Search Results - "BONFILS, Claire"

MGCD0103, a novel isotype-selective histone deacetylase inhibitor, has broad spectrum antitumor activity in vitro and in vivo by Fournel, Marielle, Bonfils, Claire, Hou, Yu, Yan, Pu Theresa, Trachy-Bourget, Marie-Claude, Kalita, Ann, Liu, Jianhong, Lu, Ai-Hua, Zhou, Nancy Z, Robert, Marie-France, Gillespie, Jeffrey, Wang, James J, Ste-Croix, Hélène, Rahil, Jubrail, Lefebvre, Sylvain, Moradei, Oscar, Delorme, Daniel, Macleod, A Robert, Besterman, Jeffrey M, Li, Zuomei

“…Nonselective inhibitors of human histone deacetylases (HDAC) are known to have antitumor activity in mice in vivo , and several of them are under clinical…”
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Evaluation of the Pharmacodynamic Effects of MGCD0103 from Preclinical Models to Human Using a Novel HDAC Enzyme Assay by BONFILS, Claire, KALITA, Ann, DUBAY, Marja, SIU, Lillian L, CARDUCCI, Michael A, REID, Gregory, MARTELL, Robert E, BESTERMAN, Jeffrey M, ZUOMEI LI

“…Purpose: The pharmacodynamic properties of MGCD0103, an isotype-selective inhibitor of histone deacetylase (HDAC), were evaluated in preclinical models and…”
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Characterization of the Human DNA Methyltransferase Splice Variant Dnmt1b by Bonfils, Claire, Beaulieu, Normand, Chan, Eric, Cotton-Montpetit, Judith, MacLeod, A.Robert

“…Tissue- and gene-specific patterns of cytosine-DNA methylation are characteristic features of vertebrate genomes. The generation and proper maintenance of DNA…”
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Identification of cis-Regulating Elements andtrans-Acting Factors Regulating the Expression of the Gene Encoding the Small Subunit of Ribonucleotide Reductase inDictyostelium discoideum by Bonfils, Claire, Gaudet, Pascale, Tsang, Adrian

“…We have examined the promoter of rnrB , the gene encoding the small subunit of ribonucleotide reductase of Dictyostelium discoideum , using lacZ as a reporter…”
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Abstract LB094: KisoBody: Development and pre-clinical assessment of a novel multispecific antibody platform by Wargachuk, Richard, Hou, Dominic, Bonfils, Claire, Morin, Nicolas, Yao, Shugang, Krstic, Milica, Cui, Yun, Toulouse, Jacynthe L., Gagné, Donald, Undzys, Elijus, Zhou, Alex, Chen, Emily, Gupta, Ashwani, DaCruz, Luis, Young, David

“…Abstract Monoclonal antibody therapy has revolutionized cancer treatment by addressing a variety of mechanisms from interfering with signaling to checkpoint…”
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Abstract LBA018: Discovery of novel functional TROP2 antibodies for treatment of epithelial cancers by Matos, Israel, Zahreddine, Hiba, Ashraf, Yahya, Pandey, Aditya, Chen, Emily, Gong, Liying, Zhou, Alex, Bonfils, Claire, Moya, Aniel, Cui, Yun, Wang, Xiaowei, Undzyz, Elijus, Yao, Shugang, Toulouse, Jacynthe, Hou, Dominic, Ngan, Gordon, da Cruz, Luis, Young, David

“…Abstract Trophoblast cell surface antigen-2 (TROP2) is a membrane-bound protein with an extracellular domain highly expressed in a wide range of late-stage…”
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Phase 1 study of the oral isotype specific histone deacetylase inhibitor MGCD0103 in leukemia by Garcia-Manero, Guillermo, Assouline, Sarit, Cortes, Jorge, Estrov, Zeev, Kantarjian, Hagop, Yang, Hui, Newsome, Willie M., Miller, Wilson H., Rousseau, Caroline, Kalita, Ann, Bonfils, Claire, Dubay, Marja, Patterson, Tracy-Ann, Li, Zuomei, Besterman, Jeffrey M., Reid, Gregory, Laille, Eric, Martell, Robert E., Minden, Mark

