Search Results - "BOURGERON, Thomas"

From the genetic architecture to synaptic plasticity in autism spectrum disorder by Bourgeron, Thomas

“…Key Points Twin and familial studies reveal that autism spectrum disorder (ASD) traits are highly heritable. The genetic landscape of ASD is made of common and…”
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Current knowledge on the genetics of autism and propositions for future research by Bourgeron, Thomas

“…Autism spectrum disorders (ASD) are a heterogeneous group of neuropsychiatric disorders characterized by problems in social communication, as well as by the…”
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The emerging role of SHANK genes in neuropsychiatric disorders by Guilmatre, Audrey, Huguet, Guillaume, Delorme, Richard, Bourgeron, Thomas

“…ABSTRACT The genetic heterogeneity of neuropsychiatric disorders is high, but some pathways emerged, notably synaptic functioning. A large number of mutations…”
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The Genetic Landscapes of Autism Spectrum Disorders by Huguet, Guillaume, Ey, Elodie, Bourgeron, Thomas

“…The autism spectrum disorders (ASD) are characterized by impairments in social interaction and stereotyped behaviors. For the majority of individuals with ASD,…”
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Progress toward treatments for synaptic defects in autism by Delorme, Richard, Ey, Elodie, Toro, Roberto, Leboyer, Marion, Gillberg, Christopher, Bourgeron, Thomas

“…Autism spectrum disorders (ASDs) are a clinically heterogeneous group of neurodevelopmental disorders characterized by social and communication deficits and…”
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Searching for ways out of the autism maze : genetic, epigenetic and environmental clues by PERSICO, Antonio M, BOURGERON, Thomas

“…Our understanding of human disorders that affect higher cognitive functions has greatly advanced in recent decades, and over 20 genes associated with…”
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HyPyP: a Hyperscanning Python Pipeline for inter-brain connectivity analysis by Ayrolles, Anaël, Brun, Florence, Chen, Phoebe, Djalovski, Amir, Beauxis, Yann, Delorme, Richard, Bourgeron, Thomas, Dikker, Suzanne, Dumas, Guillaume

“…Abstract The bulk of social neuroscience takes a ‘stimulus-brain’ approach, typically comparing brain responses to different types of social stimuli, but most…”
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Cerebellar Volume in Autism: Literature Meta-analysis and Analysis of the Autism Brain Imaging Data Exchange Cohort by Traut, Nicolas, Beggiato, Anita, Bourgeron, Thomas, Delorme, Richard, Rondi-Reig, Laure, Paradis, Anne-Lise, Toro, Roberto

“…The neuroanatomical bases of autism spectrum disorder remain largely unknown. Among the most widely discussed candidate endophenotypes, differences in…”
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Adult male mice emit context-specific ultrasonic vocalizations that are modulated by prior isolation or group rearing environment by Chabout, Jonathan, Serreau, Pierre, Ey, Elodie, Bellier, Ludovic, Aubin, Thierry, Bourgeron, Thomas, Granon, Sylvie

“…Social interactions in mice are frequently analysed in genetically modified strains in order to get insight of disorders affecting social interactions such as…”
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Fragile X syndrome and autism at the intersection of genetic and neural networks by Belmonte, Matthew K, Bourgeron, Thomas

“…Autism, an entirely behavioral diagnosis with no largely understood etiologies and no population-wide biomarkers, contrasts with fragile X syndrome (FXS), a…”
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Gender differences in autism spectrum disorders: Divergence among specific core symptoms by Beggiato, Anita, Peyre, Hugo, Maruani, Anna, Scheid, Isabelle, Rastam, Maria, Amsellem, Frederique, Gillberg, Carina I., Leboyer, Marion, Bourgeron, Thomas, Gillberg, Christopher, Delorme, Richard

“…Community‐based studies have consistently shown a sex ratio heavily skewed towards males in autism spectrum disorders (ASD). The factors underlying this…”
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Insights from an autism imaging biomarker challenge: Promises and threats to biomarker discovery by Traut, Nicolas, Heuer, Katja, Lemaître, Guillaume, Beggiato, Anita, Germanaud, David, Elmaleh, Monique, Bethegnies, Alban, Bonnasse-Gahot, Laurent, Cai, Weidong, Chambon, Stanislas, Cliquet, Freddy, Ghriss, Ayoub, Guigui, Nicolas, de Pierrefeu, Amicie, Wang, Meng, Zantedeschi, Valentina, Boucaud, Alexandre, van den Bossche, Joris, Kegl, Balázs, Delorme, Richard, Bourgeron, Thomas, Toro, Roberto, Varoquaux, Gaël

