Search Results - "BRÜNNER, NILS"

Metagenomic analysis of faecal microbiome as a tool towards targeted non-invasive biomarkers for colorectal cancer by Yu, Jun, Feng, Qiang, Wong, Sunny Hei, Zhang, Dongya, Liang, Qiao Yi, Qin, Youwen, Tang, Longqing, Zhao, Hui, Stenvang, Jan, Li, Yanli, Wang, Xiaokai, Xu, Xiaoqiang, Chen, Ning, Wu, William Ka Kei, Al-Aama, Jumana, Nielsen, Hans Jørgen, Kiilerich, Pia, Jensen, Benjamin Anderschou Holbech, Yau, Tung On, Lan, Zhou, Jia, Huijue, Li, Junhua, Xiao, Liang, Lam, Thomas Yuen Tung, Ng, Siew Chien, Cheng, Alfred Sze-Lok, Wong, Vincent Wai-Sun, Chan, Francis Ka Leung, Xu, Xun, Yang, Huanming, Madsen, Lise, Datz, Christian, Tilg, Herbert, Wang, Jian, Brünner, Nils, Kristiansen, Karsten, Arumugam, Manimozhiyan, Sung, Joseph Jao-Yiu, Wang, Jun

“…To evaluate the potential for diagnosing colorectal cancer (CRC) from faecal metagenomes. We performed metagenome-wide association studies on faecal samples…”
Get more information

High levels of microRNA-21 in the stroma of colorectal cancers predict short disease-free survival in stage II colon cancer patients by Nielsen, Boye Schnack, Jørgensen, Stine, Fog, Jacob Ulrik, Søkilde, Rolf, Christensen, Ib Jarle, Hansen, Ulla, Brünner, Nils, Baker, Adam, Møller, Søren, Nielsen, Hans Jørgen

“…Approximately 25% of all patients with stage II colorectal cancer will experience recurrent disease and subsequently die within 5 years. MicroRNA-21 (miR-21)…”
Get full text

National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines for Use of Tumor Markers in Testicular, Prostate, Colorectal, Breast, and Ovarian Cancers by Sturgeon, Catharine M, Duffy, Michael J, Stenman, Ulf-Hakan, Lilja, Hans, Brunner, Nils, Chan, Daniel W, Babaian, Richard, Bast, Robert C., Jr, Dowell, Barry, Esteva, Francisco J, Haglund, Caj, Harbeck, Nadia, Hayes, Daniel F, Holten-Andersen, Mads, Klee, George G, Lamerz, Rolf, Looijenga, Leendert H, Molina, Rafael, Nielsen, Hans Jorgen, Rittenhouse, Harry, Semjonow, Axel, Shih, Ie-Ming, Sibley, Paul, Soletormos, Gyorgy, Stephan, Carsten, Sokoll, Lori, Hoffman, Barry R, Diamandis, Eleftherios P

“…Updated National Academy of Clinical Biochemistry (NACB) Laboratory Medicine Practice Guidelines for the use of tumor markers in the clinic have been…”
Get full text

Comprehensive genomic analysis of Oesophageal Squamous Cell Carcinoma reveals clinical relevance by Du, Peina, Huang, Peide, Huang, Xuanlin, Li, Xiangchun, Feng, Zhimin, Li, Fengyu, Liang, Shaoguang, Song, Yongmei, Stenvang, Jan, Brünner, Nils, Yang, Huanming, Ou, Yunwei, Gao, Qiang, Li, Lin

“…Oesophageal carcinoma is the fourth leading cause of cancer-related death in China, and more than 90% of these tumours are oesophageal squamous cell carcinoma…”
Get full text

Detection of colorectal neoplasia: Combination of eight blood‐based, cancer‐associated protein biomarkers by Wilhelmsen, Michael, Christensen, Ib J., Rasmussen, Louise, Jørgensen, Lars N., Madsen, Mogens R., Vilandt, Jesper, Hillig, Thore, Klærke, Michael, Nielsen, Knud T., Laurberg, Søren, Brünner, Nils, Gawel, Susan, Yang, Xiaoqing, Davis, Gerard, Heijboer, Annemieke, Martens, Frans, Nielsen, Hans J.

