Search Results - "BOND, Brian R"

Transgenic Model of Aldosterone-Driven Cardiac Hypertrophy and Heart Failure by Qin, Wenning, Rudolph, Amy E, Bond, Brian R, Rocha, Ricardo, Blomme, Eric A.G, Goellner, Joseph J, Funder, John W, McMahon, Ellen G

“…ABSTRACT—Aldosterone classically promotes unidirectional transepithelial sodium transport, thereby regulating blood volume and blood pressure. Recently, both…”
Get full text

A matrix metalloproteinase induction/activation system exists in the human left ventricular myocardium and is upregulated in heart failure by SPINALE, Francis G, COKER, Mytsi L, HEUNG, Lena J, BOND, Brian R, GUNASINGHE, Himali R, ETOH, Takuma, GOLDBERG, Aron T, ZELLNER, James L, CRUMBLEY, A. Jackson

“…Matrix metalloproteinases (MMPs) contribute to matrix remodeling in disease states such as tumor metastases. Extracellular matrix metalloproteinase inducer…”
Get full text

Renal organic anion transporter-mediated drug-drug interaction between gemcabene and quinapril by Yuan, Haodan, Feng, Bo, Yu, Ying, Chupka, Jonathan, Zheng, Jenny Y, Heath, Timothy G, Bond, Brian R

“…In humans and rats, a synergistic blood pressure reduction was observed when the fibrate gemcabene (CI-1027) was coadministered with the angiotensin-converting…”
Get more information

Matrix metalloproteinase expression and activity in isolated myocytes after neurohormonal stimulation by Coker, M L, Jolly, J R, Joffs, C, Etoh, T, Holder, J R, Bond, B R, Spinale, F G

“…Changes in myocardial matrix metalloproteinase (MMP) activity and expression have been associated with left ventricular (LV) remodeling. A recent study…”
Get more information

Orally Active MMP-1 Sparing α-Tetrahydropyranyl and α-Piperidinyl Sulfone Matrix Metalloproteinase (MMP) Inhibitors with Efficacy in Cancer, Arthritis, and Cardiovascular Disease by Becker, Daniel P, Barta, Thomas E, Bedell, Louis J, Boehm, Terri L, Bond, Brian R, Carroll, Jeffery, Carron, Chris P, DeCrescenzo, Gary A, Easton, Alan M, Freskos, John N, Funckes-Shippy, Chris L, Heron, Marcia, Hockerman, Susan, Howard, Carol Pearcy, Kiefer, James R, Li, Madeleine H, Mathis, Karl J, McDonald, Joseph J, Mehta, Pramod P, Munie, Grace E, Sunyer, Teresa, Swearingen, Craig A, Villamil, Clara I, Welsch, Dean, Williams, Jennifer M, Yu, Ying, Yao, Jun

“…α-Sulfone-α-piperidine and α-tetrahydropyranyl hydroxamates were explored that are potent inhibitors of MMP’s-2, -9, and -13 that spare MMP-1, with oral…”
Get full text

Pharmacologic Comparison of Clinical Neutral Endopeptidase Inhibitors in a Rat Model of Acute Secretory Diarrhea by Griggs, David W, Prinsen, Michael J, Oliva, Jonathan, Campbell, Mary A, Arnett, Stacy D, Tajfirouz, Deena, Ruminski, Peter G, Yu, Ying, Bond, Brian R, Ji, Yuhua, Neckermann, Georg, Choy, Robert K M, de Hostos, Eugenio, Meyers, Marvin J

“…Racecadotril (acetorphan) is a neutral endopeptidase (NEP) inhibitor with known antidiarrheal activity in animals and humans; however, in humans, it suffers…”
Get more information

Endothelin-1 during and after cardiopulmonary bypass: Association to graft sensitivity and postoperative recovery by Bond, Brian R., Dorman, B.Hugh, Clair, Mark J., Walker, C.Allyson, Pinosky, Mark L., Reeves, Scott T., Walton, Scott, Kratz, John M., Zellner, James L., Crumbley, A.Jackson, Multani, Marlina M., Spinale, Francis G.