“…MGCD0103 is an isotype-selective inhibitor of histone deacetylases (HDACs) targeted to isoforms 1, 2, 3, and 11. In a phase 1 study in patients with leukemia…”
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Abstract P200: Pre-clinical development of a dopamine receptor 2, PD-1 and CD47 trispecific antibody for treatment of small cell lung cancer by Yao, Shugang, Cui, Yun, Kazanats, Anna, Gong, Liying, Bonfils, Claire, Hou, Dominic, Chen, Emily, Undzys, Elijus, Toulouse, Jacynthe, Krstic, Milica, Zahreddine, Hiba, Matos, Israel, Zhou, Alex, Moya-Torres, Aniel, Wargachuk, Richard, Gay, Carl, Byers, Lauren, Ngan, Gordon, da Cruz, Luis, Young, David

“…Abstract We developed a single domain VHH multi-specific antibody format. Multispecific antibodies have multiple mechanisms of action which may work…”
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Phase II study of the histone deacetylase inhibitor MGCD0103 in patients with previously treated chronic lymphocytic leukaemia by Blum, Kristie A., Advani, Anjani, Fernandez, Louis, Van Der Jagt, Richard, Brandwein, Joseph, Kambhampati, Suman, Kassis, Jeannine, Davis, Melanie, Bonfils, Claire, Dubay, Marja, Dumouchel, Julie, Drouin, Michel, Lucas, David M., Martell, Robert E., Byrd, John C.

“…Summary MGCD0103, an orally available class I histone deacetylase (HDAC) inhibitor, was examined for pre‐clinical activity in chronic lymphocytic leukaemia…”
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Expression and characterization of a Dictyostelium discoideum annexin by Bonfils, C, Greenwood, M, Tsang, A

“…The annexins are calcium-dependent phospholipid-binding proteins. Recently the gene encoding the homologue of a mammalian annexin has been identified in…”
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Novel Aminophenyl Benzamide-Type Histone Deacetylase Inhibitors with Enhanced Potency and Selectivity by Moradei, Oscar M, Mallais, Tammy C, Frechette, Sylvie, Paquin, Isabelle, Tessier, Pierre E, Leit, Silvana M, Fournel, Marielle, Bonfils, Claire, Trachy-Bourget, Marie-Claude, Liu, Jianhong, Yan, Theresa P, Lu, Ai-Hua, Rahil, Jubrail, Wang, James, Lefebvre, Sylvain, Li, Zuomei, Vaisburg, Arkadii F, Besterman, Jeffrey M

“…Significant effort is being made to understand the role of HDAC isotypes in human cancer and to develop antitumor agents with better therapeutic windows. A…”
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Abstract 324: Discovery of novel functional TROP2 antibodies for treatment of epithelial cancers by Matos, Israel, Ashraf, Yahya, Zahreddine, Hiba, Gong, Liying, Baumholtz, Amanda, Zhou, Alex, Bonfils, Claire, Moya-Torres, Aniel, Cui, Yun, Wang, Xiaowei, Wargachuk, Richard, Cheng, Tiffany, Undzys, Elijus, Yao, Shugang, Tolouse, Jacynthe Linda, Hou, Dominic, Ngan, Gordon, daCruz, Luis, Young, David

“…Abstract Trophoblast cell surface antigen-2 (TROP2) is a membrane-bound protein expressed during development and at lower levels in normal adult tissues. TROP2…”
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488. Development of a Robust Non-Viral Gene Delivery System for Gut Mucosal Cells by Hsu, Eric C., Mojibian, Majid, Gao, Jun, Fleet, Carlos, Chan, Helen, Tam, Natalie, Villeda-Herrera, Cynthia, Bonfils, Claire, Kieffer, Timothy J., Cheung, Anthony T.

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Abstract 1790: The combination of MGCD265, a Met/VEGFR inhibitor in clinical development, and erlotinib potently inhibits tumor growth by altering multiple pathways including glycolysis by Bonfils, Claire, Beaulieu, Normand, Fournel, Marielle, Ste-Croix, Helene, Besterman, Jeffrey M., Maroun, Christiane R.

