Search Results - "BOYLE, Glen M"

Exploring Mycosporine-like Amino Acid UV-Absorbing Natural Products for a New Generation of Environmentally Friendly Sunscreens by Rosic, Nedeljka, Climstein, Mike, Boyle, Glen M, Thanh Nguyen, Duy, Feng, Yunjiang

“…Human skin needs additional protection from damaging ultraviolet radiation (UVR: 280-400 nm). Harmful UVR exposure leads to DNA damage and the development of…”
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Validating Eaton's Hypothesis: Cubane as a Benzene Bioisostere by Chalmers, Benjamin A., Xing, Hui, Houston, Sevan, Clark, Charlotte, Ghassabian, Sussan, Kuo, Andy, Cao, Benjamin, Reitsma, Andrea, Murray, Cody-Ellen P., Stok, Jeanette E., Boyle, Glen M., Pierce, Carly J., Littler, Stuart W., Winkler, David A., Bernhardt, Paul V., Pasay, Cielo, De Voss, James J., McCarthy, James, Parsons, Peter G., Walter, Gimme H., Smith, Maree T., Cooper, Helen M., Nilsson, Susan K., Tsanaktsidis, John, Savage, G. Paul, Williams, Craig M.

“…Pharmaceutical and agrochemical discovery programs are under considerable pressure to meet increasing global demand and thus require constant innovation…”
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Characterization of the Melanoma miRNAome by Deep Sequencing by Stark, Mitchell S, Tyagi, Sonika, Nancarrow, Derek J, Boyle, Glen M, Cook, Anthony L, Whiteman, David C, Parsons, Peter G, Schmidt, Christopher, Sturm, Richard A, Hayward, Nicholas K

“…MicroRNAs (miRNAs) are 18-23 nucleotide non-coding RNAs that regulate gene expression in a sequence specific manner. Little is known about the repertoire and…”
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The cubane paradigm in bioactive molecule discovery: further scope, limitations and the cyclooctatetraene complement by Houston, Sevan D, Fahrenhorst-Jones, Tyler, Xing, Hui, Chalmers, Benjamin A, Sykes, Melissa L, Stok, Jeanette E, Farfan Soto, Clementina, Burns, Jed M, Bernhardt, Paul V, De Voss, James J, Boyle, Glen M, Smith, Maree T, Tsanaktsidis, John, Savage, G Paul, Avery, Vicky M, Williams, Craig M

“…The cubane phenyl ring bioisostere paradigm was further explored in an extensive study covering a wide range of pharmaceutical and agrochemical templates,…”
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Type I Interferons Regulate Immune Responses in Humans with Blood-Stage Plasmodium falciparum Infection by Montes de Oca, Marcela, Kumar, Rajiv, Rivera, Fabian de Labastida, Amante, Fiona H., Sheel, Meru, Faleiro, Rebecca J., Bunn, Patrick T., Best, Shannon E., Beattie, Lynette, Ng, Susanna S., Edwards, Chelsea L., Boyle, Glen M., Price, Ric N., Anstey, Nicholas M., Loughland, Jessica R., Burel, Julie, Doolan, Denise L., Haque, Ashraful, McCarthy, James S., Engwerda, Christian R.

“…The development of immunoregulatory networks is important to prevent disease. However, these same networks allow pathogens to persist and reduce vaccine…”
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Kunitz type protease inhibitor EgKI-1 from the canine tapeworm Echinococcus granulosus as a promising therapeutic against breast cancer by Ranasinghe, Shiwanthi L, Boyle, Glen M, Fischer, Katja, Potriquet, Jeremy, Mulvenna, Jason P, McManus, Donald P

“…EgKI-1, a member of the Kunitz type protease inhibitor family, is highly expressed by the oncosphere of the canine tapeworm Echinococcus granulosus, the stage…”
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Therapeutic targeting of anoikis resistance in cutaneous melanoma metastasis by Neuendorf, Hannah M, Simmons, Jacinta L, Boyle, Glen M

“…The acquisition of resistance to anoikis, the cell death induced by loss of adhesion to the extracellular matrix, is an absolute requirement for the survival…”
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Activation of PKC supports the anticancer activity of tigilanol tiglate and related epoxytiglianes by Cullen, Jason K., Boyle, Glen M., Yap, Pei-Yi, Elmlinger, Stefan, Simmons, Jacinta L., Broit, Natasa, Johns, Jenny, Ferguson, Blake, Maslovskaya, Lidia A., Savchenko, Andrei I., Mirzayans, Paul Malek, Porzelle, Achim, Bernhardt, Paul V., Gordon, Victoria A., Reddell, Paul W., Pagani, Alberto, Appendino, Giovanni, Parsons, Peter G., Williams, Craig M.

“…The long-standing perception of Protein Kinase C (PKC) as a family of oncoproteins has increasingly been challenged by evidence that some PKC isoforms may act…”
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Potential molecular targets for inhibiting bone invasion by oral squamous cell carcinoma: a review of mechanisms by Quan, Jingjing, Johnson, Newell W., Zhou, Guangbiao, Parsons, Peter G., Boyle, Glen M., Gao, Jin

“…Bone invasion is a common characteristic of oral squamous cell carcinoma (OSCC), with adverse affects on patient functionality and survival. Recent studies…”
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Intra-lesional injection of the novel PKC activator EBC-46 rapidly ablates tumors in mouse models by Boyle, Glen M, D'Souza, Marjorie M A, Pierce, Carly J, Adams, Ryan A, Cantor, Aaron S, Johns, Jenny P, Maslovskaya, Lidia, Gordon, Victoria A, Reddell, Paul W, Parsons, Peter G

