Search Results - "BOWLES, Kristian M"

NADPH oxidase-2 derived superoxide drives mitochondrial transfer from bone marrow stromal cells to leukemic blasts by Marlein, Christopher R., Zaitseva, Lyubov, Piddock, Rachel E., Robinson, Stephen D., Edwards, Dylan R., Shafat, Manar S., Zhou, Zhigang, Lawes, Matthew, Bowles, Kristian M., Rushworth, Stuart A.

“…Improvements in the understanding of the metabolic cross-talk between cancer and its microenvironment are expected to lead to novel therapeutic approaches…”
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CD38-Driven Mitochondrial Trafficking Promotes Bioenergetic Plasticity in Multiple Myeloma by Marlein, Christopher R, Piddock, Rachel E, Mistry, Jayna J, Zaitseva, Lyubov, Hellmich, Charlotte, Horton, Rebecca H, Zhou, Zhigang, Auger, Martin J, Bowles, Kristian M, Rushworth, Stuart A

“…Metabolic adjustments are necessary for the initiation, proliferation, and spread of cancer cells. Although mitochondria have been shown to move to cancer…”
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Leukemic blasts program bone marrow adipocytes to generate a protumoral microenvironment by Shafat, Manar S., Oellerich, Thomas, Mohr, Sebastian, Robinson, Stephen D., Edwards, Dylan R., Marlein, Christopher R., Piddock, Rachel E., Fenech, Matthew, Zaitseva, Lyubov, Abdul-Aziz, Amina, Turner, Jeremy, Watkins, Johnathan A., Lawes, Matthew, Bowles, Kristian M., Rushworth, Stuart A.

“…Despite currently available therapies, most patients diagnosed with acute myeloid leukemia (AML) die of their disease. Tumor-host interactions are critical for…”
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The bone marrow microenvironment – Home of the leukemic blasts by Shafat, Manar S, Gnaneswaran, Bruno, Bowles, Kristian M, Rushworth, Stuart A

“…Abstract Acute Myeloid Leukaemia (AML) is a genetically, biologically and clinically heterogeneous set of diseases, which are characterised by an increased…”
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Free fatty-acid transport via CD36 drives β-oxidation-mediated hematopoietic stem cell response to infection by Mistry, Jayna J., Hellmich, Charlotte, Moore, Jamie A., Jibril, Aisha, Macaulay, Iain, Moreno-Gonzalez, Mar, Di Palma, Federica, Beraza, Naiara, Bowles, Kristian M., Rushworth, Stuart A.

“…Acute infection is known to induce rapid expansion of hematopoietic stem cells (HSCs), but the mechanisms supporting this expansion remain incomplete. Using…”
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ROS-mediated PI3K activation drives mitochondrial transfer from stromal cells to hematopoietic stem cells in response to infection by Mistry, Jayna J., Marlein, Christopher R., Moore, Jamie A., Hellmich, Charlotte, Wojtowicz, Edyta E., Smith, James G. W., Macaulay, Iain, Sun, Yu, Morfakis, Adam, Patterson, Angela, Horton, Rebecca H., Divekar, Devina, Morris, Christopher J., Haestier, Anna, Di Palma, Federica, Beraza, Naiara, Bowles, Kristian M., Rushworth, Stuart A.

“…Hematopoietic stem cells (HSCs) undergo rapid expansion in response to stress stimuli. Here we investigate the bioenergetic processes which facilitate the HSC…”
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LC3-associated phagocytosis in bone marrow macrophages suppresses acute myeloid leukemia progression through STING activation by Moore, Jamie A, Mistry, Jayna J, Hellmich, Charlotte, Horton, Rebecca H, Wojtowicz, Edyta E, Jibril, Aisha, Jefferson, Matthew, Wileman, Thomas, Beraza, Naiara, Bowles, Kristian M, Rushworth, Stuart A

“…The bone marrow (BM) microenvironment regulates acute myeloid leukemia (AML) initiation, proliferation, and chemotherapy resistance. Following cancer cell…”
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Daratumumab inhibits acute myeloid leukaemia metabolic capacity by blocking mitochondrial transfer from mesenchymal stromal cells by Mistry, Jayna J, Moore, Jamie A, Kumar, Prakritt, Marlein, Christopher R, Hellmich, Charlotte, Pillinger, Genevra, Jibril, Aisha, Di Palma, Federica, Collins, Angela, Bowles, Kristian M, Rushworth, Stuart A

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Overcoming bortezomib resistance in multiple myeloma by Murray, Megan Y, Auger, Martin J, Bowles, Kristian M

“…The introduction of the proteasome inhibitor bortezomib in 2003 significantly improved treatment of the B-cell malignancy MM (multiple myeloma). Relapse…”
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Acute myeloid leukemia-driven IL-3-dependent upregulation of BCL2 in non-malignant hematopoietic stem and progenitor cells increases venetoclax-induced cytopenias by Fowler-Shorten, Dominic J, Maynard, Rebecca S, Hampton, Katherine, Altera, Annalisa, Markham, Matthew, Ehikioya, Martha, Wojtowicz, Edyta E, Bowles, Kristian M, Rushworth, Stuart A, Hellmich, Charlotte

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Impact of Hemoglobin Levels and Anemia on Mortality in Acute Stroke: Analysis of UK Regional Registry Data, Systematic Review, and Meta‐Analysis by Barlas, Raphae S., Honney, Katie, Loke, Yoon K., McCall, Stephen J., Bettencourt‐Silva, Joao H., Clark, Allan B., Bowles, Kristian M., Metcalf, Anthony K., Mamas, Mamas A., Potter, John F., Myint, Phyo K.

