Search Results - "BOLON, Brad"

Cellular and Molecular Mechanisms of Autoimmune Disease by Bolon, Brad

“…Autoimmune disease (AIDx) results from failure to sustain tolerance to self molecules. Dozens of AIDx involving one or multiple organ systems afflict 3% or…”
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Mini-Review: Toxic Tendinopathy by Bolon, Brad

“…Toxic tendinopathy is a rare but reproducible complication in humans, given agents of four drug classes: aromatase inhibitors, fluoroquinolone antibiotics,…”
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MICU1 regulation of mitochondrial Ca2+ uptake dictates survival and tissue regeneration by Antony, Anil Noronha, Paillard, Melanie, Moffat, Cynthia, Juskeviciute, Egle, Correnti, Jason, Bolon, Brad, Rubin, Emanuel, Csordás, György, Seifert, Erin L., Hoek, Jan B., Hajnóczky, György

“…Mitochondrial Ca 2+ uptake through the recently discovered Mitochondrial Calcium Uniporter (MCU) is controlled by its gatekeeper Mitochondrial Calcium Uptake 1…”
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The Gold Standard Paradox in Digital Image Analysis: Manual Versus Automated Scoring as Ground Truth by Aeffner, Famke, Wilson, Kristin, Martin, Nathan T, Black, Joshua C, Hendriks, Cris L Luengo, Bolon, Brad, Rudmann, Daniel G, Gianani, Roberto, Koegler, Sally R, Krueger, Joseph, Young, G Dave

“…- Novel therapeutics often target complex cellular mechanisms. Increasingly, quantitative methods like digital tissue image analysis (tIA) are required to…”
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Histology Atlas of the Developing Mouse Placenta by Elmore, Susan A., Cochran, Robert Z., Bolon, Brad, Lubeck, Beth, Mahler, Beth, Sabio, David, Ward, Jerrold M.

“…The use of the mouse as a model organism is common in translational research. This mouse–human similarity holds true for placental development as well. Proper…”
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Engineering a 3D functional human peripheral nerve in vitro using the Nerve-on-a-Chip platform by Sharma, Anup D., McCoy, Laurie, Jacobs, Elizabeth, Willey, Hannah, Behn, Jordan Q., Nguyen, Hieu, Bolon, Brad, Curley, J. Lowry, Moore, Michael J.

“…Development of “organ-on-a-chip” systems for neuroscience applications are lagging due in part to the structural complexity of the nervous system and limited…”
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MiR-494 is regulated by ERK1/2 and modulates TRAIL-induced apoptosis in non–small-cell lung cancer through BIM down-regulation by Romano, Giulia, Acunzo, Mario, Garofalo, Michela, Di Leva, Gianpiero, Cascione, Luciano, Zanca, Ciro, Bolon, Brad, Condorelli, Gerolama, Croce, Carlo M

“…MicroRNAs (miRNAs) have an important role in the development of chemosensitivity or chemoresistance in different types of cancer. Activation of the ERK1/2…”
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Targeting FGFR4 inhibits hepatocellular carcinoma in preclinical mouse models by French, Dorothy M, Lin, Benjamin C, Wang, Manping, Adams, Camellia, Shek, Theresa, Hötzel, Kathy, Bolon, Brad, Ferrando, Ronald, Blackmore, Craig, Schroeder, Kurt, Rodriguez, Luis A, Hristopoulos, Maria, Venook, Rayna, Ashkenazi, Avi, Desnoyers, Luc R

“…The fibroblast growth factor (FGF)-FGF receptor (FGFR) signaling system plays critical roles in a variety of normal developmental and physiological processes…”
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Distribution and Systemic Effects of Intranasally Administered 25 nm Silver Nanoparticles in Adult Mice by Genter, Mary Beth, Newman, Nicholas C., Shertzer, Howard G., Ali, Syed F., Bolon, Brad

“…Previous work indicates that silver nanoparticles (AgNPs) given IP to mice alter the regulation of inflammation- and oxidative stress–related genes in brain…”
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Estrogen mediated-activation of miR-191/425 cluster modulates tumorigenicity of breast cancer cells depending on estrogen receptor status by Di Leva, Gianpiero, Piovan, Claudia, Gasparini, Pierluigi, Ngankeu, Apollinaire, Taccioli, Cristian, Briskin, Daniel, Cheung, Douglas G, Bolon, Brad, Anderlucci, Laura, Alder, Hansjuerg, Nuovo, Gerard, Li, Meng, Iorio, Marilena V, Galasso, Marco, Santhanam, Ramasamy, Ramasamy, Santhanam, Marcucci, Guido, Perrotti, Danilo, Powell, Kimerly A, Bratasz, Anna, Garofalo, Michela, Nephew, Kenneth P, Croce, Carlo M

“…MicroRNAs (miRNAs), single-stranded non-coding RNAs, influence myriad biological processes that can contribute to cancer. Although tumor-suppressive and…”
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A conditional mouse model of complex II deficiency manifesting as Leigh‐like syndrome by Khazal, Fatimah Al, Holte, Molly Nelson, Bolon, Brad, White, Thomas A., LeBrasseur, Nathan, III, L. James Maher

“…Leigh syndrome embodies degenerative disorders with a collection of symptoms secondary to inborn errors of metabolism. Combinations of hypomorphic and…”
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Atlas of Normal Microanatomy, Procedural and Processing Artifacts, Common Background Findings, and Neurotoxic Lesions in the Peripheral Nervous System of Laboratory Animals by Pardo, Ingrid D., Weber, Klaus, Cramer, Sarah, Krinke, Georg J., Butt, Mark T., Sharma, Alok K., Bolon, Brad

