Search Results - "BONNETT, Shilah A"

A class of hydrazones are active against non-replicating Mycobacterium tuberculosis by Bonnett, Shilah A, Dennison, Devon, Files, Megan, Bajpai, Anumita, Parish, Tanya

“…There is an urgent need for the development of shorter, simpler and more tolerable drugs to treat antibiotic tolerant populations of Mycobacterium…”
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Spirocycle MmpL3 Inhibitors with Improved hERG and Cytotoxicity Profiles as Inhibitors of Mycobacterium tuberculosis Growth by Ray, Peter C, Huggett, Margaret, Turner, Penelope A, Taylor, Malcolm, Cleghorn, Laura A. T, Early, Julie, Kumar, Anuradha, Bonnett, Shilah A, Flint, Lindsay, Joerss, Douglas, Johnson, James, Korkegian, Aaron, Mullen, Steven, Moure, Abraham L, Davis, Susan H, Murugesan, Dinakaran, Mathieson, Michael, Caldwell, Nicola, Engelhart, Curtis A, Schnappinger, Dirk, Epemolu, Ola, Zuccotto, Fabio, Riley, Jennifer, Scullion, Paul, Stojanovski, Laste, Massoudi, Lisa, Robertson, Gregory T, Lenaerts, Anne J, Freiberg, Gail, Kempf, Dale J, Masquelin, Thierry, Hipskind, Philip A, Odingo, Joshua, Read, Kevin D, Green, Simon R, Wyatt, Paul G, Parish, Tanya

“…With the emergence of multi-drug-resistant strains of Mycobacterium tuberculosis, there is a pressing need for new oral drugs with novel mechanisms of action…”
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Zinc-Independent Folate Biosynthesis: Genetic, Biochemical, and Structural Investigations Reveal New Metal Dependence for GTP Cyclohydrolase IB by SANKARAN, Banumathi, BONNETT, Shilah A, SWAIRJO, Manal A, SHAH, Kinjal, GABRIEL, Scott, REDDY, Robert, SCHIMMEL, Paul, RODIONOV, Dmitry A, DE CRECY-LAGARD, Valérie, HELMANN, John D, IWATA-REUYL, Dirk

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Activation of 2,4-Diaminoquinazoline in Mycobacterium tuberculosis by Rv3161c, a Putative Dioxygenase by Melief, Eduard, Bonnett, Shilah A, Zuniga, Edison S, Parish, Tanya

“…The diaminoquinazoline series has good potency against Resistant isolates have mutations in Rv3161c, a putative dioxygenase. We carried out metabolite analysis…”
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Stenotrophomonas maltophilia OleC-Catalyzed ATP-Dependent Formation of Long-Chain Z-Olefins from 2-Alkyl-3-hydroxyalkanoic Acids by Kancharla, Papireddy, Bonnett, Shilah A., Reynolds, Kevin A.

“…The bacterial pathway of olefin biosynthesis starts with OleA catalyzed “head‐to‐head” condensation of two CoA‐activated long‐chain fatty acids to generate…”
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Structure-Guided Optimization of Inhibitors of Acetyltransferase Eis from Mycobacterium tuberculosis by Punetha, Ankita, Ngo, Huy X, Holbrook, Selina Y L, Green, Keith D, Willby, Melisa J, Bonnett, Shilah A, Krieger, Kyle, Dennis, Emily K, Posey, James E, Parish, Tanya, Tsodikov, Oleg V, Garneau-Tsodikova, Sylvie

“…The enhanced intracellular survival (Eis) protein of ( ) is a versatile acetyltransferase that multiacetylates aminoglycoside antibiotics abolishing their…”
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Mechanism and catalytic strategy of the prokaryotic-specific GTP cyclohydrolase-IB by Paranagama, Naduni, Bonnett, Shilah A, Alvarez, Jonathan, Luthra, Amit, Stec, Boguslaw, Gustafson, Andrew, Iwata-Reuyl, Dirk, Swairjo, Manal A

