Search Results - "BOVENZI, Veronica"

Valproate Induces Replication-independent Active DNA Demethylation by Detich, Nancy, Bovenzi, Veronica, Szyf, Moshe

“…In this report, we demonstrate that valproic acid (VPA), a drug that has been used for decades in the treatment of epilepsy and as a mood stabilizer, triggers…”
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Induction of selective blood-tumor barrier permeability and macromolecular transport by a biostable kinin B1 receptor agonist in a glioma rat model by Côté, Jérôme, Bovenzi, Veronica, Savard, Martin, Dubuc, Céléna, Fortier, Audrey, Neugebauer, Witold, Tremblay, Luc, Müller-Esterl, Werner, Tsanaclis, Ana-Maria, Lepage, Martin, Fortin, David, Gobeil, Jr, Fernand

“…Treatment of malignant glioma with chemotherapy is limited mostly because of delivery impediment related to the blood-brain tumor barrier (BTB). B1 receptors…”
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Correction: Induction of Selective Blood-Tumor Barrier Permeability and Macromolecular Transport by a Biostable Kinin B1 Receptor Agonist in a Glioma Rat Model by Côté, Jérôme, Bovenzi, Veronica, Savard, Martin, Dubuc, Céléna, Fortier, Audrey, Neugebauer, Witold, Tremblay, Luc, Müller-Esterl, Werner, Tsanaclis, Ana-Maria, Lepage, Martin, Fortin, David, Gobeil, Fernand

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Antitumor activity of cell‐penetrant kinin B1 receptor antagonists in human triple‐negative breast cancer cells by Dubuc, Céléna, Savard, Martin, Bovenzi, Veronica, Lessard, Andrée, Côté, Jérôme, Neugebauer, Witold, Geha, Sameh, Chemtob, Sylvain, Gobeil, Fernand

“…High nuclear expression of G protein‐coupled receptors, including kinin B1 receptors (B1R), has been observed in several human cancers, but the clinical…”
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Targeting intracellular B2 receptors using novel cell-penetrating antagonists to arrest growth and induce apoptosis in human triple-negative breast cancer by Dubuc, Céléna, Savard, Martin, Bovenzi, Veronica, Lessard, Andrée, Fortier, Audrey, Côté, Jérôme, Neugebauer, Witold, Rizzolio, Flavio, Geha, Sameh, Giordano, Antonio, Chemtob, Sylvain, Gobeil, Fernand

“…G protein-coupled receptors (GPCRs) are integral cell-surface proteins having a central role in tumor growth and metastasis. However, several GPCRs retain an…”
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DNA methylation and cancer by Momparler, Richard L., Bovenzi, Veronica

“…The methylation of DNA is an epigenetic modification that can play an important role in the control of gene expression in mammalian cells. The enzyme involved…”
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Bradykinin protects against brain microvascular endothelial cell death induced by pathophysiological stimuli by Bovenzi, Veronica, Savard, Martin, Morin, Josée, Cuerrier, Charles M., Grandbois, Michel, Gobeil Jr, Fernand

“…The morphological and functional integrity of the microcirculation is compromised in many cardiovascular diseases such as hypertension, diabetes, stroke, and…”
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Structure–activity relationships of novel peptide agonists of the human bradykinin B2 receptor by Bélanger, Simon, Bovenzi, Veronica, Côté, Jérome, Neugebauer, Witold, Amblard, Muriel, Martinez, Jean, Lammek, Bernard, Savard, Martin, Gobeil, Fernand

“…The nonapeptide bradykinin (BK) is involved in the genesis of inflammation, edema and in pain mediation. As such, much effort has gone into the development of…”
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Expression of endogenous nuclear bradykinin B2 receptors mediating signaling in immediate early gene activation by Savard, Martin, Barbaz, David, Bélanger, Simon, Müller-Esterl, Werner, Bkaily, Ghassan, D'orléans-Juste, Pedro, Coté, Jérôme, Bovenzi, Veronica, Gobeil Jr, Fernand

