Search Results - "BONNERT, TIMOTHY P."

Behavioral and Neurochemical Alterations in Mice Deficient in Anaplastic Lymphoma Kinase Suggest Therapeutic Potential for Psychiatric Indications by BILSLAND, James G, WHEELDON, Alan, WHITING, Paul, MCALLISTER, George, MUNOZ-SANJUAN, Ignacio, MEAD, Andrew, ZNAMENSKIY, Petr, ALMOND, Sarah, WATERS, Kerry A, THAKUR, Matthew, BEAUMONT, Vahri, BONNERT, Timothy P, HEAVENS, Robert

“…The receptor tyrosine kinase product of the anaplastic lymphoma kinase (ALK) gene has been implicated in oncogenesis as a product of several chromosomal…”
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Label-Free Detection of Differential Protein Expression by LC/MALDI Mass Spectrometry by Neubert, Hendrik, Bonnert, Timothy P, Rumpel, Klaus, Hunt, Brandon T, Henle, Ernst S, James, Ian T

“…Protein abundance changes during disease or experimental perturbation are increasingly analyzed by label-free LC/MS approaches. Here we demonstrate the use of…”
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Heteromerization and colocalization of TrpV1 and TrpV2 in mammalian cell lines and rat dorsal root ganglia by Rutter, A Richard, Ma, Qing-Ping, Leveridge, Mathew, Bonnert, Timothy P

“…Coassociation of the vanilloid transient receptor potential (Trp) ion channels, TrpV1 and TrpV2, was investigated by immunoprecipitation and immunofluorescence…”
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θ , a Novel γ -Aminobutyric Acid Type A Receptor Subunit by Bonnert, Timothy P., McKernan, Ruth M., Farrar, Sophie, le Bourdellès, Béatrice, Heavens, Robert P., Smith, David W., Hewson, Louise, Rigby, Michael R., Dalip J. S. Sirinathsinghji, Brown, Nicola, Wafford, Keith A., Whiting, Paul J.

“…γ -Aminobutyric acid type A (GABA-A) receptors are a major mediator of inhibitory neurotransmission in the mammalian central nervous system, and the site of…”
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Functional mapping of the transient receptor potential vanilloid 1 intracellular binding site by Johnson, Daniel M, Garrett, Elizabeth M, Rutter, Richard, Bonnert, Timothy P, Gao, Ying-Duo, Middleton, Richard E, Sutton, Kathy G

“…Capsaicin (vanilloid) sensitivity has long served as the functional signature of a subset of nociceptive sensory neurons. Mutagenesis studies have revealed…”
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Selection of novel reference genes for use in the human central nervous system: a BrainNet Europe Study by Durrenberger, Pascal F., Fernando, Francisca S., Magliozzi, Roberta, Kashefi, Samira N., Bonnert, Timothy P., Ferrer, Isidro, Seilhean, Danielle, Nait-Oumesmar, Brahim, Schmitt, Andrea, Gebicke-Haerter, Peter J., Falkai, Peter, Grünblatt, Edna, Palkovits, Miklos, Parchi, Piero, Capellari, Sabina, Arzberger, Thomas, Kretzschmar, Hans, Roncaroli, Federico, Dexter, David T., Reynolds, Richard

“…The use of an appropriate reference gene to ensure accurate normalisation is crucial for the correct quantification of gene expression using qPCR assays and…”
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Composition of perineuronal nets in the adult rat cerebellum and the cellular origin of their components by Carulli, Daniela, Rhodes, Kate E., Brown, David J., Bonnert, Timothy P., Pollack, Scott J., Oliver, Kevin, Strata, Piergiorgio, Fawcett, James W.

“…The decrease in plasticity that occurs in the central nervous system during postnatal development is accompanied by the appearance of perineuronal nets (PNNs)…”
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An Evaluation of a Low-Density DNA Microarray Using Cytochrome P450 Inducers by Meneses-Lorente, Georgina, de Longueville, Françoise, Dos Santos-Mendes, Sofia, Bonnert, Timothy P, Jack, Andrew, Evrard, Stéphanie, Bertholet, Vincent, Pike, Andrew, Scott-Stevens, Paul, Remacle, José, Sohal, Bindi

“…The aim of this study was to validate a low-density DNA microarray “Rat HepatoChip”, which contains 59 genes from a range of potential toxic markers and drug…”
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Identification of Two Major Sites in the Type I Interleukin-1 Receptor Cytoplasmic Region Responsible for Coupling to Pro-inflammatory Signaling Pathways by Slack, Jennifer L., Schooley, K., Bonnert, Timothy P., Mitcham, Jennifer L., Qwarnstrom, Eva E., Sims, John E., Dower, Steven K.

