Search Results - "BOULTON, Michael E"

Oxidative stress-mediated NFκB phosphorylation upregulates p62/SQSTM1 and promotes retinal pigmented epithelial cell survival through increased autophagy by Song, Chunjuan, Mitter, Sayak K, Qi, Xiaoping, Beli, Eleni, Rao, Haripriya V, Ding, Jindong, Ip, Colin S, Gu, Hongmei, Akin, Debra, Dunn, Jr, William A, Bowes Rickman, Catherine, Lewin, Alfred S, Grant, Maria B, Boulton, Michael E

“…p62 is a scaffolding adaptor implicated in the clearance of protein aggregates by autophagy. Reactive oxygen species (ROS) can either stimulate or inhibit…”
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Pathogenic role of diabetes-induced PPAR-α down-regulation in microvascular dysfunction by Hu, Yang, Chen, Ying, Ding, Lexi, He, Xuemin, Takahashi, Yusuke, Gao, Yang, Shen, Wei, Cheng, Rui, Chen, Qian, Qi, Xiaoping, Boulton, Michael E., Ma, Jian-xing

“…Two independent clinical studies have reported that fenofibrate, a peroxisome proliferator-activated receptor α (PPARα) agonist, has robust therapeutic effects…”
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PRMT5 is a therapeutic target in choroidal neovascularization by Muniyandi, Anbukkarasi, Martin, Matthew, Sishtla, Kamakshi, Motolani, Aishat, Sun, Mengyao, Jensen, Nathan R., Qi, Xiaoping, Boulton, Michael E., Prabhu, Lakshmi, Lu, Tao, Corson, Timothy W.

“…Ocular neovascular diseases including neovascular age-related macular degeneration (nvAMD) are widespread causes of blindness. Patients’ non-responsiveness to…”
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Opa1 deficiency in a mouse model of autosomal dominant optic atrophy impairs mitochondrial morphology, optic nerve structure and visual function by Davies, Vanessa J., Hollins, Andrew J., Piechota, Malgorzata J., Yip, Wanfen, Davies, Jennifer R., White, Kathryn E., Nicols, Phillip P., Boulton, Michael E., Votruba, Marcela

“…OPA1 is a ubiquitously expressed, nuclear dynamin-related GTPase, targeted to the inner mitochondrial membrane, which plays a role in mitochondrial fusion…”
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Autophagy in the retina: a potential role in age-related macular degeneration by Mitter, Sayak K, Rao, Haripriya Vittal, Qi, Xiaoping, Cai, Jun, Sugrue, Andrew, Dunn, Jr, William A, Grant, Maria B, Boulton, Michael E

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Decreased Expression of Soluble Epoxide Hydrolase Suppresses Murine Choroidal Neovascularization by Park, Bomina, Sardar Pasha, Sheik Pran Babu, Sishtla, Kamakshi L, Hartman, Gabriella D, Qi, Xiaoping, Boulton, Michael E, Corson, Timothy W

“…Neovascular or "wet" age-related macular degeneration (nAMD) is a leading cause of blindness among older adults. Choroidal neovascularization (CNV) is a major…”
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Vasoreparative dysfunction of CD34+ cells in diabetic individuals involves hypoxic desensitization and impaired autocrine/paracrine mechanisms by Jarajapu, Yagna P R, Hazra, Sugata, Segal, Mark, Li Calzi, Sergio, LiCalzi, Sergio, Jadhao, Chandra, Jhadao, Chandra, Qian, Kevin, Mitter, Sayak K, Raizada, Mohan K, Boulton, Michael E, Grant, Maria B

“…We hypothesized that endothelial progenitor cells derived from individuals with diabetes would exhibit functional defects including inability to respond to…”
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Regulation of retinal inflammation by rhythmic expression of MiR-146a in diabetic retina by Wang, Qi, Bozack, Svetlana N, Yan, Yuanqing, Boulton, Michael E, Grant, Maria B, Busik, Julia V

“…Chronic inflammation and dysregulation of circadian rhythmicity are involved in the pathogenesis of diabetic retinopathy. MicroRNAs (miRNAs) can regulate…”
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Aryl hydrocarbon receptor deficiency causes dysregulated cellular matrix metabolism and age-related macular degeneration-like pathology by Hu, Peng, Herrmann, Rolf, Bednar, Amanda, Saloupis, Peter, Dwyer, Mary A, Yang, Ping, Qi, Xiaoping, Thomas, Russell S, Jaffe, Glenn J, Boulton, Michael E, McDonnell, Donald P, Malek, Goldis

“…The aryl hydrocarbon receptor (AhR) is a nuclear receptor that regulates xenobiotic metabolism and detoxification. Herein, we report a previously undescribed…”
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Spatial and temporal VEGF receptor intracellular trafficking in microvascular and macrovascular endothelial cells by Silva, Juliete A. F., Qi, Xiaoping, Grant, Maria B., Boulton, Michael E.

“…The vascular endothelial growth factor receptors (VEGFRs) can shape the neovascular phenotype of vascular endothelial cells when translocated to the nucleus,…”
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Systemic Injection of RPE65-Programmed Bone Marrow-Derived Cells Prevents Progression of Chronic Retinal Degeneration by Qi, Xiaoping, Pay, S. Louise, Yan, Yuanqing, Thomas, James, Lewin, Alfred S., Chang, Lung-Ji, Grant, Maria B., Boulton, Michael E.

