Search Results - "BOISSONNAS, Alexandre"

Ontogeny of Tumor-Associated Macrophages by Laviron, Marie, Boissonnas, Alexandre

“…Tumor-associated macrophages (TAM) represent the main immune cell population of the tumor microenvironment in most cancer. For decades, TAM have been the focus…”
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Modulating the tumor-associated macrophage landscape by Boissonnas, Alexandre, Combadière, Christophe

“…Targeting the post-translational modification enzyme QPCTL prevents the protection of CCL2 and CCL7 from N-terminal degradation, inactivates their chemotactic…”
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Impaired Kupffer Cell Self-Renewal Alters the Liver Response to Lipid Overload during Non-alcoholic Steatohepatitis by Tran, Sophie, Baba, Ines, Poupel, Lucie, Dussaud, Sébastien, Moreau, Martine, Gélineau, Adélaïde, Marcelin, Geneviève, Magréau-Davy, Elissa, Ouhachi, Melissa, Lesnik, Philippe, Boissonnas, Alexandre, Le Goff, Wilfried, Clausen, Björn E., Yvan-Charvet, Laurent, Sennlaub, Florian, Huby, Thierry, Gautier, Emmanuel L.

“…Kupffer cells (KCs) are liver-resident macrophages that self-renew by proliferation in the adult independently from monocytes. However, how they are maintained…”
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Role of chemokines and chemokine receptors in shaping the effector phase of the antitumor immune response by Franciszkiewicz, Katarzyna, Boissonnas, Alexandre, Boutet, Marie, Combadière, Christophe, Mami-Chouaib, Fathia

“…Immune system-mediated eradication of neoplastic cells requires induction of a strong long-lasting antitumor T-cell response. However, generation of…”
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Macrophages of distinct origins contribute to tumor development in the lung by Loyher, Pierre-Louis, Hamon, Pauline, Laviron, Marie, Meghraoui-Kheddar, Aïda, Goncalves, Elena, Deng, Zihou, Torstensson, Sara, Bercovici, Nadège, Baudesson de Chanville, Camille, Combadière, Béhazine, Geissmann, Frederic, Savina, Ariel, Combadière, Christophe, Boissonnas, Alexandre

“…Tissue-resident macrophages can self-maintain without contribution of adult hematopoiesis. Herein we show that tissue-resident interstitial macrophages…”
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CSF1R inhibition prevents radiation pulmonary fibrosis by depletion of interstitial macrophages by Meziani, Lydia, Mondini, Michele, Petit, Benoît, Boissonnas, Alexandre, Thomas de Montpreville, Vincent, Mercier, Olaf, Vozenin, Marie-Catherine, Deutsch, Eric

“…Radiation-induced lung fibrosis (RIF) is a delayed side-effect of chest radiotherapy, frequently associated with macrophage infiltration.We aimed to…”
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Critical Role for Skin-Derived Migratory DCs and Langerhans Cells in TFH and GC Responses after Intradermal Immunization by Levin, Clément, Bonduelle, Olivia, Nuttens, Charles, Primard, Charlotte, Verrier, Bernard, Boissonnas, Alexandre, Combadière, Béhazine

“…Intradermal delivery of antigen represents a potent route of immunization that involves multiple blood- and skin-derived dendritic cell subpopulations endowed…”
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Immune surveillance of the lung by migrating tissue monocytes by Rodero, Mathieu P, Poupel, Lucie, Loyher, Pierre-Louis, Hamon, Pauline, Licata, Fabrice, Pessel, Charlotte, Hume, David A, Combadière, Christophe, Boissonnas, Alexandre

“…Monocytes are phagocytic effector cells in the blood and precursors of resident and inflammatory tissue macrophages. The aim of the current study was to…”
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Tracking Monocytes and Macrophages in Tumors With Live Imaging by Laviron, Marie, Combadière, Christophe, Boissonnas, Alexandre

“…In most cancers, myeloid cells represent the major component of the immune microenvironment. Deciphering the impact of these cells on tumor growth and in…”
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Revising CX3CR1 Expression on Murine Classical and Non-classical Monocytes by Meghraoui-Kheddar, Aïda, Barthelemy, Sandrine, Boissonnas, Alexandre, Combadière, Christophe

“…In mice, monocytes (Mo) are conventionally described as CX3CR1 classical Mo (CMo) and CX3CR1 non-classical Mo (NCMo) based on the expression of EGFP in Cx3cr1…”
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Ibrutinib induces multiple functional defects in the neutrophil response against Aspergillus fumigatus by Blez, Damien, Blaize, Marion, Soussain, Carole, Boissonnas, Alexandre, Meghraoui-Kheddar, Aïda, Menezes, Natacha, Portalier, Anaïs, Combadière, Christophe, Leblond, Véronique, Ghez, David, Fekkar, Arnaud

“…The Bruton tyrosine kinase inhibitor ibrutinib has become a leading therapy against chronic lymphoid leukemia. Recently, ibrutinib has been associated with the…”
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Tumor-associated macrophage heterogeneity is driven by tissue territories in breast cancer by Laviron, Marie, Petit, Maxime, Weber-Delacroix, Eléonore, Combes, Alexis J., Arkal, Arjun Rao, Barthélémy, Sandrine, Courau, Tristan, Hume, David A., Combadière, Christophe, Krummel, Matthew F., Boissonnas, Alexandre

