Search Results - "BOSMA, Madeleen"

Interleukin 34: a new modulator of human and experimental inflammatory bowel disease by Zwicker, Stephanie, Martinez, Gisele L, Bosma, Madeleen, Gerling, Marco, Clark, Reuben, Majster, Mirjam, Söderman, Jan, Almer, Sven, Boström, Elisabeth A

“…IBD (inflammatory bowel disease), where CD (Crohn's disease) and UC (ulcerative colitis) represent the two main forms, are chronic inflammatory conditions of…”
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FNDC4 acts as an anti-inflammatory factor on macrophages and improves colitis in mice by Bosma, Madeleen, Gerling, Marco, Pasto, Jenny, Georgiadi, Anastasia, Graham, Evan, Shilkova, Olga, Iwata, Yasunori, Almer, Sven, Söderman, Jan, Toftgård, Rune, Wermeling, Fredrik, Boström, Elisabeth Almer, Boström, Pontus Almer

“…FNDC4 is a secreted factor sharing high homology with the exercise-associated myokine irisin (FNDC5). Here we report that Fndc4 is robustly upregulated in…”
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Perilipin 2 Improves Insulin Sensitivity in Skeletal Muscle Despite Elevated Intramuscular Lipid Levels by BOSMA, Madeleen, HESSELINK, Matthijs K. C, KERSTEN, Sander, SCHRAUWEN, Patrick, SPARKS, Lauren M, TIMMERS, Silvie, FERRAZ, Maria Joao, MATTIJSSEN, Frits, BEURDEN, Denis Van, SCHAART, Gert, DE BAETS, Marc H, VERHEYEN, Fons K

“…Type 2 diabetes is characterized by excessive lipid storage in skeletal muscle. Excessive intramyocellular lipid (IMCL) storage exceeds intracellular needs and…”
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One-leg inactivity induces a reduction in mitochondrial oxidative capacity, intramyocellular lipid accumulation and reduced insulin signalling upon lipid infusion: a human study with unilateral limb suspension by Bilet, Lena, Phielix, Esther, van de Weijer, Tineke, Gemmink, Anne, Bosma, Madeleen, Moonen-Kornips, Esther, Jorgensen, Johanna A., Schaart, Gert, Zhang, Dongyan, Meijer, Kenneth, Hopman, Maria, Hesselink, Matthijs K. C., Ouwens, D. Margriet, Shulman, Gerald I., Schrauwen-Hinderling, Vera B., Schrauwen, Patrick

“…Aims/hypothesis Physical inactivity, low mitochondrial function, increased intramyocellular lipid (IMCL) deposition and reduced insulin sensitivity are common…”
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The lipid droplet coat protein perilipin 5 also localizes to muscle mitochondria by Bosma, Madeleen, Minnaard, Ronnie, Sparks, Lauren M., Schaart, Gert, Losen, Mario, de Baets, Marc H., Duimel, Hans, Kersten, Sander, Bickel, Perry E., Schrauwen, Patrick, Hesselink, Matthijs K. C.

“…Perilipin 5 (PLIN5/OXPAT) is a lipid droplet (LD) coat protein mainly present in tissues with a high fat-oxidative capacity, suggesting a role for PLIN5 in…”
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Augmenting muscle diacylglycerol and triacylglycerol content by blocking fatty acid oxidation does not impede insulin sensitivity by Timmers, Silvie, Nabben, Miranda, Bosma, Madeleen, van Bree, Bianca, Lenaers, Ellen, van Beurden, Denis, Schaart, Gert, Westerterp-Plantenga, Margriet S, Langhans, Wolfgang, Hesselink, Matthijs K. C, Schrauwen-Hinderling, Vera B, Schrauwen, Patrick

“…A low fat oxidative capacity has been linked to muscle diacylglycerol (DAG) accumulation and insulin resistance. Alternatively, a low fat oxidation rate may…”
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Expression Analysis of Fibronectin Type III Domain-Containing (FNDC) Genes in Inflammatory Bowel Disease and Colorectal Cancer by Weiss, Sascha, Biebl, Matthias, Pratschke, Johann, Aigner, Felix, Veltzke-Schlieker, Wilfried, Adler, Andreas, Becker, Olaf, Bosma, Madeleen, Spitz, Wolfgang, Quint, Janina, Wizenty, Jonas, Wuensch, Tilo, Stockmann, Martin

“…Background. Fibronectin type III domain-containing (FNDC) proteins fulfill manifold functions in tissue development and regulation of cellular metabolism…”
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Receptor-Type Protein-Tyrosine Phosphatase ζ and Colony Stimulating Factor-1 Receptor in the Intestine: Cellular Expression and Cytokine- and Chemokine Responses by Interleukin-34 and Colony Stimulating Factor-1 by Zwicker, Stephanie, Bureik, Daniela, Bosma, Madeleen, Martinez, Gisele Lago, Almer, Sven, Boström, Elisabeth A

“…Differential intestinal expression of the macrophage growth factors colony stimulating factor-1 (CSF-1), interleukin (IL)-34, and their shared CSF-1 receptor…”
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Chemical imaging of lipid droplets in muscle tissues using hyperspectral coherent Raman microscopy by Billecke, Nils, Rago, Gianluca, Bosma, Madeleen, Eijkel, Gert, Gemmink, Anne, Leproux, Philippe, Huss, Guillaume, Schrauwen, Patrick, Hesselink, Matthijs K. C., Bonn, Mischa, Parekh, Sapun H.