“…Objective: Our objectives are 2-fold: (1) to serially measure the release of endothelin and graft-conduit endothelin sensitivity during and after coronary…”
Get full text

Mo1233 Pharmacologic Evaluation of Clinical Neutral Endopeptidase Inhibitors in a Rat Model of Acute Secretory Diarrhea by Griggs, David W, Prinsen, Michael J, Campbell, Mary, Oliva, Jonathan, Ruminski, Peter, Yu, Ying, Bond, Brian R, Ji, Yuhua, Neckermann, Georg, Choy, Robert, de Hostos, Eugenio L, Meyers, Marvin

Get full text

1-(2-Ethoxyethyl)-1H-pyrazolo[4,3-d]pyrimidines as potent phosphodiesterase 5 (PDE5) inhibitors by TOLLEFSON, Michael B, ACKER, Brad A, JACOBSEN, E. J, HUGHES, Robert O, WALKER, John K, FOX, David N. A, PALMER, Michael J, FREEMAN, Sandra K, YING YU, BOND, Brian R

“…1H-Pyrazolo[4,3-d]pyrimidines are a class of potent and selective second generation phosphodiesterase 5 (PDE5) inhibitors. This work explores the potency,…”
Get full text

Investigation of the pyrazinones as PDE5 inhibitors: Evaluation of regioisomeric projections into the solvent region by Hughes, Robert O., Maddux, Todd, Joseph Rogier, D., Lu, Sharon, Walker, John K., Jon Jacobsen, E., Rumsey, Jeanne M., Zheng, Yi, MacInnes, Alan, Bond, Brian R., Han, Seungil

“…We describe the design, synthesis and profiling of a novel series of PDE5 inhibitors. We take advantage of an alternate projection into the solvent region to…”
Get full text

Identification of mRNA transcripts and immunohistochemical localization of Na/H exchanger isoforms in gerbil inner ear by Bond, Brian R, Ng, Leong L, Schulte, Bradley A

“…Recent physiological and pharmacological studies have implicated involvement of the Na/H exchanger (NHE) in regulating inner ear ion homeostasis, but the…”
Get full text

1-(2-(2,2,2-trifluoroethoxy)ethyl-1H-pyrazolo[4,3-d]pyrimidines as potent phosphodiesterase 5 (PDE5) inhibitors by Tollefson, Michael B, Acker, Brad A, Jacobsen, E J, Hughes, Robert O, Walker, John K, Fox, David N A, Palmer, Michael J, Freeman, Sandra K, Yu, Ying, Bond, Brian R

“…1H-Pyrazolo[4,3-d]pyrimidines were previously disclosed as a potent second generation class of phosphodiesterase 5 (PDE5) inhibitors. This work explores the…”
Get full text

Temporal synthesis and release of endothelin within the systemic and myocardial circulation during and after cardiopulmonary bypass: Relation to postoperative recovery by Dorman, B.Hugh, Bond, Brian R., Clair, Mark J., Walker, Courtney A., Pinosky, Mark L., Reeves, Scott T., Kratz, John M., Zellner, James L., Crumbley, Andrew J., Multani, Marlina M., Spinale, Francis G.

“…Objective: To determine endothelin levels in arterial, pulmonary, and myocardial vascular compartments in patients undergoing coronary artery bypass graft…”
Get full text

Design, Synthesis, and Biological Evaluation of 3-[4-(2-Hydroxyethyl)piperazin-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one, a Potent, Orally Active, Brain Penetrant Inhibitor of Phosphodiesterase 5 (PDE5) by Hughes, Robert O, Rogier, D. Joseph, Jacobsen, E. Jon, Walker, John K, MacInnes, Alan, Bond, Brian R, Zhang, Lena L, Yu, Ying, Zheng, Yi, Rumsey, Jeanne M, Walgren, Jennie L, Curtiss, Sandra W, Fobian, Yvette M, Heasley, Steven E, Cubbage, Jerry W, Moon, Joseph B, Brown, David L, Acker, Brad A, Maddux, Todd M, Tollefson, Mike B, Mischke, Brent V, Owen, Dafydd R, Freskos, John N, Molyneaux, John M, Benson, Alan G, Blevis-Bal, Rhadika M

“…We recently described a novel series of aminopyridopyrazinones as PDE5 inhibitors. Efforts toward optimization of this series culminated in the identification…”
Get full text

