Search Results - "BOMBARDIER, Eric"

Sarcolipin is a newly identified regulator of muscle-based thermogenesis in mammals by Bal, Naresh C, Maurya, Santosh K, Sopariwala, Danesh H, Sahoo, Sanjaya K, Gupta, Subash C, Shaikh, Sana A, Pant, Meghna, Rowland, Leslie A, Bombardier, Eric, Goonasekera, Sanjeewa A, Tupling, A Russell, Molkentin, Jeffery D, Periasamy, Muthu

“…Animals use their muscles to shiver to generate heat when exposed to the cold. But this is a short-term adaptation. Long term, it is believed the body relies…”
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ATP consumption by sarcoplasmic reticulum Ca²⁺ pumps accounts for 40-50% of resting metabolic rate in mouse fast and slow twitch skeletal muscle by Smith, Ian Curtis, Bombardier, Eric, Vigna, Chris, Tupling, A Russell

“…The main purpose of this study was to directly quantify the relative contribution of Ca²⁺ cycling to resting metabolic rate in mouse fast (extensor digitorum…”
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Co-expression of SERCA isoforms, phospholamban and sarcolipin in human skeletal muscle fibers by Fajardo, Val A, Bombardier, Eric, Vigna, Chris, Devji, Tahira, Bloemberg, Darin, Gamu, Daniel, Gramolini, Anthony O, Quadrilatero, Joe, Tupling, A Russell

“…Sarcolipin (SLN) and phospholamban (PLN) inhibit the activity of sarco(endo)plasmic reticulum Ca(2+)-ATPases (SERCAs) by reducing their apparent affinity for…”
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Effects of sarcolipin deletion on skeletal muscle adaptive responses to functional overload and unload by Fajardo, Val A, Rietze, Bradley A, Chambers, Paige J, Bellissimo, Catherine, Bombardier, Eric, Quadrilatero, Joe, Tupling, A Russell

“…Overexpression of sarcolipin (SLN), a regulator of sarco(endo)plasmic reticulum Ca -ATPases (SERCAs), stimulates calcineurin signaling to enhance skeletal…”
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Sarcolipin deletion exacerbates soleus muscle atrophy and weakness in phospholamban overexpressing mice by Fajardo, Val A, Gamu, Daniel, Mitchell, Andrew, Bloemberg, Darin, Bombardier, Eric, Chambers, Paige J, Bellissimo, Catherine, Quadrilatero, Joe, Tupling, A Russell

“…Sarcolipin (SLN) and phospholamban (PLN) are two small proteins that regulate the sarco(endo)plasmic reticulum Ca2+-ATPase pumps. In a recent study, we…”
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Agpat4/Lpaatδ deficiency highlights the molecular heterogeneity of epididymal and perirenal white adipose depots by Mardian, Emily B., Bradley, Ryan M., Aristizabal Henao, Juan J., Marvyn, Phillip M., Moes, Katherine A., Bombardier, Eric, Tupling, A. Russell, Stark, Ken D., Duncan, Robin E.

“…Acylglycerophosphate acyltransferase 4 (AGPAT4)/lysophosphatidic acid acyltransferase delta catalyzes the formation of phosphatidic acid (PA), a precursor of…”
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Prior Endurance Training Enhances Beta‐Adrenergic Signaling in Epidydimal Adipose from Mice Fed a High‐Fat Diet by Snook, Laelie A., Trottier, Sarah K., Worndl, Elizabeth A., Bombardier, Eric, Tupling, A. Russell, MacPherson, Rebecca E.K.

“…Objective Adipose tissue beta‐adrenergic signaling is attenuated in obesity and insulin resistance. It has been previously demonstrated that prior exercise…”
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Enhanced Ca2+ transport and muscle relaxation in skeletal muscle from sarcolipin-null mice by Tupling, A Russell, Bombardier, Eric, Gupta, Subash C, Hussain, Dawar, Vigna, Chris, Bloemberg, Darin, Quadrilatero, Joe, Trivieri, Maria G, Babu, Gopal J, Backx, Peter H, Periasamy, Muthu, MacLennan, David H, Gramolini, Anthony O

“…Sarcolipin (SLN) inhibits sarco(endo)plasmic reticulum Ca(2+)-ATPase (SERCA) pumps. To evaluate the physiological significance of SLN in skeletal muscle, we…”
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Phospholamban overexpression in mice causes a centronuclear myopathy-like phenotype by Fajardo, Val A, Bombardier, Eric, McMillan, Elliott, Tran, Khanh, Wadsworth, Brennan J, Gamu, Daniel, Hopf, Andrew, Vigna, Chris, Smith, Ian C, Bellissimo, Catherine, Michel, Robin N, Tarnopolsky, Mark A, Quadrilatero, Joe, Tupling, A Russell

“…Centronuclear myopathy (CNM) is a congenital myopathy that is histopathologically characterized by centrally located nuclei, central aggregation of oxidative…”
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Interaction between Hsp70 and the SR Ca2+ pump: a potential mechanism for cytoprotection in heart and skeletal muscle by Tupling, A Russell, Bombardier, Eric, Vigna, Chris, Quadrilatero, Joe, Fu, Minghua

