Search Results - "BOSSENMAIER, B"

382 Preclinical Pharmacokinetics of GE-huMab-HER3, a Novel Humanized, Glycoengineered Anti-HER3 Antibody Using PHER3/HER3 Ratio as Pharmacodynamics (PD) Marker by Meneses-Lorente, G, Kolm, I, Thomas, M, Friess, T, Bader, S, Meille, C, Bossenmaier, B

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315 ImmunoPET and Biodistribution with Human Epidermal Growth Factor Receptor 3 Targeting Radiolabeled Antibody 89Zr-GE-huMAb-HER3 by van Scheltinga, A.G.T. Terwisscha, Lub-de Hooge, M.N, Abiraj, K, Schröder, C.P, Pot, L, Bossenmaier, B, Pickl, M, Friess, T, Kosterink, J.G.W, de Vries, E.G.E

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Tumor necrosis factor-alpha- and hyperglycemia-induced insulin resistance. Evidence for different mechanisms and different effects on insulin signaling by Kroder, G, Bossenmaier, B, Kellerer, M, Capp, E, Stoyanov, B, Mühlhöfer, A, Berti, L, Horikoshi, H, Ullrich, A, Häring, H

“…Inhibition of insulin receptor signaling by high glucose levels and by TNF-alpha was recently observed in different cell systems. The aim of the present study…”
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Protein kinase C isoforms beta 1 and beta 2 inhibit the tyrosine kinase activity of the insulin receptor by Bossenmaier, B, Mosthaf, L, Mischak, H, Ullrich, A, Häring, H U

“…Downregulation of insulin receptor tyrosine kinase (IRK) activity yields to impaired insulin signalling and contributes to the pathogenesis of cellular insulin…”
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Protein kinase C isoforms β1 and β2 inhibit the tyrosine kinase activity of the insulin receptor by BOSSENMAIER, B, MOSTHAF, L, MISCHAK, H, ULLRICH, A, HÄRING, H. U

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The long acting human insulin analog HOE 901: characteristics of insulin signalling in comparison to Asp(B10) and regular insulin by Berti, L, Kellerer, M, Bossenmaier, B, Seffer, E, Seipke, G, Häring, H U

“…HOE 901 is a new biosynthetic long-acting human insulin analog (GLY[A21]ARG[B31]ARG[B32]). We compared HOE 901 with normal human insulin and the insulin analog…”
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Serine residues 994 and 1023/25 are important for insulin receptor kinase inhibition by protein kinase C isoforms β2 and θ by STRACK, V, HENNIGE, A. M, KRÜTZFELDT, J, BOSSENMAIER, B, KLEIN, H.-H, KELLERER, M, LAMMERS, R, HÄRING, H.-U

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Acute hyperglycemia provides an insulin-independent inducer for GLUT4 translocation in C2C12 myotubes and rat skeletal muscle by Galante, P., Mosthaf, L., Kellerer, M., Berti, L., Tippmer, S., Bossenmaier, B., Fujiwara, T., Okuno, A., Horikoshi, H., Haring, H. U.

“…Acute hyperglycemia provides an insulin-independent inducer for GLUT4 translocation in C2C12 myotubes and rat skeletal muscle. P Galante , L Mosthaf , M…”
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Differential activities of protein tyrosine phosphatases in intact cells by Lammers, R, Bossenmaier, B, Cool, D.E., Tonks, N.K., Schlessinger, J, Fischer, E.H., Ullrich, A

“…We have employed transient co-overexpression of protein tyrosine phosphatases (PTPs) with a panel of receptor tyrosine kinases (RTKs) to investigate molecular…”
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Serine residues 1177/78/82 of the insulin receptor are required for substrate phosphorylation but not autophosphorylation by BOSSENMAIER, B, STRACK, V, HÄRING, H.-U, STOYANOV, B, KRÜTZFELDT, J, BECK, A, LEHMANN, R, KELLERER, M, KLEIN, H, ULLRICH, A, LAMMERS, R

“…Serine residues 1177/78/82 of the insulin receptor are required for substrate phosphorylation but not autophosphorylation. B Bossenmaier , V Strack , B…”
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Modulation of insulin receptor signaling. Potential mechanisms of a cross talk between bradykinin and the insulin receptor by Häring, H U, Tippmer, S, Kellerer, M, Mosthaf, L, Kroder, G, Bossenmaier, B, Berti, L

“…Insulin resistance of the skeletal muscle plays a key role in the development of the metabolic endocrine syndrome and its further progression to type II…”
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A 973 valine to methionine mutation of the human insulin receptor : interaction with insulin-receptor substrate-1 and Shc in HEK 293 cells by STRACK, V, BOSSENMAIER, B, STOYANOV, B, MUSHACK, J, HÄRING, H. U

“…A population-based study in the Netherlands has recently demonstrated that a mutation of the human insulin receptor (HIR-973 valine to methionine) is…”
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Impact of tumor heregulin mRNA expression on outcome of patients with advanced/metastatic squamous NSCLC treated with lumretuzumab, a glycoengineered monoclonal antibody targeting HER3, in combination with erlotinib by Meulendijks, D., Lassen, U., Cervantes, A., Han, J.-Y., Calles, A., Felip, E., Kim, S.-W., Schellens, J.H.M., Taus, A., Sorensen, M., Fleitas, T., Bossenmaier, B., Michielin, F., Adessi, C., Meneses-Lorente, G., Ceppi, M., James, I., Jacob, W., Weisser, M., Martinez-Garcia, M.