Investigation of aminopyridiopyrazinones as PDE5 inhibitors: Evaluation of modifications to the central ring system by Hughes, Robert O., Walker, John K., Cubbage, Jerry W., Fobian, Yvette M., Rogier, D. Joseph, Heasley, Steve E., Blevis-Bal, Rhadika M., Benson, Alan G., Owen, Dafydd R., Jacobsen, E. Jon, Freskos, John N., Molyneaux, John M., Brown, David L., Stallings, William C., Acker, Brad A., Maddux, Todd M., Tollefson, Mike B., Williams, Jennifer M., Moon, Joseph B., Mischke, Brent V., Rumsey, Jeanne M., Zheng, Yi, MacInnes, Alan, Bond, Brian R., Yu, Ying

“…Efforts to improve the potency and physical properties of the aminopyridiopyrazinone class of PDE5 inhibitors through modification of the core ring system are…”
Get full text

Identification, synthesis and SAR of amino substituted pyrido[3,2b]pyrazinones as potent and selective PDE5 inhibitors by Owen, Dafydd R., Walker, John K., Jon Jacobsen, E., Freskos, John N., Hughes, Robert O., Brown, David L., Bell, Andrew S., Brown, David G., Phillips, Christopher, Mischke, Brent V., Molyneaux, John M., Fobian, Yvette M., Heasley, Steve E., Moon, Joseph B., Stallings, William C., Joseph Rogier, D., Fox, David N.A., Palmer, Michael J., Ringer, Tracy, Rodriquez-Lens, Margarita, Cubbage, Jerry W., Blevis-Bal, Radhika M., Benson, Alan G., Acker, Brad A., Maddux, Todd M., Tollefson, Michael B., Bond, Brian R., MacInnes, Alan, Yu, Yung

“…Lead-hopping of high throughput screening lead, 1, led to identification of a new potent series, 2, of PDE5 inhibitors. SAR and selectivity data for…”
Get full text

Optimization of the aminopyridopyrazinones class of PDE5 inhibitors: Discovery of 3-[( trans-4-hydroxycyclohexyl)amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4- b]pyrazin-2(1 H)-one by Hughes, Robert O., Walker, John K., Joseph Rogier, D., Heasley, Steve E., Blevis-Bal, Rhadika M., Benson, Alan G., Jon Jacobsen, E., Cubbage, Jerry W., Fobian, Yvette M., Owen, Dafydd R., Freskos, John N., Molyneaux, John M., Brown, David L., Acker, Brad A., Maddux, Todd M., Tollefson, Mike B., Moon, Joseph B., Mischke, Brent V., Rumsey, Jeanne M., Zheng, Yi, MacInnes, Alan, Bond, Brian R., Yu, Ying

“…We describe efforts to improve the pharmacokinetic profile of the aminopyridopyrazinone class of PDE5 inhibitors. These efforts led to the discovery of 3-[(…”
Get full text

Role of PYK2 in the development of obesity and insulin resistance by Yu, Ying, Ross, Stuart A., Halseth, Amy E., Hollenbach, Paul W., Hill, Ronald J., Gulve, Eric A., Bond, Brian R.

“…Non-receptor proline-rich tyrosine kinase-2 (PYK2), which is activated by phosphorylation of one or more of its tyrosine residues, has been implicated in the…”
Get full text

Differential effects of calcium channel antagonists in the amelioration of radial artery vasospasm by Bond, B R, Zellner, J L, Dorman, B H, Multani, M M, Kratz, J M, Crumbley, 3rd, A J, Crawford, Jr, F A, Spinale, F G

“…Radial artery (RA) is being used for coronary artery bypass grafting (CABG) with greater frequency. However, RA is prone to post-CABG vasospasm, which may be…”
Get full text

Endothelin receptor pathway in human left ventricular myocytes: relation to contractility by Goldberg, Aron T, Bond, Brian R, Mukherjee, Rupak, New, R.Brent, Zellner, James L, Crawford, Fred A, Spinale, Francis G

“…Background. Increased synthesis and release of the potent bioactive peptide endothelin-1 (ET-1) occurs during and after cardiac surgery. However, the cellular…”
Get full text