Search Results - "BRÜSS, M"

The norepinephrine transporter in physiology and disease by Bönisch, H, Brüss, M

“…The norepinephrine transporter (NET) terminates noradrenergic signalling by rapid re-uptake of neuronally released norepinephrine (NE) into presynaptic…”
Get more information

Direct inhibition by cannabinoids of human 5‐HT3A receptors: probable involvement of an allosteric modulatory site by Barann, M, Molderings, G, Brüss, M, Bönisch, H, Urban, B W, Göthert, M

“…Excised outside‐out patches from HEK293 cells stably transfected with the human (h) 5‐HT3A receptor cDNA were used to determine the effects of cannabinoid…”
Get full text

Molecular basis for the antiproliferative effect of agmatine in tumor cells of colonic, hepatic, and neuronal origin by Wolf, C, Brüss, M, Hänisch, B, Göthert, M, von Kügelgen, I, Molderings, G J

“…The aim of the present study was to challenge potential mechanisms of action underlying the inhibition of tumor cell proliferation by agmatine. Agmatine…”
Get more information

Structure of the human histamine H3 receptor gene (HRH3) and identification of naturally occurring variations by WIEDEMANN, P, BÖNISCH, H, OERTERS, F, BRÜSS, M

“…Neurotransmitter release is modulated by presynaptic histamine H(3) receptors located on histaminergic, noradrenergic and other nonhistaminergic neurons of the…”
Get full text

Agmatine and putrescine uptake in the human glioma cell line SK-MG-1 by Molderings, G J, Bönisch, H, Göthert, M, Brüss, M

“…The pharmacological properties of a specific agmatine uptake mechanism were investigated in the human glioma cell line SK-MG-1 and compared with those of the…”
Get full text

Systematic investigation of genetic variability in 111 human genes-implications for studying variable drug response by Freudenberg-Hua, Y, Freudenberg, J, Winantea, J, Kluck, N, Cichon, S, Brüss, M, Propping, P, Nöthen, M M

“…In order to identify single-nucleotide polymorphisms (SNPs) and analyze their characteristics in a set of 111 genes, we resequenced exons and flanking regions…”
Get full text

Pharmacological characteristics of the specific transporter for the endogenous cell growth inhibitor agmatine in six tumor cell lines by HEINEN, A, BRÜSS, M, BÖNISCH, H, GÖTHERT, M, MOLDERINGS, G. J

“…This study examined agmatine transport into six human intestinal tumor cell lines and compared the pharmacological properties of this transporter with those of…”
Get full text

Modified 5-HT3A receptor function by co-expression of alternatively spliced human 5-HT3A receptor isoforms by Brüss, M, Barann, M, Hayer-Zillgen, M, Eucker, T, Göthert, M, Bönisch, H

“…Serotonin (5-HT) exerts fast excitatory responses by activation of 5-HT3 receptors, irrespective of whether they are homomerically composed of 5-HT3A subunits…”
Get full text

Presynaptic Imidazoline Receptors: New Developments in Characterization and Classification by GÖTHERT, M., BRÜSS, M., BÖNISCH, H., MOLDERINGS, G. J.

“…Presynaptic imidazoline receptors (IRs) which inhibit norepinephrine (NE) release from sympathetic nerve endings have been identified in cardiovascular tissue…”
Get full text

Genetic Variation in Human 5-HT Receptors: Potential Pathogenetic and Pharmacological Role by GÖTHERT, M., PROPPING, P., BÖNISCH, H., BRÜSS, M., NÖTHEN, M. M.

“…Mutation screening identified variants of h5-HT1A (Gly-22-Ser, Ile-28-Val, Arg-219-Leu), h5-HT1B (Phe-124-Cys), h5-HT2A (Thr-25-Asn, His-452-Tyr), h5-HT2C…”
Get full text

Molecular Cloning of Alternatively Spliced Human 5-HT3 Receptor cDNAs by BRÜSS, M., GÖTHERT, M., HAYER, M., BÖNISCH, H.

Get full text

Chromosomal mapping of the human gene for the tricyclic antidepressant-sensitive noradrenaline transporter by BRÜSS, M, KUNZ, J, LINGEN, B, BÖNISCH, H

“…The neuronal Na(+)- and Cl(-)-dependent transporter for the neurotransmitter noradrenaline (NA) is the primary target for the tricyclic antidepressant…”
Get full text

Comparison of the pharmacological properties of cloned rat, human, and bovine norepinephrine transporters by Paczkowski, F A, Bryan-Lluka, L J, Pörzgen, P, Brüss, M, Bönisch, H

“…The aims of this study were to characterize the recently cloned rat norepinephrine transporter (NET) in more detail and in particular to study possible species…”
Get more information

Molecular cloning and functional expression of the mouse dopamine transporter by BRÜSS, M, WIELAND, A, BÖNISCH, H

“…The full coding region of the murine dopamine transporter (mDAT) cDNA was cloned by PCR with a sense primer derived from the partial mDAT gene sequence and an…”
Get full text

Analysis of the gene structure of the human (SLC22A3) and murine (SLC22A3) extraneuronal monoamine transporter by WIELAND, A, HAYER-ZILLGEN, M, BÖNISCH, H, BRÜSS, M

“…The organic cation transporter 3 (OCT3), also termed as extraneuronal monoamine transporter (EMT), is known to be expressed in glial cells where it is…”
Get full text

Species-specific pharmacological properties of human alpha(2A)-adrenoceptors by Molderings, G J, Bönisch, H, Brüss, M, Likungu, J, Göthert, M

“…On the basis of data obtained in rabbits, the imidazoline receptor ligand rilmenidine has been suggested to decrease blood pressure in humans by activating…”
Get full text

Cloning and functional characterization of the human norepinephrine transporter gene promoter by MEYER, J, WIEDEMANN, P, OKLADNOVA, O, BRÜSS, M, STAAB, T, STÖBER, G, RIEDERER, P, BÖNISCH, H, LESCH, K.-P

“…The norepinephrine transporter (NET) plays a critical role in brain norepinephrine homeostasis and is a target for antidepressants and drugs of abuse. We have…”
Get full text

Tourette syndrome and the norepinephrine transporter gene: Results of a systematic mutation screening by Stöber, Gerald, Hebebrand, Johannes, Cichon, Sven, Brüss, Michael, Bönisch, Heinz, Lehmkuhl, Gerd, Poustka, Fritz, Schmidt, Martin, Remschmidt, Helmut, Propping, Peter, Nöthen, Markus M.

“…Tourette syndrome (TS) is a complex inherited neuropsychiatric disorder characterized by multiple motor and phonic tics. Involvement of central norepinephrine…”
Get full text

Ketamine interacts with the noradrenaline transporter at a site partly overlapping the desipramine binding site by Hara, K, Yanagihara, N, Minami, K, Ueno, S, Toyohira, Y, Sata, T, Kawamura, M, Brüss, M, Bönisch, H, Shigematsu, A, Izumi, F

“…Effects of the intravenous anaesthetic ketamine on the desipramine-sensitive noradrenaline transporter (NAT) were examined in cultured bovine adrenal medullary…”
Get full text

A variant of the bovine noradrenaline transporter reveals the importance of the C-terminal region for correct targeting to the membrane and functional expression by Burton, L D, Kippenberger, A G, Lingen, B, Brüss, M, Bönisch, H, Christie, D L

“…We have characterized a cDNA clone which encodes a variant (bNAT2) of the bovine noradrenaline transporter. This cDNA differs from the previously identified…”
Get full text