Search Results - "BOYD, Helen F"

Purification, Properties, Sequencing, and Cloning of a Lipoprotein-Associated, Serine-Dependent Phospholipase Involved in the Oxidative Modification of Low-Density Lipoproteins by Tew, David G, Southan, Christopher, Rice, Simon Q.J, Li, Haodong, Boyd, Helen F, Moores, Kitty, Gloger, Israel S, Macphee, Colin H

“…A novel LDL-associated phospholipase A2 (LDL-PLA2) has been purified to homogeneity from human LDL obtained from plasma apheresis. This enzyme has activity…”
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Lipoprotein-associated phospholipase A2, platelet-activating factor acetylhydrolase, generates two bioactive products during the oxidation of low-density lipoprotein: use of a novel inhibitor by MacPhee, C H, Moores, K E, Boyd, H F, Dhanak, D, Ife, R J, Leach, C A, Leake, D S, Milliner, K J, Patterson, R A, Suckling, K E, Tew, D G, Hickey, D M

“…A novel and potent azetidinone inhibitor of the lipoprotein-associated phospholipase A2 (Lp-PLA2), i.e. platelet-activating factor acetylhydrolase, is…”
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Nanomolar Inhibitors of Staphylococcus aureus Methionyl tRNA Synthetase with Potent Antibacterial Activity against Gram-Positive Pathogens by JARVEST, Richard L., BERGE, John M., BERRY, Valerie, BOYD, Helen F., BROWN, Murray J., ELDER, John S., FORREST, Andrew K., FOSBERRY, Andrew P., GENTRY, Daniel R., HIBBS, Martin J., JAWORSKI, Deborah D., O'HANLON, Peter J., POPE, Andrew J., RITTENHOUSE, Stephen, SHEPPARD, Robert J., SLATER-RADOSTI, Courtney, WORBY, Angela

“…Potent nanomolar inhibitors of Staphylococcus aureus methionyl tRNA synthetase have been derived from a file compound high throughput screening hit. Optimized…”
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Mechanism of Inhibition of LDL Phospholipase A2 by Monocyclic-β-lactams. Burst Kinetics and the Effect of Stereochemistry by Tew, David G, Boyd, Helen F, Ashman, Stephen, Theobald, Colin, Leach, Colin A

“…Investigation of the inhibition of LDL-associated phospholipase A2 by monocyclic β-lactams has shown that LDL phospholipase A2 is capable of hydrolyzing…”
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NanoStore: a concept for logistical improvements of compound handling in high-throughput screening by Benson, Neil, Boyd, Helen F, Everett, Jeremy R, Fries, Joachim, Gribbon, Philip, Haque, Nuzrul, Henco, Karsten, Jessen, Timm, Martin, William H, Mathewson, Travis J, Sharp, R Eryl, Spencer, Robin W, Stuhmeier, Frank, Wallace, Mark S, Winkler, Dirk

“…Small molecule screening, the systematic encounter of biology space with chemical space, has provoked the emergence of a whole industry that recreates itself…”
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Potent, orally active inhibitors of lipoprotein-associated phospholipase A2: 1-(biphenylmethylamidoalkyl)-pyrimidones by BOYD, Helen F, FELL, Stephen C. M, STANSFIELD, Ian G, STANWAY, Steven J, THEOBALD, Colin J, WHITTAKER, Caroline M, HICKEY, Deirdre M. B, IFE, Robert J, LEACH, Colin A, MACPHEE, Colin H, MILLINER, Kevin J, PINTO, Ivan L, RAWLINGS, D. Anthony, SMITH, Stephen A

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Natural product derived inhibitors of lipoprotein associated phospholipase A2, synthesis and activity of analogues of SB-253514 by PINTO, I. L, BOYD, H. F, HICKEY, D. M. B

