Search Results - "BOM, Anton"

Preclinical pharmacology of sugammadex by Bom, Anton, MD, PhD, Hope, Frank, BSc, Rutherford, Samantha, PhD, Thomson, Karen, BSc

“…Abstract Since the introduction of nondepolarizing neuromuscular blocking agents, acetylcholinesterase inhibitors have been used to increase the speed of…”
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Cyclodextrin-Derived Host Molecules as Reversal Agents for the Neuromuscular Blocker Rocuronium Bromide:  Synthesis and Structure−Activity Relationships by Adam, Julia M, Bennett, D. Jonathan, Bom, Anton, Clark, John K, Feilden, Helen, Hutchinson, Edward J, Palin, Ronald, Prosser, Alan, Rees, David C, Rosair, Georgina M, Stevenson, Donald, Tarver, Gary J, Zhang, Ming-Qiang

“…A series of mono- and per-6-substituted cyclodextrin derivatives were synthesized as synthetic receptors (or host molecules) of rocuronium bromide, the most…”
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Reversal of rocuronium-induced neuromuscular block by sugammadex is independent of renal perfusion in anesthetized cats by Staals, Lonneke M., de Boer, Hans D., van Egmond, Jan, Hope, Frank, van de Pol, Francien, Bom, Anton H., Driessen, Jacques J., Booij, Leo H. D. J.

“…Purpose Sugammadex is a selective relaxant binding agent designed to encapsulate the aminosteroidal neuromuscular blocking agent rocuronium, thereby reversing…”
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Sugammadex reverses neuromuscular block induced by 3-desacetyl-vecuronium, an active metabolite of vecuronium, in the anaesthetised rhesus monkey by Staals, Lonneke M, van Egmond, Jan, Driessen, Jacques J, de Boer, Hans D, van de Pol, Francien, Bom, Anton H, Booij, Leo HDJ

“…BACKGROUND AND OBJECTIVE3-Desacetyl-vecuronium is an active metabolite of the neuromuscular blocking agent (NMBA) vecuronium, which might lead to residual…”
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Reversal of Neuromusclar Blockade and Simultaneous Increase in Plasma Rocuronium Concentration after the Intravenous Infusion of the Novel Reversal Agent Org 25970 by Epemolu, Ola, Bom, Anton, Hope, Frank, Mason, Rona

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Reversal of neuromuscular blockade and simultaneous increase in plasma Rocuronium concentration after the intravenous infusion of the novel reversal agent Org 25969 by EPEMOLU, Ola, BOM, Anton, HOPE, Frank, MASON, Rona

“…The purpose of this study was to determine the changes in the plasma concentration of rocuronium and the reversal of its neuromuscular blockade after the…”
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A Novel Concept of Reversing Neuromuscular Block: Chemical Encapsulation of Rocuronium Bromide by a Cyclodextrin-Based Synthetic Host by Bom, Anton, Bradley, Mark, Cameron, Ken, Clark, John K., van Egmond, Jan, Feilden, Helen, MacLean, Elizabeth J., Muir, Alan W., Palin, Ronald, Rees, David C., Zhang, Ming-Qiang

“…Superior to current clinically used reversal agents in terms of efficacy and side effects: The formation of a high‐affinity host–guest binary complex…”
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A novel concept of reversing neuromuscular block: chemical encapsulation of rocuronium bromide by a cyclodextrin-based synthetic host by Bom, Anton, Bradley, Mark, Cameron, Ken, Clark, John K, Van Egmond, Jan, Feilden, Helen, MacLean, Elizabeth J, Muir, Alan W, Palin, Ronald, Rees, David C, Zhang, Ming-Qiang

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A Novel Concept of Reversing Neuromuscular Block: Chemical Encapsulation of Rocuronium Bromide by a Cyclodextrin-Based Synthetic Host by Bom, Anton, Bradley, Mark, Cameron, Ken, Clark, John K., van Egmond, Jan, Feilden, Helen, MacLean, Elizabeth J., Muir, Alan W., Palin, Ronald, Rees, David C., Zhang, Ming-Qiang

“…Stark wirksam bei geringen Nebenwirkungen: In der Anästhesie dienen Muskelrelaxantien zum Einstellen guter Intubationsbedingungen über eine tiefe…”
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Selective relaxant binding agents for reversal of neuromuscular blockade by Bom, Anton, Epemolu, Ola, Hope, Frank, Rutherford, Samantha, Thomson, Karen

