Search Results - "BOTHAM, Philip A"

A framework for chemical safety assessment incorporating new approach methodologies within REACH by Ball, Nicholas, Bars, Remi, Botham, Philip A., Cuciureanu, Andreea, Cronin, Mark T. D., Doe, John E., Dudzina, Tatsiana, Gant, Timothy W., Leist, Marcel, van Ravenzwaay, Bennard

“…The long-term investment in new approach methodologies (NAMs) within the EU and other parts of the world is beginning to result in an emerging consensus of how…”
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Assessment of the Effects of MPTP and Paraquat on Dopaminergic Neurons and Microglia in the Substantia Nigra Pars Compacta of C57BL/6 Mice by Smeyne, Richard Jay, Breckenridge, Charles B, Beck, Melissa, Jiao, Yun, Butt, Mark T, Wolf, Jeffrey C, Zadory, Dan, Minnema, Daniel J, Sturgess, Nicholas C, Travis, Kim Z, Cook, Andrew R, Smith, Lewis L, Botham, Philip A

“…The neurotoxicity of paraquat dichloride (PQ) was assessed in two inbred strains of 9- or 16-week old male C57BL/6 mice housed in two different laboratories…”
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Towards a science-based testing strategy to identify maternal thyroid hormone imbalance and neurodevelopmental effects in the progeny - Part IV: the ECETOC and CLE Proposal for a Thyroid Function-Related Neurodevelopmental Toxicity Testing and Assessment Scheme (Thyroid-NDT-TAS) by Melching-Kollmuss, Stephanie, Bothe, Kathrin, Charlton, Alex, Gangadharan, Babunilayam, Ghaffari, Rashin, Jacobi, Sylvia, Marty, Sue, Marxfeld, Heike-Antje, McInnes, Elizabeth F, Sauer, Ursula G, Sheets, Larry P, Strupp, Christian, Tinwell, Helen, Wiemann, Christiane, Botham, Philip A, van Ravenzwaay, Bennard

“…Following the European Commission Endocrine Disruptor Criteria, substances shall be considered as having endocrine disrupting properties if they (a) elicit…”
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Assessing chemical carcinogenicity: hazard identification, classification, and risk assessment. Insight from a Toxicology Forum state-of-the-science workshop by Felter, Susan P., Bhat, Virunya S., Botham, Philip A., Bussard, David A., Casey, Warren, Hayes, A. Wallace, Hilton, Gina M., Magurany, Kelly A., Sauer, Ursula G., Ohanian, Edward V.

“…The Toxicology Forum convened an international state-of-the-science workshop Assessing Chemical Carcinogenicity: Hazard Identification, Classification, and…”
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Skin sensitization risk assessment for plant protection products: The applicability of sensitization assessment factors by Jowsey, Ian R., Merolla, Leona, Botham, Philip A.

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Toward a science-based testing strategy to identify maternal thyroid hormone imbalance and neurodevelopmental effects in the progeny - part I: which parameters from human studies are most relevant for toxicological assessments? by Sauer, Ursula G., Asiimwe, Alex, Botham, Philip A., Charlton, Alex, Hallmark, Nina, Jacobi, Sylvia, Marty, Sue, Melching-Kollmuss, Stephanie, Palha, Joana A., Strauss, Volker, van Ravenzwaay, Bennard, Swaen, Gerard

“…The 2018 European Food Safety Authority/European Chemicals Agency Guidance on the Identification of Endocrine Disruptors lacks clarity on how the presence or…”
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Applying genomics in regulatory toxicology: a report of the ECETOC workshop on omics threshold on non-adversity by Gant, Timothy W., Auerbach, Scott S., Von Bergen, Martin, Bouhifd, Mounir, Botham, Philip A., Caiment, Florian, Currie, Richard A., Harrill, Joshua, Johnson, Kamin, Li, Dongying, Rouquie, David, van Ravenzwaay, Ben, Sistare, Frank, Tralau, Tewes, Viant, Mark R., van de Laan, Jan Willem, Yauk, Carole

“…In a joint effort involving scientists from academia, industry and regulatory agencies, ECETOC’s activities in Omics have led to conceptual proposals for: (1)…”
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Towards a science-based testing strategy to identify maternal thyroid hormone imbalance and neurodevelopmental effects in the progeny-part III: how is substance-mediated thyroid hormone imbalance in pregnant/lactating rats or their progeny related to neurodevelopmental effects? by Marty, M. Sue, Sauer, Ursula G., Charlton, Alex, Ghaffari, Rashin, Guignard, Davy, Hallmark, Nina, Hannas, Bethany R., Jacobi, Sylvia, Marxfeld, Heike-Antje, Melching-Kollmuss, Stephanie, Sheets, Larry P., Urbisch, Daniel, Botham, Philip A., van Ravenzwaay, Bennard

“…This review investigated which patterns of thyroid- and brain-related effects are seen in rats upon gestational/lactational exposure to 14 substances causing…”
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Hazard identification, classification, and risk assessment of carcinogens: too much or too little? - Report of an ECETOC workshop by Felter, Susan P., Boobis, Alan R., Botham, Philip A., Brousse, Alice, Greim, Helmut, Hollnagel, Heli M., Sauer, Ursula G.

