Search Results - "BOURRON, OLIVIER"

Sphingolipid Metabolism: New Insight into Ceramide-Induced Lipotoxicity in Muscle Cells by Bandet, Cécile L, Tan-Chen, Sophie, Bourron, Olivier, Le Stunff, Hervé, Hajduch, Eric

“…Insulin-resistance is a characteristic feature of type 2 diabetes (T2D) and plays a major role in the pathogenesis of this disease. Skeletal muscles are…”
Get full text

Sphingolipid Metabolism and Signaling in Skeletal Muscle: From Physiology to Physiopathology by Tan-Chen, Sophie, Guitton, Jeanne, Bourron, Olivier, Le Stunff, Hervé, Hajduch, Eric

“…Sphingolipids represent one of the major classes of eukaryotic lipids. They play an essential structural role, especially in cell membranes where they also…”
Get full text

Low-dose interleukin 2 in patients with type 1 diabetes: a phase 1/2 randomised, double-blind, placebo-controlled trial by Hartemann, Agnès, Prof, Bensimon, Gilbert, MD, Payan, Christine A, MD, Jacqueminet, Sophie, MD, Bourron, Olivier, MD, Nicolas, Nathalie, MD, Fonfrede, Michèle, MD, Rosenzwajg, Michelle, MD, Bernard, Claude, PharmD, Klatzmann, David, Prof

“…Summary Background An improper balance of regulatory/effector T (Treg /Teff ) cells is central to the development of autoimmune diseases, including type 1…”
Get full text

Sustained Action of Ceramide on the Insulin Signaling Pathway in Muscle Cells: IMPLICATION OF THE DOUBLE-STRANDED RNA-ACTIVATED PROTEIN KINASE by Hage Hassan, Rima, Pacheco de Sousa, Ana Catarina, Mahfouz, Rana, Hainault, Isabelle, Blachnio-Zabielska, Agnieszka, Bourron, Olivier, Koskas, Fabien, Górski, Jan, Ferré, Pascal, Foufelle, Fabienne, Hajduch, Eric

“…In vivo, ectopic accumulation of fatty acids in muscles leads to alterations in insulin signaling at both the IRS1 and Akt steps. However, in vitro treatments…”
Get full text

Defect of insulin signal in peripheral tissues: important role of ceramide by Hage Hassan, Rima, Bourron, Olivier, Hajduch, Eric

“…In healthy people,balance between glucose production and its utilization is precisely controlled.When circulating glucose reaches a critical threshold…”
Get full text

Inactive matrix gla protein plasma levels are associated with peripheral neuropathy in Type 2 diabetes by Jeannin, Anne-Caroline, Salem, Joe-Elie, Massy, Ziad, Aubert, Carole Elodie, Vermeer, Cees, Amouyal, Chloé, Phan, Franck, Halbron, Marine, Funck-Brentano, Christian, Hartemann, Agnès, Bourron, Olivier

“…Diabetic peripheral neuropathy is a frequent and severe complication of diabetes. As Matrix-gla-protein (MGP) is expressed in several components of the nervous…”
Get full text

Rapid glycemic regulation in poorly controlled patients living with diabetes, a new associated factor in the pathophysiology of Charcot's acute neuroarthropathy by Dardari, Dured, Van, Georges Ha, M'Bemba, Jocelyne, Laborne, Francois-Xavier, Bourron, Olivier, Davaine, Jean Michel, Phan, Franck, Foufelle, Fabienne, Jaisser, Frédéric, Penfornis, Alfred, Hartemann, Agnes

“…Aggressive antidiabetic therapy and rapid glycemic control are associated with diabetic neuropathy. Here we investigated if this is also the case for Charcot…”
Get full text

Multifocal (tarsus and knee) activation of neuroarthropathy following rapid glycaemic correction by Dardari, Dured, Penfornis, Alfred, Amadou, Coralie, Phan, Franck, Bourron, Olivier, Davaine, Jean Michel, Foufelle, Fabienne, Jaisser, Frédéric, Laborne, Francois-Xavier, Hartemann, Agnes

“…To report a case of neuroarthropathy in the tarsus and knee following rapid glycaemic normalisation in a female patient with type I diabetes. A retrospective…”
Get full text

