Search Results - "BRACCI, Luisa"

Muscle Expression of Type I and Type II Interferons Is Increased in Juvenile Dermatomyositis and Related to Clinical and Histologic Features by Moneta, Gian Marco, Pires Marafon, Denise, Marasco, Emiliano, Rosina, Silvia, Verardo, Margherita, Fiorillo, Chiara, Minetti, Carlo, Bracci‐Laudiero, Luisa, Ravelli, Angelo, De Benedetti, Fabrizio, Nicolai, Rebecca

“…Objective To evaluate the expression of type I interferon (IFNα/β)– and type II IFN (IFNγ)–inducible genes in muscle biopsy specimens from patients with…”
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NGF and Its Receptors in the Regulation of Inflammatory Response by Minnone, Gaetana, De Benedetti, Fabrizio, Bracci-Laudiero, Luisa

“…There is growing interest in the complex relationship between the nervous and immune systems and how its alteration can affect homeostasis and result in the…”
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Amplification of the response to Toll-like receptor ligands by prolonged exposure to interleukin-6 in mice: Implication for the pathogenesis of macrophage activation syndrome by Strippoli, Raffaele, Carvello, Francesco, Scianaro, Roberta, De Pasquale, Loredana, Vivarelli, Marina, Petrini, Stefania, Bracci-Laudiero, Luisa, De Benedetti, Fabrizio

“…Objective To investigate whether prolonged exposure to interleukin‐6 (IL‐6) affects the inflammatory response induced by Toll‐like receptor (TLR) ligands…”
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Safety evaluations of a synthetic antimicrobial peptide administered intravenously in rats and dogs by Cresti, Laura, Falciani, Chiara, Cappello, Giovanni, Brunetti, Jlenia, Vailati, Silvia, Melloni, Elsa, Bracci, Luisa, Pini, Alessandro

“…The antimicrobial peptide SET-M33 is under study for the development of a new antibiotic against major Gram-negative pathogens. Here we report the…”
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Molecular definition of the interaction between a tumor-specific tetrabranched peptide and LRP6 receptor by Brunetti, Jlenia, Falciani, Chiara, Bernini, Andrea, Scali, Silvia, Bracci, Luisa, Lozzi, Luisa

“…The tumor-specific tetrabranched peptide NT4 binds membrane sulfate glycosaminoglycans and receptors belonging to the low density lipoprotein receptor-related…”
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In Vivo Efficacy and Toxicity of an Antimicrobial Peptide in a Model of Endotoxin-Induced Pulmonary Inflammation by Cresti, Laura, Cappello, Giovanni, Vailati, Silvia, Melloni, Elsa, Brunetti, Jlenia, Falciani, Chiara, Bracci, Luisa, Pini, Alessandro

“…SET-M33 is a synthetic peptide that is being developed as a new antibiotic against major Gram-negative bacteria. Here we report two in vivo studies to assess…”
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Models of In-Vivo Bacterial Infections for the Development of Antimicrobial Peptide-based Drugs by Brunetti, Jlenia, Falciani, Chiara, Bracci, Luisa, Pini, Alessandro

“…The increasing frequency of multi-resistant Gram-positive and Gram-negative bacteria and a long-term decreasing trend in the development of new antimicrobial…”
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A New NT4 Peptide-Based Drug Delivery System for Cancer Treatment by Brunetti, Jlenia, Piantini, Sara, Fragai, Marco, Scali, Silvia, Cipriani, Giulia, Depau, Lorenzo, Pini, Alessandro, Falciani, Chiara, Menichetti, Stefano, Bracci, Luisa

“…The development of selective tumor targeting agents to deliver multiple units of chemotherapy drugs to cancer tissue would improve treatment efficacy and…”
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The development of antimicrobial peptides as new antibacterial drugs by Roscia, Giulia, Falciani, Chiara, Bracci, Luisa, Pini, Alessandro

“…The increasing frequency of multidrug-resistant bacteria and a recent slowing in the development of new antimicrobial agents place mankind in a state of…”
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Endocytosis and Trafficking of Heparan Sulfate Proteoglycans in Triple-Negative Breast Cancer Cells Unraveled with a Polycationic Peptide by Mandarini, Elisabetta, Tollapi, Eva, Zanchi, Marta, Depau, Lorenzo, Pini, Alessandro, Brunetti, Jlenia, Bracci, Luisa, Falciani, Chiara

“…The process of heparan sulfate proteoglycan (HSPG) internalization has been described as following different pathways. The tumor-specific branched NT4 peptide…”
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The GAG-specific branched peptide NT4 reduces angiogenesis and invasiveness of tumor cells by Bracci, Luisa, Mandarini, Elisabetta, Brunetti, Jlenia, Depau, Lorenzo, Pini, Alessandro, Terzuoli, Lucia, Scali, Silvia, Falciani, Chiara