“…Tissue-resident macrophages adapt to local signals within tissues to acquire specific functions. Neoplasia transforms the tissue, raising the question as to…”
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Loss of embryonically-derived Kupffer cells during hypercholesterolemia accelerates atherosclerosis development by Fima, Rebecca, Dussaud, Sébastien, Benbida, Cheïma, Blanchet, Margault, Lanthiez, François, Poupel, Lucie, Brambilla, Claudia, Gélineau, Adélaïde, Dessena, Mattia, Blanc, Marina, Lerévérend, Cédric, Moreau, Martine, Boissonnas, Alexandre, Gautier, Emmanuel L., Huby, Thierry

“…Hypercholesterolemia is a major risk factor for atherosclerosis and associated cardiovascular diseases. The liver plays a key role in the regulation of plasma…”
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TREM-1 orchestrates angiotensin II-induced monocyte trafficking and promotes experimental abdominal aortic aneurysm by Vandestienne, Marie, Zhang, Yujiao, Santos-Zas, Icia, Al-Rifai, Rida, Joffre, Jeremie, Giraud, Andreas, Laurans, Ludivine, Esposito, Bruno, Pinet, Florence, Bruneval, Patrick, Raffort, Juliette, Lareyre, Fabien, Vilar, Jose, Boufenzer, Amir, Guyonnet, Lea, Guerin, Coralie, Clauser, Eric, Silvestre, Jean-Sébastien, Lang, Sylvie, Soulat-Dufour, Laurie, Tedgui, Alain, Mallat, Ziad, Taleb, Soraya, Boissonnas, Alexandre, Derive, Marc, Chinetti, Giulia, Ait-Oufella, Hafid

“…The triggering receptor expressed on myeloid cells 1 (TREM-1) drives inflammatory responses in several cardiovascular diseases but its role in abdominal aortic…”
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Imaging resident and recruited macrophage contribution to Wallerian degeneration by Boissonnas, Alexandre, Louboutin, Floriane, Laviron, Marie, Loyher, Pierre-Louis, Reboussin, Elodie, Barthelemy, Sandrine, Réaux-Le Goazigo, Annabelle, Lobsiger, Christian S, Combadière, Béhazine, Mélik Parsadaniantz, Stéphane, Combadière, Christophe

“…Wallerian degeneration (WD) is a process of autonomous distal degeneration of axons upon injury. Macrophages (MPs) of the peripheral nervous system (PNS) are…”
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Unveiling Cerebral Leishmaniasis: parasites and brain inflammation in Leishmania donovani infected mice by Melo, Guilherme D., Goyard, Sophie, Fiette, Laurence, Boissonnas, Alexandre, Combadiere, Christophe, Machado, Gisele F., Minoprio, Paola, Lang, Thierry

“…Visceral leishmaniasis (VL) is a systemic disease with multifaceted clinical manifestations, including neurological signs, however, the involvement of the…”
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Profiling the lymphoid-resident T cell pool reveals modulation by age and microbiota by Durand, Aurélie, Audemard-Verger, Alexandra, Guichard, Vincent, Mattiuz, Raphaël, Delpoux, Arnaud, Hamon, Pauline, Bonilla, Nelly, Rivière, Matthieu, Delon, Jérôme, Martin, Bruno, Auffray, Cédric, Boissonnas, Alexandre, Lucas, Bruno

“…Despite being implicated in non-lymphoid tissues, non-recirculating T cells may also exist in secondary lymphoid organs (SLO). However, a detailed…”
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Alternative splicing of Hepatitis B virus: a novel virus/host interaction altering liver immunity by Duriez, Marion, Mandouri, Yassmina, Lekbaby, Bouchra, Wang, Hualin, Schnuriger, Aurélie, Redelsperger, Francois, Guerrera, Chiara, Lefevre, Marine, Fauveau, Veronique, Ahodantin, James, Quetier, Ivan, Chhuon, Cerina, Gourari, Samir, Boissonas, Alexandre, Gill, Upkar, Kennedy, Patrick, Debzi, Nabil, Sitterlin, Delphine, Maini, Mala K, Kremsdorf, Dina, Soussan, Patrick

“…Graphical abstract…”
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Pharmacological Inhibition of the Chemokine Receptor, CX3CR1, Reduces Atherosclerosis in Mice by Poupel, Lucie, Boissonnas, Alexandre, Hermand, Patricia, Dorgham, Karim, Guyon, Elodie, Auvynet, Constance, Charles, Flora Saint, Lesnik, Philippe, Deterre, Philippe, Combadiere, Christophe

“…OBJECTIVE—Alterations of the chemokine receptor CX3CR1 gene were associated with a reduced risk of myocardial infarction in human and limited atherosclerosis…”
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CX3CR1 deficiency promotes muscle repair and regeneration by enhancing macrophage ApoE production by Arnold, Ludovic, Perrin, Hélène, de Chanville, Camille Baudesson, Saclier, Marielle, Hermand, Patricia, Poupel, Lucie, Guyon, Elodie, Licata, Fabrice, Carpentier, Wassila, Vilar, José, Mounier, Rémi, Chazaud, Bénédicte, Benhabiles, Nora, Boissonnas, Alexandre, Combadiere, Béhazine, Combadiere, Christophe

“…Muscle injury triggers inflammation in which infiltrating mononuclear phagocytes are crucial for tissue regeneration. The interaction of the CCL2/CCR2 and…”
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