Search Results - "BOOTH, Timothy F"
-
1
The scanning electron microscope in microbiology and diagnosis of infectious disease
Published in Scientific reports (23-05-2016)“…Despite being an excellent tool for investigating ultrastructure, scanning electron microscopy (SEM) is less frequently used than transmission electron…”
Get full text
Journal Article -
2
Structure of the Ebola virus glycoprotein spike within the virion envelope at 11 Å resolution
Published in Scientific reports (11-04-2017)“…We present the structure of the surface Ebola virus (EBOV) trimeric glycoprotein (GP) spike at 11 Å resolution, in situ within the viral plasma membrane of…”
Get full text
Journal Article -
3
Molecular Pathogenicity of Enteroviruses Causing Neurological Disease
Published in Frontiers in microbiology (09-04-2020)“…Enteroviruses are single-stranded positive-sense RNA viruses that primarily cause self-limiting gastrointestinal or respiratory illness. In some cases, these…”
Get full text
Journal Article -
4
Comparative Analysis of Outer Membrane Vesicle Isolation Methods With an Escherichia coli tolA Mutant Reveals a Hypervesiculating Phenotype With Outer-Inner Membrane Vesicle Content
Published in Frontiers in microbiology (05-03-2021)“…Outer membrane vesicles (OMVs) produced by Gram-negative bacteria are mediators of cell survival and pathogenesis by facilitating virulence factor…”
Get full text
Journal Article -
5
The organisation of Ebola virus reveals a capacity for extensive, modular polyploidy
Published in PloS one (11-01-2012)“…Filoviruses, including Ebola virus, are unusual in being filamentous animal viruses. Structural data on the arrangement, stoichiometry and organisation of the…”
Get full text
Journal Article -
6
Induction of Multiple miR-200/182 Members in the Brains of Mice Are Associated with Acute Herpes Simplex Virus 1 Encephalitis
Published in PloS one (03-01-2017)“…Important roles of microRNAs (miRNAs) in regulating the host response during viral infection have begun to be defined. However, little is known about the…”
Get full text
Journal Article -
7
Applying fluorescent dye assays to discriminate Escherichia coli chlorhexidine resistance phenotypes from porin and mlaA deletions and efflux pumps
Published in Scientific reports (15-07-2022)“…Bacterial resistance to the antiseptic chlorhexidine (CHX), is a growing problem, recently shown to be caused by deleterious mutations to the phospholipid…”
Get full text
Journal Article -
8
Characterization of a stable, metronidazole-resistant Clostridium difficile clinical isolate
Published in PloS one (17-01-2013)“…Clostridium difficile are gram-positive, spore forming anaerobic bacteria that are the leading cause of healthcare-associated diarrhea, usually associated with…”
Get full text
Journal Article -
9
MicroRNA and mRNA Dysregulation in Astrocytes Infected with Zika Virus
Published in Viruses (14-10-2017)“…The Zika virus (ZIKV) epidemic is an ongoing public health concern. ZIKV is a flavivirus reported to be associated with microcephaly, and recent work in animal…”
Get full text
Journal Article -
10
Antiseptic quaternary ammonium compound tolerance by gram-negative bacteria can be rapidly detected using an impermeant fluorescent dye-based assay
Published in Scientific reports (25-11-2020)“…Biocides such as quaternary ammonium compounds (QACs) are potentially important contributors towards bacterial antimicrobial resistance development, however,…”
Get full text
Journal Article -
11
Detection of Airborne Severe Acute Respiratory Syndrome (SARS) Coronavirus and Environmental Contamination in SARS Outbreak Units
Published in The Journal of infectious diseases (01-05-2005)“…Severe acute respiratory syndrome (SARS) is characterized by a risk of nosocomial transmission; however, the risk of airborne transmission of SARS is unknown…”
Get full text
Journal Article -
12
Correction: Induction of Multiple miR-200/182 Members in the Brains of Mice Are Associated with Acute Herpes Simplex Virus 1 Encephalitis
Published in PloS one (21-02-2017)“…[This corrects the article DOI: 10.1371/journal.pone.0169081.]…”
Get full text
Journal Article -
13
Cellular prion protein is released on exosomes from activated platelets
Published in Blood (15-05-2006)“…Cellular prion protein (PrPC) is a glycophosphatidylinositol (GPI)–anchored protein, of unknown function, found in a number of tissues throughout the body,…”
Get full text
Journal Article -
14
SARS-CoV 9b protein diffuses into nucleus, undergoes active Crm1 mediated nucleocytoplasmic export and triggers apoptosis when retained in the nucleus
Published in PloS one (27-05-2011)“…9b is an accessory protein of the SARS-CoV. It is a small protein of 98 amino acids and its structure has been solved recently. 9b is known to localize in the…”
Get full text
Journal Article -
15
Phenotypic and Multi-Omics Characterization of Escherichia coli K-12 Adapted to Chlorhexidine Identifies the Role of MlaA and Other Cell Envelope Alterations Regulated by Stress Inducible Pathways in CHX Resistance
Published in Frontiers in molecular biosciences (19-05-2021)“…Chlorhexidine (CHX) is an essential medicine used as a topical antiseptic in skin and oral healthcare treatments. The widespread use of CHX has increased…”
Get full text
Journal Article -
16
Analysis of multimerization of the SARS coronavirus nucleocapsid protein
Published in Biochemical and biophysical research communications (02-04-2004)“…Severe Acute Respiratory Syndrome (SARS), an emerging disease characterized by atypical pneumonia, has recently been attributed to a novel coronavirus. The…”
Get full text
Journal Article -
17
Wild bird influenza survey, Canada, 2005
Published in Emerging infectious diseases (01-01-2008)“…Of 4,268 wild ducks sampled in Canada in 2005, real-time reverse transcriptase-PCR detected influenza A matrix protein (M1) gene sequence in 37% and H5 gene…”
Get full text
Journal Article -
18
Molecular characterization of rotavirus isolates from select Canadian pediatric hospitals
Published in BMC infectious diseases (15-11-2012)“…We report the first multi-site rotavirus genotype analysis in Canada. Prior to this study, there was a dearth of rotavirus G and P genotyping data in Canada…”
Get full text
Journal Article -
19
MicroRNA abundance is altered in synaptoneurosomes during prion disease
Published in Molecular and cellular neuroscience (01-03-2016)“…Discrepancy in synaptic structural plasticity is one of the earliest manifestations of the neurodegenerative state. In prion diseases, a reduction in synapses…”
Get full text
Journal Article -
20
An Outbreak of Human Coronavirus OC43 Infection and Serological Cross-reactivity with SARS Coronavirus
Published in The Canadian journal of infectious diseases & medical microbiology (2006)“…In summer 2003, a respiratory outbreak was investigated in British Columbia, during which nucleic acid tests and serology unexpectedly indicated reactivity for…”
Get full text
Journal Article