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Bispecific antibody derivatives with restricted binding functionalities that are activated by proteolytic processing by Metz, Silke, Panke, Christian, Haas, Alexander K., Schanzer, Jürgen, Lau, Wilma, Croasdale, Rebecca, Hoffmann, Eike, Schneider, Britta, Auer, Johannes, Gassner, Christian, Bossenmaier, Birgit, Umana, Pablo, Sustmann, Claudio, Brinkmann, Ulrich

“…We have designed bispecific antibodies that bind one target (anti-Her3) in a bivalent IgG-like manner and contain one additional binding entity (anti-cMet)…”
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444OPHASE IB TRIAL TRIAL OF RG7116, A GLYCOENGINEERED MONOCLONAL ANTIBODY TARGETING HER3, IN COMBINATION WITH CETUXIMAB OR ERLOTINIB IN PATIENTS WITH ADVANCED/METASTATIC TUMORS OF EPITHELIAL CELL ORIGIN EXPRESSING HER3 PROTEIN by Lassen, U.N., Ruiperez, A. Cervantes, Fleitas, T., Meulendijks, D., Schellens, J., Lolkemar, M., De Jonge, M.J.A., Sleijfer, S., Mau-Soerensen, M., Taus, A., Adessi, C., Keelara, A., Michielin, F., Bossenmaier, B., Meneses-Lorente, G., James, I., Jacob, W., Weisser, M., Martinez-Garcia, M.

“…Abstract Aim: To evaluate the safety profile of RG7116 in combination with cetuximab or erlotinib. Methods: Patients (pts) with advanced or metastatic…”
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Phase Ib Trial Trial of Rg7116, a Glycoengineered Monoclonal Antibody Targeting Her3, in Combination with Cetuximab or Erlotinib in Patients with Advanced/Metastatic Tumors of Epithelial Cell Origin Expressing Her3 Protein by Lassen, U.N., Ruiperez, A. Cervantes, Fleitas, T., Meulendijks, D., Schellens, J., Lolkemar, M., De Jonge, M.J.A., Sleijfer, S., Mau-Soerensen, M., Taus, A., Adessi, C., Keelara, A., Michielin, F., Bossenmaier, B., Meneses-Lorente, G., James, I., Jacob, W., Weisser, M., Martinez-Garcia, M.

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Acute hyperglycemia provides an insulin-independent inducer for GLUT4 translocation in C2C12 myotubes and rat skeletal muscle by GALANTE, P, MOSTHAF, L, KELLERER, M, BERTI, L, TIPPMER, S, BOSSENMAIER, B, FUJIWARA, T, OKUNO, A, HORIKOSHI, H, HÄRING, H. U

“…GLUT4 translocation and activation of glucose uptake in skeletal muscle can be induced by both physiological (i.e., insulin, nerve stimulation, or exercise)…”
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Serine residues 994 and 1023/25 are important for insulin receptor kinase inhibition by protein kinase C isoforms [beta]2 and [theta] by Strack, V, Hennige, A M, Krützfeldt, J, Bossenmaier, B, H. -H. Klein, Kellerer, M, Lammers, R, H. -U. Häring

“…Aims/hypothesis. Inhibition of the signalling function of the human insulin receptor (HIR) is one of the principle mechanisms which induce cellular insulin…”
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Serine residues 994 and 1023/25 are important for insulin receptor kinase inhibition by protein kinase C isoforms beta2 and theta by Strack, V, Hennige, A M, Krützfeldt, J, Bossenmaier, B, Klein, H H, Kellerer, M, Lammers, R, Häring, H U

“…Inhibition of the signalling function of the human insulin receptor (HIR) is one of the principle mechanisms which induce cellular insulin resistance. It is…”
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Impact of Mutations at Different Serine Residues on the Tyrosine Kinase Activity of the Insulin Receptor by Strack, Volker, Stoyanov, Borislav, Bossenmaier, Birgit, Mosthaf, Luitgard, Kellerer, Monika, Häring, Hans-U.

“…Insulin binding to its receptor activates a cascade of signaling events which are initiated by tyrosine autophosphorylation of the receptor and activation of…”
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