“…The European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC) organized a workshop "Hazard Identification, Classification and Risk Assessment of…”
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Towards a science-based testing strategy to identify maternal thyroid hormone imbalance and neurodevelopmental effects in the progeny - part II: how can key events of relevant adverse outcome pathways be addressed in toxicological assessments? by Marty, Sue, Beekhuijzen, Manon, Charlton, Alex, Hallmark, Nina, Hannas, Bethany R., Jacobi, Sylvia, Melching-Kollmuss, Stephanie, Sauer, Ursula G., Sheets, Larry P., Strauss, Volker, Urbisch, Daniel, Botham, Philip A., van Ravenzwaay, Bennard

“…The current understanding of thyroid-related adverse outcome pathways (AOPs) with adverse neurodevelopmental outcomes in mammals has been reviewed. This served…”
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Paraquat pharmacokinetics in primates and extrapolation to humans by Stevens, Alexander J., Campbell, Jerry L., Travis, Kim Z., Clewell, Harvey J., Hinderliter, Paul M., Botham, Philip A., Cook, Andrew R., Minnema, Daniel J., Wolf, Douglas C.

“…By extending our Paraquat (PQ) work to include primates we have implemented a modelling and simulation strategy that has enabled PQ pharmacokinetic data to be…”
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Integration of paraquat pharmacokinetic data across species using PBPK modelling by Campbell, Jerry L., Travis, Kim Z., Clewell, Harvey J., Stevens, Alexander J., Hinderliter, Paul M., Andersen, Melvin E., Botham, Philip A., Cook, Andrew R., Minnema, Daniel J., Wolf, Douglas C.

“…Paraquat dichloride (PQ) is a non-selective herbicide which has been the subject of numerous toxicology studies over more than 50 years. This paper describes…”
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Neurotoxicity of paraquat and paraquat-induced mechanisms of developing Parkinson's disease by Cook, Andrew R, Botham, Philip A, Breckenridge, Charles B, Minnema, Daniel J, Sturgess, Nicholas C, Travis, Kim Z

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Pharmacokinetic, neurochemical, stereological and neuropathological studies on the potential effects of paraquat in the substantia nigra pars compacta and striatum of male C57BL/6J mice by Breckenridge, Charles B., Sturgess, Nicholas C., Butt, Mark, Wolf, Jeffrey C., Zadory, Dan, Beck, Melissa, Mathews, James M., Tisdel, Merrill O., Minnema, Daniel, Travis, Kim Z., Cook, Andrew R., Botham, Philip A., Smith, Lewis L.

“…The pharmacokinetics and neurotoxicity of paraquat dichloride (PQ) were assessed following once weekly administration to C57BL/6J male mice by intraperitoneal…”
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Dietary administration of paraquat for 13weeks does not result in a loss of dopaminergic neurons in the substantia nigra of C57BL/6J mice by Minnema, Daniel J., Travis, Kim Z., Breckenridge, Charles B., Sturgess, Nicholas C., Butt, Mark, Wolf, Jeffrey C., Zadory, Dan, Beck, Melissa J., Mathews, James M., Tisdel, Merrill O., Cook, Andrew R., Botham, Philip A., Smith, Lewis L.

“…•Mice were exposed to at least 10.2mg paraquat/kg bw/day in the diet for 13weeks.•The exposure duration was sufficient to achieve a steady state brain…”
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Dietary administration of paraquat for 13 weeks does not result in a loss of dopaminergic neurons in the substantia nigra of C57BL/6J mice by Minnema, Daniel J, Travis, Kim Z, Breckenridge, Charles B, Sturgess, Nicholas C, Butt, Mark, Wolf, Jeffrey C, Zadory, Dan, Beck, Melissa J, Mathews, James M, Tisdel, Merrill O, Cook, Andrew R, Botham, Philip A, Smith, Lewis L

“…Several investigations have reported that mice administered paraquat dichloride (PQ·Cl2) by intraperitoneal injection exhibit a loss of dopaminergic neurons in…”
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Dietary administration of diquat for 13 weeks does not result in a loss of dopaminergic neurons in the substantia nigra of C57BL/6J mice by Minnema, Daniel J., Travis, Kim Z., Breckenridge, Charles B., Sturgess, Nicholas C., Butt, Mark, Wolf, Jeffrey C., Zadory, Dan, Herberth, Mark T., Watson, Scott L., Cook, Andrew R., Botham, Philip A.

“…Male and female C57BL/6J mice were administered diquat dibromide (DQ∙Br2) in their diets at concentrations of 0 (control), 12.5 and 62.5 ppm for 13 weeks to…”
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Outcome of the ECVAM skin irritation validation study by Botham, Philip A

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The validation of in vitro methods for skin irritation by Botham, Philip A.

“…Several alternative in vitro methods for identifying skin irritants have been developed in the last 10 years, the most promising of which use either…”
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Acute systemic toxicity by Botham, Philip A

“…Use of the test that aimed to identify the single lethal dose of a substance that kills half the animals in a test group (the LD50 test) should finally be…”
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