Search Results - "BOTHAM, Kathleen M."

Postprandial lipoproteins and the molecular regulation of vascular homeostasis by Botham, Kathleen M., Wheeler-Jones, Caroline P.D.

“…Blood levels of triglyceride-rich lipoproteins (TRL) increase postprandially, and a delay in their clearance results in postprandial hyperlipidemia, an…”
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Vascular endothelial growth factor receptor-2 couples cyclo-oxygenase-2 with pro-angiogenic actions of leptin on human endothelial cells by Garonna, Elena, Botham, Kathleen M, Birdsey, Graeme M, Randi, Anna M, Gonzalez-Perez, Ruben R, Wheeler-Jones, Caroline P D

“…The adipocyte-derived hormone leptin influences the behaviour of a wide range of cell types and is now recognised as a pro-angiogenic and pro-inflammatory…”
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Correction: Vascular Endothelial Growth Factor Receptor-2 Couples Cyclo-Oxygenase-2 with Pro-Angiogenic Actions of Leptin on Human Endothelial Cells by Garonna, Elena, Botham, Kathleen M, Birdsey, Graeme M, Randi, Anna M, Gonzalez-Perez, Ruben R, Wheeler-Jones, Caroline P. D

“…Quantitative data are in S2 File, subfolder Fig 2C, “densitometry results”; this file includes summary-level data for this experiment rather than…”
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The Emerging Role of Disturbed CoQ Metabolism in Nonalcoholic Fatty Liver Disease Development and Progression by Botham, Kathleen M, Napolitano, Mariarosaria, Bravo, Elena

“…Although non-alcoholic fatty liver disease (NAFLD), characterised by the accumulation of triacylglycerol in the liver, is the most common liver disorder, the…”
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Understanding Postprandial Inflammation and Its Relationship to Lifestyle Behaviour and Metabolic Diseases by Klop, Boudewijn, Proctor, Spencer D., Mamo, John C. L., Botham, Kathleen M., Cabezas, Manuel Castro

“…Postprandial hyperlipidemia with accumulation of remnant lipoproteins is a common metabolic disturbance associated with atherosclerosis and vascular…”
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High fat diet-induced non alcoholic fatty liver disease in rats is associated with hyperhomocysteinemia caused by down regulation of the transsulphuration pathway by Bravo, Elena, Palleschi, Simonetta, Aspichueta, Patricia, Buqué, Xabier, Rossi, Barbara, Cano, Ainara, Napolitano, Mariarosaria, Ochoa, Begoña, Botham, Kathleen M

“…Hyperhomocysteinemia (HHcy) causes increased oxidative stress and is an independent risk factor for cardiovascular disease. Oxidative stress is now believed to…”
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Endothelial HO-1 induction by model TG-rich lipoproteins is regulated through a NOX4-Nrf2 pathway1[S] by Latham Birt, Sally H., Purcell, Robert, Botham, Kathleen M., Wheeler-Jones, Caroline P.D.

“…Circulating levels of chylomicron remnants (CMRs) increase postprandially and their composition directly reflects dietary lipid intake. These TG-rich…”
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Induction of non-alcoholic fatty liver disease and insulin resistance by feeding a high-fat diet in rats: does coenzyme Q monomethyl ether have a modulatory effect? by Safwat, Ghada M., Ph.D, Pisanò, Stefania, B.D, D'Amore, Emanuela, Ph.D, Borioni, Giorgio, Ph.D, Napolitano, Mariarosaria, Ph.D, Kamal, Adel Amin, Ph.D, Ballanti, Paola, Ph.D, Botham, Kathleen M., Ph.D., D.Sc, Bravo, Elena, Ph.D

“…Abstract Objective The aim of this study was to investigate the development of non-alcoholic fatty liver disease (NAFLD) in response to a high-fat diet in rats…”
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Effects of lycopene on the induction of foam cell formation by modified LDL by Napolitano, Mariarosaria, De Pascale, Clara, Wheeler-Jones, Caroline, Botham, Kathleen M, Bravo, Elena

“…The effect of lycopene on macrophage foam cell formation induced by modified low-density lipoprotein (LDL) was studied. Human monocyte-derived macrophages…”
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Coenzyme Q metabolism is disturbed in high fat diet-induced non-alcoholic fatty liver disease in rats by Bravo, Elena, Palleschi, Simonetta, Rossi, Barbara, Napolitano, Mariarosaria, Tiano, Luca, D'Amore, Emanuela, Botham, Kathleen M

