Search Results - "BONDANZA, Attilio"

Clinical development of CAR T cells—challenges and opportunities in translating innovative treatment concepts by Hartmann, Jessica, Schüßler‐Lenz, Martina, Bondanza, Attilio, Buchholz, Christian J

“…Chimeric antigen receptor (CAR) T cell therapy, together with checkpoint inhibition, has been celebrated as a breakthrough technology due to the substantial…”
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CAR T cell manufacturing from naive/stem memory T lymphocytes enhances antitumor responses while curtailing cytokine release syndrome by Arcangeli, Silvia, Bove, Camilla, Mezzanotte, Claudia, Camisa, Barbara, Falcone, Laura, Manfredi, Francesco, Bezzecchi, Eugenia, El Khoury, Rita, Norata, Rossana, Sanvito, Francesca, Ponzoni, Maurilio, Greco, Beatrice, Moresco, Marta Angiola, Carrabba, Matteo G, Ciceri, Fabio, Bonini, Chiara, Bondanza, Attilio, Casucci, Monica

“…Chimeric antigen receptor (CAR) T cell expansion and persistence represent key factors to achieve complete responses and prevent relapses. These features are…”
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Next-Generation Manufacturing Protocols Enriching TSCM CAR T Cells Can Overcome Disease-Specific T Cell Defects in Cancer Patients by Arcangeli, Silvia, Falcone, Laura, Camisa, Barbara, De Girardi, Federica, Biondi, Marta, Giglio, Fabio, Ciceri, Fabio, Bonini, Chiara, Bondanza, Attilio, Casucci, Monica

“…Chimeric antigen receptor (CAR) T cell expansion and persistence emerged as key efficacy determinants in cancer patients. These features are typical of…”
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Bone marrow central memory and memory stem T-cell exhaustion in AML patients relapsing after HSCT by Noviello, Maddalena, Manfredi, Francesco, Ruggiero, Eliana, Perini, Tommaso, Oliveira, Giacomo, Cortesi, Filippo, De Simone, Pantaleo, Toffalori, Cristina, Gambacorta, Valentina, Greco, Raffaella, Peccatori, Jacopo, Casucci, Monica, Casorati, Giulia, Dellabona, Paolo, Onozawa, Masahiro, Teshima, Takanori, Griffioen, Marieke, Halkes, Constantijn J. M., Falkenburg, J. H. F., Stölzel, Friedrich, Altmann, Heidi, Bornhäuser, Martin, Waterhouse, Miguel, Zeiser, Robert, Finke, Jürgen, Cieri, Nicoletta, Bondanza, Attilio, Vago, Luca, Ciceri, Fabio, Bonini, Chiara

“…The major cause of death after allogeneic Hematopoietic Stem Cell Transplantation (HSCT) for acute myeloid leukemia (AML) is disease relapse. We investigated…”
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Oncogene-induced senescence in hematopoietic progenitors features myeloid restricted hematopoiesis, chronic inflammation and histiocytosis by Biavasco, Riccardo, Lettera, Emanuele, Giannetti, Kety, Gilioli, Diego, Beretta, Stefano, Conti, Anastasia, Scala, Serena, Cesana, Daniela, Gallina, Pierangela, Norelli, Margherita, Basso-Ricci, Luca, Bondanza, Attilio, Cavalli, Giulio, Ponzoni, Maurilio, Dagna, Lorenzo, Doglioni, Claudio, Aiuti, Alessandro, Merelli, Ivan, Di Micco, Raffaella, Montini, Eugenio

“…ABSTRACT Activating mutations in the BRAF-MAPK pathway have been reported in histiocytoses, hematological inflammatory neoplasms characterized by multi-organ…”
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Interferon gene therapy reprograms the leukemia microenvironment inducing protective immunity to multiple tumor antigens by Escobar, Giulia, Barbarossa, Luigi, Barbiera, Giulia, Norelli, Margherita, Genua, Marco, Ranghetti, Anna, Plati, Tiziana, Camisa, Barbara, Brombin, Chiara, Cittaro, Davide, Annoni, Andrea, Bondanza, Attilio, Ostuni, Renato, Gentner, Bernhard, Naldini, Luigi

