Search Results - "BOYETT, Mark R"

Circadian rhythm of cardiac electrophysiology, arrhythmogenesis, and the underlying mechanisms by Black, Nicholas, D’Souza, Alicia, Wang, Yanwen, Piggins, Hugh, Dobrzynski, Halina, Morris, Gwilym, Boyett, Mark R.

“…Cardiac arrhythmias are a leading cause of cardiovascular death. It has long been accepted that life-threatening cardiac arrhythmias (ventricular tachycardia,…”
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Biophysical Characterization of the Underappreciated and Important Relationship Between Heart Rate Variability and Heart Rate by Monfredi, Oliver, Lyashkov, Alexey E, Johnsen, Anne-Berit, Inada, Shin, Schneider, Heiko, Wang, Ruoxi, Nirmalan, Mahesh, Wisloff, Ulrik, Maltsev, Victor A, Lakatta, Edward G, Zhang, Henggui, Boyett, Mark R

“…Heart rate (HR) variability (HRV; beat-to-beat changes in the R-wave to R-wave interval) has attracted considerable attention during the past 30+ years (PubMed…”
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CrossTalk opposing view: Bradycardia in the trained athlete is attributable to a downregulation of a pacemaker channel in the sinus node by D'Souza, Alicia, Sharma, Sanjay, Boyett, Mark R.

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Exercise training reduces resting heart rate via downregulation of the funny channel HCN4 by D’Souza, Alicia, Bucchi, Annalisa, Johnsen, Anne Berit, Logantha, Sunil Jit R.J., Monfredi, Oliver, Yanni, Joseph, Prehar, Sukhpal, Hart, George, Cartwright, Elizabeth, Wisloff, Ulrik, Dobryznski, Halina, DiFrancesco, Dario, Morris, Gwilym M., Boyett, Mark R.

“…Endurance athletes exhibit sinus bradycardia, that is a slow resting heart rate, associated with a higher incidence of sinus node (pacemaker) disease and…”
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Contrast enhanced micro-computed tomography resolves the 3-dimensional morphology of the cardiac conduction system in mammalian hearts by Stephenson, Robert S, Boyett, Mark R, Hart, George, Nikolaidou, Theodora, Cai, Xue, Corno, Antonio F, Alphonso, Nelson, Jeffery, Nathan, Jarvis, Jonathan C

“…The general anatomy of the cardiac conduction system (CCS) has been known for 100 years, but its complex and irregular three-dimensional (3D) geometry is not…”
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RNAseq shows an all-pervasive day-night rhythm in the transcriptome of the pacemaker of the heart by Wang, Yanwen, Anderson, Cali, Dobrzynski, Halina, Hart, George, D’Souza, Alicia, Boyett, Mark R.

“…Physiological systems vary in a day-night manner anticipating increased demand at a particular time. Heart is no exception. Cardiac output is primarily…”
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Targeting miR-423-5p Reverses Exercise Training–Induced HCN4 Channel Remodeling and Sinus Bradycardia by D’Souza, Alicia, Pearman, Charles M, Wang, Yanwen, Nakao, Shu, Logantha, Sunil Jit R.J, Cox, Charlotte, Bennett, Hayley, Zhang, Yu, Johnsen, Anne Berit, Linscheid, Nora, Poulsen, Pi Camilla, Elliott, Jonathan, Coulson, Jessica, McPhee, Jamie, Robertson, Abigail, da Costa Martins, Paula A, Kitmitto, Ashraf, Wisløff, Ulrik, Cartwright, Elizabeth J, Monfredi, Oliver, Lundby, Alicia, Dobrzynski, Halina, Oceandy, Delvac, Morris, Gwilym M, Boyett, Mark R

“…RATIONALE:Downregulation of the pacemaking ion channel, HCN4 (hyperpolarization-activated cyclic nucleotide gated channel 4), and the corresponding ionic…”
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A circadian clock in the sinus node mediates day-night rhythms in Hcn4 and heart rate by D’Souza, Alicia, Wang, Yanwen, Anderson, Cali, Bucchi, Annalisa, Baruscotti, Mirko, Olieslagers, Servé, Mesirca, Pietro, Johnsen, Anne Berit, Mastitskaya, Svetlana, Ni, Haibo, Zhang, Yu, Black, Nicholas, Cox, Charlotte, Wegner, Sven, Bano-Otalora, Beatriz, Petit, Cheryl, Gill, Eleanor, Logantha, Sunil Jit R.J., Dobrzynski, Halina, Ashton, Nick, Hart, George, Zhang, Rai, Zhang, Henggui, Cartwright, Elizabeth J., Wisloff, Ulrik, Mangoni, Matteo E., da Costa Martins, Paula A., Piggins, Hugh D., DiFrancesco, Dario, Boyett, Mark R.

