Search Results - "BOYKOW, G"

Acyl coenzyme A:cholesterol acyl transferase in macrophages utilizes a cellular pool of cholesterol oxidase-accessible cholesterol as substrate by Tabas, I, Rosoff, W J, Boykow, G C

“…Cholesterol esterification by acyl CoA:cholesterol acyl transferase (ACAT) in macrophages is a key process in atheroma foam cell formation. However, the…”
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Potent, low molecular weight thrombin receptor antagonists by Chackalamannil, Samuel, Doller, Darı́o, Eagen, Keith, Czarniecki, Michael, Ahn, Ho-Sam, Foster, Carolyn J., Boykow, George

“…Several benzimidazole derivatives have been identified as potent thrombin receptor (PAR-1) antagonists as represented by compound 1h, which showed an IC 50 of…”
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Foam cell-forming J774 macrophages have markedly elevated acyl coenzyme A:cholesterol acyl transferase activity compared with mouse peritoneal macrophages in the presence of low density lipoprotein (LDL) despite similar LDL receptor activity by TABAS, I, BOYKOW, G. C, TALL, A. R

“…Cholesteryl ester (CE) accumulation in arterial wall macrophages (foam cells) is a prominent feature of atherosclerotic lesions. We have previously shown that…”
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Protein synthesis inhibition in mouse peritoneal macrophages results in increased acyl coenzyme A:cholesterol acyl transferase activity and cholesteryl ester accumulation in the presence of native low density lipoprotein by Tabas, I, Boykow, G C

“…Cholesteryl ester (CE) accumulation in arterial wall macrophages (foam cells), mediated by the intracellular enzyme acyl coenzyme A:cholesterol acyl…”
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Discovery of Potent Orally Active Thrombin Receptor (Protease Activated Receptor 1) Antagonists as Novel Antithrombotic Agents by Chackalamannil, Samuel, Xia, Yan, Greenlee, William J, Clasby, Martin, Doller, Darìo, Tsai, Hsingan, Asberom, Theodros, Czarniecki, Michael, Ahn, Ho-Sam, Boykow, George, Foster, Carolyn, Agans-Fantuzzi, Jacqueline, Bryant, Matthew, Lau, Janice, Chintala, Madhu

“…Structurally novel thrombin receptor (protease activated receptor 1, PAR-1) antagonists based on the natural product himbacine are described. The prototypical…”
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Inhibition of cellular action of thrombin by N3-cyclopropyl-7-{[4-(1-methylethyl)phenyl]methyl}-7H-pyrrolo[3,2-f]quinazoline- 1,3-diamine (SCH 79797), a nonpeptide thrombin receptor antagonist by AHN, Ho-Sam, FOSTER, Carolyn, BOYKOW, George, STAMFORD, Andrew, MANNA, Mahua, GRAZIANO, Michael

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Development of proteinase-activated receptor 1 antagonists as therapeutic agents for thrombosis, restenosis and inflammatory diseases by Ahn, Ho-Sam, Chackalamannil, Samuel, Boykow, George, Graziano, Michael P, Foster, Carolyn

“…Thrombin, a plasma serine protease, plays a key role not only in coagulation and hemostasis but in thrombosis, restenosis and atherosclerosis. Thrombin…”
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Discovery and synthesis of a novel series of quinoline-based thrombin receptor (PAR-1) antagonists by Clasby, Martin C., Chackalamannil, Samuel, Czarniecki, Michael, Doller, Dario, Eagen, Keith, Greenlee, William J., Lin, Yan, Tsai, Hsingan, Xia, Yan, Ahn, Ho-Sam, Agans-Fantuzzi, Jacqueline, Boykow, George, Chintala, Madhu, Foster, Carolyn, Bryant, Matthew, Lau, Janice

“…The synthesis and SAR studies of a structurally novel series of highly potent thrombin receptor (PAR-1) antagonists are described. The design, synthesis, and…”
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Structure-activity relationships of pyrroloquinazolines as thrombin receptor antagonists by Ahn, Ho-Sam, Arik, Leyla, Boykow, George, Burnett, Duane A., Caplen, Mary Ann, Czarniecki, Michael, Domalski, Martin S., Foster, Carolyn, Manna, Mahua, Stamford, Andrew W., Wu, Yusheng

