Search Results - "BOUXSEIN, MARY L."

Effect of type 2 diabetes-related non-enzymatic glycation on bone biomechanical properties by Karim, Lamya, Bouxsein, Mary L

“…Abstract There is clear evidence that patients with type 2 diabetes mellitus (T2D) have increased fracture risk, despite having high bone mineral density (BMD)…”
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Atypical Femur Fractures: Review of Epidemiology, Relationship to Bisphosphonates, Prevention, and Clinical Management by Black, Dennis M, Abrahamsen, Bo, Bouxsein, Mary L, Einhorn, Thomas, Napoli, Nicola

“…Abstract Bisphosphonates (BPs) are highly effective in treating osteoporosis and reducing hip, vertebral, and other fractures by as much as 50% to 70%…”
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Development and Validation of a Musculoskeletal Model of the Fully Articulated Thoracolumbar Spine and Rib Cage by Bruno, Alexander G, Bouxsein, Mary L, Anderson, Dennis E

“…We developed and validated a fully articulated model of the thoracolumbar spine in opensim that includes the individual vertebrae, ribs, and sternum. To ensure…”
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Guidelines for assessment of bone microstructure in rodents using micro–computed tomography by Bouxsein, Mary L, Boyd, Stephen K, Christiansen, Blaine A, Guldberg, Robert E, Jepsen, Karl J, Müller, Ralph

“…Use of high‐resolution micro–computed tomography (µCT) imaging to assess trabecular and cortical bone morphology has grown immensely. There are several…”
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Comparison of non-invasive assessments of strength of the proximal femur by Johannesdottir, Fjola, Thrall, Erica, Muller, John, Keaveny, Tony M., Kopperdahl, David L., Bouxsein, Mary L.

“…It is not clear which non-invasive method is most effective for predicting strength of the proximal femur in those at highest risk of fracture. The primary aim…”
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Diabetes and Deficits in Cortical Bone Density, Microarchitecture, and Bone Size: Framingham HR‐pQCT Study by Samelson, Elizabeth J, Demissie, Serkalem, Cupples, L Adrienne, Zhang, Xiaochun, Xu, Hanfei, Liu, Ching‐Ti, Boyd, Steven K, McLean, Robert R, Broe, Kerry E, Kiel, Douglas P, Bouxsein, Mary L

“…ABSTRACT Older adults with type 2 diabetes (T2D) tend to have normal or greater areal bone mineral density (aBMD), as measured by DXA, than those who do not…”
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A Review of Rodent Models of Type 2 Diabetic Skeletal Fragility by Fajardo, Roberto J, Karim, Lamya, Calley, Virginia I, Bouxsein, Mary L

“…ABSTRACT Evidence indicating that adult type 2 diabetes (T2D) is associated with increased fracture risk continues to mount. Unlike osteoporosis, diabetic…”
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Cortical and trabecular bone microarchitecture as an independent predictor of incident fracture risk in older women and men in the Bone Microarchitecture International Consortium (BoMIC): a prospective study by Samelson, Elizabeth J, Broe, Kerry E, Xu, Hanfei, Yang, Laiji, Boyd, Steven, Biver, Emmanuel, Szulc, Pawel, Adachi, Jonathan, Amin, Shreyasee, Atkinson, Elizabeth, Berger, Claudie, Burt, Lauren, Chapurlat, Roland, Chevalley, Thierry, Ferrari, Serge, Goltzman, David, Hanley, David A, Hannan, Marian T, Khosla, Sundeep, Liu, Ching-Ti, Lorentzon, Mattias, Mellstrom, Dan, Merle, Blandine, Nethander, Maria, Rizzoli, René, Sornay-Rendu, Elisabeth, Van Rietbergen, Bert, Sundh, Daniel, Wong, Andy Kin On, Ohlsson, Claes, Demissie, Serkalem, Kiel, Douglas P, Bouxsein, Mary L

“…Although areal bone mineral density (aBMD) assessed by dual-energy x-ray absorptiometry (DXA) is the clinical standard for determining fracture risk, most…”
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Dnmt3a-mutated clonal hematopoiesis promotes osteoporosis by Kim, Peter Geon, Niroula, Abhishek, Shkolnik, Veronica, McConkey, Marie, Lin, Amy E, Słabicki, Mikołaj, Kemp, John P, Bick, Alexander, Gibson, Christopher J, Griffin, Gabriel, Sekar, Aswin, Brooks, Daniel J, Wong, Waihay J, Cohen, Drew N, Uddin, Md Mesbah, Shin, Wesley J, Pirruccello, James, Tsai, Jonathan M, Agrawal, Mridul, Kiel, Douglas P, Bouxsein, Mary L, Richards, J Brent, Evans, David M, Wein, Marc N, Charles, Julia F, Jaiswal, Siddhartha, Natarajan, Pradeep, Ebert, Benjamin L

“…Osteoporosis is caused by an imbalance of osteoclasts and osteoblasts, occurring in close proximity to hematopoietic cells in the bone marrow. Recurrent…”
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Age‐Related Changes in Trabecular Architecture Differ in Female and Male C57BL/6J Mice by Glatt, Vaida, Canalis, Ernesto, Stadmeyer, Lisa, Bouxsein, Mary L

