Search Results - "BOURDELLES, BEATRICE LE"

Molecular and Functional Diversity of the Expanding GABA-A Receptor Gene Family by WHITING, PAUL J., BONNERT, TIMOTHY P., MCKERNAN, RUTH M., FARRAR, SOPHIE, BOURDELLES, BEATRICE LE, HEAVENS, ROBERT P., SMITH, DAVID W., HEWSON, LOUISE, RIGBY, MICHAEL R., SIRINATHSINGHJI, DALIP J. S., THOMPSON, SALLY A., WAFFORD, KEITH A.

“…Fast inhibitory neurotransmission in the mammalian CNS is mediated primarily by the neurotransmitter γ‐aminobutyric acid (GABA), which, upon binding to its…”
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Preferential co-assembly of recombinant NMDA receptors composed of three different subunits by Wafford, K A, Bain, C J, Le Bourdelles, B, Whiting, P J, Kemp, J A

“…cDNAs ENCODING NMDA receptor subunits have recently been cloned and been shown to have different distributions in the CNS. However, no studies on the possible…”
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Assembly intracellular targeting and cell surface expression of the human N-methyl- d-aspartate receptor subunits NR1a and NR2A in transfected cells by McIlhinney, R.A.Jeffrey, Le Bourdellès, Beatrice, Molnár, Elek, Tricaud, Nicolas, Streit, Peter, Whiting, Paul J

“…The intracellular trafficking, assembly, and cell surface targeting of the human N-methyl- d-aspartate receptor subunits NR1a and NR2A has been studied using…”
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Gene expression profiling of drug metabolism and toxicology markers using a low-density DNA microarray by de Longueville, Françoise, Surry, Dominic, Meneses-Lorente, Georgina, Bertholet, Vincent, Talbot, Valérie, Evrard, Stephanie, Chandelier, Nathalie, Pike, Andrew, Worboys, Phil, Rasson, Jean-Paul, Le Bourdellès, Béatrice, Remacle, José

“…DNA microarrays are useful tools to study changes of gene expression in response to a treatment with drugs. Here, we describe the optimization of conditions…”
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θ , a Novel γ -Aminobutyric Acid Type A Receptor Subunit by Bonnert, Timothy P., McKernan, Ruth M., Farrar, Sophie, le Bourdellès, Béatrice, Heavens, Robert P., Smith, David W., Hewson, Louise, Rigby, Michael R., Dalip J. S. Sirinathsinghji, Brown, Nicola, Wafford, Keith A., Whiting, Paul J.

“…γ -Aminobutyric acid type A (GABA-A) receptors are a major mediator of inhibitory neurotransmission in the mammalian central nervous system, and the site of…”
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Localization of the Human NMDAR2D Receptor Subunit Gene (GRIN2D) to 19q13.1–qter, the NMDAR2A Subunit Gene to 16p13.2 (GRIN2A), and the NMDAR2C Subunit Gene (GRIN2C) to 17q24–q25 Using Somatic Cell Hybrid and Radiation Hybrid Mapping Panels by Kalsi, Gursharan, Whiting, Paul, Bourdelles, Beatrice Le, Callen, David, Barnard, Eric A, Gurling, Hugh

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Recombinant human NMDA homomeric NR1 receptors expressed in mammalian cells form a high-affinity glycine antagonist binding site by Grimwood, S, Le Bourdellès, B, Whiting, P J

“…The cDNA NYMDAR1 (NR1) encodes a single polypeptide that forms a receptor-channel complex with electrophsiological and pharmacological properties…”
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Stable Expression of Mammalian type A γ-Aminobutyric Acid Receptors in Mouse Cells: Demonstration of Functional Assembly of Benzodiazepine- Responsive Sites by Hadingham, Karen L., Harkness, Patricia C., McKernan, Ruth M., Quirk, Kathleen, Le Bourdelles, Beatrice, Horne, Anthony L., Kemp, John A., Barnard, Eric A., Ragan, C. Ian, Whiting, Paul J.

