Search Results - "BOUCHER, Matthieu"

Restoring Function in Major Depressive Disorder: A Systematic Review by Sheehan, David V, Nakagome, Kazuyuki, Asami, Yuko, Pappadopulos, Elizabeth A, Boucher, Matthieu

“…Abstract Background Functional impairment contributes to significant disability and economic burden in major depressive disorder (MDD). Treatment response is…”
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Long-term effectiveness of aripiprazole once monthly on functioning and quality of life in schizophrenia: results of year 2 of the ReLiAM study by Roy, Marc-André, Therrien, François, Boucher, Matthieu, Oluboka, Oloruntoba

“…Abstract Background Aripiprazole once-monthly (AOM) has proven effective in the treatment of schizophrenia, although little is known about its impact on global…”
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A Novel and Efficient Model of Coronary Artery Ligation and Myocardial Infarction in the Mouse by Gao, Erhe, Lei, Yong Hong, Shang, Xiying, Huang, Z Maggie, Zuo, Lin, Boucher, Matthieu, Fan, Qian, Chuprun, J Kurt, Ma, Xin L, Koch, Walter J

“…RATIONALE:Coronary artery ligation to induce myocardial infarction (MI) in mice is typically performed by an invasive and time-consuming approach that requires…”
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Effects of desvenlafaxine versus placebo on MDD symptom clusters: A pooled analysis by Katzman, Martin A, Wang, Xuemei, Wajsbrot, Dalia B, Boucher, Matthieu

“…Background: Major depressive disorder is characterized by the presence of at least five of nine specific symptoms that contribute to clinically significant…”
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Treatment with aripiprazole once-monthly injectable formulation is effective in improving symptoms and global functioning in schizophrenia with and without comorbid substance use - a post hoc analysis of the ReLiAM study by Margolese, Howard C, Boucher, Matthieu, Therrien, Francois, Clerzius, Guerline

“…ReLiAM, Real-Life Assessment of Abilify Maintena, was the first reported long-term prospective non-interventional study for patients with schizophrenia treated…”
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G Protein-Coupled Receptor Kinase 2 Ablation in Cardiac Myocytes Before or After Myocardial Infarction Prevents Heart Failure by Raake, Philip W, Vinge, Leif E, Gao, Erhe, Boucher, Matthieu, Rengo, Giuseppe, Chen, Xiongwen, DeGeorge, Brent R, Matkovich, Scot, Houser, Steven R, Most, Patrick, Eckhart, Andrea D, Dorn, Gerald W, Koch, Walter J

“…Myocardial G protein-coupled receptor kinase (GRK)2 is a critical regulator of cardiac β-adrenergic receptor (βAR) signaling and cardiac function. Its…”
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Level of G protein–Coupled Receptor Kinase-2 Determines Myocardial Ischemia/Reperfusion Injury via Pro- and Anti-Apoptotic Mechanisms by Brinks, Henriette, Boucher, Matthieu, Gao, Erhe, Chuprun, J Kurt, Pesant, Stéphanie, Raake, Philip W, Huang, Z Maggie, Wang, Xiaoliang, Qiu, Gang, Gumpert, Anna, Harris, David M, Eckhart, Andrea D, Most, Patrick, Koch, Walter J

“…RATIONALE:Activation of prosurvival kinases and subsequent nitric oxide (NO) production by certain G protein–coupled receptors (GPCRs) protects myocardium in…”
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Inhibition of Fas-associated death domain-containing protein (FADD) protects against myocardial ischemia/reperfusion injury in a heart failure mouse model by Fan, Qian, Huang, Zheng M, Boucher, Matthieu, Shang, Xiying, Zuo, Lin, Brinks, Henriette, Lau, Wayne Bond, Zhang, Jianke, Chuprun, J Kurt, Gao, Erhe

“…As technological interventions treating acute myocardial infarction (MI) improve, post-ischemic heart failure increasingly threatens patient health. The aim of…”
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Stable myocardial-specific AAV6-S100A1 gene therapy results in chronic functional heart failure rescue by PLEGER, Sven T, MOST, Patrick, KATUS, Hugo A, ECKHART, Andrea D, RABINOWITZ, Joseph E, KOCH, Walter J, BOUCHER, Matthieu, SOLTYS, Stephen, KURT CHUPRUN, J, PLEGER, Wiebke, ERHE GAO, DASGUPTA, Abhijit, RENGO, Giuseppe, REMPPIS, Andrew

