Search Results - "BOULANT, Steeve"

TMPRSS2 expression dictates the entry route used by SARS‐CoV‐2 to infect host cells by Koch, Jana, Uckeley, Zina M, Doldan, Patricio, Stanifer, Megan, Boulant, Steeve, Lozach, Pierre‐Yves

“…SARS‐CoV‐2 is a newly emerged coronavirus that caused the global COVID‐19 outbreak in early 2020. COVID‐19 is primarily associated with lung injury, but many…”
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Differential Regulation of Type I and Type III Interferon Signaling by Stanifer, Megan L, Pervolaraki, Kalliopi, Boulant, Steeve

“…Interferons (IFNs) are very powerful cytokines, which play a key role in combatting pathogen infections by controlling inflammation and immune response by…”
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SARS-CoV-2 structure and replication characterized by in situ cryo-electron tomography by Klein, Steffen, Cortese, Mirko, Winter, Sophie L., Wachsmuth-Melm, Moritz, Neufeldt, Christopher J., Cerikan, Berati, Stanifer, Megan L., Boulant, Steeve, Bartenschlager, Ralf, Chlanda, Petr

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the COVID19 pandemic, is a highly pathogenic β-coronavirus. As other…”
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The First Five Seconds in the Life of a Clathrin-Coated Pit by Cocucci, Emanuele, Aguet, François, Boulant, Steeve, Kirchhausen, Tom

“…Coated pits assemble by growth of a clathrin lattice, which is linked by adaptors to the underlying membrane. How does this process start? We used live-cell…”
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Importance of Type I and III Interferons at Respiratory and Intestinal Barrier Surfaces by Stanifer, Megan L, Guo, Cuncai, Doldan, Patricio, Boulant, Steeve

“…Interferons (IFNs) constitute the first line of defense against microbial infections particularly against viruses. They provide antiviral properties to cells…”
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Critical Role of Type III Interferon in Controlling SARS-CoV-2 Infection in Human Intestinal Epithelial Cells by Stanifer, Megan L., Kee, Carmon, Cortese, Mirko, Zumaran, Camila Metz, Triana, Sergio, Mukenhirn, Markus, Kraeusslich, Hans-Georg, Alexandrov, Theodore, Bartenschlager, Ralf, Boulant, Steeve

“…Severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2) is an unprecedented worldwide health problem that requires concerted and global approaches…”
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Actin dynamics counteract membrane tension during clathrin-mediated endocytosis by Kirchhausen, Tomas, Boulant, Steeve, Kural, Comert, Zeeh, Jean-Christophe, Ubelmann, Florent

“…Clathrin-mediated endocytosis is independent of actin dynamics in many circumstances but requires actin polymerization in others. We show that membrane tension…”
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Diverse intracellular pathogens activate type III interferon expression from peroxisomes by Odendall, Charlotte, Dixit, Evelyn, Stavru, Fabrizia, Bierne, Helene, Franz, Kate M, Durbin, Ann Fiegen, Boulant, Steeve, Gehrke, Lee, Cossart, Pascale, Kagan, Jonathan C

“…Type III interferons have important antiviral functions, but they are poorly described compared to type I interferons. Kagan and colleagues demonstrate that…”
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Dynamics of virus-receptor interactions in virus binding, signaling, and endocytosis by Boulant, Steeve, Stanifer, Megan, Lozach, Pierre-Yves

“…During viral infection the first challenge that viruses have to overcome is gaining access to the intracellular compartment. The infection process starts when…”
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NSs amyloid formation is associated with the virulence of Rift Valley fever virus in mice by Léger, Psylvia, Nachman, Eliana, Richter, Karsten, Tamietti, Carole, Koch, Jana, Burk, Robin, Kummer, Susann, Xin, Qilin, Stanifer, Megan, Bouloy, Michèle, Boulant, Steeve, Kräusslich, Hans-Georg, Montagutelli, Xavier, Flamand, Marie, Nussbaum-Krammer, Carmen, Lozach, Pierre-Yves

“…Amyloid fibrils result from the aggregation of host cell-encoded proteins, many giving rise to specific human illnesses such as Alzheimer’s disease. Here we…”
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Single‐cell analyses reveal SARS‐CoV‐2 interference with intrinsic immune response in the human gut by Triana, Sergio, Metz‐Zumaran, Camila, Ramirez, Carlos, Kee, Carmon, Doldan, Patricio, Shahraz, Mohammed, Schraivogel, Daniel, Gschwind, Andreas R, Sharma, Ashwini K, Steinmetz, Lars M, Herrmann, Carl, Alexandrov, Theodore, Boulant, Steeve, Stanifer, Megan L

