Gene therapy progress and prospects: therapeutic angiogenesis for ischemic cardiovascular disease

During the past decade, both in vitro and in vivo studies have provided new insights into the cellular and molecular mechanisms that govern angiogenesis and arteriogenesis. However, therapeutic angiogenesis clinical trials using recombinant protein or gene therapy formulations of single angiogenic g...

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Bibliographic Details
Published in:	Gene therapy Vol. 14; no. 10; pp. 781 - 789
Main Authors:	VINCENT, K. A, JIANG, C, BOLTJE, I, KELLY, R. A
Format:	Journal Article
Language:	English
Published:	Basingstoke Nature Publishing Group 01-05-2007
Subjects:	Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Angiogenesis Applied cell therapy and gene therapy Biological and medical sciences Biotechnology Cardiovascular diseases Care and treatment Cell differentiation, maturation, development, hematopoiesis Cell physiology Clinical trials Coronary artery disease Cytokines Cytokines - genetics Fundamental and applied biological sciences. Psychology Gene therapy Gene Transfer Techniques Genetic aspects Genetic Therapy - methods Genetic Therapy - trends Growth factors Health aspects Health. Pharmaceutical industry Heart diseases Humans Industrial applications and implications. Economical aspects Ischemia Medical sciences Methods Molecular and cellular biology Molecular modelling Myocardial Ischemia - physiopathology Myocardial Ischemia - therapy Neovascularization Neovascularization, Physiologic Peripheral Vascular Diseases - physiopathology Peripheral Vascular Diseases - therapy Physiological aspects Transcription Transcription Factors - genetics Transfusions. Complications. Transfusion reactions. Cell and gene therapy Transgenes Vascular diseases United States Angiogenesis Vascular endothelium growth factor Ischemia transcription factors VEGF Cardiovascular disease Inflammation HIF-1α Transcription factor Gene therapy arteriogenesis
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Summary:	During the past decade, both in vitro and in vivo studies have provided new insights into the cellular and molecular mechanisms that govern angiogenesis and arteriogenesis. However, therapeutic angiogenesis clinical trials using recombinant protein or gene therapy formulations of single angiogenic growth factors have yielded at best only modest success to date. Among the second generation of angiogenic agents are therapeutic transgenes that enhance expression of two or more proangiogenic cytokines. These include synthetic constructs that mimic that activity of endogenous transcriptional regulators and other upstream, regulatory factors that have the potential to induce formation of morphologically and physiologically functional vessels. These agents are now beginning to be evaluated in clinical trials for patients with advanced ischemic cardiac and peripheral vascular disease.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-3 ObjectType-Review-1
ISSN:	0969-7128 1476-5462
DOI:	10.1038/sj.gt.3302953