“…Type I interleukin-1 receptor is the prototype for a family of proteins, which play a central role in early responses to injury and infection. The similarity…”
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Stoichiometry of a Ligand-gated Ion Channel Determined by Fluorescence Energy Transfer by Farrar, S J, Whiting, P J, Bonnert, T P, McKernan, R M

“…We have developed a method to determine the stoichiometry of subunits within an oligomeric cell surface receptor using fluorescently tagged antibodies to the…”
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Molecular and Functional Diversity of the Expanding GABA-A Receptor Gene Family by WHITING, PAUL J., BONNERT, TIMOTHY P., MCKERNAN, RUTH M., FARRAR, SOPHIE, BOURDELLES, BEATRICE LE, HEAVENS, ROBERT P., SMITH, DAVID W., HEWSON, LOUISE, RIGBY, MICHAEL R., SIRINATHSINGHJI, DALIP J. S., THOMPSON, SALLY A., WAFFORD, KEITH A.

“…Fast inhibitory neurotransmission in the mammalian CNS is mediated primarily by the neurotransmitter γ‐aminobutyric acid (GABA), which, upon binding to its…”
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Molecular characterization of adult mouse subventricular zone progenitor cells during the onset of differentiation by Bonnert, Timothy P., Bilsland, James G., Guest, Paul C., Heavens, Robert, McLaren, Donna, Dale, Charlotte, Thakur, Matthew, McAllister, George, Munoz-Sanjuan, Ignacio

“…Adult mouse subventricular zone (SVZ) neural progenitor cells (NPCs) retain the capacity to generate multiple lineages in vitro and in vivo. Thus far, the…”
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IL-1Rrp Is a Novel Receptor-like Molecule Similar to the Type I Interleukin-1 Receptor and Its Homologues T1/ST2 and IL-1R AcP (∗) by Parnet, Patricia, Garka, Kirsten E., Bonnert, Timothy P., Dower, Steven K., Sims, John E.

“…A novel member of the interleukin-1 receptor family has been cloned by polymerase chain reaction using degenerate oligonucleotide primers derived from regions…”
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Proteomic analysis identifies alterations in cellular morphology and cell death pathways in mouse brain after chronic corticosterone treatment by Skynner, Heather A., Amos, Doran P., Murray, Fraser, Salim, Kamran, Knowles, Michael R., Munoz-Sanjuan, Ignacio, Camargo, Luis M., Bonnert, Timothy P., Guest, Paul C.

“…Some patients with Major Depression and other neurological afflictions display hyperactivity of the hypothalamic–pituitary–adrenal (HPA) axis. HPA…”
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Functional characterisation of the S512Y mutant vanilloid human TRPV1 receptor by Sutton, Kathy G, Garrett, Elizabeth M, Rutter, A Richard, Bonnert, Timothy P, Jarolimek, Wolfgang, Seabrook, Guy R

“…Mammalian transient receptor potential (TRP) channels include the nonselective cation channel TRPV1, which is activated by a range of stimuli including low pH,…”
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Functional Overexpression of γ-Secretase Reveals Protease-independent Trafficking Functions and a Critical Role of Lipids for Protease Activity by Wrigley, Jonathan D.J., Schurov, Irina, Nunn, Emma J., Martin, Agnes C.L., Clarke, Earl E., Ellis, Semantha, Bonnert, Timothy P., Shearman, Mark S., Beher, Dirk

“…Presenilins appear to form the active center of γ-secretase but require the presence of the integral membrane proteins nicastrin, anterior pharynx defective 1,…”
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Identification of proteomic changes during differentiation of adult mouse subventricular zone progenitor cells by Salim, Kamran, Guest, Paul C, Skynner, Heather A, Bilsland, James G, Bonnert, Timothy P, McAllister, George, Munoz-Sanjuan, Ignacio

“…The use of neural precursor cells (NPCs) represents a promising repair strategy for many neurological disorders. However, the molecular events and biological…”
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Selection of optical biosensors from chemisynthetic antibody libraries by Jespers, Laurent, Bonnert, Timothy P., Winter, Greg

“…We describe a method for creating antibodies with a fluorescent reporter integrated into the antigen-binding site. A reporter molecule was chemically linked to…”
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INTERLEUKIN-15 INTERACTIONS WITH INTERLEUKIN-15 RECEPTOR COMPLEXES: CHARACTERIZATION AND SPECIES SPECIFICITY by Eisenman, June, Ahdieh, Minoo, Beers, Courtney, Brasel, Kenneth, Kennedy, Mary K., Le, Tiep, Bonnert, Timothy P., Paxton, Raymond J., Park, Linda S.

“…Interleukin (IL-) 2 and IL-15 share the IL-2 receptor βγ c subunits (IL-2Rβγ c) but have specific, unique α receptor subunits. We studied species specificity…”
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The cloning and characterization of human MyD88: a member of an IL-1 receptor related family by Bonnert, Timothy P, Garka, Kirsten E, Parnet, Patricia, Sonoda, Gonosuke, Testa, Joseph R, Sims, John E

“…Murine MyD88, an RNA with homology both to the interleukin-1 receptor signaling domain and to `death-domains', is rapidly upregulated during differentiation of…”
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