Search Results - "BRACIALE, V. L"

Response to influenza infection in mice with a targeted disruption in the interferon γ gene by GRAHAM, M. B, DALTON, D. K, GILTINAN, D, BRACIALE, V. L, STEWART, T. A, BRACIALE, T. J

“…Interferon gamma (IFN-gamma) is a pleiotropic cytokine secreted by T lymphocytes and natural killer (NK) cells and has been noted to be a first line of host…”
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Partial activation of CD8 + T cells by a self-derived peptide by Cao, Wuxiong, Tykodi, Scott S, Esser, Mark T, Braciale, Vivian L, Braciale, Thomas J

“…T cells are normally activated when the peptide for which they are specific is presented to them in the context of the appropriate major histocompatibility…”
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CD8+ T cell recognition of an endogenously processed epitope is regulated primarily by residues within the epitope by HAHN, Y. S, HAHN, C. S, BRACIALE, V. L, BRACIALE, T. J, RICE, C. M

“…Cytotoxic T lymphocytes (CTL) recognize short antigenic peptides associated with cell surface class I major histocompatibility complex (MHC) molecules. This…”
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Recognition of pre-processed endogenous antigen by class I but not class II MHC-restricted T cells by Sweetser, Marianne T, Morrison, Lynda A, Braciale, Vivian L, Braciale, Thomas J

“…Class I and class II MHC-restricted T lymphocytes recognize non-native forms of antigen. The presentation of antigen to these two classes of T lymphocytes can…”
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Class I Major Histocompatibility Complex-Restricted Cytolytic T Lymphocytes Recognize a Limited Number of Sites on the Influenza Hemagglutinin by Braciale, Thomas J., Sweetser, Marianne T., Morrison, Lynda A., Kittlesen, David J., Braciale, Vivian L.

“…Two distinct regions of the influenza A/JAP/305/57 hemagglutinin molecule are identifiable as sites recognized by murine class I major histocompatibility…”
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Class I major histocompatibility complex-restricted T lymphocyte recognition of the influenza hemagglutinin: overlap between class I cytotoxic T lymphocytes and antibody sites by SWEETSER, M. T, BRACIALE, V. L, BRACIALE, T. J

“…The influenza hemagglutinin is a critical regulator of disease expression during influenza virus infection and serves as a major target for the host immune…”
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On the role of the transmembrane anchor sequence of influenza hemagglutinin in target cell recognition by class I MHC-restricted, hemagglutinin-specific cytolytic T lymphocytes by BRACIALE, T. J, BRACIALE, V. L, WINKLER, M, STROYNOWSKI, I, HOOD, L, SAMBROOK, J, GETHING, M.-J

“…We have examined the requirement for the transmembrane hydrophobic anchor sequence of the influenza hemagglutinin (HA) in the formation of the antigenic moiety…”
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Regulation of T lymphocyte proliferation. Interleukin 2-mediated induction of c-myb gene expression is dependent on T lymphocyte activation state by CHURILLA, A. M, BRACIALE, T. J, BRACIALE, V. L

“…We previously reported that with time, after antigenic stimulation of antigen-regulated murine T lymphocyte clones, total IL-2-R expression decayed 10-50-fold,…”
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Influenza virus-specific CD4+ T helper type 2 T lymphocytes do not promote recovery from experimental virus infection by Graham, M B, Braciale, V L, Braciale, T J

“…T lymphocytes play a primary role in recovery from viral infections and in antiviral immunity. Although viral-specific CD8+ and CD4+ T cells have been shown to…”
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All roads lead to actin: the intimate relationship between TCR signaling and the cytoskeleton by Fuller, Claudette L., Braciale, Vivian L., Samelson, Lawrence E.

“…Regardless of cell type, the regulation of the actin cytoskeleton is tightly linked to vital biological properties such as polarity, motility, cell–cell…”
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Class I MHC-restricted recognition of cells expressing a gene encoding a 41 amino acid product of the influenza hemagglutinin by Sweetser, MT, Braciale, VL, Braciale, TJ

“…Class I H-2Kd-restricted influenza hemagglutinin (HA)-specific CTL recognize two immuno-dominant sites as represented by synthetic peptides spanning epitopes…”
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Presentation of newly synthesized glycoproteins to CD4+ T lymphocytes. An analysis using influenza hemagglutinin transport mutants by KITTLESEN, D. J, BROWN, L. R, BRACIALE, V. L, SAMBROOK, J. P, GETHING, M.-J, BRACIALE, T. J

“…Human lymphoblastoid cells transiently expressing the hemagglutinin (HA) glycoprotein of influenza virus are rapidly and efficiently recognized by CD4+…”
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Features of target cell lysis by class I and class II MHC-restricted cytolytic T lymphocytes by Maimone, MM, Morrison, LA, Braciale, VL, Braciale, TJ

“…The lytic activity of influenza virus-specific murine cytolytic T lymphocyte (CTL) clones that are restricted by either H-2K/D (class I) or H-2I (class II)…”
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Regulation of interleukin 2 receptor expression on murine cytotoxic T lymphocyte clones by Andrew, ME, Braciale, VL, Braciale, TJ

“…We have previously reported that influenza virus-specific cytotoxic T lymphocyte (CTL) clones require antigen and exogenous growth factors for continued…”
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Antibody recognition of an immunogenic influenza hemagglutinin-human leukocyte antigen class II complex by Nygard, N R, Bono, C, Brown, L R, Gorka, J, Giacoletto, K S, Schaiff, W T, Graham, M B, McCourt, D W, Kabeer, M, Braciale, V L

“…The A/Japan/57 influenza hemagglutin (HA) peptide HA 128-145, when bound by human histocompatibility leukocyte antigen-DRw11 cells, is recognized by the human…”
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Antigen form influences induction and frequency of influenza-specific class I and class II MHC-restricted cytolytic T lymphocytes by Morrison, LA, Braciale, VL, Braciale, TJ

“…The induction of class I and class II MHC-restricted CTL in response to different forms of A/JAP/57 influenza virus was compared. Splenocytes removed from…”
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Lack of IL 2-dependent proliferation despite significant expression of high-affinity IL 2 receptor on murine cytolytic T lymphocyte clones late after antigenic stimulation by Churilla, AM, Braciale, VL

“…In this study, we examine the expression of IL 2 receptors on class I and class II MHC-restricted, influenza-specific murine T lymphocyte clones at early (day…”
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Fine specificity and antigen receptor expression among influenza virus- specific cytolytic T lymphocyte clones by Braciale, TJ, Henkel, TJ, Lukacher, A, Braciale, VL

“…Influenza virus stimulates a vigorous cytolytic T lymphocyte (CTL) response in the mouse that is directed to several virion polypeptides. This report examines…”
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Activation of virus specific CTL clones: antigen-dependent regulation of interleukin 2 receptor expression by Andrew, ME, Churilla, AM, Malek, TR, Braciale, VL, Braciale, TJ

“…Interleukin 2 (IL 2) is a lymphocyte-specific growth hormone, whose effect on lymphocyte proliferation is exerted through a cell surface receptor expressed on…”
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Anti-T cell receptor antibodies fail to inhibit specific lysis by CTL clones but activate lytic activity for irrelevant targets by Henkel, TJ, Braciale, VL, Braciale, TJ

“…In this report, we describe the functional effects of anti-T cell receptor antibodies on a panel of MHC-restricted, influenza virus-specific CTL clones…”
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