“…Exacerbated pro‐inflammatory immune response contributes to COVID‐19 pathology. However, despite the mounting evidence about SARS‐CoV‐2 infecting the human…”
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Differential induction of interferon stimulated genes between type I and type III interferons is independent of interferon receptor abundance by Pervolaraki, Kalliopi, Rastgou Talemi, Soheil, Albrecht, Dorothee, Bormann, Felix, Bamford, Connor, Mendoza, Juan L, Garcia, K Christopher, McLauchlan, John, Höfer, Thomas, Stanifer, Megan L, Boulant, Steeve

“…It is currently believed that type I and III interferons (IFNs) have redundant functions. However, the preferential distribution of type III IFN receptor on…”
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Multivalent 9-O-Acetylated-sialic acid glycoclusters as potent inhibitors for SARS-CoV-2 infection by Petitjean, Simon J. L., Chen, Wenzhang, Koehler, Melanie, Jimmidi, Ravikumar, Yang, Jinsung, Mohammed, Danahe, Juniku, Blinera, Stanifer, Megan L., Boulant, Steeve, Vincent, Stéphane P., Alsteens, David

“…The recent emergence of highly transmissible SARS-CoV-2 variants illustrates the urgent need to better understand the molecular details of the virus binding to…”
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Host factors facilitating SARS‐CoV‐2 virus infection and replication in the lungs by Boutin, Sébastien, Hildebrand, Dagmar, Boulant, Steeve, Kreuter, Michael, Rüter, Jule, Pallerla, Srinivas Reddy, Velavan, Thirumalaisamy P., Nurjadi, Dennis

“…SARS-CoV-2 is the virus causing the major pandemic facing the world today. Although, SARS-CoV-2 primarily causes lung infection, a variety of symptoms have…”
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Visualization of Double-Stranded RNA in Cells Supporting Hepatitis C Virus RNA Replication by Targett-Adams, Paul, Boulant, Steeve, McLauchlan, John

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Clathrin-adaptor ratio and membrane tension regulate the flat-to-curved transition of the clathrin coat during endocytosis by Bucher, Delia, Frey, Felix, Sochacki, Kem A., Kummer, Susann, Bergeest, Jan-Philip, Godinez, William J., Kräusslich, Hans-Georg, Rohr, Karl, Taraska, Justin W., Schwarz, Ulrich S., Boulant, Steeve

“…Although essential for many cellular processes, the sequence of structural and molecular events during clathrin-mediated endocytosis remains elusive. While it…”
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Functional comparison of MERS-coronavirus lineages reveals increased replicative fitness of the recombinant lineage 5 by Schroeder, Simon, Mache, Christin, Kleine-Weber, Hannah, Corman, Victor M., Muth, Doreen, Richter, Anja, Fatykhova, Diana, Memish, Ziad A., Stanifer, Megan L., Boulant, Steeve, Gultom, Mitra, Dijkman, Ronald, Eggeling, Stephan, Hocke, Andreas, Hippenstiel, Stefan, Thiel, Volker, Pöhlmann, Stefan, Wolff, Thorsten, Müller, Marcel A., Drosten, Christian

“…Middle East respiratory syndrome coronavirus (MERS-CoV) is enzootic in dromedary camels across the Middle East and Africa. Virus-induced pneumonia in humans…”
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Regionalization of the antiviral response in the gastrointestinal tract to provide spatially controlled host/pathogen interactions by Stanifer, Megan L, Karst, Stephanie M, Boulant, Steeve

“…As the largest mucosal surface, the gastrointestinal (GI) tract plays a key role in protecting the host against pathogen infections. It is a first line of…”
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Forces during cellular uptake of viruses and nanoparticles at the ventral side by Wiegand, Tina, Fratini, Marta, Frey, Felix, Yserentant, Klaus, Liu, Yang, Weber, Eva, Galior, Kornelia, Ohmes, Julia, Braun, Felix, Herten, Dirk-Peter, Boulant, Steeve, Schwarz, Ulrich S., Salaita, Khalid, Cavalcanti-Adam, E. Ada, Spatz, Joachim P.

“…Many intracellular pathogens, such as mammalian reovirus, mimic extracellular matrix motifs to specifically interact with the host membrane. Whether and how…”
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Editorial: Type III interferons: Emerging roles beyond antiviral barrier defense by Boulant, Steeve, Forero, Adriana, Santer, Deanna M., Broggi, Achille

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