Search Results - "BOSSEMEYER, D"

Analysis of Protein Phosphorylation by a Combination of Elastase Digestion and Neutral Loss Tandem Mass Spectrometry by Schlosser, Andreas, Pipkorn, Ruediger, Bossemeyer, Dirk, Lehmann, Wolf D

“…Loss of phosphoric acid is the most effective fragmentation reaction of pSer- and pThr-containing phosphopeptides of small size (up to 10−15 residues) in…”
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Analysis of isoaspartate in peptides by electrospray tandem mass spectrometry by LEHMANN, WOLF D., SCHLOSSER, ANDREAS, ERBEN, GERHARD, PIPKORN, RÜDIGER, BOSSEMEYER, DIRK, KINZEL, VOLKER

“…In view of the significance of Asn deamidation and Asp isomerization to isoAsp at certain sites for protein aging and turnover, it was desirable to challenge…”
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Influence of Myristoylation, Phosphorylation, and Deamidation on the Structural Behavior of the N-Terminus of the Catalytic Subunit of CAMP-Dependent Protein Kinase by Tholey, Andreas, Pipkorn, Rüdiger, Bossemeyer, Dirk, Kinzel, Volker, Reed, Jennifer

“…A number of isoenzymes of the catalytic subunit of cAMP-dependent protein kinase arise through posttranslational modifications of the enzyme outside the…”
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The amino terminus of PKA catalytic subunit— A site for introduction of posttranslational heterogeneities by deamidation: d-Asp2 and d-isoAsp2 containing isozymes by KINZEL, VOLKER, KÖNIG, NORBERT, PIPKORN, RÜDIGER, BOSSEMEYER, DIRK, LEHMANN, WOLF D.

“…Conserved deamidation of PKA catalytic subunit isozymes Cα and Cβ—more than 25% at Asn2 in vivo in both cases—has been shown to yield Asp2- and…”
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A conserved deamidation site at asn 2 in the catalytic subunit of mammalian cAMP‐dependent protein kinase detected by capillary LC‐MS and tandem mass spectrometry by Jedrzejewski, Paul T., Girod, Andreas, Tholey, Andreas, König, Norbert, Thullner, Sandra, Kinzel, Volker, Bossemeyer, Dirk

“…The N‐terminal sequence myr‐Gly‐Asn is conserved among the myristoylated cAPK (protein kinase A) catalytic subunit isozymes C, Cβ, and O. By capillary LC‐MS…”
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Specific cesium transport via the Escherichia coli Kup (TrkD) K+ uptake system by Bossemeyer, D, Schlösser, A, Bakker, E P

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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K+-transport Protein TrkA of Escherichia coli Is a Peripheral Membrane Protein That Requires other trk Gene Products for Attachment to the Cytoplasmic Membrane by Bossemeyer, D, Borchard, A, Dosch, D C, Helmer, G C, Epstein, W, Booth, I R, Bakker, E P

“…The TrkA protein, which is essential for the activity of the constitutive Trk K+-uptake system of Escherichia coli, is a peripheral membrane protein. The…”
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Protein Kinase A in Complex with Rho-Kinase Inhibitors Y-27632, Fasudil, and H-1152P: Structural Basis of Selectivity by Breitenlechner, Christine, Gaßel, Michael, Hidaka, Hiroyoshi, Kinzel, Volker, Huber, Robert, Engh, Richard A, Bossemeyer, Dirk

“…Protein kinases require strict inactivation to prevent spurious cellular signaling; overactivity can cause cancer or other diseases and necessitates selective…”
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Crystal structures of catalytic subunit of cAMP-dependent protein kinase in complex with isoquinolinesulfonyl protein kinase inhibitors H7, H8, and H89. Structural implications for selectivity by Engh, R A, Girod, A, Kinzel, V, Huber, R, Bossemeyer, D

“…The discovery of several hundred different protein kinases involved in highly diverse cellular signaling pathways is in stark contrast to the much smaller…”
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ISQUA16-1862A MOBILE DATA-DRIVEN SAFETY AND QUALITY SYSTEM FOR VOLUNTARY MEDICAL MALE CIRCUMCISION (VMMC) IN MOZAMBIQUE by Necochea, E., Nhambi, L., Mahomed, M., Bossemeyer, D.

