Search Results - "BOTTARO, D. P"

c-Met autocrine activation induces development of malignant melanoma and acquisition of the metastatic phenotype by OTSUKA, T, TAKAYAMA, H, MERLINO, G, SHARP, R, CELLI, G, LAROCHELLE, W. J, BOTTARO, D. P, ELLMORE, N, VIEIRA, W, OWENS, J. W, ANVER, M

“…The molecular and genetic events that contribute to the genesis and progression of cutaneous malignant melanoma, a complex and aggressive disease with a high…”
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Activation of RET as a Dominant Transforming Gene by Germline Mutations of MEN2A and MEN2B by Santoro, Massimo, Carlomagno, Francesca, Romano, Alfredo, Bottaro, Donald P., Dathan, Nina A., Grieco, Michele, Fusco, Alfredo, Vecchio, Giancarlo, Maťoškovt̄, Brona, Kraus, Matthias H., Di Fiore, Pier Paolo

“…Multiple endocrine neoplasia types 2A and 2B (MEN2A and MEN2B) and familial medullary thyroid carcinoma are dominantly inherited cancer syndromes. All three…”
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Determination of Ligand-Binding Specificity by Alternative Splicing: Two Distinct Growth Factor Receptors Encoded by a Single Gene by Miki, Toru, Bottaro, Donald P., Fleming, Timothy P., Smith, Cheryl L., Burgess, Wilson H., Andrew M.-L. Chan, Aaronson, Stuart A.

“…Expression cDNA cloning and structural analysis of the human keratinocyte growth factor receptor (KGFR) revealed identity with one of the fibroblast growth…”
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A Broad-Spectrum Human Lung Fibroblast-Derived Mitogen is a Variant of Hepatocyte Growth Factor by Rubin, Jeffrey S., Andrew M.-L. Chan, Bottaro, Donald P., Burgess, Wilson H., Taylor, William G., Cech, Alex C., Hirschfield, David W., Wong, Jane, Miki, Toru, Finch, Paul W., Aaronson, Stuart A.

“…A heparin-binding mitogen was isolated from conditioned medium of human embryonic lung fibroblasts. It exhibited broad target-cell specificity whose pattern…”
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Expression Cloning of a Human Dual-Specificity Phosphatase by Ishibashi, Toshio, Bottaro, Donald P., Chan, Andrew, Miki, Toru, Aaronson, Stuart A.

“…Using an expression cloning strategy, we isolated a cDNA encoding a human protein-tyrosine-phosphatase. Bacteria expressing the kinase domain of the…”
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Identification of the Hepatocyte Growth Factor Receptor as the c-met Proto-Oncogene Product by Bottaro, Donald P., Rubin, Jeffrey S., Faletto, Donna L., Andrew M.-L. Chan, Kmiecik, Thomas E., George F. Vande Woude, Aaronson, Stuart A.

“…Hepatocyte growth factor (HGF) is a plasminogen-like protein thought to be a humoral mediator of liver regeneration. A 145-kilodalton tyrosyl phosphoprotein…”
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Differential signaling by alternative HGF isoforms through c-Met : activation of both MAP kinase and PI 3-kinase pathways is insufficient for mitogenesis by DAY, R. M, CIOCE, V, BRECKENRIDGE, D, CASTAGNINO, P, BOTTARO, D. P

“…HGF/NK2, a naturally occurring truncated HGF isoform, antagonizes the mitogenic and morphogenic activities of full length HGF, but stimulates cell scatter, or…”
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Expression cDNA Cloning of the KGF Receptor by Creation of a Transforming Autocrine Loop by Miki, Toru, Fleming, Timothy P., Bottaro, Donald P., Rubin, Jeffrey S., Ron, Dina, Aaronson, Stuart A.

“…An expression cloning strategy was devised to isolate the keratinocyte growth factor (KGF) receptor complementary DNA. NIH/3T3 fibroblasts, which secrete this…”
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A novel dual specificity phosphatase induced by serum stimulation and heat shock by Ishibashi, T, Bottaro, D P, Michieli, P, Kelley, C A, Aaronson, S A

“…To identify new members of a family of protein-tyrosine phosphatases (PTPs), of which VH1 is prototype, we screened a B5/589 human mammary epithelial cell cDNA…”
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Synergistic anti-leukemic activity of imatinib in combination with a small molecule Grb2 SH2 domain binding antagonist by Zhang, M, Luo, Z, Liu, H, Croce, C M, Burke, T R, Bottaro, D P