“…Abstract MGCD265 is an oral, multitargeted, receptor tyrosine kinase inhibitor in clinical development. MGCD265 targets the Met, VEGFR1, 2, 3, Tie2 and Ron…”
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Abstract 930: Preclinical characterization of MG516, a novel inhibitor of receptor tyrosine kinases involved in resistance to targeted therapies by Beaulieu, Normand, Sainte-Croix, Helene, Bonfils, Claire, Mannion, Michael, Raeppel, Stephane, Isakovic, Lubo, Claridge, Stephen, Saavedra, Oscar, Raeppel, Franck, Vaisburg, Arkadii, Wang, James, Fournel, Marielle, Besterman, Jeffrey M., Maroun, Christiane R.

“…Abstract Despite breakthroughs in the clinical development of tyrosine kinase inhibitors, challenges remain in overcoming resistance to these molecular…”
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MGCD265, a multitargeted oral tyrosine kinase receptor inhibitor of Met and VEGFR: Dose-escalation phase I study by Kollmannsberger, Christian K., Hurwitz, Herbert, Cleary, James M., Strickler, John H., Drouin, Michel A., Juretic, Manuela, Hunt, Wendy, Reid, Gregory K., Maroun, Christiane R., Bonfils, Claire, Wang, James, Karam, Andre, Besterman, Jeffrey M., Mehran, Mariam, Shapiro, Geoffrey

“…Abstract only 3039 Background: MGCD265 is a multikinase inhibitor, with nanomolar IC 50 against Met, VEGFR 1, 2, and 3, Tie-2, and Ron. This spectrum may…”
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Abstract 3610: Potent preclinical anti-tumor activity of MGCD265, an oral Met/VEGFR multitargeted kinase inhibitor in clinical development, in combination with taxanes by Maroun, Christiane R., Ste-Croix, Helene, Beaulieu, Normand, Bonfils, Claire, Fournel, Marielle, Dupont, Isabelle, Lemoyne, Christian, Wand, James, Besterman, Jeffrey M.

“…Abstract MGCD265, a multitargeted receptor tyrosine kinase inhibitor in clinical development, inhibits the activation of Met, VEGFR1, 2, 3, Tie-2 and Ron. Met…”
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Abstract A95: The determination of the maximum tolerated dose (MTD) of MGCD265 on an intermittent schedule: Phase I study results (Study 265-102) by Wheler, Jennifer, Kurzrock, Razelle, Heath, Elizabeth I., Falchook, Gerald S., Maroun, Christiane R., Drouin, Michel A., Juretic, Manuela, Bonfils, Claire, Karam, Andre, Besterman, Jeffrey M., Wang, James, LoRusso, Patricia

“…Abstract Background: MGCD265 is an orally administered multi-targeted receptor tyrosine kinase (RTK) inhibitor that specifically targets Met RTK and the…”
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Abstract 3609: MGCD265, an orally active Met/VEGFR multitargeted kinase inhibitor in Phase II clinical development, potently inhibits clinically relevant Met mutants by Beaulieu, Normand, Dupont, Isabelle, Bonfils, Claire, Dubay, Marja, Ste-Croix, Hélène, Isakovic, Lubo, Claridge, Stephen, Saavedra, Oscar, Raeppel, Franck, Raeppel, Stephane, Mannion, Michael, Vaisburg, Arkadii, Besterman, Jeffrey M., Maroun, Christiane R.

“…Abstract MGCD265 is a multitargeted receptor tyrosine kinase inhibitor in Phase II clinical development, which inhibits the activation of regulators of cancer…”
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Sulfonamide anilides, a novel class of histone deacetylase inhibitors, are antiproliferative against human tumors by FOURNEL, Marielle, TRACHY-BOURGET, Marie-Claude, DELORME, Daniel, MACLEOD, A. Robert, BESTERMAN, Jeffrey M, ZUOMEI LI, YAN, P. Theresa, KALITA, Ann, BONFILS, Claire, BEAULIEU, Carole, FRECHETTE, Sylvie, LEIT, Silvana, ABOU-KHALIL, Elie, WOO, Soon-Hyung

“…Inhibition of histone deacetylases (HDACs) is emerging as a new strategy in human cancer therapy. We have designed and synthesized novel nonhydroxamate…”
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