“…Guanosine 5'-triphosphate (GTP) cyclohydrolase-I (GCYH-I) catalyzes the first step in folic acid biosynthesis in bacteria and plants, biopterin biosynthesis in…”
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Functional Modular Dissection of DEBS1-TE Changes Triketide Lactone Ratios and Provides Insight into Acyl Group Loading, Hydrolysis, and ACP Transfer by Yan, John, Hazzard, Christopher, Bonnett, Shilah A, Reynolds, Kevin A

“…The DEBS1-TE fusion protein is comprised of the loading module, the first two extension modules, and the terminal TE domain of the Saccharopolyspora erythraea…”
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Ultra High-plex Spatial Proteogenomic Investigation of Giant Cell Glioblastoma Multiforme Immune Infiltrates Reveals Distinct Protein and RNA Expression Profiles by Bonnett, Shilah A, Rosenbloom, Alyssa B, Ong, Giang T, Conner, Mark, Rininger, Aric B E, Newhouse, Daniel, New, Felicia, Phan, Chi Q, Ilcisin, Saskia, Sato, Hiromi, Lyssand, John S, Geiss, Gary, Beechem, Joseph M

“…A deeper understanding of complex biological processes, including tumor development and immune response, requires ultra high-plex, spatial interrogation of…”
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Functional Characterization of an NADPH Dependent 2-Alkyl-3-ketoalkanoic Acid Reductase Involved in Olefin Biosynthesis in Stenotrophomonas maltophilia by Bonnett, Shilah A, Papireddy, Kancharla, Higgins, Samuel, del Cardayre, Stephen, Reynolds, Kevin A

“…OleD is shown to play a key reductive role in the generation of alkenes (olefins) from acyl thioesters in Stenotrophomonas maltophilia. The gene coding for…”
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A Target-Based Whole Cell Screen Approach To Identify Potential Inhibitors of Mycobacterium tuberculosis Signal Peptidase by Bonnett, Shilah A, Ollinger, Juliane, Chandrasekera, Susantha, Florio, Stephanie, O’Malley, Theresa, Files, Megan, Jee, Jo-Ann, Ahn, James, Casey, Allen, Ovechkina, Yulia, Roberts, David, Korkegian, Aaron, Parish, Tanya

“…The general secretion (Sec) pathway is a conserved essential pathway in bacteria and is the primary route of protein export across the cytoplasmic membrane…”
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Structural and Stereochemical Analysis of a Modular Polyketide Synthase Ketoreductase Domain Required for the Generation of a cis-Alkene by Bonnett, Shilah A., Whicher, Jonathan R., Papireddy, Kancharla, Florova, Galina, Smith, Janet L., Reynolds, Kevin A.

“…The formation of an activated cis-3-cyclohexylpropenoic acid by Plm1, the first extension module of the phoslactomycin polyketide synthase, is proposed to…”
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Acyl-CoA Subunit Selectivity in the Pikromycin Polyketide Synthase PikAIV: Steady-State Kinetics and Active-Site Occupancy Analysis by FTICR-MS by Bonnett, Shilah A., Rath, Christopher M., Shareef, Abdur-Rafay, Joels, Joanna R., Chemler, Joseph A., Håkansson, Kristina, Reynolds, Kevin, Sherman, David H.

“…Polyketide natural products generated by type I modular polyketide synthases (PKSs) are vital components in our drug repertoire. To reprogram these…”
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Acyl-CoA subunit selectivity in the terminal pikromycin polyketide synthase module: steady-state kinetics and active-site occupancy analysis by FTICR-MS by Bonnett, Shilah A., Rath, Christopher M., Shareef, Abdur-Rafay, Joels, Joanna R., Chemler, Joseph A., Håkansson, Kristina, Reynolds, Kevin, Sherman, David H.

“…Polyketide natural products produced by type I modular polyketide synthases (PKSs) are key weapons in our drug arsenal. To reprogram these biosynthetic…”
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