Search Results - "BOUZIGON, Emmanuelle"

A Large-Scale, Consortium-Based Genomewide Association Study of Asthma by Moffatt, Miriam F, Gut, Ivo G, Demenais, Florence, Strachan, David P, Bouzigon, Emmanuelle, Heath, Simon, von Mutius, Erika, Farrall, Martin, Lathrop, Mark, Cookson, William O.C.M

“…This genomewide association study implicates variants of SMAD3 in susceptibility to asthma and confirms previously observed genetic associations. The study…”
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Vitamin D levels and susceptibility to asthma, elevated immunoglobulin E levels, and atopic dermatitis: A Mendelian randomization study by Manousaki, Despoina, Paternoster, Lavinia, Standl, Marie, Moffatt, Miriam F, Farrall, Martin, Bouzigon, Emmanuelle, Strachan, David P, Demenais, Florence, Lathrop, Mark, Cookson, William O C M, Richards, J Brent

“…Low circulating vitamin D levels have been associated with risk of asthma, atopic dermatitis, and elevated total immunoglobulin E (IgE). These epidemiological…”
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Effect of 17q21 Variants and Smoking Exposure in Early-Onset Asthma by Bouzigon, Emmanuelle, Corda, Eve, Aschard, Hugues, Dizier, Marie-Hélène, Boland, Anne, Bousquet, Jean, Chateigner, Nicolas, Gormand, Frédéric, Just, Jocelyne, Le Moual, Nicole, Scheinmann, Pierre, Siroux, Valérie, Vervloet, Daniel, Zelenika, Diana, Pin, Isabelle, Kauffmann, Francine, Lathrop, Mark, Demenais, Florence

“…A locus on chromosome 17 has previously been shown to be associated with susceptibility to asthma. This study shows that the association is specific to…”
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DNA methylation within melatonin receptor 1A (MTNR1A) mediates paternally transmitted genetic variant effect on asthma plus rhinitis by Sarnowski, Chloé, PhD, Laprise, Catherine, PhD, Malerba, Giovanni, PhD, Moffatt, Miriam F., DPhil, Dizier, Marie-Hélène, PhD, Morin, Andréanne, MSc, Vincent, Quentin B., MD, PhD, Rohde, Klaus, PhD, Esparza-Gordillo, Jorge, PhD, Margaritte-Jeannin, Patricia, PhD, Liang, Liming, PhD, Lee, Young-Ae, MD, Bousquet, Jean, MD, Siroux, Valérie, PhD, Pignatti, Pier Franco, MD, Cookson, William O., MD, DPhil, Lathrop, Mark, PhD, Pastinen, Tomi, MD, Demenais, Florence, MD, Bouzigon, Emmanuelle, MD, PhD

“…Background Asthma and allergic rhinitis (AR) are common allergic comorbidities with a strong genetic component in which epigenetic mechanisms might be…”
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Determinants of immunoglobulin G responses to respiratory syncytial virus and rhinovirus in children and adults by Guillien, Alicia, Niespodziana, Katarzyna, Mauclin, Marion, Boudier, Anne, Varraso, Raphäelle, Leynaert, Bénédicte, Dumas, Orianne, Le Moual, Nicole, Schlederer, Thomas, Bajic, Maja, Borochova, Kristina, Errhalt, Peter, Vernet, Raphaël, Nadif, Rachel, Bousquet, Jean, Bouzigon, Emmanuelle, Valenta, Rudolf, Siroux, Valérie

“…Exposure to respiratory viruses is a significant cause of morbidity and affects virus-specific antibody levels. Little is known about determinants associated…”
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Identification of SPOCK2 As a Susceptibility Gene for Bronchopulmonary Dysplasia by HADCHOUEL, Alice, DURRMEYER, Xavier, PATKAI, Juliana, BOURBON, Jacques, HALLMAN, Mikko, DANAN, Claude, DELACOURT, Christophe, BOUZIGON, Emmanuelle, INCITTI, Roberto, HUUSKO, Johanna, JARREAU, Pierre-Henri, LENCLEN, Richard, DEMENAIS, Florence, FRANCO-MONTOYA, Marie-Laure, LAYOUNI, Inès