“…The accumulation of lipids in non-adipose tissues is attracting increasing attention due to its correlation with obesity. In muscle tissue, ectopic deposition…”
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Erratum to “Expression Analysis of Fibronectin Type III Domain-Containing (FNDC) Genes in Inflammatory Bowel Disease and Colorectal Cancer” by Weiss, Sascha, Biebl, Matthias, Pratschke, Johann, Aigner, Felix, Veltzke-Schlieker, Wilfried, Adler, Andreas, Becker, Olaf, Bosma, Madeleen, Spitz, Wolfgang, Quint, Janina, Wizenty, Jonas, Wuensch, Tilo, Stockmann, Martin

“…In the article titled “Expression Analysis of Fibronectin Type III Domain-Containing (FNDC) Genes in Inflammatory Bowel Disease and Colorectal Cancer” [1],…”
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Lipid droplet dynamics in skeletal muscle by Bosma, Madeleen

“…The skeletal muscle is subjected to high mechanical and energetic demands. Lipid droplets are an important source of energy substrates for the working muscle…”
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A novel method to standardise serum IgA measurements shows an increased prevalence of IgA deficiency in young children with recurrent respiratory tract infections by Koenen, Mischa H, Bosma, Madeleen, Roorda, Udo A, Wopereis, Fabiënne MY, Roos, Anja, der Vries, Erhard, Bogaert, Debby, Sanders, Elisabeth AM, Boes, Marianne, Heidema, Jojanneke, Montfrans, Joris M, Balemans, Walter AF, Holten, Thijs C, Verhagen, Lilly M

“…Objectives While physicians are often confronted with immunoglobulin A (IgA) deficiency in children with recurrent infections, the clinical relevance of this…”
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Hairy cell leukemia in a child? by Bosma, Madeleen, Bartels, Marije

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Lipid homeostasis in exercise by Bosma, Madeleen

“…•Exercise has systemic lipid lowering effects.•Exercise training results in a remodeling of skeletal muscle lipid metabolism.•Storage of lipids in LDs and…”
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Automated Monitoring of Plasma-free Hemoglobin on Routine Clinical Chemistry Platforms by Bosma, Madeleen, Scholten, Erik, Rigter, Sander, Hackeng, Chris M.

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Coagulation assay results at birth in preterm infants: A cohort study highlighting the relevance of local reference values for interpretation by Houben, Nina, Fustolo‐Gunnink, Suzanne, Caram‐Deelder, Camila, Visser, Remco, Bosma, Madeleen, Fijnvandraat, Karin, Eikenboom, Jeroen, van der Bom, Johanna, Lopriore, Enrico

“…Abstract Background and Objectives Routine coagulation screens at birth are still standard in some European neonatal intensive care units (NICUs), although…”
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Screening for thyroid dysfunction with free T4 instead of thyroid stimulating hormone (TSH) improves efficiency in older adults in primary care by Bosma, Madeleen, Du Puy, Robert S, Ballieux, Bart E P B

“…Subclinical hypothyroidism (SCHT) is defined as a consistently elevated thyroid stimulating hormone (TSH) with a free T4 (fT4) within the reference range. This…”
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Automated Monitoring of Plasma-free Hemoglobin on Routine Clinical Chemistry Platforms by Bosma, Madeleen, Scholten, Erik, Rigter, Sander, Hackeng, Chris M.

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Associations Between Preoperative Biomarkers and Cardiac Surgery–Associated Acute Kidney Injury in Elderly Patients: A Cohort Study by Verwijmeren, Lisa, Bosma, Madeleen, Vernooij, Lisette M., Linde, Esther M., Dijkstra, Ineke M., Daeter, Edgar J., Van Dongen, Eric P. A., Van Klei, Wilton A., Noordzij, Peter G.

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Associations Between Preoperative Biomarkers and Cardiac Surgery–Associated Acute Kidney Injury in Elderly Patients: A Cohort Study by Verwijmeren, Lisa, Bosma, Madeleen, Vernooij, Lisette M., Linde, Esther M., Dijkstra, Ineke M., Daeter, Edgar J., Van Dongen, Eric P. A., Van Klei, Wilton A., Noordzij, Peter G.

“…Acute kidney injury (AKI) is associated with mortality after cardiac surgery. Novel risk factors may improve identification of patients at risk for renal…”
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