Search Results - "BOROS, Laszlo G"

Nutritional deuterium depletion and health: a scoping review by Korchinsky, Nicole, Davis, Anne M., Boros, László G.

“…Introduction Large variations in fatty and amino acid natural 2 H/ 1 H ratios in reference with solvent water point to the active involvement of compartmental,…”
Get full text

Transcription factor NRF2 regulates miR-1 and miR-206 to drive tumorigenesis by Singh, Anju, Happel, Christine, Manna, Soumen K, Acquaah-Mensah, George, Carrerero, Julian, Kumar, Sarvesh, Nasipuri, Poonam, Krausz, Kristopher W, Wakabayashi, Nobunao, Dewi, Ruby, Boros, Laszlo G, Gonzalez, Frank J, Gabrielson, Edward, Wong, Kwok K, Girnun, Geoffrey, Biswal, Shyam

“…The mechanisms by which deregulated nuclear factor erythroid-2-related factor 2 (NRF2) and kelch-like ECH-associated protein 1 (KEAP1) signaling promote…”
Get full text

PEPCK Coordinates the Regulation of Central Carbon Metabolism to Promote Cancer Cell Growth by Montal, Emily D., Dewi, Ruby, Bhalla, Kavita, Ou, Lihui, Hwang, Bor Jang, Ropell, Ashley E., Gordon, Chris, Liu, Wan-Ju, DeBerardinis, Ralph J., Sudderth, Jessica, Twaddel, William, Boros, Laszlo G., Shroyer, Kenneth R., Duraisamy, Sekhar, Drapkin, Ronny, Powers, R. Scott, Rohde, Jason M., Boxer, Matthew B., Wong, Kwok-Kin, Girnun, Geoffrey D.

“…Phosphoenolpyruvate carboxykinase (PEPCK) is well known for its role in gluconeogenesis. However, PEPCK is also a key regulator of TCA cycle flux. The TCA…”
Get full text

An Inhibitor of GSK3B and HDACs Kills Pancreatic Cancer Cells and Slows Pancreatic Tumor Growth and Metastasis in Mice by Edderkaoui, Mouad, Chheda, Chintan, Soufi, Badr, Zayou, Fouzia, Hu, Robert W., Ramanujan, V. Krishnan, Pan, Xinlei, Boros, Laszlo G., Tajbakhsh, Jian, Madhav, Anisha, Bhowmick, Neil A., Wang, Qiang, Lewis, Michael, Tuli, Richard, Habtezion, Aida, Murali, Ramachandran, Pandol, Stephen J.

“…Growth, progression, and drug resistance of pancreatic ductal adenocarcinomas (PDACs) have been associated with increased levels and activity of glycogen…”
Get full text

Fructose Induces Transketolase Flux to Promote Pancreatic Cancer Growth by HAIBO LIU, DANSHAN HUANG, MCARTHUR, David L, BOROS, Laszlo G, NISSEN, Nicholas, HEANEY, Anthony P

“…Carbohydrate metabolism via glycolysis and the tricarboxylic acid cycle is pivotal for cancer growth, and increased refined carbohydrate consumption adversely…”
Get full text

What to eat or what not to eat-that is still the question by Boros, László G, Collins, T Que, Somlyai, Gábor

Get full text

Cancer-associated Isocitrate Dehydrogenase 1 (IDH1) R132H Mutation and d-2-Hydroxyglutarate Stimulate Glutamine Metabolism under Hypoxia by Reitman, Zachary J., Duncan, Christopher G., Poteet, Ethan, Winters, Ali, Yan, Liang-Jun, Gooden, David M., Spasojevic, Ivan, Boros, Laszlo G., Yang, Shao-Hua, Yan, Hai

“…Mutations in the cytosolic NADP+-dependent isocitrate dehydrogenase (IDH1) occur in several types of cancer, and altered cellular metabolism associated with…”
Get full text

De novo lipogenesis represents a therapeutic target in mutant Kras non‐small cell lung cancer by Singh, Anju, Ruiz, Christian, Bhalla, Kavita, Haley, John A., Li, Qing Kay, Acquaah‐Mensah, George, Montal, Emily, Sudini, Kuladeep R., Skoulidis, Ferdinandos, Wistuba, Ignacio I., Papadimitrakopoulou, Vassiliki, Heymach, John V., Boros, Laszlo G., Gabrielson, Edward, Carretero, Julian, Wong, Kwok‐Kin, Haley, John D., Biswal, Shyam, Girnun, Geoffrey D.

“…ABSTRACT Oncogenic Kras mutations are one of the most common alterations in non‐small cell lung cancer and are associated with poor response to treatment and…”
Get full text

5′-AMP-activated Protein Kinase (AMPK) Supports the Growth of Aggressive Experimental Human Breast Cancer Tumors by Laderoute, Keith R., Calaoagan, Joy M., Chao, Wan-ru, Dinh, Dominc, Denko, Nicholas, Duellman, Sarah, Kalra, Jessica, Liu, Xiaohe, Papandreou, Ioanna, Sambucetti, Lidia, Boros, Laszlo G.