“…Oxidative stress is believed to be a major contributory factor in the development of non alcoholic fatty liver disease (NAFLD), the most common liver disorder…”
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Differential effects of low-density lipoprotein and chylomicron remnants on lipid accumulation in human macrophages by Batt, Kelly V, Avella, Michael, Moore, Elizabeth H, Jackson, Brian, Suckling, Keith E, Botham, Kathleen M

“…The effects of low-density lipoprotein (LDL) and chylomicron remnants on lipid accumulation in human monocyte-derived macrophages (HMDMs) and in macrophages…”
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The Oxidative State of Chylomicron Remnants Influences Their Modulation of Human Monocyte Activation by Armengol Lopez, Sandra, Botham, Kathleen M., Lawson, Charlotte

“…Chylomicron remnants (CMRs) contribute directly to human monocyte activation in vitro, by increasing reactive oxygen species (ROS) production and cell…”
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Differential modulation of hepatic very low-density lipoprotein secretion by triacylglycerol-rich lipoproteins derived from different oleic-acid rich dietary oils by Perona, Javier S., Avella, Michael, Botham, Kathleen M., Ruiz-Gutierrez, Valentina

“…Minor components from dietary oils can modulate the atherogenic response of the TAG-rich lipoproteins (TRL) in which they are transported. In the present study…”
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Myosin VI and Associated Proteins Are Expressed in Human Macrophages but Do Not Play a Role in Foam Cell Formation in THP-1 Cells by Dawson, Hayley J., Hibbert, Andrew P., Chantler, Peter D., Botham, Kathleen M.

“…Myosin VI (Myo6) functions in endocytosis in conjunction with binding partners including adaptor protein (AP)-2, disabled 2 (Dab2), and GAIP interacting…”
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Novel Aspects of Nonfasting Lipemia in relation to Vascular Biology by Cabezas, Manuel Castro, Botham, Kathleen M., Mamo, John C. L., Proctor, Spencer D.

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The effects of dietary n-3 polyunsaturated fatty acids delivered in chylomicron remnants on the transcription of genes regulating synthesis and secretion of very-low-density lipoprotein by the liver: modulation by cellular oxidative state by Botham, Kathleen M, Zheng, Xiaozhong, Napolitano, Mariarosaria, Avella, Michael, Cavallari, Claudio, Rivabene, Roberto, Bravo, Elena

“…The influence of chylomicron remnants enriched in n-3 or n-6 polyunsaturated fatty acids (PUFA) (derived from fish or corn oil, respectively) on the expression…”
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Postprandial phase time influences the uptake of TAG from postprandial TAG-rich lipoproteins by THP-1 macrophages by Cabello-Moruno, Rosana, Sinausia, Laura, Botham, Kathleen M., Montero, Emilio, Avella, Michael, Perona, Javier S.

“…Postprandial TAG-rich lipoproteins (TRL) can be taken up by macrophages, leading to the formation of foam cells, probably via receptor-mediated pathways. The…”
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Endothelial HO-1 induction by model TG-rich lipoproteins is regulated through a NOX4-Nrf2 pathway by Latham Birt, Sally H, Purcell, Robert, Botham, Kathleen M, Wheeler-Jones, Caroline P D

“…Circulating levels of chylomicron remnants (CMRs) increase postprandially and their composition directly reflects dietary lipid intake. These TG-rich…”
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Role of macrophage activation in the lipid metabolism of postprandial triacylglycerol-rich lipoproteins by Napolitano, Mariarosaria, Sennato, Simona, Botham, Kathleen M, Bordi, Federico, Bravo, Elena

“…The potential link between the inflammatory effects of postprandial lipemia and the induction of macrophage foam cell formation by triacylglycerol-rich…”
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Postprandial human triglyceride-rich lipoproteins increase chemoattractant protein secretion in human macrophages by Napolitano, Mariarosaria, Botham, Kathleen M., Bravo, Elena

“…•Postprandial triglyceride-rich lipoproteins promote pro-atherogenic pattern.•Postprandial lipoproteins isolated from human plasma after a fatty…”
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