“…Immunotherapy is emerging as a new pillar of cancer treatment with potential to cure. However, many patients still fail to respond to these therapies. Among…”
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Loss of Mismatched HLA in Leukemia after Stem-Cell Transplantation by Vago, Luca, Perna, Serena Kimi, Zanussi, Monica, Mazzi, Benedetta, Barlassina, Cristina, Stanghellini, Maria Teresa Lupo, Perrelli, Nicola Flavio, Cosentino, Cristian, Torri, Federica, Angius, Andrea, Forno, Barbara, Casucci, Monica, Bernardi, Massimo, Peccatori, Jacopo, Corti, Consuelo, Bondanza, Attilio, Ferrari, Maurizio, Rossini, Silvano, Roncarolo, Maria Grazia, Bordignon, Claudio, Bonini, Chiara, Ciceri, Fabio, Fleischhauer, Katharina

“…Five patients with acute myelogenous leukemia received hematopoietic stem-cell transplants from a haploidentical donor. They also received T cells from the…”
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Extracellular NGFR Spacers Allow Efficient Tracking and Enrichment of Fully Functional CAR-T Cells Co-Expressing a Suicide Gene by Casucci, Monica, Falcone, Laura, Camisa, Barbara, Norelli, Margherita, Porcellini, Simona, Stornaiuolo, Anna, Ciceri, Fabio, Traversari, Catia, Bordignon, Claudio, Bonini, Chiara, Bondanza, Attilio

“…Chimeric antigen receptor (CAR)-T cell immunotherapy is at the forefront of innovative cancer therapeutics. However, lack of standardization of cellular…”
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CD4 CAR-T cells targeting CD19 play a key role in exacerbating cytokine release syndrome, while maintaining long-term responses by Bove, Camilla, Arcangeli, Silvia, Falcone, Laura, Camisa, Barbara, El Khoury, Rita, Greco, Beatrice, De Lucia, Anna, Bergamini, Alice, Bondanza, Attilio, Ciceri, Fabio, Bonini, Chiara, Casucci, Monica

“…To date, T cells redirected with CD19-specific chimeric antigen receptors (CAR) have gained impressive success in B-cell malignancies. However, treatment…”
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The IL-1/IL-1 receptor axis and tumor cell released inflammasome adaptor ASC are key regulators of TSLP secretion by cancer associated fibroblasts in pancreatic cancer by Brunetto, Emanuela, De Monte, Lucia, Balzano, Gianpaolo, Camisa, Barbara, Laino, Vincenzo, Riba, Michela, Heltai, Silvia, Bianchi, Marco, Bordignon, Claudio, Falconi, Massimo, Bondanza, Attilio, Doglioni, Claudio, Protti, Maria Pia

“…The thymic stromal lymphopoietin (TSLP), a key cytokine for development of Th2 immunity, is produced by cancer associated fibroblasts (CAFs) in pancreatic…”
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Autologous hematopoietic stem cell transplantation in neuromyelitis optica: A registry study of the EBMT Autoimmune Diseases Working Party by Greco, Raffaella, Bondanza, Attilio, Oliveira, Maria Carolina, Badoglio, Manuela, Burman, Joachim, Piehl, Fredrik, Hagglund, Hans, Krasulova, Eva, Simões, Belinda Pinto, Carlson, Kristina, Pohlreich, David, Labopin, Myriam, Saccardi, Riccardo, Comi, Giancarlo, Mancardi, Gian Luigi, Bacigalupo, Andrea, Ciceri, Fabio, Farge, Dominique

“…Background: Neuromyelitis optica (NMO) is an inflammatory autoimmune disorder of the central nervous system, hallmarked by pathogenic anti-aquaporin 4…”
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Stability of human rapamycin-expanded CD4+CD25+ T regulatory cells by TRESOLDI, Eleonora, DELL'ALBANI, Ilaria, STABILINI, Angela, JOFRA, Tatiana, VALLE, Andrea, GAGLIANI, Nicola, BONDANZA, Attilio, GRAZIA RONCAROLO, Maria, BATTAGLIA, Manuela

“…The clinical use of ex vivo-expanded T-regulatory cells for the treatment of T-cell-mediated diseases has gained increasing momentum. However, the recent…”
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Suicide gene therapy to increase the safety of chimeric antigen receptor-redirected T lymphocytes by Casucci, Monica, Bondanza, Attilio

“…Chimeric antigen receptors (CARs) are generated by fusing the antigen-binding motif of a monoclonal antibody (mAb) with the signal transduction machinery of…”
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432 Pharmacological inhibition with anti-CD38 mAb protects NK-mediated off-the-shelf CAR T cells allorejection by Rhoo, Jules, Steinhardt, James, Davies, Owanaemi, Simon, Carl, Bondanza, Attilio, Moody, Gordon, Cobbold, Mark, Carlesso, Gianluca, Vian, Laura

