Search Results - "BOHRER, R"

Macrophages promote fibroblast growth factor receptor-driven tumor cell migration and invasion in a CXCR2-dependent manner by Bohrer, Laura R, Schwertfeger, Kathryn L

“…Infiltration of immune cells, specifically macrophages, into the tumor microenvironment has been linked to increased mammary tumor formation and progression…”
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Androgens Suppress EZH2 Expression Via Retinoblastoma (RB) and p130-Dependent Pathways: A Potential Mechanism of Androgen-Refractory Progression of Prostate Cancer by Bohrer, Laura R, Chen, Shuai, Hallstrom, Timothy C, Huang, Haojie

“…Androgens and the androgen receptor are important for both normal prostate development and progression of prostate cancer (PCa). However, the underlying…”
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Automating iPSC generation to enable autologous photoreceptor cell replacement therapy by Bohrer, Laura R, Stone, Nicholas E, Mullin, Nathaniel K, Voigt, Andrew P, Anfinson, Kristin R, Fick, Jessica L, Luangphakdy, Viviane, Hittle, Bradley, Powell, Kimerly, Muschler, George F, Mullins, Robert F, Stone, Edwin M, Tucker, Budd A

“…Inherited retinal degeneration is a leading cause of incurable vision loss in the developed world. While autologous iPSC mediated photoreceptor cell…”
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Biocompatibility of Human Induced Pluripotent Stem Cell–Derived Retinal Progenitor Cell Grafts in Immunocompromised Rats by Han, Ian C., Bohrer, Laura R., Gibson-Corley, Katherine N., Wiley, Luke A., Shrestha, Arwin, Harman, Brynnon E., Jiao, Chunhua, Sohn, Elliott H., Wendland, Rion, Allen, Brittany N., Worthington, Kristan S., Mullins, Robert F., Stone, Edwin M., Tucker, Budd A.

“…Loss of photoreceptor cells is a primary feature of inherited retinal degenerative disorders including age-related macular degeneration and retinitis…”
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Feeder-free differentiation of cells exhibiting characteristics of corneal endothelium from human induced pluripotent stem cells by Wagoner, Michael D, Bohrer, Laura R, Aldrich, Benjamin T, Greiner, Mark A, Mullins, Robert F, Worthington, Kristan S, Tucker, Budd A, Wiley, Luke A

“…The purpose of this study was to devise a strategy for the derivation of corneal endothelial cells (CEnCs) from adult fibroblast-derived induced pluripotent…”
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Natriuretic peptide system regulation in granulosa cells during follicle deviation and ovulation in cattle by De Cesaro, MP, Santos, JT, Ferst, JG, Nóbrega, JE, Rosa, PRA, Rovani, MT, Ilha, GF, Bohrer, RC, Ferreira, R, Gasperin, BG, Bordignon, V, Gonçalves, PBD

“…Contents Natriuretic peptides (NPs) are known to regulate reproductive events in polyovulatory species, but their function and regulation in monovulatory…”
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Prolactin and growth hormone immunoactivity in canine mammary adenomas and adenocarcinomas by Bohrer, ER, Löhr, CV, Kutzler, MA

“…Contents It is now widely accepted in human medicine that prolactin (PRL) and growth hormone (GH) function in the mammary gland in an autocrine and paracrine…”
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LSD1 promotes S-phase entry and tumorigenesis via chromatin co-occupation with E2F1 and selective H3K9 demethylation by He, Y, Zhao, Y, Wang, L, Bohrer, L R, Pan, Y, Wang, L, Huang, H

“…Histone H3 lysine-9 (H3K9) methylation is essential for retinoblastoma protein (RB)-mediated heterochromatin formation, epigenetic silencing of S-phase genes…”
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Grb14 mRNA Levels During Follicular Deviation in Cattle are Higher in Granulosa Cells of Subordinate Compared to Dominant Follicles by Bohrer, RC, Rosa, PRA, Ferreira, R, Bordignon, V, Oliveira, JFC, Gonçalves, PBD

“…Contents The growth factor receptor‐bound protein 14 (Grb14) is a cellular adapter protein belonging to the Grb7 family of proteins. Studies with human and…”
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Cyclin-dependent kinases regulate epigenetic gene silencing through phosphorylation of EZH2 by Chen, Shuai, Simon, Jeffrey A, Bohrer, Laura R, Pan, Yunqian, Rai, Aswathy N, Huang, Haojie, Bagchi, Anindya, Zhou, Xianzheng, Gan, Lu

“…The Polycomb group (PcG) protein, enhancer of zeste homologue 2 (EZH2), has an essential role in promoting histone H3 lysine 27 trimethylation (H3K27me3) and…”
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CGMP Compliant Microfluidic Transfection of Induced Pluripotent Stem Cells for CRISPR-Mediated Genome Editing by Bohrer, Laura R, Stone, Nicholas E, Wright, Allison T, Han, Sewoon, Sicher, Ian, Sulchek, Todd A, Mullins, Robert F, Tucker, Budd A