“…The ability to differentiate among normal structures, procedural and processing artifacts, spontaneous background changes, and test article–related effects in…”
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MAP3K1 regulates female reproductive tract development by Kimura, Eiki, Mongan, Maureen, Xiao, Bo, Christianto, Antonius, Wang, Jingjing, Carreira, Vinicius S, Bolon, Brad, Zhang, Xiang, Burns, Katherine A, Biesiada, Jacek, Medvedovic, Mario, Puga, Alvaro, Xia, Ying

“…Mitogen-activated protein 3 kinase 1 (MAP3K1) has a plethora of cell type-specific functions not yet fully understood. Herein, we describe a role for MAP3K1 in…”
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Therapeutic potential of the translation inhibitor silvestrol in hepatocellular cancer by Kogure, Takayuki, Kinghorn, A Douglas, Yan, Irene, Bolon, Brad, Lucas, David M, Grever, Michael R, Patel, Tushar

“…Although hepatocellular cancers (HCC) frequently arise in the setting of fibrosis and a hepatic regenerative response requiring new cell growth, therapeutic…”
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Haschek and Rousseaux's Handbook of Toxicologic Pathology: Volume 1: Principles and Practice of Toxicologic Pathology by Haschek, Wanda M, Rousseaux, Colin G, Wallig, Matthew A, Bolon, Brad

“…Haschek and Rousseaux's Handbook of Toxicologic Pathology: Volume 1: Principles and Practice of Toxicologic Pathology is a key reference on the integration of…”
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Perinatal inflammation results in decreased oligodendrocyte numbers in adulthood by Graf, Amanda E., Haines, Krista M., Pierson, Christopher R., Bolon, Brad N., Houston, Ronald H., Velten, Markus, Heyob, Kathryn M., Rogers, Lynette K.

“…Maternal inflammation is a risk factor for preterm birth, and premature infants are often exposed to supplemental oxygen as a life-sustaining therapy. While…”
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Immune cell populations differ in patients undergoing revision total knee arthroplasty for arthrofibrosis by Limberg, Afton K., Salib, Christopher G., Tibbo, Meagan E., Vargas-Hernandez, Juan S., Bettencourt, Jacob W., Bayram, Banu, Berry, Charlotte E., Dudakovic, Amel, Bolon, Brad, van Wijnen, Andre J., Morrey, Mark E., Sanchez-Sotelo, Joaquin, Berry, Daniel J., Carter, Jodi M., Abdel, Matthew P.

“…Arthrofibrosis following total knee arthroplasty (TKA) is a debilitating condition typically diagnosed based on clinical findings. To gain insight into the…”
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SPARC promotes leukemic cell growth and predicts acute myeloid leukemia outcome by Alachkar, Houda, Santhanam, Ramasamy, Maharry, Kati, Metzeler, Klaus H, Huang, Xiaomeng, Kohlschmidt, Jessica, Mendler, Jason H, Benito, Juliana M, Hickey, Christopher, Neviani, Paolo, Dorrance, Adrienne M, Anghelina, Mirela, Khalife, Jihane, Tarighat, Somayeh S, Volinia, Stefano, Whitman, Susan P, Paschka, Peter, Hoellerbauer, Pia, Wu, Yue-Zhong, Han, Lina, Bolon, Brad N, Blum, William, Mrózek, Krzysztof, Carroll, Andrew J, Perrotti, Danilo, Andreeff, Michael, Caligiuri, Michael A, Konopleva, Marina, Garzon, Ramiro, Bloomfield, Clara D, Marcucci, Guido

“…Aberrant expression of the secreted protein, acidic, cysteine-rich (osteonectin) (SPARC) gene, which encodes a matricellular protein that participates in…”
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Context-dependent role of angiopoietin-1 inhibition in the suppression of angiogenesis and tumor growth: implications for AMG 386, an angiopoietin-1/2-neutralizing peptibody by Coxon, Angela, Bready, James, Min, Hosung, Kaufman, Stephen, Leal, Juan, Yu, Dongyin, Lee, Tani Ann, Sun, Ji-Rong, Estrada, Juan, Bolon, Brad, McCabe, James, Wang, Ling, Rex, Karen, Caenepeel, Sean, Hughes, Paul, Cordover, David, Kim, Haejin, Han, Seog Joon, Michaels, Mark L, Hsu, Eric, Shimamoto, Grant, Cattley, Russell, Hurh, Eunju, Nguyen, Linh, Wang, Shao Xiong, Ndifor, Anthony, Hayward, Isaac J, Falcón, Beverly L, McDonald, Donald M, Li, Luke, Boone, Tom, Kendall, Richard, Radinsky, Robert, Oliner, Jonathan D

“…AMG 386 is an investigational first-in-class peptide-Fc fusion protein (peptibody) that inhibits angiogenesis by preventing the interaction of angiopoietin-1…”
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Effect of cell seeding on neotissue formation in a tissue engineered trachea by Clark, Elizabeth S, Best, Cameron, Onwuka, Ekene, Sugiura, Tadahisa, Mahler, Nathan, Bolon, Brad, Niehaus, Andrew, James, Iyore, Hibino, Narutoshi, Shinoka, Toshiharu, Johnson, Jed, Breuer, Christopher K

“…Abstract Background Surgical management of long segment tracheal disease is limited by a paucity of donor tissue and poor performance of synthetic materials. A…”
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