“…We used μCT and histomorphometry to assess age‐related changes in bone architecture in male and female C57BL/6J mice. Deterioration in vertebral and femoral…”
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Mechanisms of Disease: is osteoporosis the obesity of bone? by Rosen, Clifford J, Bouxsein, Mary L

“…Osteoporosis and obesity, two disorders of body composition, are growing in prevalence. Interestingly, these diseases share several features including a…”
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Irisin directly stimulates osteoclastogenesis and bone resorption in vitro and in vivo by Estell, Eben G, Le, Phuong T, Vegting, Yosta, Kim, Hyeonwoo, Wrann, Christiane, Bouxsein, Mary L, Nagano, Kenichi, Baron, Roland, Spiegelman, Bruce M, Rosen, Clifford J

“…Irisin, a skeletal-muscle secreted myokine, facilitates muscle-bone crosstalk and skeletal remodeling in part by its action on osteoblasts and osteocytes. In…”
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Type 2 diabetes and the skeleton: new insights into sweet bones by Shanbhogue, Vikram V, MD, Mitchell, Deborah M, MD, Rosen, Clifford J, Prof, Bouxsein, Mary L, Dr

“…Summary Substantial evidence shows that skeletal fragility should be considered among the complications associated with type 2 diabetes. Individuals with type…”
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Osteoporosis and Hip Fracture Risk From Routine Computed Tomography Scans: The Fracture, Osteoporosis, and CT Utilization Study (FOCUS) by Adams, Annette L, Fischer, Heidi, Kopperdahl, David L, Lee, David C, Black, Dennis M, Bouxsein, Mary L, Fatemi, Shireen, Khosla, Sundeep, Orwoll, Eric S, Siris, Ethel S, Keaveny, Tony M

“…ABSTRACT Methods now exist for analyzing previously taken clinical computed tomography (CT) scans to measure a dual‐energy X‐ray absorptiometry…”
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Cathepsin K-deficient osteocytes prevent lactation-induced bone loss and parathyroid hormone suppression by Lotinun, Sutada, Ishihara, Yoshihito, Nagano, Kenichi, Kiviranta, Riku, Carpentier, Vincent T, Neff, Lynn, Parkman, Virginia, Ide, Noriko, Hu, Dorothy, Dann, Pamela, Brooks, Daniel, Bouxsein, Mary L, Wysolmerski, John, Gori, Francesca, Baron, Roland

“…Lactation induces bone loss to provide sufficient calcium in the milk, a process that involves osteoclastic bone resorption but also osteocytes and perilacunar…”
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A FAK/HDAC5 signaling axis controls osteocyte mechanotransduction by Sato, Tadatoshi, Verma, Shiv, Andrade, Christian D. Castro, Omeara, Maureen, Campbell, Nia, Wang, Jialiang S., Cetinbas, Murat, Lang, Audrey, Ausk, Brandon J., Brooks, Daniel J., Sadreyev, Ruslan I., Kronenberg, Henry M., Lagares, David, Uda, Yuhei, Pajevic, Paola Divieti, Bouxsein, Mary L., Gross, Ted S., Wein, Marc N.

“…Osteocytes, cells ensconced within mineralized bone matrix, are the primary skeletal mechanosensors. Osteocytes sense mechanical cues by changes in fluid flow…”
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A novel partial gravity ground-based analogue for rats via quadrupedal unloading by Mortreux, Marie, Nagy, Janice A, Ko, Frank C, Bouxsein, Mary L, Rutkove, Seward B

“…Musculoskeletal deconditioning is a well-known consequence of microgravity; however, the effects of partial gravity such as that experienced on the Moon…”
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Effects of Denosumab and Teriparatide Transitions on Bone Microarchitecture and Estimated Strength: the DATA‐Switch HR‐pQCT study by Tsai, Joy N, Nishiyama, Kyle K, Lin, David, Yuan, Amy, Lee, Hang, Bouxsein, Mary L, Leder, Benjamin Z

“…ABSTRACT In postmenopausal osteoporosis, switching from teriparatide to denosumab results in continued bone mineral density (BMD) gains whereas switching from…”
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Progenitor recruitment and adipogenic lipolysis contribute to the anabolic actions of parathyroid hormone on the skeleton by Maridas, David E., Rendina-Ruedy, Elizabeth, Helderman, Ron C., DeMambro, Victoria E., Brooks, Daniel, Guntur, Anyonya R., Lanske, Beate, Bouxsein, Mary L., Rosen, Clifford J.

“…ABSTRACT Intermittent administration of parathyroid hormone (PTH) stimulates bone formation in vivo and also suppresses the volume of bone marrow adipose…”
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Cortical and trabecular load sharing in the human femoral neck by Nawathe, Shashank, Nguyen, Bich Phuong, Barzanian, Nasim, Akhlaghpour, Hosna, Bouxsein, Mary L, Keaveny, Tony M

“…Abstract The relative role of the cortical vs trabecular bone in the load-carrying capacity of the proximal femur—a fundamental issue in both basic-science and…”
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