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Physical mapping of the K+ transport trkA gene of Escherichia coli and overproduction of the TrkA protein by HAMANN, A, BOSSEMEYER, D, BAKKER, E. P

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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The glycine-rich sequence of protein kinases: a multifunctional element by Bossemeyer, D

“…Evolution favours the use of glycine-rich loops for nucleotide binding in proteins. In the large family of protein kinases, the catalytic domain of which has…”
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Structural aspects of protein kinase control—role of conformational flexibility by Engh, Richard A., Bossemeyer, Dirk

“…Protein kinases catalyze the phosphotransfer reaction fundamental to most signaling and regulatory processes in the eukaryotic cell. Absolute control of…”
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Phosphotransferase and substrate binding mechanism of the cAMP‐dependent protein kinase catalytic subunit from porcine heart as deduced from the 2.0 A structure of the complex with Mn2+ adenylyl imidodiphosphate and inhibitor peptide PKI(5‐24) by Bossemeyer, D., Engh, R.A., Kinzel, V., Ponstingl, H., Huber, R.

“…The crystal structure of the porcine heart catalytic subunit of cAMP‐dependent protein kinase in a ternary complex with the MgATP analogue MnAMP‐PNP and a…”
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Protein kinases — structure and function by Bossemeyer, Dirk

“…The solution of crystal structures from half a dozen protein kinases during the last four years in different laboratories has deepened our understanding of the…”
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Staurosporine-induced conformational changes of cAMP-dependent protein kinase catalytic subunit explain inhibitory potential by Prade, Lars, Engh, Richard A, Girod, Andreas, Kinzel, Volker, Huber, Robert, Bossemeyer, Dirk

“…Background: Staurosporine inhibits most protein kinases at low nanomolar concentrations. As most tyrosine kinases, along with many serine/threonine kinases,…”
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Design and Crystal Structures of Protein Kinase B-Selective Inhibitors in Complex with Protein Kinase A and Mutants by Breitenlechner, Christine B, Friebe, Walter-Gunar, Brunet, Emmanuel, Werner, Guido, Graul, Klaus, Thomas, Ulrike, Künkele, Klaus-Peter, Schäfer, Wolfgang, Gassel, Michael, Bossemeyer, Dirk, Huber, Robert, Engh, Richard A, Masjost, Birgit

“…Protein kinase B (PKB)-selective inhibitors were designed, synthesized, and cocrystallized using the AGC kinase family protein kinase A (PKA, often called…”
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Phosphorylation of protein kinase C delta (PKC delta ) at threonine 505 is not a prerequisite for enzymatic activity: Expression of rat PKC delta and an alanine 505 mutant in bacteria in a functional form by Stempka, L, Girod, A, Mueller, HJ, Rincke, G, Marks, F, Gschwendt, M, Bossemeyer, D

“…A structural feature shared by many protein kinases is the requirement for phosphorylation of threonine or tyrosine in the so-called activation loop for full…”
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Mutants of Protein Kinase A that Mimic the ATP-binding Site of Protein Kinase B (AKT) by Gaßel, Michael, Breitenlechner, Christine B., Rüger, Petra, Jucknischke, Ute, Schneider, Thorsten, Huber, Robert, Bossemeyer, Dirk, Engh, Richard A.

“…The mutation of well behaved enzymes in order to simulate less manageable cognates is the obvious approach to study specific features of the recalcitrant…”
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The Protein Kinase C Inhibitor Bisindolyl Maleimide 2 Binds with Reversed Orientations to Different Conformations of Protein Kinase A by Gassel, Michael, Breitenlechner, Christine B., König, Norbert, Huber, Robert, Engh, Richard A., Bossemeyer, Dirk

“…As the key mediators of eukaryotic signal transduction, the protein kinases often cause disease, and in particular cancer, when disregulated. Appropriately…”
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