Search Results - "BOOKCHIN, ROBERT M"

Ion Transport Pathology in the Mechanism of Sickle Cell Dehydration by Lew, Virgilio L, Bookchin, Robert M

“…Physiological Laboratory, University of Cambridge, Cambridge, United Kingdom; and Department of Medicine, Albert Einstein College of Medicine, Bronx, New York…”
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Identification and Characterization of a Newly Recognized Population of High-Na+, Low-K+, Low-Density Sickle and Normal Red Cells by Bookchin, Robert M., Etzion, Zipora, Sorette, Martin, Mohandas, Narla, Skepper, Jeremy N., Lew, Virgilio L.

“…We describe a population of sickle cell anemia red cells (SS RBCs) (≈ 4%) and a smaller fraction of normal RBCs (<0.03%) that fail to dehydrate when…”
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Effects of age-dependent membrane transport changes on the homeostasis of senescent human red blood cells by Lew, Virgilio L., Daw, Nuala, Etzion, Zipora, Tiffert, Teresa, Muoma, Adaeze, Vanagas, Laura, Bookchin, Robert M.

“…Little is known about age-related changes in red blood cell (RBC) membrane transport and homeostasis. We investigated first whether the known large variation…”
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Age decline in the activity of the Ca2+-sensitive K+ channel of human red blood cells by Tiffert, Teresa, Daw, Nuala, Etzion, Zipora, Bookchin, Robert M, Lew, Virgilio L

“…The Ca(2+)-sensitive K(+) channel of human red blood cells (RBCs) (Gardos channel, hIK1, hSK4) was implicated in the progressive densification of RBCs during…”
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Sickle Hemoglobin Polymer Stability Probed by Triple and Quadruple Mutant Hybrids by Li, Xianfeng, Briehl, Robin W., Bookchin, Robert M., Josephs, Robert, Wei, Baoyang, Manning, James M., Ferrone, Frank A.

“…As part of an effort to understand the interactions in HbS polymerization, we have produced and studied a recombinant triple mutant, D6A(α)/D75Y(α)/E121R(β),…”
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Free Energy of Sickle Hemoglobin Polymerization: A Scaled-Particle Treatment for Use with Dextran as a Crowding Agent by Liu, Zenghui, Weng, Weijun, Bookchin, Robert M., Lew, Virgilio L., Ferrone, Frank A.

“…Fundamental to the analysis of protein polymerization is the free energy of association, typically determined from solubility. It has been previously shown…”
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Characterization of the phosphatidylserine-exposing subpopulation of sickle cells by de Jong, Kitty, Larkin, Sandra K., Styles, Lori A., Bookchin, Robert M., Kuypers, Frans A.

“…Phosphatidylserine (PS), exclusively present in the inner monolayer of the normal red blood cell (RBC) membrane, is exposed in subpopulations of sickle cells…”
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Preserved function of the plasma membrane calcium pump of red blood cells from diabetic subjects with high levels of glycated haemoglobin by Bookchin, Robert M, Etzion, Zipora, Lew, Virgilio L, Tiffert, Teresa

“…Abstract The activity of the plasma membrane Ca2+ -pump decreases steeply throughout the 120 days lifespan of normal human red blood cells. Experiments with…”
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Distribution of plasma membrane Ca2+ pump activity in normal human red blood cells by Lew, Virgilio L., Daw, Nuala, Perdomo, Deisy, Etzion, Zipora, Bookchin, Robert M., Tiffert, Teresa

“…The plasma membrane calcium pump (PMCA) is the only active Ca2+ transporter in human red blood cells (RBCs). Previous measurements of maximal Ca2+ extrusion…”
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Distribution of dehydration rates generated by maximal Gardos-channel activation in normal and sickle red blood cells by Lew, Virgilio L., Tiffert, Teresa, Etzion, Zipora, Perdomo, Deisy, Daw, Nuala, Macdonald, Lynn, Bookchin, Robert M.

“…The Ca2+-activated K+ channels of human red blood cells (RBCs) (Gardos channels, hIK1, hSK4) can mediate rapid cell dehydration, of particular relevance to the…”
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Oxidative status of valinomycin-resistant normal, β-thalassemia and sickle red blood cells by Amer, Johnny, Etzion, Zipora, Bookchin, Robert M., Fibach, Eitan

“…Exposure of red blood cells (RBC) to the K +-ionophore valinomycin (val), causes loss of KCl and water, resulting in cell dehydration, manifested by increased…”
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Dehydration response of sickle cells to sickling-induced Ca++ permeabilization by Lew, Virgilio L., Etzion, Zipora, Bookchin, Robert M.

“…Interaction of hemoglobin S polymers with the red blood cell (RBC) membrane induces a reversible increase in permeability (“Psickle”) to (at least) Na+, K+,…”
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Physiological [Ca 2+ ] i level and pump-leak turnover in intact red cells measured using an incorporated Ca chelator by Lew, Virgilio L, Tsien, Roger Y, Miner, Cristina, Bookchin, Robert M

“…The physiological actions of Ca2+ as a trigger and second messenger depend on the maintenance of large inward resting Ca2+ gradients across the cell plasma…”
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The Effects of Erythrocyte Membranes on the Nucleation of Sickle Hemoglobin by Aprelev, Alexey, Rotter, Maria A., Etzion, Zipora, Bookchin, Robert M., Briehl, Robin W., Ferrone, Frank A.

“…Pathology in sickle cell disease begins with nucleation-dependent polymerization of deoxyhemoglobin S into stiff, rodlike fibers that deform and rigidify red…”
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Sickle red cell dehydration: mechanisms and interventions by Bookchin, Robert M, Lew, Virgilio L

“…A critical link between the single molecular defect in sickle cell anemia and the extensive pathology of this disease is the reversible increase in red cell…”
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Effect of a `sickling pulse' on calcium and potassium transport in sickle cell trait red cells by Bookchin, Robert M., Lew, Virgilio L.

“…1. To trace the early development of the extensive functional membrane abnormalities found in sickle cell anaemia red cells which result from polymerization of…”
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Polymer Structure and Solubility of Deoxyhemoglobin S in the Presence of High Concentrations of Volume-excluding 70-kDa Dextran by Bookchin, Robert M., Balazs, Tania, Wang, Zhiping, Josephs, Robert, Lew, Virgilio L.

“…Earlier observations indicated that volume exclusion by admixed non-hemoglobin macromolecules lowered the polymer solubility (“ C sat ”) of deoxyhemoglobin…”
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A Recombinant Sickle Hemoglobin Triple Mutant with Independent Inhibitory Effects on Polymerization by Himanen, Juha-Pekka, Mirza, Urooj A., Chait, Brian T., Bookchin, Robert M., Manning, James M.

“…As part of a comprehensive effort to map the most important regions of sickle hemoglobin that are involved in polymerization, we have determined whether two…”
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Compartmentalization of sickle-cell calcium in endocytic inside-out vesicles by Lew, Virgilio L, Hockaday, Austin, Sepulveda, Maria-Isabel, Somlyo, Andrew P, Somlyo, Avril V, Ortiz, Olga E, Bookchin, Robert M

“…Much recent interest in the mechanism of dehydration of the dense subpopulation of sickle-cell anaemia (SS) red cells, including the 'irreversibly sickled…”
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Progressive inhibition of the Ca pump and Ca : Ca exchange in sickle red cells by Bookchin, Robert M, Lew, Virgilio L

“…Sickle cell anaemia red cells (SS) were reported to have a high Ca content and an increased Ca uptake on deoxygenation, but their Ca-pump activity was…”
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