Search Results - "BONAR, Sheri L"

NLRP3 mediates osteolysis through inflammation‐dependent and ‐independent mechanisms by Qu, Chao, Bonar, Sheri L., Hickman‐Brecks, Cynthia L., Abu‐Amer, Samer, McGeough, Matthew D., Peña, Carla A., Broderick, Lori, Yang, Chang, Grimston, Susan K., Kading, Jacqueline, Abu‐Amer, Yousef, Novack, Deborah V., Hoffman, Hal M., Civitelli, Roberto, Mbalaviele, Gabriel

“…Activating‐mutations in NOD‐like receptor (NLR) family, pyrin domain‐containing 3 (NLRP3) cause neonatal‐onset multisystem inflammatory disease. However, the…”
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Constitutively activated NLRP3 inflammasome causes inflammation and abnormal skeletal development in mice by Bonar, Sheri L, Brydges, Susannah D, Mueller, James L, McGeough, Matthew D, Pena, Carla, Chen, Debbie, Grimston, Susan K, Hickman-Brecks, Cynthia L, Ravindran, Soumya, McAlinden, Audrey, Novack, Deborah V, Kastner, Daniel L, Civitelli, Roberto, Hoffman, Hal M, Mbalaviele, Gabriel

“…The NLRP3 inflammasome complex is responsible for maturation of the pro-inflammatory cytokine, IL-1β. Mutations in NLRP3 are responsible for the…”
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Selective inhibition of the p38α MAPK-MK2 axis inhibits inflammatory cues including inflammasome priming signals by Wang, Chun, Hockerman, Susan, Jacobsen, E Jon, Alippe, Yael, Selness, Shaun R, Hope, Heidi R, Hirsch, Jeffrey L, Mnich, Stephen J, Saabye, Matthew J, Hood, William F, Bonar, Sheri L, Abu-Amer, Yousef, Haimovich, Ariela, Hoffman, Hal M, Monahan, Joseph B, Mbalaviele, Gabriel

“…p38α activation of multiple effectors may underlie the failure of global p38α inhibitors in clinical trials. A unique inhibitor (CDD-450) was developed that…”
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JAK inhibition with tofacitinib suppresses arthritic joint structural damage through decreased RANKL production by LaBranche, Timothy P., Jesson, Michael I., Radi, Zaher A., Storer, Chad E., Guzova, Julia A., Bonar, Sheri L., Thompson, Janice M., Happa, Fernando A., Stewart, Zachary S., Zhan, Yutian, Bollinger, Chris S., Bansal, Prashant N., Wellen, Jeremy W., Wilkie, Dean P., Bailey, Steven A., Symanowicz, Peter T., Hegen, Martin, Head, Richard D., Kishore, Nandini, Mbalaviele, Gabriel, Meyer, Debra M.

“…Objective The mechanistic link between Janus kinase (JAK) signaling and structural damage to arthritic joints in rheumatoid arthritis (RA) is poorly…”
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Novel Insights into the Cellular Mechanisms of the Anti-inflammatory Effects of NF-κB Essential Modulator Binding Domain Peptides by Baima, Eric T., Guzova, Julia A., Mathialagan, Sumathy, Nagiec, Eva E., Hardy, Medora M., Song, Lily R., Bonar, Sheri L., Weinberg, Robin A., Selness, Shaun R., Woodard, Scott S., Chrencik, Jill, Hood, William F., Schindler, John F., Kishore, Nandini, Mbalaviele, Gabriel

“…The classical nuclear factor κB (NF-κB) signaling pathway is under the control of the IκB kinase (IKK) complex, which consists of IKK-1, IKK-2, and NF-κB…”
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Aminopyridinecarboxamide-based inhaled IKK-2 inhibitors for asthma and COPD: Structure–activity relationship by Xie, Jin, Poda, Gennadiy I., Hu, Yiding, Chen, Natalie X., Heier, Richard F., Wolfson, Serge G., Reding, Matthew T., Lennon, Patrick J., Kurumbail, Ravi G., Selness, Shaun R., Li, Xiong, Kishore, Nandini N., Sommers, Cynthia D., Christine, Lori, Bonar, Sheri L., Venkatraman, Neetu, Mathialagan, Sumathy, Brustkern, Sarah J., Huang, Horng-Chih

“…Installation of sites for metabolism in the lead compound PHA-767408 was the key focus of the IKK-2 inhaled program. This paper reports our efforts to identify…”
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Aminopyridinecarboxamide-based inhibitors: Structure–activity relationship by Bonafoux, Dominique F., Bonar, Sheri L., Clare, Michael, Donnelly, Ann M., Glaenzer, Jeanette L., Guzova, Julia A., Huang, He, Kishore, Nandidni N., Koszyk, Francis J., Lennon, Patrick J., Libby, Adam, Mathialagan, Sumathy, Oburn, David S., Rouw, Sharon A, Sommers, Cynthia D., Tripp, Catherine S., Vanella, Lori J., Weier, Richard, Wolfson, Serge G., Huang, Horng-Chih