Ceramide Transporter CERT Is Involved in Muscle Insulin Signaling Defects Under Lipotoxic Conditions by Bandet, Cécile L, Mahfouz, Rana, Véret, Julien, Sotiropoulos, Athanassia, Poirier, Maxime, Giussani, Paola, Campana, Mélanie, Philippe, Erwann, Blachnio-Zabielska, Agnieszka, Ballaire, Raphaëlle, Le Liepvre, Xavier, Bourron, Olivier, Berkeš, Dušan, Górski, Jan, Ferré, Pascal, Le Stunff, Hervé, Foufelle, Fabienne, Hajduch, Eric

“…One main mechanism of insulin resistance (IR), a key feature of type 2 diabetes, is the accumulation of saturated fatty acids (FAs) in the muscles of obese…”
Get full text

Non-alcoholic fatty liver disease biomarkers estimate cardiovascular risk based on coronary artery calcium score in type 2 diabetes: a cross-sectional study with two independent cohorts by Denimal, Damien, Ponnaiah, Maharajah, Jeannin, Anne-Caroline, Phan, Franck, Hartemann, Agnès, Boussouar, Samia, Charpentier, Etienne, Redheuil, Alban, Foufelle, Fabienne, Bourron, Olivier

“…Studies have demonstrated that coronary artery calcification on one hand and non-alcoholic fatty liver disease (NAFLD) on the other hand are strongly…”
Get full text

Characterising the inhibitory actions of ceramide upon insulin signaling in different skeletal muscle cell models: a mechanistic insight by Mahfouz, Rana, Khoury, Rhéa, Blachnio-Zabielska, Agnieszka, Turban, Sophie, Loiseau, Nicolas, Lipina, Christopher, Stretton, Clare, Bourron, Olivier, Ferré, Pascal, Foufelle, Fabienne, Hundal, Harinder S, Hajduch, Eric

“…Ceramides are known to promote insulin resistance in a number of metabolically important tissues including skeletal muscle, the predominant site of…”
Get full text

Sphingosine-1-Phosphate Metabolism in the Regulation of Obesity/Type 2 Diabetes by Guitton, Jeanne, Bandet, Cécile L, Mariko, Mohamed L, Tan-Chen, Sophie, Bourron, Olivier, Benomar, Yacir, Hajduch, Eric, Le Stunff, Hervé

“…Obesity is a pathophysiological condition where excess free fatty acids (FFA) target and promote the dysfunctioning of insulin sensitive tissues and of…”
Get full text

Impaired hypoxic ventilatory drive induced by diabetic autonomic neuropathy, a cause of misdiagnosed severe cardiac events: brief report of two cases by Schubert, Louis, Laroche, Suzanne, Hartemann, Agnès, Bourron, Olivier, Phan, Franck

“…Sudden cardiac deaths are twice more frequent in diabetic patients with cardiac autonomic neuropathy. Sudden cardiac death etiologies remain unclear and no…”
Get full text

Vascular calcification in patients with type 2 diabetes: the involvement of matrix Gla protein by Liabeuf, Sophie, Bourron, Olivier, Olivier, Bourron, Vemeer, Cees, Theuwissen, Elke, Magdeleyns, Elke, Aubert, Carole Elodie, Brazier, Michel, Mentaverri, Romuald, Hartemann, Agnes, Massy, Ziad A

“…Matrix Gla protein (MGP) is an important inhibitor of calcification. The objective of the present study of patients with type 2 diabetes and normal or slightly…”
Get full text

Correction: Inactive matrix gla protein plasma levels are associated with peripheral neuropathy in Type 2 diabetes by Jeannin, Anne-Caroline, Salem, Joe-Elie, Massy, Ziad, Aubert, Carole Elodie, Vemeer, Cees, Amouyal, Chloé, Phan, Franck, Halbron, Marine, Funck-Brentano, Christian, Hartemann, Agnès, Bourron, Olivier