“…The synthesis of analogues of SB-253514, a novel natural product derived inhibitor of lipoprotein associated phospholipase A2 (Lp-PLA2), is described together…”
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Expression, purification and characterization of a human serine-dependent phospholipase A2 with high specificity for oxidized phospholipids and platelet activating factor by Rice, S Q, Southan, C, Boyd, H F, Terrett, J A, MacPhee, C H, Moores, K, Gloger, I S, Tew, D G

“…Using expressed sequence tag (EST) homology screening, a new human serine dependent phospholipase A2 (HSD-PLA2) was identified that has 40% amino acid identity…”
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N-1 substituted pyrimidin-4-ones: Novel, orally active inhibitors of lipoprotein-associated phospholipase A2 by BOYD, Helen F, FELL, Stephen C. M, PORTER, Rod A, RAWLINGS, D. Anthony, SMITH, Stephen A, STANSFIELD, Ian G, TEW, David G, THEOBALD, Colin J, WHITTAKER, Caroline M, FLYNN, Sean T, HICKEY, Deirdre M. B, IFE, Robert J, LEACH, Colin A, MACPHEE, Colin H, MILLINER, Kevin J, MOORES, Kitty E, PINTO, Ivan L

“…From two related series of 2-(alkylthio)-pyrimidones, a novel series of 1-((amidolinked)-alkyl)-pyrimidones has been designed as nanomolar inhibitors of human…”
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1-(Arylpiperazinylamidoalkyl)-pyrimidones : Orally active inhibitors of lipoprotein-associated phospholipase A2 by BLOOMER, Jackie C, BOYD, Helen F, STANSFIELD, Ian G, STANWAY, Steven J, TAYLOR, Maxine A, THEOBALD, Colin J, WHITTAKER, Caroline M, HICKEY, Deirdre M. B, IFE, Robert J, LEACH, Colin A, MACPHEE, Colin H, MILLINER, Kevin J, PINTO, Ivan L, RAWLINGS, D. Anthony, SMITH, Stephen A

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The identification of a potent, water soluble inhibitor of lipoprotein-associated phospholipase A2 by BOYD, Helen F, HAMMOND, Beverley, STANSFIELD, Ian G, THEOBALD, Colin J, WHITTAKER, Caroline M, HICKEY, Deirdre M. B, IFE, Robert J, LEACH, Colin A, LEWIS, V. Ann, MACPHEE, Colin H, MILLINER, Kevin J, PINTO, Ivan L, SMITH, Stephen A

“…Modification of the pyrimidone 5-substituent in a series of 1-((amidolinked)-alkyl)-pyrimidones, lipophilic inhibitors of lipoprotein-associated phospholipase…”
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Nanomolar Inhibitors of Staphylococcus a ureus Methionyl tRNA Synthetase with Potent Antibacterial Activity against Gram-Positive Pathogens by Jarvest, Richard L, Berge, John M, Berry, Valerie, Boyd, Helen F, Brown, Murray J, Elder, John S, Forrest, Andrew K, Fosberry, Andrew P, Gentry, Daniel R, Hibbs, Martin J, Jaworski, Deborah D, O'Hanlon, Peter J, Pope, Andrew J, Rittenhouse, Stephen, Sheppard, Robert J, Slater-Radosti, Courtney, Worby, Angela

“…Potent nanomolar inhibitors of Staphylococcus aureus methionyl tRNA synthetase have been derived from a file compound high throughput screening hit. Optimized…”
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Lipoprotein-associated phospholipase A2, platelet-activating factor acetylhydrolase, generates two bioactive products during the oxidation of low-density lipoprotein: use of a novel inhibitor by MACPHEE, Colin H., MOORES, Kitty E., BOYD, Helen F., DHANAK, Dash, IFE, Robert J., LEACH, Colin A., LEAKE, David S., MILLINER, Kevin J., PATTERSON, Rebecca A., SUCKLING, Keith E., TEW, David G., HICKEY, Deirdre M. B.