“…Background The impact of hemoglobin levels and anemia on stroke mortality remains controversial. We aimed to systematically assess this association and…”
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Acute Myeloid Leukaemia Drives Metabolic Changes in the Bone Marrow Niche by Maynard, Rebecca S., Hellmich, Charlotte, Bowles, Kristian M., Rushworth, Stuart A.

“…Acute myeloid leukaemia (AML) is a highly proliferative cancer characterised by infiltration of immature haematopoietic cells in the bone marrow (BM). AML…”
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Attenuation of dexamethasone-induced cell death in multiple myeloma is mediated by miR-125b expression by Murray, Megan, Rushworth, Stuart A., Zaitseva, Lyubov, Bowles, Kristian M., MacEwan, David J.

“…Dexamethasone is a key front-line chemotherapeutic for B-cell malignant multiple myeloma (MM). Dexamethasone modulates MM cell survival signaling but fails to…”
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Siglec-7 Mediates Immunomodulation by Colorectal Cancer-Associated Fusobacterium nucleatum ssp. animalis by Lamprinaki, Dimitra, Garcia-Vello, Pilar, Marchetti, Roberta, Hellmich, Charlotte, McCord, Kelli A, Bowles, Kristian M, Macauley, Matthew S, Silipo, Alba, De Castro, Cristina, Crocker, Paul R, Juge, Nathalie

“…is involved in the development of colorectal cancer (CRC) through innate immune cell modulation. However, the receptors of the interaction between ssp. and…”
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Dectin-2 Recognizes Mannosylated O-antigens of Human Opportunistic Pathogens and Augments Lipopolysaccharide Activation of Myeloid Cells by Wittmann, Alexandra, Lamprinaki, Dimitra, Bowles, Kristian M., Katzenellenbogen, Ewa, Knirel, Yuriy A., Whitfield, Chris, Nishimura, Takashi, Matsumoto, Naoki, Yamamoto, Kazuo, Iwakura, Yoichiro, Saijo, Shinobu, Kawasaki, Norihito

“…LPS consists of a relatively conserved region of lipid A and core oligosaccharide and a highly variable region of O-antigen polysaccharide. Whereas lipid A is…”
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Bone Marrow Senescence and the Microenvironment of Hematological Malignancies by Hellmich, Charlotte, Moore, Jamie A, Bowles, Kristian M, Rushworth, Stuart A

“…Senescence is the irreversible arrest of cell proliferation that has now been shown to play an important role in both health and disease. With increasing age…”
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Panhematopoietic RNA barcoding enables kinetic measurements of nucleate and anucleate lineages and the activation of myeloid clones following acute platelet depletion by Wojtowicz, Edyta E, Mistry, Jayna J, Uzun, Vladimir, Hellmich, Charlotte, Scoones, Anita, Chin, Desmond W, Kettyle, Laura M, Grasso, Francesca, Lord, Allegra M, Wright, David J, Etherington, Graham J, Woll, Petter S, Belderbos, Mirjam E, Bowles, Kristian M, Nerlov, Claus, Haerty, Wilfried, Bystrykh, Leonid V, Jacobsen, Sten Eirik W, Rushworth, Stuart A, Macaulay, Iain C

“…Platelets and erythrocytes constitute over 95% of all hematopoietic stem cell output. However, the clonal dynamics of HSC contribution to these lineages…”
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Ibrutinib inhibits SDF1/CXCR4 mediated migration in AML by Zaitseva, Lyubov, Murray, Megan Y, Shafat, Manar S, Lawes, Matthew J, MacEwan, David J, Bowles, Kristian M, Rushworth, Stuart A

“…Pharmacological targeting of BTK using ibrutinib has recently shown encouraging clinical activity in a range of lymphoid malignancies. Recently we reported…”
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Targeting BTK for the treatment of FLT3-ITD mutated acute myeloid leukemia by Pillinger, Genevra, Abdul-Aziz, Amina, Zaitseva, Lyubov, Lawes, Matthew, MacEwan, David J., Bowles, Kristian M., Rushworth, Stuart A.

“…Approximately 20% of patients with acute myeloid leukaemia (AML) have a mutation in FMS-like-tyrosine-kinase-3 (FLT3). FLT3 is a trans-membrane receptor with a…”
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Inflammatory Differences in Plaque Erosion and Rupture in Patients With ST-Segment Elevation Myocardial Infarction by Chandran, Sujay, Watkins, Johnathan, Abdul-Aziz, Amina, Shafat, Manar, Calvert, Patrick A, Bowles, Kristian M, Flather, Marcus D, Rushworth, Stuart A, Ryding, Alisdair D

“…Plaque erosion causes 30% of ST-segment elevation myocardial infarctions, but the underlying cause is unknown. Inflammatory infiltrates are less abundant in…”
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