“…The overexpression of heat shock protein 70 (Hsp70) provides cytoprotection to cells, making them resistant to otherwise lethal levels of stress. In this…”
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Ca²⁺ dysregulation in Ryr1I⁴⁸⁹⁵T/wt mice causes congenital myopathy with progressive formation of minicores, cores, and nemaline rods by Zvaritch, Elena, Kraeva, Natasha, Bombardier, Eric, McCloy, Robert A, Depreux, Frederic, Holmyard, Douglas, Kraev, Alexander, Seidman, Christine E, Seidman, J.G, Tupling, A. Russell, MacLennan, David H

“…Ryr1I⁴⁸⁹⁵T/wt (IT/+) mice express a knockin mutation corresponding to the human I4898T EC-uncoupling mutation in the type 1 ryanodine receptor/Ca²⁺ release…”
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Estrogen effect on post-exercise skeletal muscle neutrophil infiltration and calpain activity by Tiidus, P M, Holden, D, Bombardier, E, Zajchowski, S, Enns, D, Belcastro, A

“…We hypothesized that estrogen administration would attenuate skeletal muscle neutrophil infiltration, indices of muscle membrane disruption, and muscle calpain…”
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Phospholamban and sarcolipin prevent thermal inactivation of sarco(endo)plasmic reticulum Ca2+-ATPases by Fu, Minghua, Bombardier, Eric, Gamu, Daniel, Tupling, A Russell

“…Na+-K+-ATPase from mice lacking the γ subunit exhibits decreased thermal stability. Phospholamban (PLN) and sarcolipin (SLN) are small homologous proteins that…”
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Cellular assessment of muscle in COPD: case studies of two males by Green, Howard J, Bombardier, Eric, Burnett, Margaret E, D'Arsigny, Christine L, Iqbal, Sobia, Webb, Katherine A, Ouyang, Jing, O'Donnell, Denis E

“…The objective of this paper is to provide an overview of the recent developments in muscle physiology and biochemistry in general, and with respect to chronic…”
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The Loss of ARNT/HIF1β in Male Pancreatic β-Cells Is Protective Against High-Fat Diet-Induced Diabetes by Hoang, Monica, Paglialunga, Sabina, Bombardier, Eric, Tupling, A Russell, Joseph, Jamie W

“…The transcription factor aryl hydrocarbon receptor nuclear translocator (ARNT)/hypoxia-inducible factor (HIF)-1β (ARNT/HIF1β) plays a key role in maintaining…”
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The Loss of ARNT/HIF1[beta] in Male Pancreatic [beta]-Cells Is Protective Against High-Fat Diet-Induced Diabetes by Hoang, Monica, Paglialunga, Sabina, Bombardier, Eric, Tupling, A. Russell, Joseph, Jamie W

“…The transcription factor aryI hydrocarbon receptor nuclear translocator (ARNT)/hypoxia-inducible factor (HIF)-1 [beta] (ARNT/HIF1[beta]) plays a key role in…”
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Phospholamban deficiency does not alter skeletal muscle SERCA pumping efficiency or predispose mice to diet-induced obesity by Gamu, Daniel, Juracic, Emma Sara, Fajardo, Val A, Rietze, Bradley Alexander, Tran, Khanh, Bombardier, Eric, Tupling, A Russell

“…The sarco(endo)plasmic reticulum Ca -ATPase (SERCA) pump is a major contributor to skeletal muscle Ca homeostasis and metabolic rate. SERCA activity can become…”
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Quadriceps metabolism during constant workrate cycling exercise in chronic obstructive pulmonary disease by SAEY, Didier, LEMIRE, Bruno B, GAGNON, Philippe, BOMBARDIER, Eric, RUSSELL TUPLING, A, DEBIGARE, Richard, COTE, Claude H, MALTAIS, François

“…Impaired resting metabolism in peripheral muscles potentially contributes to exercise intolerance in chronic obstructive pulmonary disease (COPD). This study…”
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DJ-1 links muscle ROS production with metabolic reprogramming and systemic energy homeostasis in mice by Shi, Sally Yu, Lu, Shun-Yan, Sivasubramaniyam, Tharini, Revelo, Xavier S., Cai, Erica P., Luk, Cynthia T., Schroer, Stephanie A., Patel, Prital, Kim, Raymond H., Bombardier, Eric, Quadrilatero, Joe, Tupling, A. Russell, Mak, Tak W., Winer, Daniel A., Woo, Minna

“…Reactive oxygen species (ROS) have been linked to a wide variety of pathologies, including obesity and diabetes, but ROS also act as endogenous signalling…”
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Ablation of sarcolipin decreases the energy requirements for Ca2+ transport by sarco(endo)plasmic reticulum Ca2+-ATPases in resting skeletal muscle by Bombardier, Eric, Smith, Ian C., Vigna, Chris, Fajardo, Val A., Tupling, A. Russell

“…•SLN ablation reduces slippage and back-inhibition of SERCA pump activity.•SLN ablation increases the efficiency of SERCA pumps in vivo.•SLN ablation reduces…”
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