“…Traditionally, reversal of neuromuscular blockade during anaesthesia was achieved by increasing the acetylcholine concentration in the neuromuscular junction…”
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Reversal of profound rocuronium neuromuscular blockade by sugammadex in anesthetized rhesus monkeys by DE BOER, Hans D, VAN EGMOND, Jan, VAN DE POL, Francien, BOM, Anton, BOOIJ, Leo H. D. J

“…Reversal of neuromuscular blockade can be accomplished by chemical encapsulation of rocuronium by sugammadex, a synthetic gamma-cyclodextrin derivative. The…”
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Org 25969 Causes Rapid Reversal of Rocuronium-Induced Neuromuscular Block, Independent of Acid-Base Status: 2002[A-1009 by Bom, Anton H., Mason, Rona, McIndewar, Ian

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Synthesis and evaluation of N-3 substituted phenoxypropyl piperidine benzimidazol-2-one analogues as NOP receptor agonists with analgesic and sedative properties by Palin, Ronald, Bom, Anton, Clark, John K., Evans, Louise, Feilden, Helen, Houghton, Andrea K., Jones, Philip S., Montgomery, Brian, Weston, Mark A., Wishart, Grant

“…A series of N-3 substituted phenoxypropyl piperidine benzimidazol-2-one analogues were prepared and evaluated as NOP agonists. The selective NOP agonist (+)-…”
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Effects of 5-hydroxytryptamine on capillary and arteriovenous anastomotic blood flow in the human hand and forearm and in the pig hind leg by Blauw, G, Bom, A H, van Brummelen, P, Camps, J, Arndt, J W, Verdouw, P D, Chang, P C, van Zwieten, P A, Saxena, P R

“…The effects of intraarterially infused serotonin (5-HT) on capillary and arteriovenous anastomotic (AVA) blood flow were investigated in the hand and forearm…”
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2- O-Substituted Cyclodextrins as Reversal Agents for the Neuromuscular Blocker Rocuronium Bromide by Tarver, Gary J, Grove, Simon J.A, Buchanan, Kirsteen, Bom, Anton, Cooke, Andrew, Rutherford, Samantha J, Zhang, Ming-Qiang

“…A series of secondary face modified cyclodextrins (CDs) were synthesised with the aim of constructing host molecules capable of forming host–guest complexes…”
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Parallel solid-phase synthesis of zatebradine analogues as potential If channel blockers by BOM, Anton, BOOTH, Susan, BRUIN, John, CLARK, John, MILLER, Susan, WATHEY, Bernard

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Parallel solid-Phase synthesis of zatebradine analogues as potential I f channel blockers by Bom, Anton, Booth, Susan, Bruin, John, Clark, John, Miller, Susan, Wathey, Bernard

“…The first solid-phase synthesis of zatebradine 1 and its analogues is reported. This has resulted in the preparation of compounds with increased ability to…”
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A Novel Concept of Reversing Neuromuscular Block: Chemical Encapsulation of Rocuronium Bromide by a Cyclodextrin-Based Synthetic Host The discovery of Org 25969 is the result of teamwork with contributions from a number of scientists both inside Organon and outside the company. We would like in particular to acknowledge the following scientists for their invaluable contributions: E. Hutchinson, D. Stevenson, R. Roy, and J. Pick for scaling-up the synthesis; F. Hope, S. Miller, and R. Mason for v by Bom, Anton, Bradley, Mark, Cameron, Ken, Clark, John K., van Egmond, Jan, Feilden, Helen, MacLean, Elizabeth J., Muir, Alan W., Palin, Ronald, Rees, David C., Zhang, Ming-Qiang

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Carotid haemodynamics in pigs during infusions of 8‐O‐DPAT: reduction in arteriovenous shunting is mediated by 5‐HT1‐like receptors by Bom, Anton H., Verdouw, Pieter D., Saxena, Pramod R.

“…1 The effects of intracarotid infusions of 8‐hydroxy‐2‐[di‐n‐propyl‐amino]‐tetralin (8‐OH‐DPAT) on heart rate, blood pressure and carotid blood flow and its…”
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Carotid haemodynamics in pigs during infusions of 8‐O‐DPAT: reduction in arteriovenous shunting is mediated by 5‐HT 1 ‐like receptors by Bom, Anton H., Verdouw, Pieter D., Saxena, Pramod R.

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