“…MRI has been extensively used to identify anatomical and functional differences in Autism Spectrum Disorder (ASD). Yet, many of these findings have proven…”
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Disruption of melatonin synthesis is associated with impaired 14-3-3 and miR-451 levels in patients with autism spectrum disorders by Pagan, Cécile, Goubran-Botros, Hany, Delorme, Richard, Benabou, Marion, Lemière, Nathalie, Murray, Kerren, Amsellem, Frédérique, Callebert, Jacques, Chaste, Pauline, Jamain, Stéphane, Fauchereau, Fabien, Huguet, Guillaume, Maronde, Erik, Leboyer, Marion, Launay, Jean-Marie, Bourgeron, Thomas

“…Autism spectrum disorders (ASD) are characterized by a wide genetic and clinical heterogeneity. However, some biochemical impairments, including decreased…”
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Reduced social interaction and ultrasonic communication in a mouse model of monogenic heritable autism by Jamain, Stephane, Radyushkin, Konstantin, Hammerschmidt, Kurt, Granon, Sylvie, Boretius, Susann, Varoqueaux, Frederique, Ramanantsoa, Nelina, Gallego, Jorge, Ronnenberg, Anja, Winter, Dorina, Frahm, Jens, Fischer, Julia, Bourgeron, Thomas, Ehrenreich, Hannelore, Brose, Nils

“…Autism spectrum conditions (ASCs) are heritable conditions characterized by impaired reciprocal social interactions, deficits in language acquisition, and…”
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LMT USV Toolbox, a Novel Methodological Approach to Place Mouse Ultrasonic Vocalizations in Their Behavioral Contexts—A Study in Female and Male C57BL/6J Mice and in Shank3 Mutant Females by de Chaumont, Fabrice, Lemière, Nathalie, Coqueran, Sabrina, Bourgeron, Thomas, Ey, Elodie

“…Ultrasonic vocalizations (USVs) are used as a phenotypic marker in mouse models of neuropsychiatric disorders. Nevertheless, current methodologies still…”
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Association of modifiers and other genetic factors explain Marfan syndrome clinical variability by Aubart, Melodie, Gazal, Steven, Arnaud, Pauline, Benarroch, Louise, Gross, Marie-Sylvie, Buratti, Julien, Boland, Anne, Meyer, Vincent, Zouali, Habib, Hanna, Nadine, Milleron, Olivier, Stheneur, Chantal, Bourgeron, Thomas, Desguerre, Isabelle, Jacob, Marie-Paule, Gouya, Laurent, Génin, Emmanuelle, Deleuze, Jean-François, Jondeau, Guillaume, Boileau, Catherine

“…Marfan syndrome (MFS) is a rare autosomal dominant connective tissue disorder related to variants in the FBN1 gene. Prognosis is related to aortic risk of…”
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Phelan-McDermid syndrome: a classification system after 30 years of experience by Phelan, Katy, Boccuto, Luigi, Powell, Craig M, Boeckers, Tobias M, van Ravenswaaij-Arts, Conny, Rogers, R Curtis, Sala, Carlo, Verpelli, Chiara, Thurm, Audrey, Bennett, Jr, William E, Winrow, Christopher J, Garrison, Sheldon R, Toro, Roberto, Bourgeron, Thomas

“…Phelan-McDermid syndrome (PMS) was initially called the 22q13 deletion syndrome based on its etiology as a deletion of the distal long arm of chromosome 22…”
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Mutations associated with neuropsychiatric conditions delineate functional brain connectivity dimensions contributing to autism and schizophrenia by Moreau, Clara A., Urchs, Sebastian G. W., Kuldeep, Kumar, Orban, Pierre, Schramm, Catherine, Dumas, Guillaume, Labbe, Aurélie, Huguet, Guillaume, Douard, Elise, Quirion, Pierre-Olivier, Lin, Amy, Kushan, Leila, Grot, Stephanie, Luck, David, Mendrek, Adrianna, Potvin, Stephane, Stip, Emmanuel, Bourgeron, Thomas, Evans, Alan C., Bearden, Carrie E., Bellec, Pierre, Jacquemont, Sebastien

“…16p11.2 and 22q11.2 Copy Number Variants (CNVs) confer high risk for Autism Spectrum Disorder (ASD), schizophrenia (SZ), and…”
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Behavioral profiles of mouse models for autism spectrum disorders by Ey, Elodie, Leblond, Claire S., Bourgeron, Thomas

“…Autism spectrum disorders (ASD) are characterized by impairments in reciprocal social communication, and stereotyped verbal and nonverbal behaviors. In…”
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Development of an autism severity score for mice using Nlgn4 null mutants as a construct-valid model of heritable monogenic autism by El-Kordi, Ahmed, Winkler, Daniela, Hammerschmidt, Kurt, Kästner, Anne, Krueger, Dilja, Ronnenberg, Anja, Ritter, Caroline, Jatho, Jasmin, Radyushkin, Konstantin, Bourgeron, Thomas, Fischer, Julia, Brose, Nils, Ehrenreich, Hannelore

“…► Loss-of-function mutations of NLGN4X are the most frequent monogenic autism cause. ► Nlgn4KO mice show reduced social functions/communication and increased…”
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