Search Results - "BOUCHER, Colette"
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Enantiomeric Atropisomers Inhibit HCV Polymerase and/or HIV Matrix: Characterizing Hindered Bond Rotations and Target Selectivity
Published in Journal of medicinal chemistry (13-03-2014)“…An anthranilic acid series of allosteric thumb pocket 2 HCV NS5B polymerase inhibitors exhibited hindered rotation along a covalent bond axis, and the…”
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Synthesis of (1R,2S)-1-Amino-2-vinylcyclopropanecarboxylic Acid Vinyl-ACCA) Derivatives: Key Intermediates for the Preparation of Inhibitors of the Hepatitis C Virus NS3 Protease
Published in Journal of organic chemistry (22-07-2005)“…(1R,2S)-1-Amino-2-vinylcyclopropanecarboxylic acid (vinyl-ACCA) is a key building block in the synthesis of potent inhibitors of the hepatitis C virus NS3…”
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Design, synthesis and biological evaluation of novel aminothiazoles as antiviral compounds acting against human rhinovirus
Published in Bioorganic & medicinal chemistry letters (01-07-2013)“…We describe here the design, synthesis and biological evaluation of antiviral compounds acting against human rhinovirus (HRV). A series of aminothiazoles…”
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RCM of Tripeptide Dienes Containing a Chiral Vinylcyclopropane Moiety: Impact of Different Ru-Based Catalysts on the Stereochemical Integrity of the Macrocyclic Products
Published in Journal of organic chemistry (23-12-2005)“…Tripeptide dienes containing an (1R,2S)-vinyl aminocyclopropylcarboxylate residue were cyclized to β-strand scaffolds under ring-closing metathesis (RCM)…”
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Toward a Motivational Model of Couple Happiness
Published in Journal of personality and social psychology (01-11-1990)“…The present study had two major objectives. The first was to investigate the validity of a motivational model of couple happiness based on self-determination…”
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Practical, Stereoselective Synthesis of Palinavir, a Potent HIV Protease Inhibitor
Published in Journal of organic chemistry (30-05-1997)“…Palinavir is a potent peptidomimetic-based HIV protease inhibitor. We have developed a highly convergent and stereoselective synthesis which is amenable to the…”
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The relationship between maternal psychiatric disorder and very young children's coping behaviors
Published in Infant mental health journal (1997)“…The coping behavior of high‐risk infants aged 4 to 36 months was investigated. Two groups of infants (n = 60) (mothers with and without psychiatric disorders)…”
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