“…A series of pyrroloquinazolines has been discovered that represent novel small molecule inhibitors of the intramolecular ligand of the thrombin receptor…”
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Potent Tetracyclic Guanine Inhibitors of PDE1 and PDE5 Cyclic Guanosine Monophosphate Phosphodiesterases with Oral Antihypertensive Activity by Ahn, Ho-Sam, Bercovici, Ana, Boykow, George, Bronnenkant, Alan, Chackalamannil, Samuel, Chow, Jason, Cleven, Renee, Cook, John, Czarniecki, Michael, Domalski, Carol, Fawzi, Ahmad, Green, Michael, Gündes, Asli, Ho, Ginny, Laudicina, Malvina, Lindo, Neil, Ma, Ke, Manna, Mahua, McKittrick, Brian, Mirzai, Bita, Nechuta, Terry, Neustadt, Bernard, Puchalski, Chester, Pula, Kathryn, Silverman, Lisa, Smith, Elizabeth, Stamford, Andrew, Tedesco, Richard P, Tsai, Hsingan, Tulshian, Deen, Vaccaro, Henry, Watkins, Robert W, Weng, Xiaoyu, Witkowski, Joseph T, Xia, Yan, Zhang, Hongtao

“…Tetracyclic guanines have been shown to be potent and selective inhibitors of the cGMP-hydrolyzing enzymes PDE1 and PDE5. In general, these compounds are…”
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Binding of a thrombin receptor tethered ligand analogue to human platelet thrombin receptor by Ahn, H S, Foster, C, Boykow, G, Arik, L, Smith-Torhan, A, Hesk, D, Chatterjee, M

“…A thrombin receptor-radioligand binding assay was developed using [3H]A(pF-F)R(ChA)(hR)Y-NH2 ([3H]haTRAP), a high affinity thrombin receptor-activating peptide…”
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Inhibition of cellular action of thrombin by N3-cyclopropyl-7-[[4-(1-methylethyl)phenyl]methyl]-7H-pyrrolo[3, 2-f]quinazoline-1,3-diamine (SCH 79797), a nonpeptide thrombin receptor antagonist by Ahn, H S, Foster, C, Boykow, G, Stamford, A, Manna, M, Graziano, M

“…A growing body of evidence suggests an important contribution of the cellular actions of thrombin to thrombosis and restenosis following angioplasty. Recently…”
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Hypocholesterolemic activity of a novel inhibitor of cholesterol absorption, SCH 48461 by Salisbury, Brian G, Davis, Harry R, Burrier, Robert E, Burnett, Duane A, Boykow, George, Caplen, Mary Ann, Clemmons, Anthony L, Compton, Douglas S, Hoos, Lizbeth M, McGregor, Daniel G, Schnitzer-Polokoff, Robin, Smith, April A, Weig, Blair C, Zilli, Deborah L, Clader, John W, Sybertz, Edmund J

“…The amount of cholesterol that circulates in the plasma as lipoproteins can be affected by the balance of cholesterol metabolism within and between the…”
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Novel inhibitors of cholesteryl ester transfer protein by Chackalamannil, Samuel, Xia, Yan, Wang, Yuguang, Tsai, Hsingan, Czarniecki, Michael, Wang, Suke, Clemmons, Anthony, Ahn, Ho-Sam, Boykow, George

“…The synthesis and CETP inhibitory activity of a series of compounds related to wiedendiols ( 1a,1b) are reported. It is proposed that a two point pharmacophore…”
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Cyclic nucleotide phosphodiesterase isozymes in rat mesangial cells by Ahn, Ho-Sam, Foster, Michael, Arik, Leyla, Boykow, George, Foster, Carolyn

“…We characterized cyclic nucleotide phosphodiesterases isolated from rat mesangial cells and asserted their roles in regulating cellular cyclic nucleotide…”
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Rabbit and human liver contain a novel pentacyclic triterpene ester with acyl-CoA: cholesterol acyltransferase inhibitory activity by TABAS, I, LI-LING CHEN, ZIPKIN, R. E, BOYKOW, G, VITA, G, TALL, A. R, CLADER, J. W, MCPHAIL, A. T, BURNETT, D. A, BARTNER, P, DAS, P. R, PRAMANIK, B. N, PUAR, M. S, FEINMARK, S. J

“…Acyl-coenzyme A (CoA):cholesterol acyltransferase (ACAT) catalyzes the intracellular fatty acid esterification of cholesterol and is thought to play a key role…”
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Substituted 1,3,5-triazines as cholesteryl ester transfer protein inhibitors by Yan Xia, Mirzai, Bita, Chackalamannil, Samuel, Czarniecki, Michael, Wang, Suke, Clemmons, Anthony, Ahn, Ho-Sam, Boykow, George C.

“…A series of substituted 1,3,5-triazines (represented by 2) were synthesized and evaluated for their cholesteryl ester transfer protein (CETP) inhibitory…”
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Effects of acyl-CoA: cholesterol O-acyltransferase inhibition on cholesterol absorption and plasma lipoprotein composition in hamsters by Schnitzer-Polokoff, R, Compton, D, Boykow, G, Davis, H, Burrier, R

“…1. The ACAT inhibitors, CL 277082 and SA 58-035 were administered for 7 days to hamsters fed diets containing 0.5% cholesterol. 2. Both agents inhibited…”
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