Search Results - "BORRIE, Michael"

Association of Dual-Task Gait With Incident Dementia in Mild Cognitive Impairment: Results From the Gait and Brain Study by Montero-Odasso, Manuel M, Sarquis-Adamson, Yanina, Speechley, Mark, Borrie, Michael J, Hachinski, Vladimir C, Wells, Jennie, Riccio, Patricia M, Schapira, Marcelo, Sejdic, Ervin, Camicioli, Richard M, Bartha, Robert, McIlroy, William E, Muir-Hunter, Susan

“…Gait performance is affected by neurodegeneration in aging and has the potential to be used as a clinical marker for progression from mild cognitive impairment…”
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Trial of Solanezumab for Mild Dementia Due to Alzheimer’s Disease by Honig, Lawrence S, Vellas, Bruno, Woodward, Michael, Boada, Mercè, Bullock, Roger, Borrie, Michael, Hager, Klaus, Andreasen, Niels, Scarpini, Elio, Liu-Seifert, Hong, Case, Michael, Dean, Robert A, Hake, Ann, Sundell, Karen, Poole Hoffmann, Vicki, Carlson, Christopher, Khanna, Rashna, Mintun, Mark, DeMattos, Ronald, Selzler, Katherine J, Siemers, Eric

“…In a randomized trial, solanezumab, a humanized monoclonal antibody against soluble amyloid, did not slow cognitive decline over a period of 80 weeks in…”
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Reduced Hippocampal Glutamate and Posterior Cingulate N-Acetyl Aspartate in Mild Cognitive Impairment and Alzheimer's Disease Is Associated with Episodic Memory Performance and White Matter Integrity in the Cingulum: A Pilot Study by Wong, Dickson, Atiya, Samir, Fogarty, Jennifer, Montero-Odasso, Manuel, Pasternak, Stephen H, Brymer, Chris, Borrie, Michael J, Bartha, Robert

“…Identification of biological changes underlying the early symptoms of Alzheimer's disease (AD) will help to identify and stage individuals prior to symptom…”
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Disentangling Cognitive-Frailty: Results From the Gait and Brain Study by Montero-Odasso, Manuel M, Barnes, Brittany, Speechley, Mark, Muir Hunter, Susan W, Doherty, Timothy J, Duque, Gustavo, Gopaul, Karen, Sposato, Luciano A, Casas-Herrero, Alvaro, Borrie, Michael J, Camicioli, Richard, Wells, Jennie L

“…Cognitive-frailty, defined as the presence of both frailty and cognitive impairment, is proposed as a distinctive entity that predicts dementia. However, it…”
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Gait assessment in mild cognitive impairment and Alzheimer's disease: The effect of dual-task challenges across the cognitive spectrum by Muir, Susan W, Speechley, Mark, Wells, Jennie, Borrie, Michael, Gopaul, Karen, Montero-Odasso, Manuel

“…Highlights ► We tested gait under single and dual-task conditions in adults with normal cognition, MCI, and AD. ► Single-task testing, walking at usual speed,…”
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Motor and Cognitive Trajectories Before Dementia: Results from Gait and Brain Study by Montero‐Odasso, Manuel, Speechley, Mark, Muir‐Hunter, Susan W., Sarquis‐Adamson, Yanina, Sposato, Luciano A., Hachinski, Vladimir, Borrie, Michael, Wells, Jennie, Black, Alanna, Sejdić, Ervin, Bherer, Louis, Chertkow, Howard

“…Objectives To compare the trajectories of motor and cognitive decline in older adults who progress to dementia with the trajectories of those who do not. To…”
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Spontaneous low frequency BOLD signal variations from resting-state fMRI are decreased in Alzheimer disease by Kazemifar, Samaneh, Manning, Kathryn Y, Rajakumar, Nagalingam, Gómez, Francisco A, Soddu, Andrea, Borrie, Michael J, Menon, Ravi S, Bartha, Robert

“…Previous studies have demonstrated altered brain activity in Alzheimer's disease using task based functional MRI (fMRI), network based resting-state fMRI, and…”
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Frailty is associated with postoperative complications in older adults with medical problems by Dasgupta, Monidipa, Rolfson, Darryl B, Stolee, Paul, Borrie, Michael J, Speechley, Mark

“…Abstract We sought to test whether frailty may be predictive of operative risk in older adults with medical problems. One hundred and twenty-five patients at…”
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Quantitative gait analysis under dual-task in older people with mild cognitive impairment: a reliability study by Montero-Odasso, Manuel, Casas, Alvaro, Hansen, Kevin T, Bilski, Patricia, Gutmanis, Iris, Wells, Jennie L, Borrie, Michael J

“…Reliability of quantitative gait assessment while dual-tasking (walking while doing a secondary task such as talking) in people with cognitive impairment is…”
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Motor cortex and gait in mild cognitive impairment: a magnetic resonance spectroscopy and volumetric imaging study by ANNWEILER, Cedric, BEAUCHET, Olivier, BARTHA, Robert, WELLS, Jennie L, BORRIE, Michael J, HACHINSKI, Vladimir, MONTERO-ODASSO, Manuel

“…Gait disorders are common in the course of dementia, even at the stage of mild cognitive impairment, owing to probable changes in higher levels of motor…”
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A "Patient Preference" Model of Recruitment for Research from Primary-Care-Based Memory Clinics: A Promising New Approach by Lee, Linda, Hillier, Loretta M, Patel, Tejal, Gregg, Susie, Hickman, Kathy, Lu, Stephanie K, Lee, Michael, Borrie, Michael J

“…Recruiting persons with dementia for clinical trials can be challenging. Building on a guide initially developed to assist primary-care-based memory clinics in…”
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Elicited clinician knowledge did not improve dementia risk prediction in individuals with mild cognitive impairment by Wang, Meng, Chekouo, Thierry, Ismail, Zahinoor, Forkert, Nils D., Hogan, David B., Ganesh, Aravind, Camicioli, Richard, Seitz, Dallas, Borrie, Michael J., Hsiung, Ging-Yuek Robin, Masellis, Mario, Moorhouse, Paige, Tartaglia, Carmela, Smith, Eric E., Sajobi, Tolulope T.