“…Bronchopulmonary dysplasia is the most common chronic respiratory disease in premature infants. Genetic factors might contribute to bronchopulmonary dysplasia…”
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The role of eosinophils and basophils in allergic diseases considering genetic findings by Nadif, Rachel, Zerimech, Farid, Bouzigon, Emmanuelle, Matran, Regis

“…PURPOSE OF REVIEWBasophils and eosinophils represent less than 1 and 5% of white blood cells, respectively. Their role in asthma and allergic inflammation…”
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Analysis of GWAS-nominated loci for lung cancer and COPD revealed a new asthma locus by Madore, Anne-Marie, Bossé, Yohan, Margaritte-Jeannin, Patricia, Vucic, Emily, Lam, Wan L, Bouzigon, Emmanuelle, Bourbeau, Jean, Laprise, Catherine

“…Asthma, lung cancer (LC) and chronic obstructive pulmonary disease (COPD) are three respiratory diseases characterized by complex mechanisms underlying and…”
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Identification of a new locus at 16q12 associated with time to asthma onset by Sarnowski, Chloé, PhD, Sugier, Pierre-Emmanuel, MSc, Granell, Raquel, PhD, Jarvis, Debbie, MD, Dizier, Marie-Hélène, PhD, Ege, Markus, MD, Imboden, Medea, PhD, Laprise, Catherine, PhD, Khusnutdinova, Elza K., PhD, Freidin, Maxim B., PhD, Cookson, William O.C., MD, DPhil, Moffatt, Miriam, DPhil, Lathrop, Mark, PhD, Siroux, Valérie, PhD, Ogorodova, Ludmila M., MD, PhD, Karunas, Alexandra S., MD, PhD, James, Alan, MD, Probst-Hensch, Nicole M., PhD, von Mutius, Erika, MD, Pin, Isabelle, MD, PhD, Kogevinas, Manolis, MD, PhD, Henderson, A. John, MD, Demenais, Florence, MD, Bouzigon, Emmanuelle, MD, PhD

“…Background Asthma is a heterogeneous disease in which age of onset plays an important role. Objective We sought to identify the genetic variants associated…”
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Trait selection strategy in multi-trait GWAS: Boosting SNP discoverability by Suzuki, Yuka, Ménager, Hervé, Brancotte, Bryan, Vernet, Raphaël, Nerin, Cyril, Boetto, Christophe, Auvergne, Antoine, Linhard, Christophe, Torchet, Rachel, Lechat, Pierre, Troubat, Lucie, Cho, Michael H., Bouzigon, Emmanuelle, Aschard, Hugues, Julienne, Hanna

“…Since the first genome-wide association studies (GWASs), thousands of variant-trait associations have been discovered. However, comprehensively mapping the…”
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Transient receptor potential genes, smoking, occupational exposures and cough in adults by Smit, Lidwien A M, Kogevinas, Manolis, Antó, Josep M, Bouzigon, Emmanuelle, González, Juan Ramón, Le Moual, Nicole, Kromhout, Hans, Carsin, Anne-Elie, Pin, Isabelle, Jarvis, Deborah, Vermeulen, Roel, Janson, Christer, Heinrich, Joachim, Gut, Ivo, Lathrop, Mark, Valverde, Miguel A, Demenais, Florence, Kauffmann, Francine

“…Transient receptor potential (TRP) vanilloid and ankyrin cation channels are activated by various noxious chemicals and may play an important role in the…”
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Interaction between the DNAH9 gene and early smoke exposure in bronchial hyperresponsiveness by Dizier, Marie-Hélène, Nadif, Rachel, Margaritte-Jeannin, Patricia, Barton, Sheila J, Sarnowski, Chloé, Gagné-Ouellet, Valérie, Brossard, Myriam, Lavielle, Nolwenn, Just, Jocelyne, Lathrop, Mark, Holloway, John W, Laprise, Catherine, Bouzigon, Emmanuelle, Demenais, Florence