“…Bradykinin (BK) represents a pro‐inflammatory mediator that partakes in many inflammatory diseases. The mechanism of action of BK is thought to be primarily…”
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Methylated DNA-binding protein 2 antisense inhibitors suppress tumourigenesis of human cancer cell lines in vitro and in vivo by Campbell, Paul M., Bovenzi, Veronica, Szyf, Moshe

“…Methylated DNA-binding protein 2 (MBD2) has been proposed to function both as a silencer of methylated genes and as a DNA demethylase. Our previous data…”
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Antineoplastic action of 5-aza-2'-deoxycytidine and histone deacetylase inhibitor and their effect on the expression of retinoic acid receptor β and estrogen receptor α genes in breast carcinoma cells by BOVENZI, Veronica, MOMPARLER, Richard L

“…During tumorigenesis several cancer-related genes can be silenced by aberrant methylation. In many cases these silenced genes can be reactivated by exposure to…”
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Selective tumor blood–brain barrier opening with the kinin B2 receptor agonist [Phe8 ψ (CH2 NH)Arg9 ]-BK in a F98 glioma rat model: An MRI study by Côté, Jérôme, Savard, Martin, Bovenzi, Veronica, Dubuc, Céléna, Tremblay, Luc, Tsanaclis, Ana Maria, Fortin, David, Lepage, Martin, Gobeil, Fernand

“…Abstract Treatment of malignant glioma with chemotherapy is limited mostly because of delivery impediment related to the blood–brain barrier (BBB). One…”
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Novel kinin B1 receptor agonists with improved pharmacological profiles by Côté, Jérôme, Savard, Martin, Bovenzi, Veronica, Bélanger, Simon, Morin, Josée, Neugebauer, Witold, Larouche, Annie, Dubuc, Céléna, Gobeil, Fernand

“…There is some evidence to suggest that inducible kinin B1 receptors (B1R) may play beneficial and protecting roles in cardiovascular-related pathologies such…”
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Selective tumor blood-brain barrier opening with the kinin B2 receptor agonist [Phe super(8)[psi](CH sub(2)NH)Arg super(9)]-BK in a F98 glioma rat model: An MRI study by Cote, Jerome, Savard, Martin, Bovenzi, Veronica, Dubuc, Celena, Tremblay, Luc, Tsanaclis, Ana Maria, tin, David, Lepage, Martin, Gobeil, Fernand

“…Treatment of malignant glioma with chemotherapy is limited mostly because of delivery impediment related to the blood-brain barrier (BBB). One approach for…”
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Antisense MBD2 gene therapy inhibits tumorigenesis by Slack, Andrew, Bovenzi, Veronica, Bigey, Pascal, Ivanov, M. A., Ramchandani, Shyam, Bhattacharya, Sanjoy, tenOever, Benjamin, Lamrihi, B., Scherman, Daniel, Szyf, Moshe

“…Background Aberration in the pattern of DNA methylation is one of the hallmarks of cancer. We present data suggesting that dysregulation of MBD2, a recently…”
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Preclinical evaluation of 5-aza-2'-deoxycytidine, an inhibitor of DNA methylation, for therapy of breast cancer by Bovenzi, Veronica

“…Breast cancer is the second most common cause of cancer death among women in the United States. Chemotherapy and hormonal therapy have proven to be effective…”
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DNA methylation of retinoic acid receptor beta in breast cancer and possible therapeutic role of 5-aza-2'-deoxycytidine by Bovenzi, V, Lê, N L, Côte, S, Sinnett, D, Momparler, L F, Momparler, R L

“…The retinoic acid receptor beta (RARbeta), a putative tumor suppressor gene, has been reported to be poorly expressed in breast cancer. In this report using…”
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Quantitation of Inhibition of DNA Methylation of the Retinoic Acid Receptor β Gene by 5-Aza-2′-deoxycytidine in Tumor Cells Using a Single-Nucleotide Primer Extension Assay by Bovenzi, Veronica, Momparler, Richard L.

“…The expression of several cancer-related genes has been reported to be silenced by DNA methylation of their promoter region. 5-Aza-2′-deoxycytidine…”
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