“…This study aims to develop and validate a Bayesian risk prediction model that combines research cohort data with elicited expert knowledge to predict dementia…”
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Standing middle cerebral artery velocity predict cognitive performance on working memory tasks in adults with varying levels of cognitive abilities by Fitzgibbon-Collins, Laura, Shoemaker, J. Kevin, Borrie, Michael, Bhangu, Jaspreet

“…The pathophysiology of dementia is multifactorial and reduced cerebral blood flow (CBF) is a predictor of cognitive impairment. The majority of research on CBF…”
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Expert elicitation of risk factors for progression to dementia in individuals with mild cognitive impairment by Wang, Meng, Sajobi, Tolulope T, Hogan, David B, Ganesh, Aravind, Seitz, Dallas P, Chekouo, Thierry, Forkert, Nils D, Borrie, Michael J, Camicioli, Richard, Hsiung, Ging-Yuek Robin, Masellis, Mario, Moorhouse, Paige, Tartaglia, Maria Carmela, Ismail, Zahinoor, Smith, Eric E

“…This study assesses experts' beliefs about important predictors of developing dementia in persons with mild cognitive impairment (MCI). Structured expert…”
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Distinct spatial contributions of amyloid pathology and cerebral small vessel disease to hippocampal morphology by Xhima, Kristiana, Ottoy, Julie, Gibson, Erin, Zukotynski, Katherine, Scott, Christopher, Feliciano, Ginelle J., Adamo, Sabrina, Kuo, Phillip H., Borrie, Michael J., Chertkow, Howard, Frayne, Richard, Laforce, Robert, Noseworthy, Michael D., Prato, Frank S., Sahlas, Demetrios J., Smith, Eric E., Sossi, Vesna, Thiel, Alexander, Soucy, Jean‐Paul, Tardif, Jean‐Claude, Goubran, Maged, Black, Sandra E., Ramirez, Joel

“…INTRODUCTION Cerebral small vessel disease (SVD) and amyloid beta (Aβ) pathology frequently co‐exist. The impact of concurrent pathology on the pattern of…”
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Diagnosis and treatment of dementia: 2. Diagnosis by Feldman, Howard H, Jacova, Claudia, Robillard, Alain, Garcia, Angeles, Chow, Tiffany, Borrie, Michael, Schipper, Hyman M, Blair, Mervin, Kertesz, Andrew, Chertkow, Howard

“…Dementia can now be accurately diagnosed through clinical evaluation, cognitive screening, basic laboratory evaluation and structural imaging. A large number…”
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Primary Care-Based Memory Clinics: Expanding Capacity for Dementia Care by Lee, Linda, Hillier, Loretta M, Heckman, George, Gagnon, Micheline, Borrie, Michael J, Stolee, Paul, Harvey, David

“…The implementation in Ontario of 15 primary-care-based interprofessional memory clinics represented a unique model of team-based case management aimed at…”
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Automated algorithm to measure changes in medial temporal lobe volume in Alzheimer disease by Kazemifar, Samaneh, Drozd, John J., Rajakumar, Nagalingam, Borrie, Michael J., Bartha, Robert

“…•Fully automated medial temporal lobe (MTL) atrophy measurement.•Significant MTL atrophy over 24 months in NEC, MCI, and AD groups.•A significant difference in…”
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White matter hyperintensities and smaller cortical thickness are associated with neuropsychiatric symptoms in neurodegenerative and cerebrovascular diseases by Ozzoude, Miracle, Varriano, Brenda, Beaton, Derek, Ramirez, Joel, Adamo, Sabrina, Holmes, Melissa F, Scott, Christopher J M, Gao, Fuqiang, Sunderland, Kelly M, McLaughlin, Paula, Goubran, Maged, Kwan, Donna, Roberts, Angela, Bartha, Robert, Symons, Sean, Tan, Brian, Swartz, Richard H, Abrahao, Agessandro, Saposnik, Gustavo, Masellis, Mario, Lang, Anthony E, Marras, Connie, Zinman, Lorne, Shoesmith, Christen, Borrie, Michael, Fischer, Corinne E, Frank, Andrew, Freedman, Morris, Montero-Odasso, Manuel, Kumar, Sanjeev, Pasternak, Stephen, Strother, Stephen C, Pollock, Bruce G, Rajji, Tarek K, Seitz, Dallas, Tang-Wai, David F, Turnbull, John, Dowlatshahi, Dar, Hassan, Ayman, Casaubon, Leanne, Mandzia, Jennifer, Sahlas, Demetrios, Breen, David P, Grimes, David, Jog, Mandar, Steeves, Thomas D L, Arnott, Stephen R, Black, Sandra E, Finger, Elizabeth, Rabin, Jennifer, Tartaglia, Maria Carmela

“…Neuropsychiatric symptoms (NPS) are a core feature of most neurodegenerative and cerebrovascular diseases. White matter hyperintensities and brain atrophy have…”
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Increased glutamate in the hippocampus after galantamine treatment for Alzheimer disease by Penner, Jacob, Rupsingh, Raul, Smith, Matthew, Wells, Jennie L., Borrie, Michael J., Bartha, Robert

“…Galantamine is a cholinesterase inhibitor and allosteric potentiating ligand modulating presynaptic nicotinic acetylcholine receptors that is used in the…”
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