Search Results - "BOOMER, Jonathan S"

Reactivation of multiple viruses in patients with sepsis by Walton, Andrew H, Muenzer, Jared T, Rasche, David, Boomer, Jonathan S, Sato, Bryan, Brownstein, Bernard H, Pachot, Alexandre, Brooks, Terrence L, Deych, Elena, Shannon, William D, Green, Jonathan M, Storch, Gregory A, Hotchkiss, Richard S

“…A current controversy is whether patients with sepsis progress to an immunosuppressed state. We hypothesized that reactivation of latent viruses occurred with…”
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Targeted Knock-In Mice Expressing Mutations of CD28 Reveal an Essential Pathway for Costimulation by Dodson, Lindzy F., Boomer, Jonathan S., Deppong, Christine M., Shah, Dulari D., Sim, Julia, Bricker, Traci L., Russell, John H., Green, Jonathan M.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Increased Nasal Plasmacytoid Dendritic Cells Are Associated with Recurrent Wheezing Following Severe RSV Bronchiolitis by Kitcharoensakkul, Maleewan, Dr, Bacharier, Leonard B., MD FAAAAI, Yin-Declue, Huiqing, PhD, Schweiger, Toni, Goss, Charles W, Boomer, Jonathan S., PhD, Sajol, Geneline, Schectman, Kenneth, Castro, Mario, Dr

“…Conclusions Children with recurrent wheezing following severe RSV bronchiolitis had higher proportion of nasal pDCs which may reflect a heightened antiviral…”
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Vitamin D3 treatment of vitamin D–insufficient asthmatic patients does not alter immune cell function by Reid, Brandy, MS, Girodet, Pierre-Olivier, MD, PhD, Boomer, Jonathan S., PhD, Abdel-Gadir, Azza, PhD, Zheng, Kathy, MPH, Wechsler, Michael E., MD, Bacharier, Leonard B., MD, Kunselman, Susan J., MA, King, Tonya S., PhD, Israel, Elliot, MD, Castro, Mario, MD, Cernadas, Manuela, MD, Green, Jonathan M., MD

“…To the Editor: Low vitamin D levels have been associated with increased asthma exacerbations and decreased lung function, as reviewed by Paul et al.1 Studies…”
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Impaired tumor necrosis factor‐α secretion by CD4 T cells during respiratory syncytial virus bronchiolitis associated with recurrent wheeze by Kitcharoensakkul, Maleewan, Bacharier, Leonard B., Yin‐Declue, Huiqing, Boomer, Jonathan S., Sajol, Geneline, Leung, Marilyn K., Wilson, Brad, Schechtman, Kenneth B., Atkinson, John P., Green, Jonathan M., Castro, Mario

“…Background Infants with severe respiratory syncytial virus (RSV) bronchiolitis have an increased risk of recurrent wheezing and asthma. We aimed to evaluate…”
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Biological Variability of Dendritic Cells and Regulatory T Cells in Peripheral Blood of Normal Adults by Kitcharoensakkul, Maleewan, MD, Bacharier, Leonard B., MD, FAAAAI, Burgdorf, Dana, Yin-Declue, Huiqing, PhD, Boomer, Jonathan S., PhD, Wilson, Brad, Schectman, Kenneth, Castro, Mario, MD, MPH

“…Methods We investigated the day-to-day variability of DCs, nTregs (FoxP3+CD25+CD4+) and iTregs (Granzyme B -GZB, Th1/2 cytokines following CD3/46 activation in…”
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The changing immune system in sepsis: Is individualized immuno-modulatory therapy the answer? by Boomer, Jonathan S, Green, Jonathan M, Hotchkiss, Richard S

“…Sepsis remains the leading cause of death in most intensive care units. Advances in understanding the immune response to sepsis provide the opportunity to…”
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Immunosuppression in Patients Who Die of Sepsis and Multiple Organ Failure by Boomer, Jonathan S, To, Kathleen, Chang, Kathy C, Takasu, Osamu, Osborne, Dale F, Walton, Andrew H, Bricker, Traci L, Jarman, Stephen D, Kreisel, Daniel, Krupnick, Alexander S, Srivastava, Anil, Swanson, Paul E, Green, Jonathan M, Hotchkiss, Richard S

“…CONTEXT Severe sepsis is typically characterized by initial cytokine-mediated hyperinflammation. Whether this hyperinflammatory phase is followed by…”
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A prospective analysis of lymphocyte phenotype and function over the course of acute sepsis by Boomer, Jonathan S, Shuherk-Shaffer, Jennifer, Hotchkiss, Richard S, Green, Jonathan M