“…A novel and potent azetidinone inhibitor of the lipoprotein-associated phospholipase A2 (Lp-PLA2), i.e. platelet-activating factor acetylhydrolase, is…”
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natural product derived inhibitors of lipoprotein associated phospholipase a 2, synthesis and activity of analogues of sb-253514 by Pinto, Ivan L, Boyd, Helen F, Hickey, Deirdre M.B

“…The synthesis of analogues of SB-253514, a novel natural product derived inhibitor of lipoprotein associated phospholipase A 2 (Lp-PLA 2), is described…”
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Potent, orally active inhibitors of lipoprotein-associated phospholipase A(2): 1-(biphenylmethylamidoalkyl)-pyrimidones by Boyd, Helen F, Fell, Stephen C M, Hickey, Deirdre M B, Ife, Robert J, Leach, Colin A, Macphee, Colin H, Milliner, Kevin J, Pinto, Ivan L, Rawlings, D Anthony, Smith, Stephen A, Stansfield, Ian G, Stanway, Steven J, Theobald, Colin J, Whittaker, Caroline M

“…A series of 1-(biphenylmethylamidoalkyl)-pyrimidones has been designed as nanomolar inhibitors of recombinant lipoprotein-associated phospholipase A(2) with…”
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Mechanism of Inhibition of LDL Phospholipase A 2 by Monocyclic-β-lactams. Burst Kinetics and the Effect of Stereochemistry by Tew, David G., Boyd, Helen F., Ashman, Stephen, Theobald, Colin, Leach, Colin A.

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Potent, orally active inhibitors of lipoprotein-associated phospholipase A 2: 1-(biphenylmethylamidoalkyl)-pyrimidones by Boyd, Helen F., Fell, Stephen C.M., Hickey, Deirdre M.B., Ife, Robert J., Leach, Colin A., Macphee, Colin H., Milliner, Kevin J., Pinto, Ivan L., Rawlings, D.Anthony, Smith, Stephen A., Stansfield, Ian G., Stanway, Steven J., Theobald, Colin J., Whittaker, Caroline M.

“…A series of 1-(biphenylmethylamidoalkyl)-pyrimidones has been designed as nanomolar inhibitors of recombinant lipoprotein-associated phospholipase A 2 with…”
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The identification of a potent, water soluble inhibitor of lipoprotein-associated phospholipase A 2 by Boyd, Helen F., Hammond, Beverley, Hickey, Deirdre M.B., Ife, Robert J., Leach, Colin A., Lewis, V.Ann, Macphee, Colin H., Milliner, Kevin J., Pinto, Ivan L., Smith, Stephen A., Stansfield, Ian G., Theobald, Colin J., Whittaker, Caroline M.

“…Modification of the pyrimidone 5-substituent in a series of 1-((amidolinked)-alkyl)-pyrimidones, lipophilic inhibitors of lipoprotein-associated phospholipase…”
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2-(alkylthio)pyrimidin-4-ones as novel, reversible inhibitors of lipoprotein-associated phospholipase A2 by BOYD, H. F, FLYNN, S. T, SMITH, S. A, STANSFIELD, I. G, TEW, D. G, THEOBALD, C. J, HICKEY, D. M. B, IFE, R. J, JONES, M, LEACH, C. A, MACPHEE, C. H, MILLINER, K. J, RAWLINGS, D. A, SLINGSBY, B. P

“…Starting from two weakly active hits from high throughput screening, a novel series of 2-(alkylthio)-pyrimidin-4-ones with high potency and selectivity for…”
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1-(Arylpiperazinylamidoalkyl)-pyrimidones: orally active inhibitors of lipoprotein-associated phospholipase A 2 by Bloomer, Jackie C., Boyd, Helen F., Hickey, Deirdre M.B., Ife, Robert J., Leach, Colin A., Macphee, Colin H., Milliner, Kevin J., Pinto, Ivan L., Rawlings, D.Anthony, Smith, Stephen A., Stansfield, Ian G., Stanway, Steven J., Taylor, Maxine A., Theobald, Colin J., Whittaker, Caroline M.

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