Search Results - "BORGOGNONI, Lorenzo"

ERK5 is activated by oncogenic BRAF and promotes melanoma growth by Tusa, Ignazia, Gagliardi, Sinforosa, Tubita, Alessandro, Pandolfi, Silvia, Urso, Carmelo, Borgognoni, Lorenzo, Wang, Jinhua, Deng, Xianming, Gray, Nathanael S, Stecca, Barbara, Rovida, Elisabetta

“…Malignant melanoma is among the most aggressive cancers and its incidence is increasing worldwide. Targeted therapies and immunotherapy have improved the…”
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Tolerogenic IDO1 + CD83 - Langerhans Cells in Sentinel Lymph Nodes of Patients with Melanoma by Gerlini, Gianni, Di Gennaro, Paola, Pimpinelli, Nicola, Sestini, Serena, Borgognoni, Lorenzo

“…Langerhans cells (LCs) are crucial regulators of anti-cancer immune responses. Cancer, however, can alter DCs functions leading to tolerance. The enzyme…”
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HEDGEHOG-GLI Signaling Drives Self-Renewal and Tumorigenicity of Human Melanoma-Initiating Cells by Santini, Roberta, Vinci, Maria C., Pandolfi, Silvia, Penachioni, Junia Y., Montagnani, Valentina, Olivito, Biagio, Gattai, Riccardo, Pimpinelli, Nicola, Gerlini, Gianni, Borgognoni, Lorenzo, Stecca, Barbara

“…The question of whether cancer stem/tumor‐initiating cells (CSC/TIC) exist in human melanomas has arisen in the last few years. Here, we have used nonadherent…”
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Targeting GLI1 and GLI2 with small molecule inhibitors to suppress GLI-dependent transcription and tumor growth by Maresca, Luisa, Crivaro, Enrica, Migliorini, Francesca, Anichini, Giulia, Giammona, Alessandro, Pepe, Sara, Poggialini, Federica, Vagaggini, Chiara, Giannini, Giuseppe, Sestini, Serena, Borgognoni, Lorenzo, Lapucci, Andrea, Dreassi, Elena, Taddei, Maurizio, Manetti, Fabrizio, Petricci, Elena, Stecca, Barbara

“…Aberrant activation of Hedgehog (HH) signaling in cancer is the result of genetic alterations of upstream pathway components (canonical) or other oncogenic…”
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New paradigm for stage III melanoma: from surgery to adjuvant treatment by Ascierto, Paolo Antonio, Borgognoni, Lorenzo, Botti, Gerardo, Guida, Michele, Marchetti, Paolo, Mocellin, Simone, Muto, Paolo, Palmieri, Giuseppe, Patuzzo, Roberto, Quaglino, Pietro, Stanganelli, Ignazio, Caracò, Corrado

“…Recently the 8th version of the American Joint Committee on Cancer (AJCC) classification has been introduced, and has attempted to define a more accurate and…”
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Adjuvant Ganglioside GM2-KLH/QS-21 Vaccination Versus Observation After Resection of Primary Tumor > 1.5 mm in Patients With Stage II Melanoma: Results of the EORTC 18961 Randomized Phase III Trial by EGGERMONT, Alexander M. M, SUCIU, Stefan, BASTHOLT, Lars, BORGOGNONI, Lorenzo, GRAZIA BERNENGO, Maria, DAVIDSON, Neville, POLDERS, Larissa, PRAET, Michel, SPATZ, Alan, RUTKOWSKI, Piotr, MARSDEN, Jeremy, SANTINAMI, Mario, CORRIE, Philippa, AAMDAL, Steinar, ASCIERTO, Paolo A, PATEL, Poulam M, KRUIT, Wim H