“…Serological biomarkers may be an option for early detection of colorectal cancer (CRC). The present study assessed eight cancer‐associated protein biomarkers…”
Get full text

Co-expression of TIMP-1 and its cell surface binding partner CD63 in glioblastomas by Aaberg-Jessen, Charlotte, Sørensen, Mia D, Matos, Ana L S A, Moreira, José M, Brünner, Nils, Knudsen, Arnon, Kristensen, Bjarne W

“…We have previously identified tissue inhibitor of metalloproteinases-1 (TIMP-1) as a prognostic marker in glioblastomas. TIMP-1 has been associated with…”
Get full text

Implications of ABCG2 Expression on Irinotecan Treatment of Colorectal Cancer Patients: A Review by Nielsen, Dorte Lisbet, Palshof, Jesper Andreas, Brünner, Nils, Stenvang, Jan, Viuff, Birgitte Martine

“…One of the main chemotherapeutic drugs used on a routine basis in patients with metastatic colorectal cancer ((m)CRC) is the topoisomerase-1 inhibitor,…”
Get full text

Drug Resistance in Colorectal Cancer Cell Lines is Partially Associated with Aneuploidy Status in Light of Profiling Gene Expression by Guo, Jiao, Xu, Shaohang, Huang, Xuanlin, Li, Lin, Zhang, Congmin, Pan, Qingfei, Ren, Zhen, Zhou, Ruo, Ren, Yan, Zi, Jin, Wu, Lin, Stenvang, Jan, Brünner, Nils, Wen, Bo, Liu, Siqi

“…A priority in solving the problem of drug resistance is to understand the molecular mechanism of how a drug induces the resistance response within cells…”
Get full text

ABCG2 Protein Levels and Association to Response to First-Line Irinotecan-Based Therapy for Patients with Metastatic Colorectal Cancer by Palshof, Jesper Andreas, Cederbye, Camilla Natasha, Høgdall, Estrid Vilma Solyom, Poulsen, Tim Svenstrup, Linnemann, Dorte, Nygaard, Sune Boris, Stenvang, Jan, Christensen, Ib Jarle, Jensen, Benny Vittrup, Pfeiffer, Per, Brünner, Nils, Yilmaz, Mette, Viuff, Birgitte Martine, Nielsen, Dorte Lisbet

“…In this study we investigated the use of cancer cell protein expression of ABCG2 to predict efficacy of systemic first-line irinotecan containing therapy in…”
Get full text

Establishment and characterization of models of chemotherapy resistance in colorectal cancer: Towards a predictive signature of chemoresistance by Jensen, Niels F., Stenvang, Jan, Beck, Mette K., Hanáková, Barbora, Belling, Kirstine C., Do, Khoa N., Viuff, Birgitte, Nygård, Sune B., Gupta, Ramneek, Rasmussen, Mads H., Tarpgaard, Line S., Hansen, Tine P., Budinská, Eva, Pfeiffer, Per, Bosman, Fred, Tejpar, Sabine, Roth, Arnaud, Delorenzi, Mauro, Andersen, Claus L., Rømer, Maria U., Brünner, Nils, Moreira, José M.A.

“…Current standard treatments for metastatic colorectal cancer (CRC) are based on combination regimens with one of the two chemotherapeutic drugs, irinotecan or…”
Get full text

TIMP-1 Is Significantly Associated with Objective Response and Survival in Metastatic Colorectal Cancer Patients Receiving Combination of Irinotecan, 5-Fluorouracil, and Folinic Acid by SORENSEN, Nanna M, BYSTRÖM, Per, CHRISTENSEN, Ib J, BERGLUND, Ake, NIELSEN, Hans Jørgen, BRÜNNER, Nils, GLIMELIUS, Bengt

“…Purpose: Tissue inhibitor of metalloproteinase-1 (TIMP-1) is known to protect cells against apoptosis. We raised the hypothesis that elevated tumor tissue…”
Get full text

The invariant chain CD74 protein is a cell surface binding partner of TIMP‐1 in breast cancer cells by Høeberg, Mikkel, Noer, Julie Boertmann, Vistesen, Mette Vixø, Bartels, Annette, Bech, Esben Matzen, Nygård, Sune Boris, Lademann, Ulrik, Stenvang, Jan, Liu, Siqi, Fuglsang, Anja Thoe, Brünner, Nils, Moreira, José Manuel Afonso

“…Tissue inhibitor of metalloproteinases‐1 (TIMP‐1) regulates the proteolytic activity of matrix metalloproteinases (MMPs), playing an important role in the…”
Get full text

The stepwise evolution of the exome during acquisition of docetaxel resistance in breast cancer cells by Hansen, Stine Ninel, Ehlers, Natasja Spring, Zhu, Shida, Thomsen, Mathilde Borg Houlberg, Nielsen, Rikke Linnemann, Liu, Dongbing, Wang, Guangbiao, Hou, Yong, Zhang, Xiuqing, Xu, Xun, Bolund, Lars, Yang, Huanming, Wang, Jun, Moreira, Jose, Ditzel, Henrik J, Brünner, Nils, Schrohl, Anne-Sofie, Stenvang, Jan, Gupta, Ramneek

“…Resistance to taxane-based therapy in breast cancer patients is a major clinical problem that may be addressed through insight of the genomic alterations…”
Get full text