“…Rapid tumor growth can establish metabolically stressed microenvironments that activate 5′-AMP-activated protein kinase (AMPK), a ubiquitous regulator of ATP…”
Get full text

Metabolic reprogramming for producing energy and reducing power in fumarate hydratase null cells from hereditary leiomyomatosis renal cell carcinoma by Yang, Youfeng, Lane, Andrew N, Ricketts, Christopher J, Sourbier, Carole, Wei, Ming-Hui, Shuch, Brian, Pike, Lisa, Wu, Min, Rouault, Tracey A, Boros, Laszlo G, Fan, Teresa W-M, Linehan, W Marston

“…Fumarate hydratase (FH)-deficient kidney cancer undergoes metabolic remodeling, with changes in mitochondrial respiration, glucose, and glutamine metabolism…”
Get full text

Contextual inhibition of fatty acid synthesis by metformin involves glucose-derived acetyl-CoA and cholesterol in pancreatic tumor cells by Cantoria, Mary Jo, Boros, László G., Meuillet, Emmanuelle J.

“…Metformin, a generic glucose lowering drug, inhibits cancer growth expressly in models that employ high fat/cholesterol intake and/or low glucose availability…”
Get full text

Abnormalities in glucose uptake and metabolism in imatinib-resistant human BCR-ABL-positive cells by Kominsky, Douglas J, Klawitter, Jelena, Brown, Jaimi L, Boros, Laszlo G, Melo, Junia V, Eckhardt, S Gail, Serkova, Natalie J

“…The development of imatinib resistance has become a significant therapeutic problem in which the etiology seems to be multifactorial and poorly understood. As…”
Get full text

Survival Pathways of HIF-Deficient Tumour Cells: TCA Inhibition, Peroxisomal Fatty Acid Oxidation Activation and an AMPK-PGC-1α Hypoxia Sensor by Golinska, Monika A, Stubbs, Marion, Harris, Adrian L, Boros, Laszlo G, Basetti, Madhu, McIntyre, Dominick J O, Griffiths, John R

“…The HIF-1 and HIF-2 (HIF1/2) hypoxia responses are frequently upregulated in cancers, and HIF1/2 inhibitors are being developed as anticancer drugs. How could…”
Get full text

AMPK activation through mitochondrial regulation results in increased substrate oxidation and improved metabolic parameters in models of diabetes by Jenkins, Yonchu, Sun, Tian-Qiang, Markovtsov, Vadim, Foretz, Marc, Li, Wei, Nguyen, Henry, Li, Yingwu, Pan, Alison, Uy, Gerald, Gross, Lisa, Baltgalvis, Kristen, Yung, Stephanie L, Gururaja, Tarikere, Kinoshita, Taisei, Owyang, Alexander, Smith, Ira J, McCaughey, Kelly, White, Kathy, Godinez, Guillermo, Alcantara, Raniel, Choy, Carmen, Ren, Hong, Basile, Rachel, Sweeny, David J, Xu, Xiang, Issakani, Sarkiz D, Carroll, David C, Goff, Dane A, Shaw, Simon J, Singh, Rajinder, Boros, Laszlo G, Laplante, Marc-André, Marcotte, Bruno, Kohen, Rita, Viollet, Benoit, Marette, André, Payan, Donald G, Kinsella, Todd M, Hitoshi, Yasumichi

“…Modulation of mitochondrial function through inhibiting respiratory complex I activates a key sensor of cellular energy status, the 5'-AMP-activated protein…”
Get full text

Impact of the solvent capacity constraint on E. coli metabolism by Vazquez, Alexei, Beg, Qasim K, Demenezes, Marcio A, Ernst, Jason, Bar-Joseph, Ziv, Barabási, Albert-László, Boros, László G, Oltvai, Zoltán N

“…Obtaining quantitative predictions for cellular metabolic activities requires the identification and modeling of the physicochemical constraints that are…”
Get full text

Fructose Alters Intermediary Metabolism of Glucose in Human Adipocytes and Diverts Glucose to Serine Oxidation in the One-Carbon Cycle Energy Producing Pathway by Varma, Vijayalakshmi, Boros, László G, Nolen, Greg T, Chang, Ching-Wei, Wabitsch, Martin, Beger, Richard D, Kaput, Jim

“…Increased consumption of sugar and fructose as sweeteners has resulted in the utilization of fructose as an alternative metabolic fuel that may compete with…”
Get full text

Direct spectrophotometric determination of serum fructose in pancreatic cancer patients by Hui, Hongxiang, Huang, Danshan, McArthur, David, Nissen, Nicholas, Boros, Laszlo G, Heaney, Anthony P

“…We sought to develop an assay to measure circulating fructose concentrations in pancreatic cancer patients. Using fructose dehydrogenase-catalyzed conversion…”
Get full text

Fructose impairs glucose-induced hepatic triglyceride synthesis by Huang, Danshan, Dhawan, Tania, Young, Stephen, Yong, William H, Boros, Laszlo G, Heaney, Anthony P

“…Obesity, type 2 diabetes and hyperlipidemia frequently coexist and are associated with significantly increased morbidity and mortality. Consumption of refined…”
Get full text

Metabolic control analysis in drug discovery and disease by Cascante, Marta, Boros, Laszlo G, Comin-Anduix, Begoña, de Atauri, Pedro, Centelles, Josep J, Lee, Paul W.-N

“…Metabolic control analysis (MCA) provides a quantitative description of substrate flux in response to changes in system parameters of complex enzyme systems…”
Get full text

K-ras codon-specific mutations produce distinctive metabolic phenotypes in human fibroblasts by VIZAN, Pedro, BOROS, Laszlo G, FIGUERAS, Agnes, CAPELLA, Gabriel, MANGUES, Ramon, BASSILIAN, Sara, LIM, Shu, LEE, Wai-Nang P, CASCANTE, Marta

“…Among K-ras mutations, codon 12 mutations have been identified as those conferring a more aggressive phenotype. This aggressiveness is primarily associated…”
Get full text