Search Results - "BONN, Tomas"

Discovery of Phenyl Acetic Acid Substituted Quinolines as Novel Liver X Receptor Agonists for the Treatment of Atherosclerosis by Hu, Baihua, Collini, Michael, Unwalla, Rayomand, Miller, Christopher, Singhaus, Robert, Quinet, Elaine, Savio, Dawn, Halpern, Anita, Basso, Michael, Keith, James, Clerin, Valerie, Chen, Liang, Resmini, Christine, Liu, Qiang-Yuan, Feingold, Irene, Huselton, Christine, Azam, Farooq, Farnegardh, Mathias, Enroth, Cristofer, Bonn, Tomas, Goos-Nilsson, Annika, Wilhelmsson, Anna, Nambi, Ponnal, Wrobel, Jay

“…A structure-based approach was used to optimize our new class of quinoline LXR modulators leading to phenyl acetic acid substituted quinolines 15 and 16. Both…”
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Structure of the ligand-binding domain of oestrogen receptor beta in the presence of a partial agonist and a full antagonist by Pike, Ashley C. W., Brzozowski, Andrzej M., Hubbard, Roderick E., Bonn, Tomas, Thorsell, Ann-Gerd, Engström, Owe, Ljunggren, Jan, Gustafsson, Jan-Åke, Carlquist, Mats

“…Oestrogens exert their physiological effects through two receptor subtypes. Here we report the three‐dimensional structure of the oestrogen receptor beta…”
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Indazole-Based Liver X Receptor (LXR) Modulators with Maintained Atherosclerotic Lesion Reduction Activity but Diminished Stimulation of Hepatic Triglyceride Synthesis by Wrobel, Jay, Steffan, Robert, Bowen, S. Marc, Magolda, Ronald, Matelan, Edward, Unwalla, Rayomand, Basso, Michael, Clerin, Valerie, Gardell, Stephen J, Nambi, Ponnal, Quinet, Elaine, Reminick, Jason I, Vlasuk, George P, Wang, Shuguang, Feingold, Irene, Huselton, Christine, Bonn, Tomas, Farnegardh, Mathias, Hansson, Tomas, Nilsson, Annika Goos, Wilhelmsson, Anna, Zamaratski, Edouard, Evans, Mark J

“…A series of substituted 2-benzyl-3-aryl-7-trifluoromethylindazoles were prepared as LXR modulators. These compounds were partial agonists in transactivation…”
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Molecular basis of agonism and antagonism in the oestrogen receptor by Brzozowski, Andrzej M, Pike, Ashley C. W, Dauter, Zbigniew, Hubbard, Roderick E, Bonn, Tomas, Engström, Owe, Öhman, Lars, Greene, Geoffrey L, Gustafsson, Jan-Åke, Carlquist, Mats

“…Oestrogens are involved in the growth, development and homeostasis of a number of tissues. The physiological effects of these steroids are mediated by a…”
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The Three-dimensional Structure of the Liver X Receptor β Reveals a Flexible Ligand-binding Pocket That Can Accommodate Fundamentally Different Ligands by Färnegårdh, Mathias, Bonn, Tomas, Sun, Sherry, Ljunggren, Jan, Ahola, Harri, Wilhelmsson, Anna, Gustafsson, Jan-Åke, Carlquist, Mats

“…The structures of the liver X receptor LXRβ (NR1H2) have been determined in complexes with two synthetic ligands, T0901317 and GW3965, to 2.1 and 2.4 Å,…”
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A novel analytical tool for quantification of estrogenicity in river water based on fluorescence labelled estrogen receptor a by Le Blanc, Alexander Fabian, Albrecht, Christiane, Bonn, Tomas, Fechner, Peter, Proll, Gunther, Proll, Florian, Carlquist, Mats, Gauglitz, Gunter

“…A novel combined procedure for estrogen-affinity purification and labelling of estrogen receptor *a ligand-binding domain with CyTM 5.5 cystein reactive dye…”
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novel analytical tool for quantification of estrogenicity in river water based on fluorescence labelled estrogen receptor α by Le Blanc, Alexander Fabian, Albrecht, Christiane, Bonn, Tomas, Fechner, Peter, Proll, Günther, Pröll, Florian, Carlquist, Mats, Gauglitz, Günter

“…A novel combined procedure for estrogen-affinity purification and labelling of estrogen receptor α ligand-binding domain with Cy™ 5.5 cystein reactive dye was…”
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A novel analytical tool for quantification of estrogenicity in river water based on fluorescence labelled estrogen receptor α: Analytical Science in Germany by LE BLANC, Alexander Fabian, ALBRECHT, Christiane, BONN, Tomas, FECHNER, Peter, PROLL, Günther, PRÖLL, Florian, CARLQUIST, Mats, GAUGLITZ, Günter

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The Three-dimensional Structure of the Liver X Receptor β Reveals a Flexible Ligand-binding Pocket That Can Accommodate Fundamentally Different Ligands by Mathias Färnegårdh, Tomas Bonn, Sherry Sun, Jan Ljunggren, Harri Ahola, Anna Wilhelmsson, Jan-Åke Gustafsson, Mats Carlquist

“…The structures of the liver X receptor LXRβ (NR1H2) have been determined in complexes with two synthetic ligands, T0901317 and GW3965, to 2.1 and 2.4 Å,…”
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Characterization of bacterially expressed rat estrogen receptor β ligand binding domain by mass spectrometry: Structural comparison with estrogen receptor α by Witkowska, H.Ewa, Carlquist, Mats, Engström, Owe, Carlsson, Bo, Bonn, Tomas, Gustafsson, Jan-Åke, Shackleton, Cedric H.L.

“…Functional rat estrogen receptor β ligand binding domain (rERβ LBD, aa 210–485) and human estrogen receptor α ligand binding domain (hERα LBD, aa 301–553) were…”
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Carboxymethylation of the human estrogen receptor ligand-binding domain-estradiol complex: HPLC/ESMS peptide mapping shows that cysteine 447 does not react with iodoacetic acid by Hegy, Gilbert B., Shackleton, Cedric H.L., Carlquist, Mats, Bonn, Thomas, Engström, Owe, Sjöholm, Pelle, Witkowska, H.Ewa

“…Experiments were carried out to determine the degree of solvent and reagent accessibility of the cysteines in the ligand-binding domain of the human estrogen…”
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