Search Results - "BOURRAIN, Sylvie"

Synthesis of pyrido[2,3-d]pyridazines and pyrazino[2,3-d]-pyridazines—novel classes of GABAA receptor benzodiazepine binding site ligands by Mitchinson, Andrew, Blackaby, Wesley P., Bourrain, Sylvie, Carling, Robert W., Lewis, Richard T.

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Synthesis of pyrido[2,3- d]pyridazines and pyrazino[2,3- d]-pyridazines—novel classes of GABA A receptor benzodiazepine binding site ligands by Mitchinson, Andrew, Blackaby, Wesley P., Bourrain, Sylvie, Carling, Robert W., Lewis, Richard T.

“…Novel syntheses of 2,3,8-trisubstituted pyrido[2,3- d]pyridazines and 2,3,5-trisubstituted pyrazino[2,3- d]pyridazines are described. Two complementary routes…”
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3-(4-Piperidinyl)- and 3-(8-aza-bicyclo[3.2.1]oct-3-yl)-2-phenyl-1h-indoles as bioavailable h5-HT2A antagonists by CRAWFORTH, James, GOODACRE, Simon, MAXEY, Robert, BOURRAIN, Sylvie, PATEL, Smita, MARWOOD, Rosemarie, O'CONNOR, Desmond, HERBERT, Richard, HUTSON, Peter, ROWLEY, Michael

“…A series of 3-(4-piperidinyl)- and 3-(8-aza-bicyclo[3.2.1]oct-3-yl)-2-phenyl-1H-indoles have been prepared and evaluated as ligands for the h5-HT2A receptor…”
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3-(4-Piperidinyl)- and 3-(8-aza-bicyclo[3.2.1]oct-3-yl)-2-phenyl-1 H-indoles as bioavailable h5-HT 2A antagonists by Crawforth, James, Goodacre, Simon, Maxey, Robert, Bourrain, Sylvie, Patel, Smita, Marwood, Rosemarie, O'Connor, Desmond, Herbert, Richard, Hutson, Peter, Rowley, Michael

“…A series of 3-(4-piperidinyl)- and 3-(8-aza-bicyclo[3.2.l]oct-3-yl)-2-phenyl-1 H-indoles have been prepared and evaluated as ligands for the h5-HT 2A receptor…”
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High-Affinity and Potent, Water-Soluble 5-Amino-1,4-benzodiazepine CCKB/Gastrin Receptor Antagonists Containing a Cationic Solubilizing Group by Showell, Graham A, Bourrain, Sylvie, Neduvelil, Joseph G, Fletcher, Stephen R, Baker, Raymond, Watt, Alan P, Fletcher, Alan E, Freedman, Stephen B, Kemp, John A

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Substituted pyrazoles as novel selective ligands for the human dopamine D 4 receptor by Bourrain, Sylvie, Collins, Ian, Neduvelil, Joseph G., Rowley, Michael, Leeson, Paul D., Patel, Smita, Patel, Shil, Emms, Frances, Marwood, Rosemarie, Chapman, Kerry L., Fletcher, Alan E., Showell, Graham A.

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Substituted pyrazoles as novel selective ligands for the human dopamine D4 receptor by Bourrain, S, Collins, I, Neduvelil, J G, Rowley, M, Leeson, P D, Patel, S, Emms, F, Marwood, R, Chapman, K L, Fletcher, A E, Showell, G A

“…Two novel series of 3-(heterocyclylmethyl)pyrazoles have been synthesised and evaluated as ligands for the human dopamine D4 receptor. Compounds in series I…”
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4-Hydroxy-1-[3-(5-(1,2,4-triazol-4-yl)-1 H-indol-3-yl)propyl]piperidines: Selective h5-HT 1D agonists for the treatment of migraine by Bourrain, Sylvie, Neduvelil, Joseph G., Beer, Margaret S., Stanton, Josephine A., Showell, Graham A., MacLeod, Angus M.

“…A series of 4-hydroxy-1-[3-(5-(1,2,4-triazol-4-yl)-1 H-indol-3-yl)propyl] piperidines was investigated as potential selective h5-HT 1D agonists for the…”
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4-Hydroxy-1-[3-(5-(1,2,4-triazol-4-yl)-1H-indol-3-yl)propyl]piperidines : Selective h5-HT1D agonists for the treatment of migraine by BOURRAIN, S, NEDUVELIL, J. G, BEER, M. S, STANTON, J. A, SHOWELL, G. A, MACLEOD, A. M

“…A series of 4-hydroxy-1-[3-(5-(1,2,4-triazol-4-yl)-1H-indol-3-yl)propyl] piperidines was investigated as potential selective h5-HT1D agonists for the treatment…”
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C5-piperazinyl-1,4-benzodiazepines, water-soluble, orally bioa vailable CCKB/gastrin receptor antagonists by Showell, Graham A., Bourrain, Sylvie, Fletcher, Stephen R., Neduvelil, Joseph G., Fletcher, Alan E., Freedman, Stephen B., Patel, Smita, Smith, Alison J., Marshall, George R., Graham, Michael I., Sohal, Bindi, Matassa, Victor G.

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Biological properties of the benzodiazepine amidine derivative L-740,093, a cholecystokinin-B/gastrin receptor antagonist with high affinity in vitro and high potency in vivo by Patel, S, Smith, A J, Chapman, K L, Fletcher, A E, Kemp, J A, Marshall, G R, Hargreaves, R J, Ryecroft, W, Iversen, L L, Iversen, S D

“…A novel series of 5-amino-1,4-benzodiazepin-2-one derivatives (amidines), which contain a cationic solubilizing group and which are antagonists for the…”
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C5-piperazinyl-1,4-benzodiazepines, water-soluble, orally bioa vailable CCK B/gastrin receptor antagonists by Showell, Graham A., Bourrain, Sylvie, Fletcher, Stephen R., Neduvelil, Joseph G., Fletcher, Alan E., Freedman, Stephen B., Patel, Smita, Smith, Alison J., Marshall, George R., Graham, Michael I., Sohal, Bindi, Matassa, Victor G.

“…A novel series of potent, water-soluble benzodiazepine based CCK B/gastrin antagonists has been prepared which incorporate an N-methylpiperazine group at the…”
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