“…Bone marrow stem and progenitor cells can differentiate into a range of non-hematopoietic cell types, including retinal pigment epithelium (RPE)-like cells. In…”
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β‐Secretase (BACE1) inhibition causes retinal pathology by vascular dysregulation and accumulation of age pigment by Cai, Jun, Qi, Xiaoping, Kociok, Norbert, Skosyrski, Sergej, Emilio, Alonso, Ruan, Qing, Han, Song, Liu, Li, Chen, Zhijuan, Bowes Rickman, Catherine, Golde, Todd, Grant, Maria B., Saftig, Paul, Serneels, Lutgarde, de Strooper, Bart, Joussen, Antonia M., Boulton, Michael E.

“…β‐Secretase (BACE1) is a major drug target for combating Alzheimer's disease (AD). Here we show that BACE1 −/− mice develop significant retinal pathology…”
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Diurnal Rhythmicity of Autophagy Is Impaired in the Diabetic Retina by Qi, Xiaoping, Mitter, Sayak K, Yan, Yuanqing, Busik, Julia V, Grant, Maria B, Boulton, Michael E

“…Retinal homeostasis is under both diurnal and circadian regulation. We sought to investigate the diurnal expression of autophagy proteins in normal rodent…”
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Per2 Mutation Recapitulates the Vascular Phenotype of Diabetes in the Retina and Bone Marrow by BHATWADEKAR, Ashay D, YUANQING YAN, BOULTON, Michael E, GRANT, Maria B, XIAOPING QI, THINSCHMIDT, Jeffrey S, NEU, Matthew B, LI CALZI, Sergio, SHAW, Lynn C, DOMINIGUEZ, James M, BUSIK, Julia V, LEE, Choogon

“…In this study, we assessed whether Per2 clock gene-mutant mice exhibit a vascular phenotype similar to diabetes. Per2 (B6.129-Per2(tm1Drw)/J) or wild-type…”
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Ferrochelatase is a therapeutic target for ocular neovascularization by Basavarajappa, Halesha D, Sulaiman, Rania S, Qi, Xiaoping, Shetty, Trupti, Sheik Pran Babu, Sardar, Sishtla, Kamakshi L, Lee, Bit, Quigley, Judith, Alkhairy, Sameerah, Briggs, Christian M, Gupta, Kamna, Tang, Buyun, Shadmand, Mehdi, Grant, Maria B, Boulton, Michael E, Seo, Seung‐Yong, Corson, Timothy W

“…Ocular neovascularization underlies major blinding eye diseases such as “wet” age‐related macular degeneration (AMD). Despite the successes of treatments…”
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Immune complex formation in human diabetic retina enhances toxicity of oxidized LDL towards retinal capillary pericytes by Fu, Dongxu, Yu, Jeremy Y, Wu, Mingyuan, Du, Mei, Chen, Ying, Abdelsamie, Souzan A, Li, Yanchun, Chen, Junping, Boulton, Michael E, Ma, Jian-Xing, Lopes-Virella, Maria F, Virella, Gabriel, Lyons, Timothy J

“…Recently it has been shown that levels of circulating oxidized LDL immune complexes (ox-LDL-ICs) predict the development of diabetic retinopathy (DR). This…”
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Changes in the daily rhythm of lipid metabolism in the diabetic retina by Wang, Qi, Tikhonenko, Maria, Bozack, Svetlana N, Lydic, Todd A, Yan, Lily, Panchy, Nicholas L, McSorley, Kelly M, Faber, Matthew S, Yan, Yuanqing, Boulton, Michael E, Grant, Maria B, Busik, Julia V

“…Disruption of circadian regulation was recently shown to cause diabetes and metabolic disease. We have previously demonstrated that retinal lipid metabolism…”
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Repurposing antimalarial aminoquinolines and related compounds for treatment of retinal neovascularization by McAnally, Danielle, Siddiquee, Khandaker, Gomaa, Ahmed, Szabo, Andras, Vasile, Stefan, Maloney, Patrick R, Divlianska, Daniela B, Peddibhotla, Satyamaheshwar, Morfa, Camilo J, Hershberger, Paul, Falter, Rebecca, Williamson, Robert, Terry, David B, Farjo, Rafal, Pinkerton, Anthony B, Qi, Xiaping, Quigley, Judith, Boulton, Michael E, Grant, Maria B, Smith, Layton H

“…Neovascularization is the pathological driver of blinding eye diseases such as retinopathy of prematurity, proliferative diabetic retinopathy, and wet…”
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Dicer expression exhibits a tissue-specific diurnal pattern that is lost during aging and in diabetes by Yan, Yuanqing, Salazar, Tatiana E, Dominguez, 2nd, James M, Nguyen, Dung V, Li Calzi, Sergio, Bhatwadekar, Ashay D, Qi, Xiaoping, Busik, Julia V, Boulton, Michael E, Grant, Maria B

“…Dysregulation of circadian rhythmicity is identified as a key factor in disease pathogenesis. Circadian rhythmicity is controlled at both a transcriptional and…”
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CNS Inflammation and Bone Marrow Neuropathy in Type 1 Diabetes by Hu, Ping, Thinschmidt, Jeffrey S, Yan, Yuanqing, Hazra, Sugata, Bhatwadekar, Ashay, Caballero, Sergio, Salazar, Tatiana, Miyan, Jaleel A, Li, Wencheng, Derbenev, Andrei, Zsombok, Andrea, Tikhonenko, Maria, Dominguez, James M, McGorray, Susan P, Saban, Daniel R, Boulton, Michael E, Busik, Julia V, Raizada, Mohan K, Chan-Ling, Tailoi, Grant, Maria B

“…By using pseudorabies virus expressing green fluorescence protein, we found that efferent bone marrow–neural connections trace to sympathetic centers of the…”
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