“…The incidence of heart failure is ever-growing, and it is urgent to develop improved treatments. An attractive approach is gene therapy; however, the clinical…”
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Targeted Inhibition of Cardiomyocyte Gi Signaling Enhances Susceptibility to Apoptotic Cell Death in Response to Ischemic Stress by DEGEORGE, Brent R, ERHE GAO, ECKHART, Andrea D, KOCH, Walter J, BOUCHER, Matthieu, VINGE, Leif E, MARTINI, Jeffrey S, RAAKE, Philip W, CHUPRUN, J. Kurt, HARRIS, David M, KIM, Gilbert W, SOLTYS, Stephen

“…A salient characteristic of dysfunctional myocardium progressing to heart failure is an upregulation of the adenylyl cyclase inhibitory guanine nucleotide (G)…”
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Darbepoetin alfa, a long-acting erythropoietin analog, offers novel and delayed cardioprotection for the ischemic heart by Gao, Erhe, Boucher, Matthieu, Chuprun, J Kurt, Zhou, Rui-Hai, Eckhart, Andrea D, Koch, Walter J

“…Recent studies from our lab and others have shown that the hematopoietic cytokine erythropoietin (EPO) can protect the heart from ischemic damage in a red…”
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Apoptosis Detected in the Amygdala Following Myocardial Infarction in the Rat by Wann, Boubacar Pasto, Boucher, Matthieu, Kaloustian, Sevan, Nim, Satra, Godbout, Roger, Rousseau, Guy

“…Myocardial infarction (MI) contains a risk factor for developing episodes of Major Depressive Disorder (MDD). Apoptosis is commonly observed in the reperfused…”
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Targeting Myocardial β-Adrenergic Receptor Signaling and Calcium Cycling for Heart Failure Gene Therapy by Pleger, Sven T., MD, Boucher, Matthieu, PhD, Most, Patrick, MD, Koch, Walter J., PhD

“…Abstract Heart failure (HF) is a leading cause of morbidity and mortality in Western countries and projections reveal that HF incidence in the coming years…”
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Tissue selective estrogen complex (TSEC): a review by Pickar, James H, Boucher, Matthieu, Morgenstern, Diana

“…OBJECTIVE:This review describes historical development of selective estrogen receptor modulators (SERMs) and their combination with estrogens, termed a tissue…”
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Darbepoetin Alpha and Insulin-Like Growth Factor-1 Protect the Rat Myocardium Against Myocardial Infarction and Lead To Enhance Angiogenesis by Boucher, Matthieu, Gao, Erhe, Pesant, Stephanie, Zhou, Rui-Hai, Chuprun, J. Kurt, Eckhart, Andrea D, Koch, Walter J

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Determinants Present in the Receptor Carboxy Tail Are Responsible for Differences in Subtype-Specific Coupling of β-Adrenergic Receptors to Phosphoinositide 3-Kinase by Simard, Julie, Boucher, Matthieu, Massé, Rachel, Hébert, Terence E., Rousseau, Guy

“…An agonist-occupied β2-adrenergic receptor (β2-AR) recruits G protein receptor kinase-2 (GRK2) which is recruited to the membrane. Thus, the physical proximity…”
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Efficacy of Desvenlafaxine Compared With Placebo in Major Depressive Disorder Patients by Age Group and Severity of Depression at Baseline by Mosca, Daniel, Zhang, Min, Prieto, Rita, Boucher, Matthieu

“…This post hoc meta-analysis evaluated the efficacy and safety of desvenlafaxine 50 and 100 mg versus placebo across age groups and severity of depression at…”
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Trajectories of Function and Symptom Change in Desvenlafaxine Clinical Trials: Toward Personalized Treatment for Depression by Zilcha-Mano, Sigal, Wang, Xuemei, Wajsbrot, Dalia B., Boucher, Matthieu, Fine, Stuart A., Rutherford, Bret R.

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Effects of Adjunctive Brexpiprazole on Individual Depressive Symptoms and Functioning in Patients With Major Depressive Disorder and Anxious Distress: Post Hoc Analysis of Three Placebo-Controlled Studies by McIntyre, Roger S, Bubolic, Suzy, Zhang, Zhen, MacKenzie, Erin M, Therrien, François, Miguelez, Maia, Boucher, Matthieu

“…Anxiety symptoms in major depressive disorder (MDD) are frequent, and they decrease response to antidepressant treatment (ADT), and affect patient functioning…”
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Efficacy of adjunctive brexpiprazole on symptom clusters of major depressive disorder: A post hoc analysis of four clinical studies by Katzman, Martin A., Therrien, François, MacKenzie, Erin M., Wang, Fan, de Jong-Laird, Anne, Boucher, Matthieu

“…Major depressive disorder (MDD) is a clinically heterogenous condition and its treatment should be individualized according to the presence of particular…”
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