HLA Polymorphism and Evaluation of European, African, and Amerindian Contribution to the White and Mulatto Populations from Paraná, Brazil

Polymorphism of classical HLA-A, HLA-B, HLA-C, HLADR, and HLA-DQ genes differs greatly among populations, both in frequencies and in the presence of alíeles and haplotypes particular to population groups, making these genes powerful tools for the study of origins of populations and their degree of a...

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Bibliographic Details
Published in:	Human biology Vol. 72; no. 4; pp. 597 - 617
Main Authors:	PROBST, C.M., BOMPEIXE, E.P., PEREIRA, N.F., de O. DALALIO, M.M., VISENTAINER, J.E.L., TSUNETO, L.T., PETZL-ERLER, M.L.
Format:	Journal Article
Language:	English
Published:	United States Wayne State University Press 01-08-2000 Johns Hopkins Press
Subjects:	Admixtures Adult Africa - ethnology African Continental Ancestry Group - genetics Alleles Ancestry Antigens Brazil Brazilians Europe - ethnology European Continental Ancestry Group - genetics Female Gene Frequency - genetics Gene Pool Genetic aspects Genetic Variation - genetics Genetics Haplotypes Histocompatibility antigens HLA A antigens HLA antigens HLA B antigens HLA histocompatibility antigens HLA-A Antigens - genetics HLA-B Antigens - genetics HLA-C Antigens - genetics HLA-DQ Antigens - genetics HLA-DR Antigens - genetics Human population genetics Humans Indians, South American - genetics Linkage Disequilibrium Male Middle Aged Minority & ethnic groups Phenotype Polymorphism, Genetic - genetics Population Population genetics Racially mixed people White people Whites Brazil Europe Africa Parana Brazil
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Summary:	Polymorphism of classical HLA-A, HLA-B, HLA-C, HLADR, and HLA-DQ genes differs greatly among populations, both in frequencies and in the presence of alíeles and haplotypes particular to population groups, making these genes powerful tools for the study of origins of populations and their degree of admixture. Antigen, alíele, and haplotype frequencies, together with linkage disequilibrium patterns, are reported for 2 populations in the southern Brazilian state of Paraná, one of predominantly European ancestry (white), the other of predominantly African and European ancestry (mulatto). Genetic distance estimates between the 2 groups and other populations studied previously, and of degree of admixture, were performed. In accordance with phenotypic classification, the white population is of predominantly European origin (80.6%), with a smaller contribution of African (12.5%) and Amerindian (7.0%) genes. The mulatto population consists of African (49.5%) and European (41.8%) ancestry, with a smaller but significant contribution of Amerindian (8.7%) ancestry. On the basis of history and population genetics, there is controversy regarding the Amerindian contribution to Parana's gene pool. These results provide a better picture of Parana's ethnic constitution and on the Amerindian contribution to the white and mulatto populations.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0018-7143 1534-6617