“…BackgroundAutologous CAR-T therapy has revolutionized the treatment of multiple myeloma (MM), but many patients still face obstacles in accessing these…”
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Harnessing the reverse cholesterol transport pathway to favor differentiation of monocyte-derived APCs and antitumor responses by Raccosta, Laura, Marinozzi, Maura, Costantini, Susan, Maggioni, Daniela, Ferreira, Lorena Maria, Corna, Gianfranca, Zordan, Paola, Sorice, Angela, Farinello, Diego, Bianchessi, Silvia, Riba, Michela, Lazarevic, Dejan, Provero, Paolo, Mack, Matthias, Bondanza, Attilio, Nalvarte, Ivan, Gustafsson, J-A, Ranzani, Valeria, De Sanctis, Francesco, Ugel, Stefano, Baron, Silvère, Lobaccaro, Jean-Marc A., Pontini, Lorenzo, Pacciarini, Manuela, Traversari, Catia, Pagani, Massimiliano, Bronte, Vincenzo, Sitia, Giovanni, Antonson, Per, Brendolan, Andrea, Budillon, Alfredo, Russo, Vincenzo

“…Lipid and cholesterol metabolism play a crucial role in tumor cell behavior and in shaping the tumor microenvironment. In particular, enzymatic and…”
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Antitumor effects of HSV-TK–engineered donor lymphocytes after allogeneic stem-cell transplantation by Ciceri, Fabio, Bonini, Chiara, Marktel, Sarah, Zappone, Elisabetta, Servida, Paolo, Bernardi, Massimo, Pescarollo, Alessandra, Bondanza, Attilio, Peccatori, Jacopo, Rossini, Silvano, Magnani, Zulma, Salomoni, Monica, Benati, Claudia, Ponzoni, Maurilio, Callegaro, Luciano, Corradini, Paolo, Bregni, Marco, Traversari, Catia, Bordignon, Claudio

“…The extensive exploitation of the antitumor effect of donor lymphocytes infused after allogeneic hematopoietic stem-cell transplantation (allo-HSCT) is limited…”
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Temporal, quantitative, and functional characteristics of single-KIR–positive alloreactive natural killer cell recovery account for impaired graft-versus-leukemia activity after haploidentical hematopoietic stem cell transplantation by Vago, Luca, Forno, Barbara, Sormani, Maria Pia, Crocchiolo, Roberto, Zino, Elisabetta, Di Terlizzi, Simona, Lupo Stanghellini, Maria Teresa, Mazzi, Benedetta, Perna, Serena K., Bondanza, Attilio, Middleton, Derek, Palini, Alessio, Bernardi, Massimo, Bacchetta, Rosa, Peccatori, Jacopo, Rossini, Silvano, Roncarolo, Maria Grazia, Bordignon, Claudio, Bonini, Chiara, Ciceri, Fabio, Fleischhauer, Katharina

“…In this study, we have characterized reconstitution of the natural killer (NK) cell repertoire after haploidentical CD34+ selected hematopoietic stem cell…”
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Retroviral Vector Integration Deregulates Gene Expression but Has No Consequence on the Biology and Function of Transplanted T Cells by Recchia, Alessandra, Bonini, Chiara, Magnani, Zulma, Urbinati, Fabrizia, Sartori, Daniela, Muraro, Sara, Tagliafico, Enrico, Bondanza, Attilio, Stanghellini, Maria Teresa Lupo, Bernardi, Massimo, Pescarollo, Alessandra, Ciceri, Fabio, Bordignon, Claudio, Mavilio, Fulvio

“…The use of retroviral vectors in gene therapy has raised safety concerns for the genotoxic risk associated with their uncontrolled insertion into the human…”
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Th22 cells increase in poor prognosis multiple myeloma and promote tumor cell growth and survival by Di Lullo, Giulia, Marcatti, Magda, Heltai, Silvia, Brunetto, Emanuela, Tresoldi, Cristina, Bondanza, Attilio, Bonini, Chiara, Ponzoni, Maurilio, Tonon, Giovanni, Ciceri, Fabio, Bordignon, Claudio, Protti, Maria Pia

“…There is increased production of plasmacytoid dendritic cells (pDCs) in the bone marrow (BM) of multiple myeloma (MM) patients and these favor Th22 cell…”
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ERK1 and ERK2 mitogen-activated protein kinases affect Ras-dependent cell signaling differentially by Vantaggiato, Chiara, Formentini, Ivan, Bondanza, Attilio, Bonini, Chiara, Naldini, Luigi, Brambilla, Riccardo

“…The mitogen-activated protein (MAP) kinases p44ERK1 and p42ERK2 are crucial components of the regulatory machinery underlying normal and malignant cell…”
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