“…A previous genome-wide linkage scan of bronchial hyperresponsiveness (BHR) in the French Epidemiological study on the Genetics and Environment of Asthma (EGEA)…”
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Novel childhood asthma genes interact with in utero and early-life tobacco smoke exposure by Scholtens, Salome, PhD, Postma, Dirkje S., PhD, Moffatt, Miriam F., PhD, Panasevich, Sviatlana, PhD, Granell, Raquel, PhD, Henderson, A. John, MD, Melén, Erik, PhD, Nyberg, Fredrik, PhD, Pershagen, Göran, PhD, Jarvis, Deborah, PhD, Ramasamy, Adaikalavan, PhD, Wjst, Matthias, PhD, Svanes, Cecilie, PhD, Bouzigon, Emmanuelle, PhD, Demenais, Florence, PhD, Kauffmann, Francine, PhD, Siroux, Valérie, PhD, von Mutius, Erika, PhD, Ege, Markus Johannes, MD, Braun-Fahrländer, Charlotte, PhD, Genuneit, Jon, PhD, Brunekreef, Bert, PhD, Smit, Henriette A., PhD, Wijga, Alet H., PhD, Kerkhof, Marjan, PhD, Curjuric, Ivan, PhD, Imboden, Medea, PhD, Thun, Gian A., PhD, Probst-Hensch, Nicole, PhD, Freidin, Maxim B., PhD, Bragina, Elena Iu., PhD, Deev, I.A., PhD, Puzyrev, V.P., PhD, Daley, Denise, PhD, Park, Julie, MMath, Becker, Allan, MD, Chan-Yeung, Moira, PhD, Kozyrskyj, Anita L., PhD, Pare, Peter, MD, Marenholz, Ingo, PhD, Lau, Susanne, PhD, Keil, Thomas, PhD, Lee, Young-Ae, PhD, Kabesch, Michael, PhD, Wijmenga, Cisca, PhD, Franke, Lude, PhD, Nolte, Ilja M., PhD, Vonk, Judith, PhD, Kumar, Ashish, PhD, Farrall, Martin, PhD, Cookson, William O.C.M., PhD, Strachan, David P., PhD, Koppelman, Gerard H., PhD, Boezen, H. Marike, PhD

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Genome-Wide Association Study of Fluorescent Oxidation Products Accounting for Tobacco Smoking Status in Adults from the French EGEA Study by Orsi, Laurent, Margaritte-Jeannin, Patricia, Andrianjafimasy, Miora, Dumas, Orianne, Mohamdi, Hamida, Bouzigon, Emmanuelle, Demenais, Florence, Matran, Régis, Zerimech, Farid, Nadif, Rachel, Dizier, Marie-Hélène

“…Oxidative stress (OS) is the main pathophysiological mechanism involved in several chronic diseases, including asthma. Fluorescent oxidation products (FlOPs),…”
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Correction to: Functional variation in allelic methylomes underscores a strong genetic contribution and reveals novel epigenetic alterations in the human epigenome by Cheung, Warren A, Shao, Xiaojian, Morin, Andréanne, Siroux, Valérie, Kwan, Tony, Ge, Bing, Aïssi, Dylan, Chen, Lu, Vasquez, Louella, Allum, Fiona, Guénard, Frédéric, Bouzigon, Emmanuelle, Simon, Marie-Michelle, Boulier, Elodie, Redensek, Adriana, Watt, Stephen, Datta, Avik, Clarke, Laura, Flicek, Paul, Mead, Daniel, Paul, Dirk S, Beck, Stephan, Bourque, Guillaume, Lathrop, Mark, Tchernof, André, Vohl, Marie-Claude, Demenais, Florence, Pin, Isabelle, Downes, Kate, Stunnenberg, Hendrick G, Soranzo, Nicole, Pastinen, Tomi, Grundberg, Elin