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PDGF induction of tyrosine phosphorylation of GTPase activating protein by Molloy, Christopher J, Bottaro, Donald P, Fleming, Timothy P, Marshall, Mark S, Gibbs, Jackson B, Aaronson, Stuart A

“…The cascade of biochemical events triggered by growth factors and their receptors is central to understanding normal cell-growth regulation and its subversion…”
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Expression of biologically active recombinant keratinocyte growth factor. Structure/function analysis of amino-terminal truncation mutants by RON, D, BOTTARO, D. P, FINCH, P. W, MORRIS, D, RUBIN, J. S, AARONSON, S. A

“…Keratinocyte growth factor (KGF) is a newly identified member of the fibroblast growth factor (FGF) family (FGF-7). KGF is expressed by stromal fibroblasts and…”
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Hepatocyte Growth Factor and Macrophage Inflammatory Protein 1β: Structurally Distinct Cytokines that Induce Rapid Cytoskeletal Changes and Subset-Preferential Migration in T Cells by Adams, David H., Harvath, Liana, Bottaro, Donald P., Interrante, Robert, Catalano, Gianfranco, Tanaka, Yoshiya, Strain, Alastair, Hubscher, Stefan G., Shaw, Stephen

“…T-cell migration into tissue depends on a cascade of rapid and selective adhesive interactions with endothelium. "Triggering" is a step in that cascade…”
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High-Affinity Binding Sites for Related Fibroblast Growth Factor Ligands Reside Within Different Receptor Immunoglobulin-Like Domains by Cheon, Hyae-Gyeong, LaRochelle, William J., Bottaro, Donald P., Burgess, Wilson H., Aaronson, Stuart A.

“…Growth factors of the fibroblast growth factor (FGF) family bind receptors whose external domains are organized in a series of immunoglobulin-like loops. We…”
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A keratinocyte growth factor receptor-derived peptide antagonist identifies part of the ligand binding site by BOTTARO, D. P, FOTNEY, E, RUBIN, J. S, AARONSON, S. A

“…Keratinocyte growth factor (KGF) is a fibroblast growth factor (FGF) family member that acts specifically on cells of epithelial origin. Its receptor (KGFR) is…”
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Hyperphosphorylation and increased proteolytic breakdown of c-Myb induced by the inhibition of Ser/Thr protein phosphatases by BIES, J, FEIKOVA, S, BOTTARO, D. P, WOLFF, L

“…The c-myb proto-oncogene encodes a nuclear phosphoprotein that plays a crucial role in normal hematopoiesis. It is a short-lived transcription factor rapidly…”
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Characterization of the receptor for keratinocyte growth factor. Evidence for multiple fibroblast growth factor receptors by Bottaro, D P, Rubin, J S, Ron, D, Finch, P W, Florio, C, Aaronson, S A

“…Keratinocyte growth factor (KGF) is a member of the fibroblast growth factor (FGF) family. KGF exhibits potent mitogenic activity for a variety of epithelial…”
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Neu differentiation factor/heregulin induction by hepatocyte and keratinocyte growth factors by CASTAGNINO, P, LORENZI, M. V, YEH, J, BRECKENRIDGE, D, SAKATA, H, MUNZ, B, WERNER, S, BOTTARO, D. P

“…Hepatocyte growth-factor (HGF) is a potent, widely produced, pleiotropic mediator of mesenchymal-epithelial interaction. In a study of changes in gene…”
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Secreted Frizzled-related Protein-1 Binds Directly to Wingless and Is a Biphasic Modulator of Wnt Signaling by Üren, Aykut, Reichsman, Frieda, Anest, Vasiliki, Taylor, William G., Muraiso, Kanae, Bottaro, Donald P., Cumberledge, Susan, Rubin, Jeffrey S.

“…Secreted Frizzled-related protein-1 (sFRP-1) contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzleds. To facilitate the…”
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Hepatocyte growth factor enhances endothelial cell barrier function and cortical cytoskeletal rearrangement: potential role of glycogen synthase kinase‐3β by LIU, FENG, SCHAPHORST, KANE L., VERIN, ALEXANDER D., JACOBS, KERI, BIRUKOVA, ANNA, DAY, REGINA M., BOGATCHEVA, NATALIA, BOTTARO, D. P., GARCIA, JOE G. N.

“…ABSTRACT The stabilization of endothelial cell (EC) barrier function within newly formed capillaries is a critical feature of angiogenesis. We examined human…”
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