“…The GM2 ganglioside is an antigen expressed in the majority of melanomas. The GM2-KLH/QS-21 vaccine induces high immunoglobulin M (IgM) and IgG antibody…”
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The role of sentinel node tumor burden in modeling the prognosis of melanoma patients with positive sentinel node biopsy: an Italian melanoma intergroup study (N = 2,086) by Tropea, Saveria, Del Fiore, Paolo, Maurichi, Andrea, Patuzzo, Roberto, Santinami, Mario, Ribero, Simone, Quaglino, Pietro, Caliendo, Virginia, Borgognoni, Lorenzo, Sestini, Serena, Giudice, Giuseppe, Nacchiero, Eleonora, Caracò, Corrado, Cordova, Adriana, Solari, Nicola, Piazzalunga, Dario, Tauceri, Francesca, Carcoforo, Paolo, Lombardo, Maurizio, Cavallari, Sara, Mocellin, Simone

“…The management of melanoma patients with metastatic melanoma in the sentinel nodes (SN) is evolving based on the results of trials questioning the impact of…”
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CD63 Tetraspanin Is a Negative Driver of Epithelial-to-Mesenchymal Transition in Human Melanoma Cells by Lupia, Antonella, Peppicelli, Silvia, Witort, Ewa, Bianchini, Francesca, Carloni, Vinicio, Pimpinelli, Nicola, Urso, Carmelo, Borgognoni, Lorenzo, Capaccioli, Sergio, Calorini, Lido, Lulli, Matteo

“…The CD63 tetraspanin is highly expressed in the early stages of melanoma and decreases in advanced lesions, suggesting it as a possible suppressor of tumor…”
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Enhancing anti-melanoma immunity by electrochemotherapy and in vivo dendritic-cell activation by Gerlini, Gianni, Di Gennaro, Paola, Borgognoni, Lorenzo

“…Combining electrochemotherapy with dendritic cell-based immunotherapy is a promising strategy against human metastatic melanoma that deserves to be clinically…”
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Multiple primary melanomas (MPMs) and criteria for genetic assessment: MultiMEL, a multicenter study of the Italian Melanoma Intergroup by Bruno, William, MD, PhD, Pastorino, Lorenza, PhD, Ghiorzo, Paola, PhD, Andreotti, Virginia, PhD, Martinuzzi, Claudia, MSc, Menin, Chiara, PhD, Elefanti, Lisa, PhD, Stagni, Camilla, PhD, Vecchiato, Antonella, MD, Rodolfo, Monica, PhD, Maurichi, Andrea, MD, Manoukian, Siranoush, MD, PhD, De Giorgi, Vincenzo, MD, Savarese, Imma, MD, Gensini, Francesca, MD, PhD, Borgognoni, Lorenzo, MD, Testori, Alessandro, MD, Spadola, Giuseppe, MD, Mandalà, Mario, MD, Imberti, Gianlorenzo, MD, Savoia, Paola, MD, Astrua, Chiara, MD, Ronco, Anna Maria, MD, Farnetti, Alessandra, MD, Tibiletti, Maria Grazia, PhD, Lombardo, Maurizio, MD, Palmieri, Giuseppe, PhD, Ayala, Fabrizio, MD, Ascierto, Paolo, MD, Ghigliotti, Giovanni, MD, Muggianu, Marisa, MD, Spagnolo, Francesco, MD, Picasso, Virginia, MD, Tanda, Enrica Teresa, MD, Queirolo, Paola, MD, Bianchi-Scarrà, Giovanna, PhD

“…Background Multiple primary melanoma (MPM), in concert with a positive family history, is a predictor of cyclin-dependent kinase (CDK) inhibitor 2A ( CDKN2A )…”
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Correction to: New paradigm for stage III melanoma: from surgery to adjuvant treatment by Ascierto, Paolo Antonio, Borgognoni, Lorenzo, Botti, Gerardo, Guida, Michele, Marchetti, Paolo, Mocellin, Simone, Muto, Paolo, Palmieri, Giuseppe, Patuzzo, Roberto, Quaglino, Pietro, Stanganelli, Ignazio, Caracò, Corrado

“…Following publication of the original article [1], the authors reported that one of the authors, Corrado Caracò, has been accidentally omitted from the author…”
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Biological effects of silicone gel sheeting by BORGOGNONI, LORENZO