“…The differential sensitivity of type A γ-aminobutyric acid (GABAA) receptors to benzodiazepine ligands seen in the mammalian nervous system is thought to be…”
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Identification of Molecular Determinants That Are Important in the Assembly of N-Methyl-d-aspartate Receptors by Meddows, Elisabeth, Le Bourdellès, Béatrice, Grimwood, Sarah, Wafford, Keith, Sandhu, Satpal, Whiting, Paul, McIlhinney, R. A. Jeffrey

“…To determine which domains of theN-methyl-d-aspartate (NMDA) receptor are important for the assembly of functional receptors, a number of N- and C-terminal…”
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Pharmacological properties of recombinant human N-methyl-D-aspartate receptors comprising NR1a/NR2A and NR1a/NR2B subunit assemblies expressed in permanently transfected mouse fibroblast cells by Priestley, T, Laughton, P, Myers, J, Le Bourdellés, B, Kerby, J, Whiting, P J

“…The pharmacological properties of two recombinant human N-methyl-D-aspartate (NMDA) receptor subtypes, comprising either NR1a/NR2A or NR1a/NR2B subunits…”
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Recombinant human tyrosine hydroxylase isozymes : reconstitution with iron and inhibitory effect of other metal ions by HAAVIK, J, LE BOURDELLES, B, MARTINEZ, A, FLATMARK, T, MALLET, J

“…Human tyrosine 3-monooxygenase (tyrosine hydroxylase) exists as four different isozymes (TH1-TH4), generated by alternative splicing of pre-mRNA. Recombinant…”
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Regulation of recombinant human tyrosine hydroxylase isozymes by catecholamine binding and phosphorylation : structure/activity studies and mechanistic implications by ALMAS, B, LE BOURDELLES, B, FLATMARK, T, MALLET, J, HAAVIK, J

“…Three isozymes of human tyrosine hydroxylase (hTH1, hTH2 and hTH4) were expressed in Escherichia coli and purified to homogeneity. Natural catecholamines and…”
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Phosphorylation and activation of human tyrosine hydroxylase in vitro by mitogen‐activated protein (MAP) kinase and MAP‐kinase‐activated kinases 1 and 2 by SUTHERLAND, Calum, ALTERIO, Janine, CAMPBELL, David G., BOURDELLÈS, Béatrice, MALLET, Jacques, HAAVIK, Jan, COHEN, Philip

“…Mitogen‐activated protein‐kinase (MAP) kinase‐activated protein kinases 1 and 2 (MAPKAP kinase‐1, MAPKAP kinase‐2), were found to phosphorylate bacterially…”
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Generation and characterisation of stable cell lines expressing recombinant human N-methyl-D-aspartate receptor subtypes by Grimwood, S, Le Bourdellès, B, Atack, J R, Barton, C, Cockett, W, Cook, S M, Gilbert, E, Hutson, P H, McKernan, R M, Myers, J, Ragan, C I, Wingrove, P B, Whiting, P J

“…Transfection of mouse L(tk-) cells with human N-methyl-D-aspartate (NMDA) receptor subunit cDNAs under the control of a dexamethasone-inducible promoter has…”
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Phosphorylation of human recombinant tyrosine hydroxylase isoforms 1 and 2: an additional phosphorylated residue in isoform 2, generated through alternative splicing by LE BOURDELLES, B, HORELLOU, P, LE CAER, J.-P, DENEFLE, P, LATTA, M, HAAVIK, J, GUIBERT, B, MAYAUX, J.-F, MALLET, J

“…The single human tyrosine hydroxylase (TH) gene generates four different mRNA species through alternative splicing events. TH-1 and TH-2 mRNAs are expressed…”
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Delineation of the Structural Determinants of the N‐Methyl‐D‐Aspartate Receptor Glycine Binding Site by Sandhu, Satpal, Grimwood, Sarah, Mortishire‐Smith, Russell J., Whiting, Paul J., Le Bourdellès, Béatrice

“…: In this study, we have further delineated the domains of the N‐methyl‐D‐aspartate receptor NR1 subunit that contribute to the glycine co‐agonist binding…”
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