“…Severe sepsis is characterized by an initial hyper-inflammatory response that may progress to an immune-suppressed state associated with increased…”
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Costimulation via the tumor-necrosis factor receptor superfamily couples TCR signal strength to the thymic differentiation of regulatory T cells by Mahmud, Shawn A, Manlove, Luke S, Schmitz, Heather M, Xing, Yan, Wang, Yanyan, Owen, David L, Schenkel, Jason M, Boomer, Jonathan S, Green, Jonathan M, Yagita, Hideo, Chi, Hongbo, Hogquist, Kristin A, Farrar, Michael A

“…The precise mechanisms of the thymic development T reg cells are still being determined. Farrar and colleagues demonstrate that signals from a triumvirate of…”
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An enigmatic tail of CD28 signaling by Boomer, Jonathan S, Green, Jonathan M

“…CD28 costimulation regulates a wide range of cellular processes, from proliferation and survival to promoting the differentiation of specialized T-cell…”
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Protein Phosphatase 4 Is a Positive Regulator of Hematopoietic Progenitor Kinase 1 by Zhou, Guisheng, Boomer, Jonathan S, Tan, Tse-Hua

“…Hematopoietic progenitor kinase 1 (HPK1) is a hematopoietic specific mammalian Ste20-like protein kinase and has been implicated in many cellular signaling…”
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Type 2 inflammation in the sputum of adolescents with asthma by Coverstone, Andrea M., Boomer, Jonathan S., Lew, Daphne, Bacharier, Leonard B., Castro, Mario

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Increased nasal plasmacytoid dendritic cells are associated with recurrent wheezing following severe respiratory syncytial virus bronchiolitis in infancy by Kitcharoensakkul, Maleewan, Bacharier, Leonard B., Yin‐Declue, Huiqing, Boomer, Jonathan S., Lew, Daphne, Goss, Charles W., Castro, Mario

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Hematopoietic progenitor kinase 1 negatively regulates T cell receptor signaling and T cell-mediated immune responses by Tan, Tse-Hua, Shui, Jr-Wen, Boomer, Jonathan S, Han, Jin, Xu, Jun, Dement, Gregory A, Zhou, Guisheng

“…HPK1 is a Ste20-related serine-threonine kinase that inducibly associates with the adaptors SLP-76 and Gads after T cell receptor (TCR) signaling. Here, HPK1…”
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Clinical significance of the bronchodilator response in children with severe asthma by Coverstone, Andrea M., Bacharier, Leonard B., Wilson, Bradley S., Fitzpatrick, Anne M., Teague, William Gerald, Phipatanakul, Wanda, Wenzel, Sally E., Gaston, Benjamin M., Bleecker, Eugene R., Moore, Wendy C., Ramratnam, Sima, Jarjour, Nizar N., Ly, Ngoc P., Fahy, John V., Mauger, David T., Schechtman, Kenneth B., Yin‐DeClue, Huiqing, Boomer, Jonathan S., Castro, Mario

“…Background Our objective was to determine those characteristics associated with reversibility of airflow obstruction and response to maximal bronchodilation in…”
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Temporal biological variability in dendritic cells and regulatory T cells in peripheral blood of healthy adults by Kitcharoensakkul, Maleewan, Bacharier, Leonard B., Yin-Declue, Huiqing, Boomer, Jonathan S., Burgdorf, Dana, Wilson, Brad, Schechtman, Kenneth, Castro, Mario

“…Studies evaluating circulating dendritic cells (DCs) and natural and induced regulatory T cells (nTregs, iTregs) are often obtained at a single time point and…”
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Cutting edge: A double-mutant knockin of the CD28 YMNM and PYAP motifs reveals a critical role for the YMNM motif in regulation of T cell proliferation and Bcl-xL expression by Boomer, Jonathan S, Deppong, Christine M, Shah, Dulari D, Bricker, Traci L, Green, Jonathan M

“…CD28 is a critical regulator of T cell function, augmenting proliferation, cytokine secretion, and cell survival. Our previous work using knockin mice…”
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A Randomized Controlled Trial to Evaluate Inhibition of T-Cell Costimulation in Allergen-induced Airway Inflammation by PARULEKAR, Amit D, BOOMER, Jonathan S, PATTERSON, Brenda M, YIN-DECLUE, Huiqing, DEPPONG, Christine M, WILSON, Brad S, JARJOUR, Nizar N, CASTRO, Mario, GREEN, Jonathan M

“…T lymphocytes are important in the pathogenesis of allergic asthma. Costimulation through CD28 is critical for optimal activation of T cells, and inhibition of…”
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CTLA4-Ig inhibits allergic airway inflammation by a novel CD28-independent, nitric oxide synthase-dependent mechanism by Deppong, Christine M, Parulekar, Amit, Boomer, Jonathan S, Bricker, Traci L, Green, Jonathan M

“…The T-cell response to antigen depends on coordinate signaling between costimulatory and inhibitory receptors. The altered function of either may underlie the…”
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