“…Heart rate follows a diurnal variation, and slow heart rhythms occur primarily at night. The lower heart rate during sleep is assumed to be neural in origin,…”
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Intrinsic Electrical Remodeling Underlies Atrioventricular Block in Athletes by Mesirca, Pietro, Nakao, Shu, Nissen, Sarah Dalgas, Forte, Gabriella, Anderson, Cali, Trussell, Tariq, Li, Jue, Cox, Charlotte, Zi, Min, Logantha, Sunil, Yaar, Sana, Cartensen, Helena, Bidaud, Isabelle, Stuart, Luke, Soattin, Luca, Morris, Gwilym M., da Costa Martins, Paula A., Cartwright, Elizabeth J., Oceandy, Delvac, Mangoni, Matteo E., Jespersen, Thomas, Buhl, Rikke, Dobrzynski, Halina, Boyett, Mark R., D’Souza, Alicia

“…[Figure: see text]…”
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Point: Exercise training-induced bradycardia is caused by changes in intrinsic sinus node function by Boyett, Mark R, Wang, Yanwen, Nakao, Shu, Ariyaratnam, Jonathan, Hart, George, Monfredi, Oliver, D'Souza, Alicia

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Viewpoint: is the resting bradycardia in athletes the result of remodeling of the sinoatrial node rather than high vagal tone? by Boyett, Mark R, D'Souza, Alicia, Zhang, Henggui, Morris, Gwilym M, Dobrzynski, Halina, Monfredi, Oliver

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Supraventricular Arrhythmias in Athletes: Basic Mechanisms and New Directions by D'Souza, Alicia, Trussell, Tariq, Morris, Gwilym M, Dobrzynski, Halina, Boyett, Mark R

“…Athletes are prone to supraventricular rhythm disturbances including sinus bradycardia, heart block, and atrial fibrillation. Mechanistically, this is…”
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Atrioventricular node dysfunction in pressure overload-induced heart failure-Involvement of the immune system and transcriptomic remodelling by Wilson, Claire, Zi, Min, Smith, Matthew, Hussain, Munir, D'Souza, Alicia, Dobrzynski, Halina, Boyett, Mark R

“…Heart failure is associated with atrioventricular (AV) node dysfunction, and AV node dysfunction in the setting of heart failure is associated with an…”
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‘And the beat goes on' The cardiac conduction system: the wiring system of the heart by Boyett, Mark R.

“…The cardiac conduction system (CCS), consisting of the sino-atrial node, atrioventricular node and His–Purkinje system, is responsible for the initiation and…”
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Structure, function and clinical relevance of the cardiac conduction system, including the atrioventricular ring and outflow tract tissues by DOBRZYNSKI, Halina, ANDERSON, Robert H, MOORMAN, Anton F. M, NIKOLAIDOU, Thodora, SCHNEIDER, Heiko, SZUTS, Viktoria, TEMPLE, Ian P, YANNI, Joseph, BOYETT, Mark R, ATKINSON, Andrew, BORBAS, Zoltan, D'SOUZA, Alicia, FRASER, John F, INADA, Shin, LOGANTHA, Sunil J. R. J, MONFREDI, Oliver, MORRIS, Gwilym M

“…It is now over 100years since the discovery of the cardiac conduction system, consisting of three main parts, the sinus node, the atrioventricular node and the…”
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Cardiac Pacemaker Dysfunction Arising From Different Studies of Ion Channel Remodeling in the Aging Rat Heart by Alghamdi, Aaazh M, Boyett, Mark R, Hancox, Jules C, Zhang, Henggui

“…The function of the sinoatrial node (SAN), the pacemaker of the heart, declines with age, resulting in increased incidence of sinoatrial node dysfunction (SND)…”
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The Anatomy and Physiology of the Sinoatrial Node-A Contemporary Review by MONFREDI, OLIVER, DOBRZYNSKI, HALINA, MONDAL, TAPAS, BOYETT, MARK R., MORRIS, GWILYM M.

“…The sinoatrial node is the primary pacemaker of the heart. Nodal dysfunction with aging, heart failure, atrial fibrillation, and even endurance athletic…”
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Importance of gradients in membrane properties and electrical coupling in sinoatrial node pacing by Inada, Shin, Zhang, Henggui, Tellez, James O, Shibata, Nitaro, Nakazawa, Kazuo, Kamiya, Kaichiro, Kodama, Itsuo, Mitsui, Kazuyuki, Dobrzynski, Halina, Boyett, Mark R, Honjo, Haruo

“…The sinoatrial node (SAN) is heterogeneous in terms of cell size, ion channels, current densities, connexins and electrical coupling. For example, Nav1.5…”
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Regulation of sinus node pacemaking and atrioventricular node conduction by HCN channels in health and disease by Boyett, Mark R., Yanni, Joseph, Tellez, James, Bucchi, Annalisa, Mesirca, Pietro, Cai, Xue, Logantha, Sunil Jit R.J., Wilson, Claire, Anderson, Cali, Ariyaratnam, Jonathan, Stuart, Luke, Nakao, Shu, Abd Allah, Eman, Jones, Sandra, Lancaster, Matthew, Stephenson, Robert, Chandler, Natalie, Smith, Matthew, Bussey, Carol, Monfredi, Oliver, Morris, Gwilym, Billeter, Rudi, Mangoni, Matteo E., Zhang, Henggui, Hart, George, D'Souza, Alicia

“…The funny current, If, was first recorded in the heart 40 or more years ago by Dario DiFrancesco and others. Since then, we have learnt that If plays an…”
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Mathematical models of the electrical action potential of Purkinje fibre cells by Stewart, Philip, Aslanidi, Oleg V., Noble, Denis, Noble, Penelope J., Boyett, Mark R., Zhang, Henggui

“…-induced Ca…”
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