“…Aminopyridinecarboxamide-based iKK-2 inhibitors were synthesized and tested leading to the 2-amino-5-chloropyridine-4-carboxamides as potent inhibitors with…”
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Virulence of a phosphoribosylaminoimidazole carboxylase-deficient Candida albicans strain in an immunosuppressed murine model of systemic candidiasis by DONOVAN, Matthew, SCHUMUKE, Jon J, FONZI, William A, BONAR, Sheri L, GHEESLING-MULLIS, Karen, JACOB, Gary S, DAVISSON, Vincent Jo, DOTSON, Stanton B

“…The relative pathogenicities of three Candida albicans strains differing in the function of ADE2 (the gene encoding phosphoribosylaminoimidazole carboxylase)…”
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Aminopyridinecarboxamide-based inhaled IKK-2 inhibitors for asthma and COPD: activity relationship by Xie, Jin, Poda, Gennadiy I, Hu, Yiding, Chen, Natalie X, Heier, Richard F, Wolfson, Serge G, Reding, Matthew T, Lennon, Patrick J, Kurumbail, Ravi G, Selness, Shaun R, Li, Xiong, Kishore, Nandini N, Sommers, Cynthia D, Christine, Lori, Bonar, Sheri L, Venkatraman, Neetu, Mathialagan, Sumathy, Brustkern, Sarah J, Huang, Horng-Chih

“…Installation of sites for metabolism in the lead compound PHA-767408 was the key focus of the IKK-2 inhaled program. This paper reports our efforts to identify…”
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Novel insights into the cellular mechanisms of the anti-inflammatory effects of NF-kappaB essential modulator binding domain peptides by Baima, Eric T, Guzova, Julia A, Mathialagan, Sumathy, Nagiec, Eva E, Hardy, Medora M, Song, Lily R, Bonar, Sheri L, Weinberg, Robin A, Selness, Shaun R, Woodard, Scott S, Chrencik, Jill, Hood, William F, Schindler, John F, Kishore, Nandini, Mbalaviele, Gabriel

“…The classical nuclear factor kappaB (NF-kappaB) signaling pathway is under the control of the IkappaB kinase (IKK) complex, which consists of IKK-1, IKK-2, and…”
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A novel, highly selective, tight binding IkappaB kinase-2 (IKK-2) inhibitor: a tool to correlate IKK-2 activity to the fate and functions of the components of the nuclear factor-kappaB pathway in arthritis-relevant cells and animal models by Mbalaviele, Gabriel, Sommers, Cynthia D, Bonar, Sheri L, Mathialagan, Sumathy, Schindler, John F, Guzova, Julia A, Shaffer, Alexander F, Melton, Michele A, Christine, Lori J, Tripp, Catherine S, Chiang, Po-Chang, Thompson, David C, Hu, Yiding, Kishore, Nandini

“…Nuclear factor (NF)-kappaB activation has been clearly linked to the pathogenesis of multiple inflammatory diseases including arthritis. The central role that…”
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Novel tight-binding inhibitory factor-kappaB kinase (IKK-2) inhibitors demonstrate target-specific anti-inflammatory activities in cellular assays and following oral and local delivery in an in vivo model of airway inflammation by Sommers, Cynthia D, Thompson, Janice M, Guzova, Julia A, Bonar, Sheri L, Rader, Randall K, Mathialagan, Sumathy, Venkatraman, Neetu, Holway, Vicky Walker, Kahn, Larry E, Hu, George, Garner, Debra S, Huang, Horng-Chih, Chiang, Po-Chang, Schindler, John F, Hu, Yiding, Meyer, Debra M, Kishore, Nandini N

“…Nuclear factor-kappaB (NF-kappaB) is one of the major families of transcription factors activated during the inflammatory response in asthma and chronic…”
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Virulence of a Phosphoribosylaminoimidazole Carboxylase-DeficientCandida albicans Strain in an Immunosuppressed Murine Model of Systemic Candidiasis by Matthew Donovan, Jon J. Schumuke, William A. Fonzi, Sheri L. Bonar, Karen Gheesling-Mullis, Gary S. Jacob, Vincent Jo Davisson, Stanton B. Dotson

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Epidermal growth factor precursor is present in a variety of human renal cyst fluids by Moskowitz, D W, Bonar, S L, Liu, W, Sirgi, C F, Marcus, M D, Clayman, R V

“…Progressive human renal cystic diseases are characterized by proliferation of the epithelial cells lining the cyst. The kidney synthesizes epidermal growth…”
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Sequence Analysis of theCandida albicans ADE2 Gene and Physical Separation of the Two Functionally Distinct Domains of the Phosphoribosylaminoimidazole Carboxylase by SCHMUKE, JON J., DAVISSON, V. JO, BONAR, SHERI L., MULLIS, KAREN GHEESLING, DOTSON, STANTON B.

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Sequence Analysis of the Candida albicans ADE2 Gene and Physical Separation of the Two Functionally Distinct Domains of the Phosphoribosylaminoimidazole Carboxylase by SCHMUKE, JON J., DAVISSON, V. JO, BONAR, SHERI L., MULLIS, KAREN GHEESLING, DOTSON, STANTON B.

“…An ADE2 genomic clone from the pathogenic fungus, Candida albicans, was isolated by complementation of an Escherichia coli purK mutant and the gene was…”
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