“…Abstract Inherited retinal degeneration is a term used to describe heritable disorders that result from the death of light sensing photoreceptor cells…”
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Demonstration of the pathogenicity of a common non-exomic mutation in ABCA4 using iPSC-derived retinal organoids and retrospective clinical data by Burnight, Erin R, Fenner, Beau J, Han, Ian C, DeLuca, Adam P, Whitmore, S Scott, Bohrer, Laura R, Andorf, Jeaneen L, Sohn, Elliott H, Mullins, Robert F, Tucker, Budd A, Stone, Edwin M

“…Abstract Mutations in ABCA4 are the most common cause of Mendelian retinal disease. Clinical evaluation of this gene is challenging because of its extreme…”
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CRISPR-Cas9 genome engineering: Treating inherited retinal degeneration by Burnight, Erin R., Giacalone, Joseph C., Cooke, Jessica A., Thompson, Jessica R., Bohrer, Laura R., Chirco, Kathleen R., Drack, Arlene V., Fingert, John H., Worthington, Kristan S., Wiley, Luke A., Mullins, Robert F., Stone, Edwin M., Tucker, Budd A.

“…Gene correction is a valuable strategy for treating inherited retinal degenerative diseases, a major cause of irreversible blindness worldwide. Single gene…”
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NR2E3 loss disrupts photoreceptor cell maturation and fate in human organoid models of retinal development by Mullin, Nathaniel K, Bohrer, Laura R, Voigt, Andrew P, Lozano, Lola P, Wright, Allison T, Bonilha, Vera L, Mullins, Robert F, Stone, Edwin M, Tucker, Budd A

“…While dysfunction and death of light-detecting photoreceptor cells underlie most inherited retinal dystrophies, knowledge of the species-specific details of…”
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p300 Acetyltransferase Regulates Androgen Receptor Degradation and PTEN-Deficient Prostate Tumorigenesis by JIAN ZHONG, LIYA DING, HAOJIE HUANG, BOHRER, Laura R, YUNQIAN PAN, PING LIU, JUN ZHANG, SEBO, Thomas J, KARNES, R. Jeffrey, TINDALL, Donald J, VAN DEURSEN, Jan

“…Overexpression of the histone acetyltransferase p300 is implicated in the proliferation and progression of prostate cancer, but evidence of a causal role is…”
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Patient derived stem cells for discovery and validation of novel pathogenic variants in inherited retinal disease by Mullin, Nathaniel K., Voigt, Andrew P., Cooke, Jessica A., Bohrer, Laura R., Burnight, Erin R., Stone, Edwin M., Mullins, Robert F., Tucker, Budd A.

“…Our understanding of inherited retinal disease has benefited immensely from molecular genetic analysis over the past several decades. New technologies that…”
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fCO2 variability at the CARIACO tropical coastal upwelling time series station by ASTOR, Y. M, SCRANTON, M. I, MULLER-KARGER, F, BOHRER, R, GARCIA, J

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Activation of the FGFR―STAT3 Pathway in Breast Cancer Cells Induces a Hyaluronan-Rich Microenvironment That Licenses Tumor Formation by BOHRER, Laura R, CHUNTOVA, Pavlina, MCCARTHY, James B, SCHWERTFEGER, Kathryn L, BADE, Lindsey K, BEADNELL, Thomas C, LEON, Ronald P, BRADY, Nicholas J, YUNGIL RYU, GOLDBERG, Jodi E, SCHMECHEL, Stephen C, KOOPMEINERS, Joseph S

“…Aberrant activation of fibroblast growth factor receptors (FGFR) contributes to breast cancer growth, progression, and therapeutic resistance. Because of the…”
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FOXO1 binds to the TAU5 motif and inhibits constitutively active androgen receptor splice variants by Bohrer, Laura R., Liu, Ping, Zhong, Jian, Pan, Yunqian, Angstman, James, Brand, Lucas J., Dehm, Scott M., Huang, Haojie

“…BACKGROUND Aberrant activation of the androgen receptor (AR) is a major factor highly relevant to castration‐resistant progression of prostate cancer (PCa)…”
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Epiregulin contributes to breast tumorigenesis through regulating matrix metalloproteinase 1 and promoting cell survival by Farooqui, Mariya, Bohrer, Laura R, Brady, Nicholas J, Chuntova, Pavlina, Kemp, Sarah E, Wardwell, C Taylor, Nelson, Andrew C, Schwertfeger, Kathryn L

“…The epidermal growth factor (EGF) family of ligands has been implicated in promoting breast cancer initiation, growth and progression. The contributions of EGF…”
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