“…Intra-lesional chemotherapy for treatment of cutaneous malignancies has been used for many decades, allowing higher local drug concentrations and less toxicity…”
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Cross-platform array screening identifies COL1A2, THBS1, TNFRSF10D and UCHL1 as genes frequently silenced by methylation in melanoma by Bonazzi, Vanessa F, Nancarrow, Derek J, Stark, Mitchell S, Moser, Ralf J, Boyle, Glen M, Aoude, Lauren G, Schmidt, Christopher, Hayward, Nicholas K

“…Epigenetic regulation of tumor suppressor genes (TSGs) has been shown to play a central role in melanomagenesis. By integrating gene expression and methylation…”
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Cytokine/Chemokine assessment as a complementary diagnostic tool for inflammatory skin diseases by Liu, Timothy J., Lin, Lynlee L., McMeniman, Erin, Wu, Jason, Kao, Yung-Ching, Kumari, Snehlata, Boyle, Glen M., Wells, James W., Soyer, H. Peter, Gonzalez-Cruz, Jazmina L.

“…Inflammatory skin conditions are the 4 th leading cause of non-fatal health burden in the general population worldwide. The diagnosis of skin lesions due to…”
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Melanoma cell invasiveness is regulated by miR-211 suppression of the BRN2 transcription factor by Boyle, Glen M., Woods, Susan L., Bonazzi, Vanessa F., Stark, Mitchell S., Hacker, Elke, Aoude, Lauren G., Dutton-Regester, Ken, Cook, Anthony L., Sturm, Richard A., Hayward, Nicholas K.

“…Summary To identify microRNAs potentially involved in melanomagenesis, we compared microRNA expression profiles between melanoma cell lines and cultured…”
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Cyclooctatetraene: A Bioactive Cubane Paradigm Complement by Xing, Hui, Houston, Sevan D., Chen, Xuejie, Ghassabian, Sussan, Fahrenhorst‐Jones, Tyler, Kuo, Andy, Murray, Cody‐Ellen P., Conn, Kyna‐Anne, Jaeschke, Kara N., Jin, Da‐Yun, Pasay, Cielo, Bernhardt, Paul V., Burns, Jed M., Tsanaktsidis, John, Savage, G. Paul, Boyle, Glen M., De Voss, James J., McCarthy, James, Walter, Gimme H., Burne, Thomas H. J., Smith, Maree T., Tie, Jian‐Ke, Williams, Craig M.

“…Cubane was recently validated as a phenyl ring (bio)isostere, but highly strained caged carbocyclic systems lack π character, which is often critical for…”
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Basimarols A, B, and C, Highly Oxygenated Pimarane Diterpenoids from Basilicum polystachyon by Tan, Yuen P, Xue, Yongbo, Savchenko, Andrei I, Houston, Sevan D, Modhiran, Naphak, McMillan, Christopher L. D, Boyle, Glen M, Bernhardt, Paul V, Young, Paul R, Watterson, Daniel, Williams, Craig M

“…The highly oxygenated pimarane diterpenoids basimarols A, B, and C (3–5) were isolated from the plant species Basilicum polystachyon, which was collected…”
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Development of an in vivo murine model of perineural invasion and spread of cutaneous squamous cell carcinoma of the head and neck by de Lima, Priscila O., Broit, Natasa, Huang, Johnson D., Lim, Jae H., Gardiner, Damien J., Brown, Ian S., Panizza, Benedict J., Boyle, Glen M., Simpson, Fiona

“…Introduction Cutaneous squamous cell carcinoma of the head and neck (cSCCHN) can metastasize by invading nerves and spread toward the central nervous system…”
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Kallikrein-Related Peptidase 7 Promotes Multicellular Aggregation via the α5β1 Integrin Pathway and Paclitaxel Chemoresistance in Serous Epithelial Ovarian Carcinoma by YING DONG, TAN, Olivia L, LOESSNER, Daniela, STEPHENS, Carson, WALPOLE, Carina, BOYLE, Glen M, PARSONS, Peter G, CLEMENTS, Judith A

“…Abstract Kallikrein-related peptidase 7 (KLK7) is upregulated in epithelial ovarian carcinoma (EOC) with high levels correlated with poor prognosis. However,…”
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Mechanisms contributing to differential regulation of PAX3 downstream target genes in normal human epidermal melanocytes versus melanoma cells by Bartlett, Danielle, Boyle, Glen M, Ziman, Mel, Medic, Sandra

“…Melanoma is a highly aggressive and drug resistant form of skin cancer. It arises from melanocytes, the pigment producing cells of the skin. The formation of…”
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Paclitaxel resistance and multicellular spheroid formation are induced by kallikrein-related peptidase 4 in serous ovarian cancer cells in an ascites mimicking microenvironment by Dong, Ying, Stephens, Carson, Walpole, Carina, Swedberg, Joakim E, Boyle, Glen M, Parsons, Peter G, McGuckin, Michael A, Harris, Jonathan M, Clements, Judith A

“…High tumor kallikrein-related-peptidase 4 (KLK4) levels are associated with a poor outcome for women with serous epithelial ovarian cancer (EOC), for which…”
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Autophagy is required for stem cell mobilization by G-CSF by Leveque-El Mouttie, Lucie, Vu, Therese, Lineburg, Katie E., Kuns, Rachel D., Bagger, Frederik O., Teal, Bianca E., Lor, Mary, Boyle, Glen M., Bruedigam, Claudia, Mintern, Justine D., Hill, Geoffrey R., MacDonald, Kelli P.A., Lane, Steven W.

“…Granulocyte colony-stimulating factor (G-CSF) is widely used clinically to prevent neutropenia after cytotoxic chemotherapy and to mobilize hematopoietic stem…”
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