“…[This corrects the article DOI: 10.1371/journal.pone.0229145.]…”
Get full text

Cardiac adipose tissue volume and IL-6 level at admission are complementary predictors of severity and short-term mortality in COVID-19 diabetic patients by Phan, Franck, Boussouar, Samia, Lucidarme, Olivier, Zarai, Mohamed, Salem, Joe-Elie, Kachenoura, Nadjia, Bouazizi, Khaoula, Charpentier, Etienne, Niati, Yasmine, Bekkaoui, Hasnae, Amoura, Zahir, Mathian, Alexis, Benveniste, Olivier, Cacoub, Patrice, Allenbach, Yves, Saadoun, David, Lacorte, Jean-Marc, Fourati, Salma, Laroche, Suzanne, Hartemann, Agnes, Bourron, Olivier, Andreelli, Fabrizio, Redheuil, Alban

“…Background COVID-19 diabetic adults are at increased risk of severe forms irrespective of obesity. In patients with type-II diabetes, fat distribution is…”
Get full text

Relationship between sleep parameters, insulin resistance and age-adjusted insulin like growth factor-1 score in non diabetic older patients by Damanti, Sarah, Bourron, Olivier, Doulazmi, Mohamed, Mandengue Sosso, Anne-Laure, Nguyen-Michel, Vi-Huong, Mariani, Jean, Kinugawa, Kiyoka

“…Sleep complaints are prevalent in older patients. Sleepiness, short or long sleep duration and obstructive sleep apnea (OSA) are associated with insulin…”
Get full text

Cardiac adipose tissue volume assessed by computed tomography is a specific and independent predictor of early mortality and critical illness in COVID-19 in type 2-diabetic patients by Charpentier, Etienne, Redheuil, Alban, Bourron, Olivier, Boussouar, Samia, Lucidarme, Olivier, Zarai, Mohamed, Kachenoura, Nadjia, Bouazizi, Khaoula, Salem, Joe-Elie, Hekimian, Guillaume, Kerneis, Matthieu, Amoura, Zahir, Allenbach, Yves, Hatem, Stephane, Jeannin, Anne-Caroline, Andreelli, Fabrizio, Phan, Franck

“…Patients with type 2-diabetes mellitus (T2D), are characterized by visceral and ectopic adipose tissue expansion, leading to systemic chronic low-grade…”
Get full text

Differential prognostic burden of cardiovascular disease and lower-limb amputation on the risk of all-cause death in people with long-standing type 1 diabetes by Camoin, Marion, Velho, Gilberto, Saulnier, Pierre-Jean, Potier, Louis, Abouleka, Yawa, Carpentier, Charlyne, Dubois, Severine, Larroumet, Alice, Rigalleau, Vincent, Gand, Elise, Bourron, Olivier, Bordier, Lyse, Scheen, André, Hadjadj, Samy, Roussel, Ronan, Marre, Michel, Mohammedi, Kamel

“…Cardiovascular disease (CVD) and nontraumatic lower-limb amputation (LLA) each results in reduced life expectancy in patients with type 1 diabetes, but the…”
Get full text

Blood glucose levels and COVID-19. Reply to Sardu C, D’Onofrio N, Balestrieri ML et al [letter] and Lepper PM, Bals R, Jüni P et al [letter] by Cariou, Bertrand, Hadjadj, Samy, Wargny, Matthieu, Pichelin, Matthieu, Al-Salameh, Abdallah, Allix, Ingrid, Amadou, Coralie, Arnault, Gwénaëlle, Baudoux, Florence, Bauduceau, Bernard, Borot, Sophie, Bourgeon-Ghittori, Muriel, Bourron, Olivier, Boutoille, David, Cazenave-Roblot, France, Chaumeil, Claude, Cosson, Emmanuel, Coudol, Sandrine, Darmon, Patrice, Disse, Emmanuel, Ducet-Boiffard, Amélie, Gaborit, Bénédicte, Joubert, Michael, Kerlan, Véronique, Laviolle, Bruno, Marchand, Lucien, Meyer, Laurent, Potier, Louis, Prevost, Gaëtan, Riveline, Jean-Pierre, Robert, René, Saulnier, Pierre-Jean, Sultan, Ariane, Thébaut, Jean-François, Thivolet, Charles, Tramunt, Blandine, Vatier, Camille, Roussel, Ronan, Gautier, Jean-François, Gourdy, Pierre

Get full text