TIMP‑1 Increases Expression and Phosphorylation of Proteins Associated with Drug Resistance in Breast Cancer Cells by Hekmat, Omid, Munk, Stephanie, Fogh, Louise, Yadav, Rachita, Francavilla, Chiara, Horn, Heiko, Würtz, Sidse Ørnbjerg, Schrohl, Anne-Sofie, Damsgaard, Britt, Rømer, Maria Unni, Belling, Kirstine C, Jensen, Niels Frank, Gromova, Irina, Bekker-Jensen, Dorte B, Moreira, José M, Jensen, Lars J, Gupta, Ramneek, Lademann, Ulrik, Brünner, Nils, Olsen, Jesper V, Stenvang, Jan

“…Tissue inhibitor of metalloproteinase 1 (TIMP-1) is a protein with a potential biological role in drug resistance. To elucidate the unknown molecular…”
Get full text

HER2, TOP2A, and TIMP-1 and Responsiveness to Adjuvant Anthracycline-Containing Chemotherapy in High-Risk Breast Cancer Patients by EJLERTSEN, Bent, JENSEN, Maj-Britt, NIELSEN, Kirsten V, BALSLEV, Eva, RASMUSSEN, Birgitte B, WILLEMOE, Gro L, HERTEL, Pernille B, KNOOP, Ann S, MOURIDSEN, Henning T, RÜNNER, Nils

“…PURPOSE To evaluate whether the combination of HER2 with TIMP-1 (HT) or TOP2A with TIMP-1 (2T) more accurately identifies patients who benefit from…”
Get full text

BMP-2 induces EMT and breast cancer stemness through Rb and CD44 by Huang, Peide, Chen, Anan, He, Weiyi, Li, Zhen, Zhang, Guanglin, Liu, Zhong, Liu, Ge, Liu, Xueting, He, Shuilian, Xiao, Gang, Huang, Feicheng, Stenvang, Jan, Brünner, Nils, Hong, An, Wang, Ju

“…Bone morphogenetic protein 2 (BMP-2) has been reported to facilitate epithelial-to-mesenchymal transition (EMT) and bone metastasis in breast cancer xenograft…”
Get full text

Mechanisms of topoisomerase I (TOP1) gene copy number increase in a stage III colorectal cancer patient cohort by Smith, David Hersi, Christensen, Ib Jarle, Jensen, Niels Frank, Markussen, Bo, Rømer, Maria Unni, Nygård, Sune Boris, Müller, Sven, Nielsen, Hans Jørgen, Brünner, Nils, Nielsen, Kirsten Vang

“…Topoisomerase I (Top1) is the target of Top1 inhibitor chemotherapy. The TOP1 gene, located at 20q12-q13.1, is frequently detected at elevated copy numbers in…”
Get full text

Molecular characterization of irinotecan (SN-38) resistant human breast cancer cell lines by Jandu, Haatisha, Aluzaite, Kristina, Fogh, Louise, Thrane, Sebastian Wingaard, Noer, Julie B, Proszek, Joanna, Do, Khoa Nguyen, Hansen, Stine Ninel, Damsgaard, Britt, Nielsen, Signe Lykke, Stougaard, Magnus, Knudsen, Birgitta R, Moreira, José, Hamerlik, Petra, Gajjar, Madhavsai, Smid, Marcel, Martens, John, Foekens, John, Pommier, Yves, Brünner, Nils, Schrohl, Anne-Sofie, Stenvang, Jan

“…Studies in taxane and/or anthracycline refractory metastatic breast cancer (mBC) patients have shown approximately 30% response rates to irinotecan. Hence, a…”
Get full text

Tissue Inhibitor Of Matrix Metalloproteinase-1 Is Required for High-Fat Diet-Induced Glucose Intolerance and Hepatic Steatosis in Mice by Fjære, Even, Andersen, Charlotte, Myrmel, Lene Secher, Petersen, Rasmus Koefoed, Hansen, Jakob Bondo, Tastesen, Hanne Sørup, Mandrup-Poulsen, Thomas, Brünner, Nils, Kristiansen, Karsten, Madsen, Lise, Rømer, Maria Unni

“…Plasma levels of tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) are elevated in obesity and obesity-related disorders, such as steatosis, but the…”
Get full text

Plasma TIMP-1 and CEA in detection of primary colorectal cancer: a prospective, population based study of 4509 high-risk individuals by Nielsen, Hans J., Brünner, Nils, Jorgensen, Lars N., Olsen, Jesper, Rahr, Hans B., Thygesen, Knud, Hoyer, Ute, Laurberg, Søren, Stieber, Petra, Blankenstein, Marinus A., Davis, Gerard, Dowell, Barry L., Christensen, Ib J.

“…Abstract Objective. The combination of plasma tissue inhibitor of metalloproteinases-1 (TIMP-1) and carcinoembryonic antigen (CEA) may be valuable biomarkers…”
Get full text