“…Following publication of the original article [1], the authors reported an error in Additional file 1…”
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Fraction of exhaled nitric oxide values in childhood are associated with 17q11.2-q12 and 17q12-q21 variants by van der Valk, Ralf J.P., PhD, Duijts, Liesbeth, MD, PhD, Timpson, Nicolas J., MD, PhD, Salam, Muhammad T., MD, PhD, Standl, Marie, MSc, Curtin, John A., PhD, Genuneit, Jon, MD, MSc, Kerhof, Marjan, MD, PhD, Kreiner-Møller, Eskil, MD, Cáceres, Alejandro, MD, PhD, Gref, Anna, MSc, Liang, Liming L., MD, PhD, Taal, H. Rob, MD, PhD, Bouzigon, Emmanuelle, MD, PhD, Demenais, Florence, MD, Nadif, Rachel, PhD, Ober, Carole, PhD, Thompson, Emma E., PhD, Estrada, Karol, PhD, Hofman, Albert, MD, PhD, Uitterlinden, André G., PhD, van Duijn, Cornélia, PhD, Rivadeneira, Fernando, MD, PhD, Li, Xia, MS, Eckel, Sandrah P., PhD, Berhane, Kiros, PhD, Gauderman, W. James, MD, PhD, Granell, Raquel, PhD, Evans, David M., PhD, St Pourcain, Beate, PhD, McArdle, Wendy, PhD, Kemp, John P., MSc, Smith, George Davey, MD, PhD, Tiesler, Carla M.T., MSc, Flexeder, Claudia, MSc, Simpson, Angela, MD, PhD, Murray, Clare S., MD, PhD, Fuchs, Oliver, MD, PhD, Postma, Dirkje S., MD, PhD, Bønnelykke, Klaus, MD, PhD, Torrent, Maties, MD, PhD, Andersson, Martin, MD, PhD, Sleiman, Patrick, MD, PhD, Hakonarson, Hakon, MD, PhD, Cookson, William O., MD, PhD, Moffatt, Miriam F., PhD, Paternoster, Lavinia, PhD, Melén, Erik, MD, PhD, Sunyer, Jordi, MD, PhD, Bisgaard, Hans, MD, DMSci, Koppelman, Gerard H., MD, PhD, Ege, Markus, MD, PhD, Custovic, Adnan, MD, PhD, Heinrich, Joachim, PhD, Gilliland, Frank D., MD, PhD, Henderson, Alexander J., MD, Jaddoe, Vincent W.V, de Jongste, Johan C., MD, PhD

“…Background The fraction of exhaled nitric oxide (F eno ) value is a biomarker of eosinophilic airway inflammation and is associated with childhood asthma…”
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Associations between nitric oxide synthase genes and exhaled NO-related phenotypes according to asthma status by Bouzigon, Emmanuelle, Monier, Florent, Boussaha, Mekki, Le Moual, Nicole, Huyvaert, Hélène, Matran, Régis, Letort, Sébastien, Bousquet, Jean, Pin, Isabelle, Lathrop, Mark, Kauffmann, Francine, Demenais, Florence, Nadif, Rachel

“…The nitric oxide (NO) pathway is involved in asthma, and eosinophils participate in the regulation of the NO pool in pulmonary tissues. We investigated…”
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The nuclear factor I/A ( NFIA ) gene is associated with the asthma plus rhinitis phenotype by Dizier, Marie-Hélène, PhD, Margaritte-Jeannin, Patricia, PhD, Madore, Anne-Marie, PhD, Moffatt, Miriam, PhD, Brossard, Myriam, MSc, Lavielle, Nolwenn, MSc, Sarnowski, Chloé, MSc, Just, Jocelyne, MD, Cookson, William, MD, Lathrop, Mark, PhD, Laprise, Catherine, PhD, Bouzigon, Emmanuelle, MD, PhD, Demenais, Florence, MD

“…Background A previous genome-wide linkage scan in 295 families of the French Epidemiological Study on the Genetics and Environment of Asthma (EGEA) showed…”
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Mold allergen sensitization in adult asthma according to integrin β3 polymorphisms and Toll-like receptor 2/+596 genotype by Smit, Lidwien A.M., PhD, Bouzigon, Emmanuelle, MD, PhD, Bousquet, Jean, MD, Le Moual, Nicole, PhD, Nadif, Rachel, PhD, Pin, Isabelle, MD, Lathrop, Mark, PhD, Demenais, Florence, MD, Kauffmann, Francine, MD, Siroux, Valérie, PhD

“…Background Integrin β3 ( ITGB3 ) and Toll-like receptor 2 ( TLR2 ) are candidate genes for asthma and sensitization to mold allergens. Integrin β3 forms a…”
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EGEA Collection: A Biobank Devoted to Asthma and Asthma-related Phenotypes by Nadif, Rachel, Bouzigon, Emmanuelle, Le Moual, Nicole, Siroux, Valérie

“…The Epidemiological study on the Genetics and Environment of Asthma (EGEA) is a 20-year cohort including cases with asthma (n = 388), their first degree…”
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