“…Heparan sulfate proteoglycans, HSPGs, modulate major transformations of cancer cells, leading to tumor growth, invasion and metastasis. HSPGs also regulate…”
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Peptides and small molecules blocking the CXCR4/CXCL12 axis overcome bone marrow‑induced chemoresistance in acute leukemias by Pillozzi, Serena, Bernini, Andrea, Spiga, Ottavia, Lelli, Barbara, Petroni, Giulia, Bracci, Luisa, Niccolai, Neri, Arcangeli, Annarosa

“…Notable advances in treatment have been made and increases in the cure rates of pediatric leukemia have been achieved. However, the majority of children with…”
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Near-infrared quantum dots labelled with a tumor selective tetrabranched peptide for in vivo imaging by Brunetti, Jlenia, Riolo, Giulia, Gentile, Mariangela, Bernini, Andrea, Paccagnini, Eugenio, Falciani, Chiara, Lozzi, Luisa, Scali, Silvia, Depau, Lorenzo, Pini, Alessandro, Lupetti, Pietro, Bracci, Luisa

“…Near-infrared quantum dots (NIR QDs) are a new class of fluorescent labels with excellent bioimaging features, such as high fluorescence intensity, good…”
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Inhalable Polymeric Nanoparticles for Pulmonary Delivery of Antimicrobial Peptide SET-M33: Antibacterial Activity and Toxicity In Vitro and In Vivo by Cresti, Laura, Conte, Gemma, Cappello, Giovanni, Brunetti, Jlenia, Falciani, Chiara, Bracci, Luisa, Quaglia, Fabiana, Ungaro, Francesca, d'Angelo, Ivana, Pini, Alessandro

“…Development of inhalable formulations for delivering peptides to the conductive airways and shielding their interactions with airway barriers, thus enhancing…”
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Isomerization of an antimicrobial peptide broadens antimicrobial spectrum to gram-positive bacterial pathogens by Falciani, Chiara, Lozzi, Luisa, Pollini, Simona, Luca, Vincenzo, Carnicelli, Veronica, Brunetti, Jlenia, Lelli, Barbara, Bindi, Stefano, Scali, Silvia, Di Giulio, Antonio, Rossolini, Gian Maria, Mangoni, Maria Luisa, Bracci, Luisa, Pini, Alessandro

“…The branched M33 antimicrobial peptide was previously shown to be very active against Gram-negative bacterial pathogens, including multidrug-resistant strains…”
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Branched oncolytic peptides target HSPGs, inhibit metastasis, and trigger the release of molecular determinants of immunogenic cell death in pancreatic cancer by Rencinai, Alessandro, Tollapi, Eva, Marianantoni, Giulia, Brunetti, Jlenia, Henriquez, Tania, Pini, Alessandro, Bracci, Luisa, Falciani, Chiara

“…Immunogenic cell death (ICD) can be exploited to treat non-immunoreactive tumors that do not respond to current standard and innovative therapies. Not all…”
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Analysis of the utility of a rapid vesicle isolation method for clinical strains of Pseudomonas aeruginosa by Henriquez, Tania, Santoro, Francesco, Medaglini, Donata, Pallecchi, Lucia, Clemente, Ilaria, Bonechi, Claudia, Magnani, Agnese, Paccagnini, Eugenio, Gentile, Mariangela, Lupetti, Pietro, Marvasi, Massimiliano, Pini, Alessandro, Bracci, Luisa, Falciani, Chiara

“…, a pathogen capable of causing diseases ranging from mild to life-threatening, has a large arsenal of virulence factors. Notably, extracellular vesicles have…”
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Unraveling Heparan Sulfate Proteoglycan Binding Motif for Cancer Cell Selectivity by Brunetti, Jlenia, Riolo, Giulia, Depau, Lorenzo, Mandarini, Elisabetta, Bernini, Andrea, Karousou, Evgenia, Passi, Alberto, Pini, Alessandro, Bracci, Luisa, Falciani, Chiara

“…Membrane heparan sulfate proteoglycans (HSPG) regulate cell proliferation, migration, and differentiation and are therefore considered key players in cancer…”
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Branched peptides as therapeutics by Pini, Alessandro, Falciani, Chiara, Bracci, Luisa

“…The concept of 'magic bullet', initially ascribed to immunoglobulins by Paul Ehrlich at the beginning of the 20th century and strengthened by the hybridoma…”
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Exploiting Free-Energy Minima to Design Novel EphA2 Protein-Protein Antagonists: From Simulation to Experiment and Return by Russo, Simonetta, Callegari, Donatella, Incerti, Matteo, Pala, Daniele, Giorgio, Carmine, Brunetti, Jlenia, Bracci, Luisa, Vicini, Paola, Barocelli, Elisabetta, Capoferri, Luigi, Rivara, Silvia, Tognolini, Massimiliano, Mor, Marco, Lodola, Alessio

“…The free‐energy surface (FES) of protein–ligand binding contains information useful for drug design. Here we show how to exploit a free‐energy minimum of a…”
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