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A rare case of anal porocarcinoma treated by electrochemotherapy by Borgognoni, Lorenzo, Lorenzo, Borgognoni, Pescitelli, Leonardo, Leonardo, Pescitelli, Urso, Carmelo, Carmelo, Urso, Brandani, Paola, Paola, Brandani, Sestini, Serena, Serena, Sestini, Chiarugi, Cristina, Cristina, Chiarugi, Gelli, Riccardo, Riccardo, Gelli, Giannotti, Vanni, Vanni, Giannotti, Gerlini, Gianni, Gianni, Gerlini

“…We report the case of an old woman with an eccrine porocarcinoma unusually localized in the perianal area treated by electrochemotherapy, a new technique,…”
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IDO and CD83 expression in human epidermal Langerhans cells by Di Gennaro, Paola, Romoli, Maria Raffaella, Gerlini, Gianni, D’Amico, Massimo, Brandani, Paola, Pimpinelli, Nicola, Borgognoni, Lorenzo

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A key role for poly(ADP-ribose) polymerase-1 activity during human dendritic cell maturation by Aldinucci, Alessandra, Gerlini, Gianni, Fossati, Silvia, Cipriani, Giulia, Ballerini, Clara, Biagioli, Tiziana, Pimpinelli, Nicola, Borgognoni, Lorenzo, Massacesi, Luca, Moroni, Flavio, Chiarugi, Alberto

“…Poly(ADP-ribose) (PAR) polymerase (PARP)-1 is a nuclear enzyme regulating protein that functions by targeting PAR chains. Besides its classic role in DNA…”
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Efficacy of Electrochemotherapy in the Treatment of Cutaneous Melanoma Metastases and Rare Non-melanoma Skin Cancer by Borgognoni, Lorenzo, Pescitelli, Leonardo, Gerlini, Gianni, Brandani, Paola, Gelli, Riccardo, Giannotti, Vanni, Bellucci, Francesco, Sestini, Serena

“…We aimed to verify the clinical efficacy and safety of the electrochemotherapy in melanoma metastases and in cases of rare non-melanoma tumors that were…”
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Langerhans Cells in Sentinel Lymph Nodes from Melanoma Patients by Gerlini, Gianni, Susini, Pietro, Sestini, Serena, Brandani, Paola, Giannotti, Vanni, Borgognoni, Lorenzo

“…Langerhans cells (LCs) are professional Dendritic Cells (DCs) involved in immunoregulatory functions. At the skin level, LCs are immature. In response to…”
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The importance of mitosis ≥2 in selecting patients with T1 cutaneous melanomas for sentinel lymph node biopsy by Borgognoni, Lorenzo, Crocetti, Emanuele, Sestini, Serena, Brandani, Paola, Giannotti, Vanni, Gerlini, Gianni

“…The 8th Edition of the American Joint Committee on Cancer (AJCC) Staging Manual removed the mitotic rate (MR) as a staging criterion for T1 melanomas, thus…”
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Down-Regulation of SOX2 Underlies the Inhibitory Effects of the Triphenylmethane Gentian Violet on Melanoma Cell Self-Renewal and Survival by Pietrobono, Silvia, Morandi, Andrea, Gagliardi, Sinforosa, Gerlini, Gianni, Borgognoni, Lorenzo, Chiarugi, Paola, Arbiser, Jack L., Stecca, Barbara

“…Human melanomas contain a population of tumor-initiating cells that are able to maintain the growth of the tumor. We previously showed that the embryonic…”
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Prediction of Non-sentinel Node Status in Patients with Melanoma and Positive Sentinel Node Biopsy: An Italian Melanoma Intergroup (IMI) Study by Rossi, Carlo Riccardo, Mocellin, Simone, Campana, Luca Giovanni, Borgognoni, Lorenzo, Sestini, Serena, Giudice, Giuseppe, Caracò, Corrado, Cordova, Adriana, Solari, Nicola, Piazzalunga, Dario, Carcoforo, Paolo, Quaglino, Pietro, Caliendo, Virginia, Ribero, Simone

“…Background and Purpose Approximately 20% of melanoma patients harbor metastases in non-sentinel nodes (NSNs) after a positive sentinel node biopsy (SNB), and…”
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