridges, R J, Bradbury, N A

“…Cystic fibrosis (CF) is an autosomal genetic disease associated with impaired epithelial ion transport. Mutations in the CF gene alter the primary sequence of…”
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An altered calmodulin binding protein in cystic fibrosis--a clue to the biochemical defect by Shori, D K, Bradbury, N A, Goodchild, M C, Dormer, R L, McPherson, M A

“…Cytosolic extracts prepared from submandibular tissues of CF patients showed a greater ability to activate calmodulin-deficient cyclic AMP phosphodiesterase…”
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